公开(公告)号：US08565475B2

公开(公告)日：2013-10-22

申请号：US13243422

申请日：2011-09-23

Applicant: John A. Moon ,  Martin A. Putnam

Inventor： John A. Moon ,  Martin A. Putnam

IPC: G06K9/00 ,  G06K5/00

CPC classification number: G06K7/10821 ,  B01J2219/00459 ,  B01J2219/005 ,  B01J2219/00704 ,  B82Y20/00 ,  G01N15/1468 ,  G02B1/005 ,  G06E3/005 ,  G06K7/10722

Abstract: An optical system for reading encoded microbeads. The microbeads provide output light signals onto a Fourier plane when illuminated by an incident light. The system includes an input light source that is configured to illuminate the microbeads thereby providing the output light signals. The output light signals are configured to be projected onto the Fourier plane in a readable manner. The system also includes a reading device that is positioned to detect the output light signals from the Fourier plane. The system also includes a processor that is configured to perform Fourier plane analysis of the optical light signals to determine corresponding codes of the microbeads.

Abstract translation: 用于读取编码微珠的光学系统。 当由入射光照射时，微珠将输出光信号提供到傅立叶平面上。 该系统包括被配置为照亮微珠从而提供输出光信号的输入光源。 输出光信号被配置为以可读方式投影到傅立叶平面上。 该系统还包括读取装置，其被定位成检测来自傅里叶平面的输出光信号。 该系统还包括处理器，其被配置为对光信号进行傅立叶平面分析以确定微珠的相应代码。

公开(公告)号：US08333325B2

公开(公告)日：2012-12-18

申请号：US13014298

申请日：2011-01-26

Applicant: John A. Moon ,  David R. Fournier ,  Martin A. Putnam ,  Alan D Kersey ,  Tuo Li

Inventor： John A. Moon ,  David R. Fournier ,  Martin A. Putnam ,  Alan D Kersey ,  Tuo Li

IPC: G06K7/10

CPC classification number: G06K7/12 ,  G06K19/06084 ,  G06K19/06178 ,  G06K2019/06225

Abstract: An optical reader system including a source light assembly that has a code-reading beam and a fluorescence-excitation beam that are configured to illuminate encoded substrates. The substrates have optically readable codes that provide output signals when the code-reading beam is incident thereon. The output signals are indicative of the codes. The reader system also includes a fluorescence detector that is configured to detect fluorescent signals from the substrates and code pickup optics that are configured to project the output signals from the optically readable codes onto a Fourier plane. The reader system also includes a code detector that is positioned to detect the output signals in the Fourier plane.

Abstract translation: 一种光学读取器系统，包括具有代码读取光束的源光组件和被配置为照亮编码的基板的荧光激发光束。 衬底具有光学可读代码，当代码读取光束入射时，其提供输出信号。 输出信号表示代码。 读取器系统还包括荧光检测器，其被配置为检测来自基板的荧光信号和被配置为将来自光学可读代码的输出信号投影到傅立叶平面上的代码拾取光学器件。 读取器系统还包括代码检测器，其被定位成检测傅立叶平面中的输出信号。

公开(公告)号：US20110105361A1

公开(公告)日：2011-05-05

申请号：US12916242

申请日：2010-10-29

Applicant: JOHN A. MOON ,  M. SHANE BOWEN ,  RYAN C. SMITH ,  MICHEL PERBOST ,  MICHAL LEBL ,  STEVEN H. MODIANO

Inventor： JOHN A. MOON ,  M. SHANE BOWEN ,  RYAN C. SMITH ,  MICHEL PERBOST ,  MICHAL LEBL ,  STEVEN H. MODIANO

IPC: C40B30/10 ,  C40B40/00

CPC classification number: G01N33/50 ,  B01J19/0046 ,  B01J2219/00306 ,  B01J2219/00511 ,  B01J2219/0052 ,  B01J2219/00524 ,  B01J2219/00545 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00673 ,  B01J2219/00702 ,  B01J2219/0072 ,  B01L3/502761 ,  B01L3/5082 ,  B01L3/50857 ,  B01L3/5088 ,  B01L3/545 ,  C40B20/04 ,  G01N21/01 ,  G01N21/253 ,  G01N21/6452 ,  G01N35/00732

