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    Optical reader system for substrates having an optically readable code
    1.
    发明授权
    Optical reader system for substrates having an optically readable code 有权
    具有光学可读代码的基板的光学读取器系统

    公开(公告)号：US08333325B2

    公开(公告)日：2012-12-18

    申请号：US13014298

    申请日：2011-01-26

    申请人： John A. Moon ,  David R. Fournier ,  Martin A. Putnam ,  Alan D Kersey ,  Tuo Li

    发明人： John A. Moon ,  David R. Fournier ,  Martin A. Putnam ,  Alan D Kersey ,  Tuo Li

    IPC分类号： G06K7/10

    CPC分类号： G06K7/12 ,  G06K19/06084 ,  G06K19/06178 ,  G06K2019/06225

    摘要： An optical reader system including a source light assembly that has a code-reading beam and a fluorescence-excitation beam that are configured to illuminate encoded substrates. The substrates have optically readable codes that provide output signals when the code-reading beam is incident thereon. The output signals are indicative of the codes. The reader system also includes a fluorescence detector that is configured to detect fluorescent signals from the substrates and code pickup optics that are configured to project the output signals from the optically readable codes onto a Fourier plane. The reader system also includes a code detector that is positioned to detect the output signals in the Fourier plane.

    摘要翻译： 一种光学读取器系统，包括具有代码读取光束的源光组件和被配置为照亮编码的基板的荧光激发光束。 衬底具有光学可读代码，当代码读取光束入射时，其提供输出信号。 输出信号表示代码。 读取器系统还包括荧光检测器，其被配置为检测来自基板的荧光信号和被配置为将来自光学可读代码的输出信号投影到傅立叶平面上的代码拾取光学器件。 读取器系统还包括代码检测器，其被定位成检测傅立叶平面中的输出信号。

    Optical reader system for substrates having an optically readable code
    2.
    发明授权
    Optical reader system for substrates having an optically readable code 有权
    具有光学可读代码的基板的光学读取器系统

    公开(公告)号：US07900836B2

    公开(公告)日：2011-03-08

    申请号：US12174490

    申请日：2008-07-16

    申请人： John A. Moon ,  David R. Fournier ,  Martin A. Putnam ,  Alan D. Kersey ,  Tuo Li

    发明人： John A. Moon ,  David R. Fournier ,  Martin A. Putnam ,  Alan D. Kersey ,  Tuo Li

    IPC分类号： G06K7/10

    CPC分类号： G06K7/12 ,  G06K19/06084 ,  G06K19/06178 ,  G06K2019/06225

    摘要： An optical reader system that includes a plurality of substrates. The substrates have an optically readable code disposed therein and a source light assembly that is configured to illuminate the substrates with a code-reading beam and another beam for detecting another optically readable property of the substrate. The code-reading beam and the other beam form beam spots on the substrates that have different shapes. The system also includes a reader that is configured to receive output signals from the code-reading beam and the other beam when the substrates are illuminated. The output signals from the code-reading beam are indicative of the code.

    摘要翻译： 一种包括多个基板的光学读取器系统。 基板具有设置在其中的光学可读代码，以及源光组件，其被配置为用代码读取光束照射基板，另一个光束用于检测基板的另一光学可读性。 代码读取光束和另一个光束在具有不同形状的基板上形成光束点。 该系统还包括读取器，其被配置为当基板被照亮时从代码读取光束和另一个光束接收输出信号。 代码读取波束的输出信号表示代码。

    Methods of identifying an analyte and nucleic acid analysis
    3.
    发明授权
    Methods of identifying an analyte and nucleic acid analysis 有权
    识别分析物和核酸分析的方法

    公开(公告)号：US07843567B2

    公开(公告)日：2010-11-30

    申请号：US12644255

    申请日：2009-12-22

    申请人： John A. Moon ,  Alan D. Kersey ,  Martin A. Putnam ,  Tuo Li

    发明人： John A. Moon ,  Alan D. Kersey ,  Martin A. Putnam ,  Tuo Li

    IPC分类号： G01N21/25

    CPC分类号： G01N33/552 ,  G01N21/4788 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/7743 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/54386 ,  G03H1/0005 ,  G03H1/02 ,  G03H1/0236 ,  G03H1/26 ,  G03H2001/0033 ,  G03H2001/0044 ,  G03H2210/53 ,  G03H2210/63 ,  G03H2230/10 ,  G03H2250/12 ,  G06K19/04 ,  G06K19/06009

    摘要： A method of identifying an analyte. The method includes providing a plurality of microparticles. The microparticles have optically detectable codes extending along bodies of the corresponding microparticle. The microparticles have the chemical probes attached thereto. Each of the chemical probes is associated with a corresponding one of the codes. The method also includes selectively binding target analytes to the chemical probes on the microparticles to produce labeled microparticles and distributing the labeled microparticles to random locations of a substrate. The method also includes determining the codes for the labeled microparticles in the random array and code positions of the codes in the random array. The method further includes detecting the label on the labeled microparticles in the random array and label positions of the labels in the random array. The method also includes using the code positions and the label positions to analyze the target analyte.

