公开(公告)号：US20130143229A1

公开(公告)日：2013-06-06

申请号：US13638622

申请日：2011-03-31

申请人： Yasuyuki Hara ,  Tetsuya Ota ,  Michiko Kawamoto ,  Shinya Sato ,  Shigehisa Iwamoto ,  Tatsuro Shimaoka ,  Shigeo Sudo

发明人： Yasuyuki Hara ,  Tetsuya Ota ,  Michiko Kawamoto ,  Shinya Sato ,  Shigehisa Iwamoto ,  Tatsuro Shimaoka ,  Shigeo Sudo

IPC分类号： C07K14/20 ,  G01N33/68

CPC分类号： C07K14/20 ,  G01N33/545 ,  G01N33/571 ,  G01N33/6854 ,  G01N2333/20 ,  G01N2469/20

摘要： To provide a reagent for assaying anti-Treponema pallidum antibody which reagent contains a polypeptide antigen and which reagent provides high assay sensitivity and high specificity, and to provide an assay method employing the assay reagent.The reagent for assaying anti-Treponema pallidum antibody, for use in an assay of anti-Treponema pallidum antibody on the basis of antigen-antibody reaction is characterized in that the reagent contains, as an antigen, a recombinant polypeptide containing at least domain C and domain D of Treponema pallidum 47 kDa antigen but containing no domain A1 of the 47 kDa antigen.

摘要翻译： 提供用于测定抗梅毒螺旋体抗体的试剂，该试剂含有多肽抗原，该试剂提供高测定灵敏度和高特异性，并提供使用测定试剂的测定方法。 基于抗原 - 抗体反应用于测定抗梅毒螺旋体抗体的抗梅毒螺旋体抗体的试剂的特征在于，所述试剂含有至少含有结构域C和 梅毒螺旋体47kDa抗原的结构域D，但不包含47kDa抗原的结构域A1。

公开(公告)号：US08969520B2

公开(公告)日：2015-03-03

申请号：US13638622

申请日：2011-03-31

申请人： Yasuyuki Hara ,  Tetsuya Ota ,  Michiko Kawamoto ,  Shinya Sato ,  Shigehisa Iwamoto ,  Tatsuro Shimaoka ,  Shigeo Sudo

发明人： Yasuyuki Hara ,  Tetsuya Ota ,  Michiko Kawamoto ,  Shinya Sato ,  Shigehisa Iwamoto ,  Tatsuro Shimaoka ,  Shigeo Sudo

IPC分类号： C07K14/20 ,  G01N33/571 ,  G01N33/545 ,  A61K39/02 ,  G01N33/68

CPC分类号： C07K14/20 ,  G01N33/545 ,  G01N33/571 ,  G01N33/6854 ,  G01N2333/20 ,  G01N2469/20

摘要： To provide a reagent for assaying anti-Treponema pallidum antibody which reagent contains a polypeptide antigen and which reagent provides high assay sensitivity and high specificity, and to provide an assay method employing the assay reagent.The reagent for assaying anti-Treponema pallidum antibody, for use in an assay of anti-Treponema pallidum antibody on the basis of antigen-antibody reaction is characterized in that the reagent contains, as an antigen, a recombinant polypeptide containing at least domain C and domain D of Treponema pallidum 47 kDa antigen but containing no domain A1 of the 47 kDa antigen.

摘要翻译： 提供用于测定抗梅毒螺旋体抗体的试剂，该试剂含有多肽抗原，该试剂提供高测定灵敏度和高特异性，并提供使用测定试剂的测定方法。 基于抗原 - 抗体反应用于测定抗梅毒螺旋体抗体的抗梅毒螺旋体抗体的试剂的特征在于，所述试剂含有至少含有结构域C和 梅毒螺旋体47kDa抗原的结构域D，但不包含47kDa抗原的结构域A1。

公开(公告)号：US5439827A

公开(公告)日：1995-08-08

申请号：US148321

申请日：1993-11-08

申请人： Yuji Yagi ,  Tamaki Kagawa ,  Hiroshi Tamura ,  Tetsuya Ota

发明人： Yuji Yagi ,  Tamaki Kagawa ,  Hiroshi Tamura ,  Tetsuya Ota

IPC分类号： C12Q1/26 ,  C12Q1/28 ,  G01N31/00 ,  G01N31/22 ,  G01N33/72 ,  G01N33/82 ,  G01N21/75

CPC分类号： G01N33/82 ,  C12Q1/26 ,  C12Q1/28 ,  G01N33/725 ,  C12Q2326/12 ,  Y10T436/144444 ,  Y10T436/25125

摘要： A composition for detecting or quantitatively measuring a peroxide active material in a sample, containing an organic hydroperoxide, a chromogen, and an iron (111) complex of the formula: [(OOC-X-COO).sub.3 Fe]M.sub.3 in which X is an alkylene group:-(CH.sub.2).sub.n - (n=0-5) or an allyl group, and M is a monovalent cation, which can eliminate the influence of reducing compounds such as ascorbic acid contained in the sample.

