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1.发明公开公开(公告)号：US20240342139A1
公开(公告)日：2024-10-17
申请号：US18615330
申请日：2024-03-25
发明人： Brian Kraemer
IPC分类号： A61K31/429 , A61P25/28 , C07C317/14 , C07D231/14 , C07D277/40 , C07D277/60 , C07D403/06 , C07D409/06 , C07D513/04 , C07D513/10 , C07D513/14
CPC分类号： A61K31/429 , A61P25/28 , C07C317/14 , C07D231/14 , C07D277/40 , C07D277/60 , C07D403/06 , C07D409/06 , C07D513/04 , C07D513/10 , C07D513/14
摘要： The present disclosure is concerned with substituted thiochromenothiazole compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds in the treatment of neurodegenerative disorders associated with dysregulation of MSUT2 signaling such as, for example, amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), motor neuron disease, ataxia, progressive supranuclear palsy (PSP), multiple system atrophy, corticobasal degeneration (CBD), argyrophilic grain disease (AGD), Pick's disease (PiD), dementia, Huntington's disease (HD), primary age-related tauopathy (PART), and aging-related tau astrogliopathy (ARTAG). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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2.发明公开公开(公告)号：US20240335503A1
公开(公告)日：2024-10-10
申请号：US18579252
申请日：2022-07-15
发明人： Andrew Tan
摘要： The invention generally relates to methods of treating spasticity and/or neuropathic pain using known romidepsin and pharmaceutical compositions comprising same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20240287175A1
公开(公告)日：2024-08-29
申请号：US18526952
申请日：2023-12-01
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
发明人： Anton Wyss-Coray , John Vincent Pluvinage , Michael C. Bassik , Michael Haney , Benjamin Smith , Carolyn Bertozzi
IPC分类号： C07K16/28 , A61K38/47 , A61K39/00 , A61K39/395 , A61K47/68 , A61M25/00 , A61P25/28 , C12N9/24
CPC分类号： C07K16/2803 , A61K38/47 , A61K39/001113 , A61K39/3955 , A61K47/6815 , A61K47/6849 , A61P25/28 , C12N9/2402 , C12Y302/01018 , A61K2039/505 , A61M25/0097 , C07K2317/76 , C07K2317/77
摘要： Provided herein are compositions, methods, kits and systems for treating cells, tissues and subjects to alter age-related biology (e.g., to study or to treat age-related diseases and conditions). In particular, provided herein are compositions, methods, and uses for inhibition or modification of sialic acid or its cognate receptor to restore phagocytosis in aged cells.
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公开(公告)号：US20240239913A1
公开(公告)日：2024-07-18
申请号：US18411242
申请日：2024-01-12
申请人： The United States Government As Represented By The Department Of Veterans Affairs , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , OKLAHOMA MEDICAL RESEARCH FOUNDATION
CPC分类号： C07K16/2896 , A61P19/02 , C07K14/7455 , C12N9/12 , A61K38/00 , A61K2039/505 , C12Y207/12002
摘要： Disclosed herein are methods of treating or preventing the development of osteoarthritis after a joint injury by administering a CD14 inhibitor capable of neutralizing or blocking CD14, inhibiting CD14 function, inhibiting CD14 production, or a combination thereof. Also disclosed herein are methods of reducing or ameliorating one or more symptoms of osteoarthritis, reducing inflammation, reducing cartilage degradation, or treating or preventing subchondral bone sclerosis in a subject.
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公开(公告)号：US20240207491A1
公开(公告)日：2024-06-27
申请号：US18380135
申请日：2023-10-13
申请人： VANDERBILT UNIVERSITY , THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
发明人： Timothy C. Boire , Hak-Joon Sung , Colleen Brophy
CPC分类号： A61L31/06 , A61F2/07 , A61F2/90 , A61L31/041 , A61L31/16 , C08G63/08 , A61L2400/16
摘要： The presently-disclosed subject matter includes a compound comprising a first monomer, which is allyl-functionalized and crosslinkable, and a second monomer, which is not crosslinkable. In some embodiments the compounds are photocrosslinkable, and in certain embodiments are photo crosslinkable by ultraviolet light. Also provided are shape memory vascular grafts comprised the of present compounds that can transition from a temporary shape to an original shape when heated above a melting temperature of the graft. Still further provided are methods for treating vascular conditions that utilize embodiments of the present grafts.