    摘要翻译： 识别分析物的方法。 该方法包括提供多个微粒。 微粒具有沿相应微粒的主体延伸的光学检测码。 微粒具有附着于其上的化学探针。 每个化学探针与相应的一个代码相关联。 该方法还包括将目标分析物选择性地结合到微粒上的化学探针以产生标记的微粒并将标记的微粒分布到基底的随机位置。 该方法还包括确定随机阵列中的标记微粒的代码和随机阵列中代码的代码位置。 该方法还包括随机阵列中标记的微粒上的标记和随机阵列中的标记的标记位置的检测。 该方法还包括使用代码位置和标签位置来分析目标分析物。

    METHODS OF IDENTIFYING AN ANALYTE AND NUCLEIC ACID ANALYSIS
    4.
    发明申请
    METHODS OF IDENTIFYING AN ANALYTE AND NUCLEIC ACID ANALYSIS 有权
    鉴定分析和核酸分析的方法

    公开(公告)号：US20100099574A1

    公开(公告)日：2010-04-22

    申请号：US12644255

    申请日：2009-12-22

    申请人： JOHN A. MOON ,  ALAN D. KERSEY ,  MARTIN A. PUTNAM ,  TUO LI

    发明人： JOHN A. MOON ,  ALAN D. KERSEY ,  MARTIN A. PUTNAM ,  TUO LI

    IPC分类号： C40B20/02

    CPC分类号： G01N33/552 ,  G01N21/4788 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/7743 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/54386 ,  G03H1/0005 ,  G03H1/02 ,  G03H1/0236 ,  G03H1/26 ,  G03H2001/0033 ,  G03H2001/0044 ,  G03H2210/53 ,  G03H2210/63 ,  G03H2230/10 ,  G03H2250/12 ,  G06K19/04 ,  G06K19/06009

    摘要： A method of identifying an analyte. The method includes providing a plurality of microparticles. The microparticles have optically detectable codes extending along bodies of the corresponding microparticle. The microparticles have the chemical probes attached thereto. Each of the chemical probes is associated with a corresponding one of the codes. The method also includes selectively binding target analytes to the chemical probes on the microparticles to produce labeled microparticles and distributing the labeled microparticles to random locations of a substrate. The method also includes determining the codes for the labeled microparticles in the random array and code positions of the codes in the random array. The method further includes detecting the label on the labeled microparticles in the random array and label positions of the labels in the random array. The method also includes using the code positions and the label positions to analyze the target analyte.

    摘要翻译： 识别分析物的方法。 该方法包括提供多个微粒。 微粒具有沿相应微粒的主体延伸的光学检测码。 微粒具有附着于其上的化学探针。 每个化学探针与相应的一个代码相关联。 该方法还包括将目标分析物选择性地结合到微粒上的化学探针以产生标记的微粒并将标记的微粒分布到基底的随机位置。 该方法还包括确定随机阵列中的标记微粒的代码和随机阵列中代码的代码位置。 该方法还包括随机阵列中标记的微粒上的标记和随机阵列中的标记的标记位置的检测。 该方法还包括使用代码位置和标签位置来分析目标分析物。

    Multifunctional neck brace
    5.
    发明申请
    Multifunctional neck brace 审中-公开
    多功能颈部支架

    公开(公告)号：US20080004556A1

    公开(公告)日：2008-01-03

    申请号：US11798041

    申请日：2007-05-09

    申请人： Peter Gehlbach ,  Brian Benson ,  Helena Cortes ,  Michael Davenport ,  Ryan Harrison ,  Karin Hwang ,  Gregory Kapp ,  Christopher Lee ,  Joshua Lerman ,  Tuo Li ,  Johnson Wong

    发明人： Peter Gehlbach ,  Brian Benson ,  Helena Cortes ,  Michael Davenport ,  Ryan Harrison ,  Karin Hwang ,  Gregory Kapp ,  Christopher Lee ,  Joshua Lerman ,  Tuo Li ,  Johnson Wong

    IPC分类号： A61F5/055

    CPC分类号： A61F5/055

    摘要： A cervical collar that allows varying mobility to the cervical region with the range of motion or degree of mobility being adjustable and quantifiable. The customizable collar having adjustable and quantifiable mobility allows not only graduated mobility for the patient and consequently progressive strengthening but still protects the injured or diseased cervical segments. The cervical collar may also provide a user-defined and adjustable distraction force that in the medical setting allows physicians or rehabilitating specialists to adjust, graduate and monitor the amount of distraction force being applied to the cervical column. In a home use setting, patients are able to select a comfortable amount of force to counter the weight of the head. In addition to graduated rotation and/or an adjustable distraction force, a minimalist cervical collar configuration is provided that is less obtrusive, less conspicuous, light weight and can be worn in part under clothing.