摘要翻译： 一种用于检测或定量测量样品中过氧化物活性物质的组合物，其含有下式的有机氢过氧化物，色原和铁（111）络合物：其中X为 亚烷基： - （CH 2）n - （n = 0-5）或烯丙基，M是一价阳离子，其可以消除样品中所含的还原化合物如抗坏血酸的影响。

公开(公告)号：US20130029429A1

公开(公告)日：2013-01-31

申请号：US13638724

申请日：2011-03-31

申请人： Takayuki Abe ,  Yuki Takahashi ,  Tetsuya Ota

发明人： Takayuki Abe ,  Yuki Takahashi ,  Tetsuya Ota

IPC分类号： G01N33/53

CPC分类号： G01N33/54393 ,  G01N1/34 ,  G01N33/57434 ,  G01N33/92 ,  G01N2333/4718 ,  G01N2333/96455 ,  G01N2405/04

摘要： To identify the aforementioned interference component present in serum or plasma, to thereby provide means for avoiding any interference effect caused by the component.

摘要翻译： 鉴定血清或血浆中存在的上述干扰成分，从而提供避免由该成分引起的干扰作用的手段。

公开(公告)号：US20130023061A1

公开(公告)日：2013-01-24

申请号：US13638780

申请日：2011-03-31

申请人： Takayuki Abe ,  Tetsuya Ota

发明人： Takayuki Abe ,  Tetsuya Ota

IPC分类号： G01N21/75

CPC分类号： G01N33/564 ,  G01N33/54393 ,  G01N33/571 ,  G01N33/92 ,  G01N2405/04 ,  G01N2405/06

摘要： Disclosed is an accurate and stable immunoassay reagent using a glycerophospholipid and a method for stabilizing the reagent. The reagent for assaying an analyte in blood by immune reaction with an antigen when the analyte is an antibody or with an antibody when the analyte is an antigen, wherein a glycerophospholipid and a polyvinylpyrrolidone are incorporated into the immune reaction system.

摘要翻译： 公开了使用甘油磷脂的精确稳定的免疫测定试剂和稳定试剂的方法。 当分析物是抗体时或与分析物为抗原时的抗体通过与抗原的免疫反应来测定血液中的分析物的试剂，其中将甘油磷脂和聚乙烯吡咯烷酮引入到免疫反应系统中。

公开(公告)号：US20110263048A1

公开(公告)日：2011-10-27

申请号：US13128718

申请日：2009-11-12

申请人： Takayuki Akamine ,  Shinichiro Kitahara ,  Tetsuya Ota ,  Takayuki Abe

发明人： Takayuki Akamine ,  Shinichiro Kitahara ,  Tetsuya Ota ,  Takayuki Abe

IPC分类号： G01N33/543

CPC分类号： G01N33/54313 ,  G01N33/544 ,  G01N33/6854

摘要： The present invention has an object to provide an insoluble carrier for an antiphospholipid antibody detection reagent having a high reactivity. The present invention also has an object to provide an antiphospholipid antibody detection reagent, and a method of detecting an antiphospholipid antibody. The present invention directs to an insoluble carrier for an antiphospholipid antibody detection reagent, having a zeta potential of lower than −45 mV in the case that the insoluble carrier is suspended in a 20 mmol/L aqueous sodium phosphate solution with a pH of 7.4 so that the resulting suspension has a solids concentration of 0.1%.

摘要翻译： 本发明的目的是提供具有高反应性的抗磷脂抗体检测试剂的不溶性载体。 本发明的目的还在于提供抗磷脂抗体检测试剂和检测抗磷脂抗体的方法。 在不溶性载体悬浮于pH7.4的20mmol / L磷酸钠水溶液的情况下，本发明指出了抗磷脂抗体检测试剂的不溶性载体，其具有低于-45mV的ζ电位 所得悬浮液的固体浓度为0.1％。

公开(公告)号：US20090246884A1

公开(公告)日：2009-10-01

申请号：US12086082

申请日：2006-12-07

申请人： Takayuki Akamine ,  Tetsuya Ota ,  Yan Li

发明人： Takayuki Akamine ,  Tetsuya Ota ,  Yan Li

IPC分类号： G01N33/566

CPC分类号： G01N33/571 ,  G01N2333/20 ,  G01N2469/20

摘要： It is an object of the present invention to provide a reagent for assaying anti-phospholipid antibodies, which is excellent in long-term storage stability and enables an accurate diagnosis of syphilitic infection, and a reagent for assaying anti-Treponema pallidum antibodies, which enables an accurate diagnosis of syphilitic infection by preventing an occurrence of serum interference.The present invention is a reagent for assaying anti-phospholipid antibodies used for diagnosing syphilitic infection, which contains an insoluble carrier supporting an anti-phospholipid antigen thereon and a copolymer having a segment derived from 2-methacryloyloxyethyl phosphorylcholine and having a segment derived from a hydrophilic monomer.

摘要翻译： 本发明的目的是提供一种用于测定抗磷脂抗体的试剂，其具有优异的长期保存稳定性并且能够准确诊断梅毒感染，以及用于测定抗梅毒螺旋体抗体的试剂，其使得能够 通过预防血清干扰的发生准确诊断梅毒感染。 本发明是用于测定用于诊断梅毒感染的抗磷脂抗体的试剂，其含有支持其上的抗磷脂抗原的不溶性载体和具有源自2-甲基丙烯酰氧基乙基磷酸胆碱的区段并具有衍生自亲水性的区段的共聚物 单体。