Abstract: A method of reading a plurality of encoded microvessels used in an assay for biological or chemical analysis. The method can include providing a plurality of encoded microvessels. The microvessels can include a respective microbody and a reservoir core configured to hold a substance in the reservoir core. The microbody can include a material that surrounds the reservoir core and facilitates detection of a characteristic of the substance within the reservoir core. Optionally, the material can be transparent so as to facilitate detection of an optical characteristic of a substance within the reservoir core. The microbody can include an identifiable code associated with the substance. The method can also include determining the corresponding codes of the microvessels.

Abstract translation: 读取用于生物或化学分析的测定中使用的多个编码微血管的方法。 该方法可以包括提供多个编码微血管。 微血管可以包括相应的微体和被配置为将物质保持在储存器芯中的储存器芯。 微体可以包括围绕储存器芯的材料，并且有助于检测储存器芯内物质的特性。 任选地，材料可以是透明的，以便于检测储存器芯内的物质的光学特性。 微体可以包括与物质相关联的可识别代码。 该方法还可以包括确定微血管的相应代码。

公开(公告)号：US07900836B2

公开(公告)日：2011-03-08

申请号：US12174490

申请日：2008-07-16

Applicant: John A. Moon ,  David R. Fournier ,  Martin A. Putnam ,  Alan D. Kersey ,  Tuo Li

Inventor： John A. Moon ,  David R. Fournier ,  Martin A. Putnam ,  Alan D. Kersey ,  Tuo Li

IPC: G06K7/10

CPC classification number: G06K7/12 ,  G06K19/06084 ,  G06K19/06178 ,  G06K2019/06225

Abstract: An optical reader system that includes a plurality of substrates. The substrates have an optically readable code disposed therein and a source light assembly that is configured to illuminate the substrates with a code-reading beam and another beam for detecting another optically readable property of the substrate. The code-reading beam and the other beam form beam spots on the substrates that have different shapes. The system also includes a reader that is configured to receive output signals from the code-reading beam and the other beam when the substrates are illuminated. The output signals from the code-reading beam are indicative of the code.

Abstract translation: 一种包括多个基板的光学读取器系统。 基板具有设置在其中的光学可读代码，以及源光组件，其被配置为用代码读取光束照射基板，另一个光束用于检测基板的另一光学可读性。 代码读取光束和另一个光束在具有不同形状的基板上形成光束点。 该系统还包括读取器，其被配置为当基板被照亮时从代码读取光束和另一个光束接收输出信号。 代码读取波束的输出信号表示代码。

公开(公告)号：US07843567B2

公开(公告)日：2010-11-30

申请号：US12644255

申请日：2009-12-22

Applicant: John A. Moon ,  Alan D. Kersey ,  Martin A. Putnam ,  Tuo Li

Inventor： John A. Moon ,  Alan D. Kersey ,  Martin A. Putnam ,  Tuo Li

IPC: G01N21/25

CPC classification number: G01N33/552 ,  G01N21/4788 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/7743 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/54386 ,  G03H1/0005 ,  G03H1/02 ,  G03H1/0236 ,  G03H1/26 ,  G03H2001/0033 ,  G03H2001/0044 ,  G03H2210/53 ,  G03H2210/63 ,  G03H2230/10 ,  G03H2250/12 ,  G06K19/04 ,  G06K19/06009

Abstract: A method of identifying an analyte. The method includes providing a plurality of microparticles. The microparticles have optically detectable codes extending along bodies of the corresponding microparticle. The microparticles have the chemical probes attached thereto. Each of the chemical probes is associated with a corresponding one of the codes. The method also includes selectively binding target analytes to the chemical probes on the microparticles to produce labeled microparticles and distributing the labeled microparticles to random locations of a substrate. The method also includes determining the codes for the labeled microparticles in the random array and code positions of the codes in the random array. The method further includes detecting the label on the labeled microparticles in the random array and label positions of the labels in the random array. The method also includes using the code positions and the label positions to analyze the target analyte.