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公开(公告)号：US20240182421A1
公开(公告)日：2024-06-06
申请号：US18547129
申请日：2022-03-17
申请人： Oregon Health & Science University , The United States Government as Represented by the Department of Veterans Affairs
发明人： Michael K. Riscoe , Aaron Nilsen , Haihong Jin , Sovitj Pou , Rolf W. Winter , Rozalia Ana Dodean , Katherine M. Liebman
IPC分类号： C07D215/233
CPC分类号： C07D215/233
摘要： Described herein are new synthetic routes for production of Endochin-Like Quinolone (ELQ) compounds. Synthetic routes to 3-substituted 4(1H)-quinolones are presented that are amenable to industrial scale preparation. One herein presented approach is relatively short, does not require palladium, and involves no chromatographic separation. A second herein presented approach is similarly relatively short, does not require palladium, involves no chromatographic separation, and also avoids high vacuum distillation. Additionally, both approaches require no protecting group chemistry because the insoluble 4(1H)-quinolone is not formed until the final reaction step.
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公开(公告)号：US11972050B2
公开(公告)日：2024-04-30
申请号：US17978271
申请日：2022-11-01
申请人： BROWN UNIVERSITY , THE GENERAL HOSPITAL CORPORATION , The United States Government as represented by the Department of Veterans Affairs
发明人： Leigh Hochberg , John D. Simeral , Tyler Singer-Clark , Ronnie Gross , Thomas Hosman , Anastasia Kapitonava , Rekha Crawford
IPC分类号： G06F3/01
CPC分类号： G06F3/015
摘要： Instances of a single brain computer interface (BCI) system can be implemented on multiple devices. An active instance can control the associated device. The instances can each communicate with a neural decoding system that can receive neural signals from a user, process the neural signals, and output a command based on the processed neural signals. A device running the active instance of can be in communication with the neural decoding system to receive a command. The device can include a display, a non-transitory memory storing instructions, and a processor to execute the instructions to: run an instance of a control program; and execute the task based on the command.
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公开(公告)号：US20240091279A1
公开(公告)日：2024-03-21
申请号：US18464152
申请日：2023-09-08
申请人： University of lowa Research Foundation , The United States Government, as Represented by the Department of Veterans Affairs
IPC分类号： A61K35/741 , A61K31/353 , A61P37/06
CPC分类号： A61K35/741 , A61K31/353 , A61P37/06 , A61K2035/115
摘要： A method to prevent, inhibit or treat an inflammatory disease in a mammal, is provided that includes administering to a mammal in need thereof an effective amount of one or more isolated gut microbes and one or more phytoestrogens.
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公开(公告)号：US11921118B2
公开(公告)日：2024-03-05
申请号：US17090261
申请日：2020-11-05
申请人： The Board of Trustees of the Leland Stanford Junior University , The United States Government as represented by the Department of Veterans Affairs
发明人： Andrew Yang , Anton Wyss-Coray , Kyle Brewer
CPC分类号： G01N33/6842 , C12N9/93 , C12Y601/01001 , C12Y601/0102 , G01N2333/9015
摘要： Provided herein are methods for labeling the proteomes of cells, as well as methods for labeling proteins or populations of proteins produced by cells. In some embodiments, the methods comprise introducing variant aminoacyl-tRNA synthetases and noncanonical amino acids into cells. Also provided herein are polynucleotides encoding variant aminoacyl-tRNA synthetases that recognize noncanonical amino acids. The methods and compositions provided herein are useful for, among other things, identifying target cells and identifying biomarkers of interest.
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10.发明公开公开(公告)号：US20240067926A1
公开(公告)日：2024-02-29
申请号：US18501837
申请日：2023-11-03
申请人： The Board of Trustees of the Leland Stanford Junior University , The United States Government as represented by the Department of Veterans Affairs
发明人： Zurab Siprashvili , Ngon T. Nguyen , M. Peter Marinkovich , Jean Tang , Alfred T. Lane , Paul A. Khavari
CPC分类号： C12N5/0629 , A61K48/0058 , A61K48/0075 , A61K48/0091 , C12N2510/00 , C12N2760/16043
摘要： Methods are provided for the cell-based delivery of collagen VII for the treatment of Epidermolysis Bullosa and corneal erosion. The disclosure also provides a composition and a pharmaceutical composition comprises, comprise, or alternatively consist essentially of, or yet further consist of a keratinocyte sheet or a corneal cell sheet.
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