Systems and methods for drug infusion with feedback control
    4.
    发明授权
    Systems and methods for drug infusion with feedback control 失效
    药物输注系统和方法与反馈控制

    公开(公告)号:US07744559B2

    公开(公告)日:2010-06-29

    申请号:US11959143

    申请日:2007-12-18

    Applicant: Suhas Krishna

    Inventor: Suhas Krishna

    Abstract: A system and method for infusing a drug under continuous positive pressure (such as convection enhanced deliver) to a target tissue to be treated is particularly useful for post-resection anticancer drug therapy. The system comprises a drug infusion catheter having an expandable device which is expanded within the target tissue such that the target tissue conforms to an outer surface of the expandable device, thereby creating a form of seal around the target volume in order to maintain an effective drug pressure gradient within the target tissue. The system further comprises a sensor to measure a parameter which can be correlated to the degree of conformance between the target tissue and the outer surface of the expandable device. The sensor is coupled to a feedback control system to determine whether there is a loss of conformance, and to adjust the expansion of the expandable device in order to maintain good conformance.

    Abstract translation: 用于将待治疗的目标组织在连续正压(例如对流增强递送)下输注药物的系统和方法对于切除后抗癌药物治疗特别有用。 该系统包括药物输注导管,其具有在目标组织内扩张的可扩张装置,使得目标组织符合可扩张装置的外表面,由此产生围绕靶体积的密封形式,以便维持有效药物 目标组织内的压力梯度。 该系统还包括用于测量可与目标组织与可扩张装置的外表面之间的一致程度相关的参数的传感器。 传感器耦合到反馈控制系统以确定是否存在一致性的损失,并且调整可扩展装置的扩展以便保持良好的一致性。

    Systems and Methods for Drug Infusion with Feedback Control
    5.
    发明申请
    Systems and Methods for Drug Infusion with Feedback Control 失效
    药物输注系统与方法与反馈控制

    公开(公告)号:US20080146993A1

    公开(公告)日:2008-06-19

    申请号:US11959143

    申请日:2007-12-18

    Applicant: Suhas Krishna

    Inventor: Suhas Krishna

    Abstract: A system and method for infusing a drug under continuous positive pressure (such as convection enhanced deliver) to a target tissue to be treated is particularly useful for post-resection anticancer drug therapy. The system comprises a drug infusion catheter having an expandable device which is expanded within the target tissue such that the target tissue conforms to an outer surface of the expandable device, thereby creating a form of seal around the target volume in order to maintain an effective drug pressure gradient within the target tissue. The system further comprises a sensor to measure a parameter which can be correlated to the degree of conformance between the target tissue and the outer surface of the expandable device. The sensor is coupled to a feedback control system to determine whether there is a loss of conformance, and to adjust the expansion of the expandable device in order to maintain good conformance.

    Abstract translation: 用于将待治疗的目标组织在连续正压(例如对流增强递送)下输注药物的系统和方法对于切除后抗癌药物治疗特别有用。 该系统包括药物输注导管,其具有在目标组织内扩张的可扩张装置,使得目标组织符合可扩张装置的外表面,由此产生围绕靶体积的密封形式,以便维持有效药物 目标组织内的压力梯度。 该系统还包括用于测量可与目标组织与可扩张装置的外表面之间的一致程度相关的参数的传感器。 传感器耦合到反馈控制系统以确定是否存在一致性的损失,并且调整可扩展装置的扩展以便保持良好的一致性。

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