Abstract translation: 识别分析物的方法。 该方法包括提供多个微粒。 微粒具有沿相应微粒的主体延伸的光学检测码。 微粒具有附着于其上的化学探针。 每个化学探针与相应的一个代码相关联。 该方法还包括将目标分析物选择性地结合到微粒上的化学探针以产生标记的微粒并将标记的微粒分布到基底的随机位置。 该方法还包括确定随机阵列中的标记微粒的代码和随机阵列中代码的代码位置。 该方法还包括随机阵列中标记的微粒上的标记和随机阵列中的标记的标记位置的检测。 该方法还包括使用代码位置和标签位置来分析目标分析物。

公开(公告)号：US07791802B2

公开(公告)日：2010-09-07

申请号：US12144209

申请日：2008-06-23

Applicant: Martin A. Putnam ,  John A. Moon

Inventor： Martin A. Putnam ,  John A. Moon

IPC: G02B5/18

CPC classification number: G02B6/021 ,  G06K19/06018 ,  G06K19/06046

Abstract: An optical identification element including a non-waveguide optical substrate. The optical substrate has a volume and includes an inner region surrounded by an outer region. The inner region has an index of refraction that prevents the optical substrate from forming an optical waveguide. The optical substrate includes a diffraction grating within the volume, and the grating provides an output signal indicative of a code when illuminated by an incident light.

Abstract translation: 一种包括非波导光学基片的光学识别元件。 光学基板具有体积并且包括被外部区域包围的内部区域。 内部区域具有防止光学基板形成光波导的折射率。 光学基板包括体积内的衍射光栅，并且当由入射光照射时，光栅提供指示代码的输出信号。

公开(公告)号：US20100099574A1

公开(公告)日：2010-04-22

申请号：US12644255

申请日：2009-12-22

Applicant: JOHN A. MOON ,  ALAN D. KERSEY ,  MARTIN A. PUTNAM ,  TUO LI

Inventor： JOHN A. MOON ,  ALAN D. KERSEY ,  MARTIN A. PUTNAM ,  TUO LI

IPC: C40B20/02

CPC classification number: G01N33/552 ,  G01N21/4788 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/7743 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/54386 ,  G03H1/0005 ,  G03H1/02 ,  G03H1/0236 ,  G03H1/26 ,  G03H2001/0033 ,  G03H2001/0044 ,  G03H2210/53 ,  G03H2210/63 ,  G03H2230/10 ,  G03H2250/12 ,  G06K19/04 ,  G06K19/06009

Abstract: A method of identifying an analyte. The method includes providing a plurality of microparticles. The microparticles have optically detectable codes extending along bodies of the corresponding microparticle. The microparticles have the chemical probes attached thereto. Each of the chemical probes is associated with a corresponding one of the codes. The method also includes selectively binding target analytes to the chemical probes on the microparticles to produce labeled microparticles and distributing the labeled microparticles to random locations of a substrate. The method also includes determining the codes for the labeled microparticles in the random array and code positions of the codes in the random array. The method further includes detecting the label on the labeled microparticles in the random array and label positions of the labels in the random array. The method also includes using the code positions and the label positions to analyze the target analyte.

Abstract translation: 识别分析物的方法。 该方法包括提供多个微粒。 微粒具有沿相应微粒的主体延伸的光学检测码。 微粒具有附着于其上的化学探针。 每个化学探针与相应的一个代码相关联。 该方法还包括将目标分析物选择性地结合到微粒上的化学探针以产生标记的微粒并将标记的微粒分布到基底的随机位置。 该方法还包括确定随机阵列中的标记微粒的代码和随机阵列中代码的代码位置。 该方法还包括随机阵列中标记的微粒上的标记和随机阵列中的标记的标记位置的检测。 该方法还包括使用代码位置和标签位置来分析目标分析物。

公开(公告)号：US20090034078A1

公开(公告)日：2009-02-05

申请号：US12144209

申请日：2008-06-23

Applicant: Martin A. Putnam ,  John A. Moon

Inventor： Martin A. Putnam ,  John A. Moon

IPC: G02B5/18 ,  G06K19/06

CPC classification number: G02B6/021 ,  G06K19/06018 ,  G06K19/06046

Abstract: An optical identification element including a non-waveguide optical substrate. The optical substrate has a volume and includes an inner region surrounded by an outer region. The inner region has an index of refraction that prevents the optical substrate from forming an optical waveguide. The optical substrate includes a diffraction grating within the volume, and the grating provides an output signal indicative of a code when illuminated by an incident light.