    摘要翻译： 一个可以调节和量化的运动范围或移动程度的颈椎区域可以使颈椎区域变化的颈圈。 具有可调节和可定量的移动性的可定制衣领不仅允许患者的渐进移动性，并且因此逐渐增强，但仍保护受伤或患病的子宫颈节段。 颈环还可以提供用户定义和可调节的牵引力，其在医疗设置中允许医师或康复专家调整，研究和监测施加到颈椎柱的牵引力的量。 在家庭使用环境中，患者能够选择舒适的力量来抵抗头部的重量。 除了刻度旋转和/或可调节的牵引力之外，还提供了一种极简主义的颈环结构，其较少突出，不显眼，重量轻并且可以部分穿在衣服下。

    Multi-well plate with alignment grooves for encoded microparticles
    7.
    发明申请
    Multi-well plate with alignment grooves for encoded microparticles 审中-公开
    具有用于编码微粒的对准槽的多孔板

    公开(公告)号：US20060160208A1

    公开(公告)日：2006-07-20

    申请号：US11063665

    申请日：2005-02-22

    申请人： Martin Putnam ,  James Sirkis ,  John Moon ,  Tuo Li ,  Joseph Traynor ,  Robert Brucato

    发明人： Martin Putnam ,  James Sirkis ,  John Moon ,  Tuo Li ,  Joseph Traynor ,  Robert Brucato

    IPC分类号： C12M1/34 ,  G06K7/00 ,  G01N33/551 ,  C12M3/00

    CPC分类号： G01N33/54313 ,  G01N33/54393

    摘要： A method and apparatus are provided for aligning optical elements or microbeads, wherein each microbead has an elongated body with a code embedded therein along a longitudinal axis thereof to be read by a code reading device. The microbeads are aligned with a positioning device so the longitudinal axis of the microbeads is positioned in a fixed orientation relative to the code reading device. The microbeads are typically cylindrically shaped glass beads between 25 and 250 microns (μm) in diameter and between 100 and 500 μm long, and have a holographic code embedded in the central region of the bead, which is used to identify it from the rest of the beads in a batch of beads with many different chemical probes. A cross reference is used to determine which probe is attached to which bead, thus allowing the researcher to correlate the chemical content on each bead with the measured fluorescence signal. Because the code consists of a diffraction grating typically disposed along an axis, there is a particular alignment required between the incident readout laser beam and the readout detector in two of the three rotational axes. The third axis, rotation about the center axis of the cylinder, is azimuthally symmetric and therefore does not require alignment.

    摘要翻译： 提供了一种用于对准光学元件或微珠的方法和装置，其中每个微珠具有细长体，其沿着其纵向轴线嵌入其中的代码，以被代码读取装置读取。 微珠与定位装置对准，使得微珠的纵向轴线相对于代码读取装置定位成固定的取向。 微珠通常为直径为25至250微米（母体）和长度为100至500毫米的圆柱形玻璃珠，并且具有嵌入珠的中心区域中的全息代码，其用于从其余部分识别它 珠子中有一批具有许多不同化学探针的珠粒。 交叉参考用于确定哪个探针连接到哪个珠，从而允许研究者将每个珠上的化学成分与测量的荧光信号相关联。 由于代码由通常沿轴线设置的衍射光栅组成，所以在三个旋转轴中的两个中存在入射读出激光束和读出检测器之间所需的特定对准。 第三轴，围绕气缸的中心轴的旋转是方位对称的，因此不需要对准。

    OPTICAL READER SYSTEM FOR SUBSTRATES HAVING AN OPTICALLY READABLE CODE
    8.
    发明申请
    OPTICAL READER SYSTEM FOR SUBSTRATES HAVING AN OPTICALLY READABLE CODE 有权
    具有光学可读代码的基板的光学读取器系统

    公开(公告)号：US20090194589A1

    公开(公告)日：2009-08-06

    申请号：US12174490

    申请日：2008-07-16

    申请人： JOHN A. MOON ,  DAVID R. FOURNIER ,  MARTIN A. PUTNAM ,  ALAN D. KERSEY ,  TUO LI

    发明人： JOHN A. MOON ,  DAVID R. FOURNIER ,  MARTIN A. PUTNAM ,  ALAN D. KERSEY ,  TUO LI

    IPC分类号： G06K7/10

    CPC分类号： G06K7/12 ,  G06K19/06084 ,  G06K19/06178 ,  G06K2019/06225

    摘要： An optical reader system that includes a plurality of substrates. The substrates have an optically readable code disposed therein and a source light assembly that is configured to illuminate the substrates with a code-reading beam and another beam for detecting another optically readable property of the substrate. The code-reading beam and the other beam form beam spots on the substrates that have different shapes. The system also includes a reader that is configured to receive output signals from the code-reading beam and the other beam when the substrates are illuminated. The output signals from the code-reading beam are indicative of the code.

    摘要翻译： 一种包括多个基板的光学读取器系统。 基板具有设置在其中的光学可读代码，以及源光组件，其被配置为用代码读取光束照射基板，另一个光束用于检测基板的另一光学可读性。 代码读取光束和另一个光束在具有不同形状的基板上形成光束点。 该系统还包括读取器，其被配置为当基板被照亮时从代码读取光束和另一个光束接收输出信号。 代码读取波束的输出信号表示代码。