Abstract translation: 一种包括非波导光学基片的光学识别元件。 光学基板具有体积并且包括被外部区域包围的内部区域。 内部区域具有防止光学基板形成光波导的折射率。 光学基板包括体积内的衍射光栅，并且当由入射光照射时，光栅提供指示代码的输出信号。

公开(公告)号：US07126740B2

公开(公告)日：2006-10-24

申请号：US10353772

申请日：2003-01-28

Applicant: Paul Szczepanek ,  John A. Moon ,  Alan D. Kersey ,  James S. Sirkis ,  James R. Dunphy ,  Joseph Pinto ,  Christian O'Keefe ,  Michael A. Davis

Inventor： Paul Szczepanek ,  John A. Moon ,  Alan D. Kersey ,  James S. Sirkis ,  James R. Dunphy ,  Joseph Pinto ,  Christian O'Keefe ,  Michael A. Davis

IPC: G02B26/00

CPC classification number: H04J14/0221 ,  G02B6/262 ,  G02B6/264 ,  G02B6/266 ,  G02B6/29383 ,  G02B6/3516 ,  G02B6/3546 ,  G02B6/356 ,  G02B6/4215 ,  G02B6/4226 ,  G02B26/0833 ,  G02B26/0841 ,  G02B27/1086 ,  H04B10/00 ,  H04J14/0208 ,  H04J14/021 ,  H04J14/0212 ,  H04J14/0213 ,  H04Q2011/0009 ,  H04Q2011/0018 ,  H04Q2011/0026

Abstract: A reconfigurable multifunctional optical device has an optical arrangement for receiving an optical signal, each having optical bands or channels, and a spatial light modulator for reflecting the at least one optical signal provided thereon. The optical arrangement features a free optics configuration with a light dispersion element for spreading each optical signal into one or more respective optical bands or channels for performing separate optical functions on each optical signal. The spatial light modulator includes a micro-mirror device with an array of micro-mirrors, and the respective optical bands or channels reflect off respective micro-mirrors. The free optics configuration includes a common set of optical components for performing each separate optical function on each optical signal. The separate optical functions reflect off separate non-overlapping areas on the spatial light modulator. The separate optical functions include optical switching, conditioning or monitoring functions.

Abstract translation: 可重新配置的多功能光学装置具有用于接收光信号的光学装置，每个光信号具有光带或通道，以及用于反射其上提供的至少一个光信号的空间光调制器。 光学布置具有光学配置，其具有光色散元件，用于将每个光信号扩展到一个或多个相应的光带或通道中，用于在每个光信号上执行分离的光学功能。 空间光调制器包括具有微镜阵列的微镜装置，并且相应的光带或通道反射出各自的微镜。 自由光学配置包括用于在每个光信号上执行每个单独光学功能的一组共同的光学部件。 分离的光学功能反射在空间光调制器上的单独的非重叠区域。 独立的光学功能包括光学切换，调理或监视功能。

公开(公告)号：USH2045H2

公开(公告)日：2002-09-03

申请号：US08848623

申请日：1997-04-29

Applicant: Lynda E. Busse ,  Ishwar D. Aggarwal ,  John A. Moon

Inventor： Lynda E. Busse ,  Ishwar D. Aggarwal ,  John A. Moon

IPC: G02B626

Abstract: A method and apparatus for reducing points of zero intensity, i.e. speckle pattern, emerging from a multimode fiber. The apparatus comprises a beam deflector for rotating an input beam in a conical shape around a launch lens for projecting the beam into the fiber. The rotation of the beam further incorporates the use of two tilting mirrors being 90° out of phase to ensure a conical rotation. The conical rotation of the beam deflector ensures that the lens aberrations, which are rotationally symmetric, do not play a factor in beam alignment into the fiber aperture.