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    Gene chip technology for determining memory genes
    1.
    发明申请
    Gene chip technology for determining memory genes 有权
    用于确定记忆基因的基因芯片技术

    公开(公告)号：US20060068422A1

    公开(公告)日：2006-03-30

    申请号：US11199563

    申请日：2005-08-08

    Applicant: Timothy Tully ,  Joshua Dubnau ,  Michael Davis ,  Jan Mous ,  Ulrich Certa

    Inventor： Timothy Tully ,  Joshua Dubnau ,  Michael Davis ,  Jan Mous ,  Ulrich Certa

    IPC: C12Q1/68

    CPC classification number: C12Q1/6883 ,  Y02A90/24

    Abstract: The present invention relates to methods of identifying genes involved in memory formation. This is accomplished by performing a gene chip identification of those genes expressed during transcription-dependent memory formation but not during transcription-independent memory formation. A statistical analysis of the gene chip identification output yields a set of genes that are involved in transcription-dependent memory formation.

    Abstract translation: 本发明涉及识别与记忆形成有关的基因的方法。 这是通过对在转录依赖记忆形成期间表达的那些基因进行基因芯片鉴定而不是在转录无关的记忆形成过程中完成的。 基因芯片识别输出的统计分析产生参与转录依赖记忆形成的一组基因。

    Altering memory by affecting STAUFEN function
    4.
    发明申请
    Altering memory by affecting STAUFEN function 审中-公开
    通过影响STAUFEN功能来改变内存

    公开(公告)号：US20050158243A1

    公开(公告)日：2005-07-21

    申请号：US11020026

    申请日：2004-12-21

    Applicant: Timothy Tully ,  Roderick Scott ,  Rusiko Bourtchouladze

    Inventor： Timothy Tully ,  Roderick Scott ,  Rusiko Bourtchouladze

    IPC: G01N33/50 ,  G01N33/68 ,  A61K49/00 ,  A61K48/00 ,  C12Q1/68

    CPC classification number: G01N33/5035 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5023 ,  G01N33/5058 ,  G01N33/5088 ,  G01N33/6896 ,  G01N2500/00

    Abstract: The present invention provides methods for screening a pharmaceutical agent for its ability to modulate long term memory formation, performance of a hippocampal-dependent cognitive task or STAUFEN function. The present invention also provides methods for modulating long term memory formation or performance of a hippocampal-dependent cognitive task by modulating staufen-dependent protein expression. The present invention further provides methods for treating a defect in long term memory formation associated with a defect in STAUFEN and methods for treating a defect in performance of a hippocampal-dependent cognitive task associated with a defect in STAUFEN.

    Abstract translation: 本发明提供了用于筛选药剂以调节长期记忆形成，执行海马依赖性认知任务或STAUFEN功能的能力的方法。 本发明还提供了通过调节staufen依赖性蛋白质表达来调节长期记忆形成或海马依赖性认知任务的表现的方法。 本发明还提供了用于治疗与STAUFEN中的缺陷相关的长期记忆形成缺陷的方法和用于治疗与STAUFEN中的缺陷相关的海马依赖性认知任务的缺陷的缺陷的方法。

    METHOD OF TRACKING OFFLINE USER INTERACTION IN A RENDERED DOCUMENT ON A MOBILE DEVICE
    6.
    发明申请
    METHOD OF TRACKING OFFLINE USER INTERACTION IN A RENDERED DOCUMENT ON A MOBILE DEVICE 有权
    在移动设备上跟踪文档中的离线用户交互的方法

    公开(公告)号：US20130103740A1

    公开(公告)日：2013-04-25

    申请号：US13278999

    申请日：2011-10-21

    Applicant: Timothy Tully ,  Benjamin Graham

    Inventor： Timothy Tully ,  Benjamin Graham

    IPC: G06F15/16

    CPC classification number: H04N21/251 ,  H04L67/22 ,  H04N21/41407 ,  H04N21/44222 ,  H04N21/44245 ,  H04N21/6582

    Abstract: While a device is offline, usage data is tracked on the device. The usage data is uploaded to a server after the device is again connected to a network. Applications that run on mobile devices typically embed a browser to display content. Unfortunately, mobile devices also frequently disconnect from the associated network. A system tracks usage data by using JavaScript in the browser to communicate with the native device, which then buffers the usage data for future upload. This is done by installing, in each application, a “protocol handler” that listens for a request over a particular protocol. The protocol handler intercepts the requests and stores the usage data locally on the device. Subsequently, when the device detects network connectivity, the device uploads the data to servers that collect data for aggregation and presentation.

    Abstract translation: 当设备脱机时，在设备上跟踪使用数据。 设备再次连接到网络后，将使用数据上传到服务器。 在移动设备上运行的应用程序通常嵌入浏览器来显示内容。 不幸的是，移动设备也经常与相关联的网络断开连接。 系统通过浏览器中的JavaScript来跟踪使用数据，以便与本地设备进行通信，然后缓存用于将来上传的使用数据。 这通过在每个应用程序中安装通过特定协议来侦听请求的“协议处理程序”来完成。 协议处理程序拦截请求并将使用数据本地存储在设备上。 随后，当设备检测到网络连接时，设备将数据上传到收集用于聚合和呈现的数据的服务器。

    Associative learning and the linotte gene
    9.
    发明授权
    Associative learning and the linotte gene 失效
    关联学习和线粒体基因

    公开(公告)号：US5831057A

    公开(公告)日：1998-11-03

    申请号：US723585

    申请日：1996-10-01

    Applicant: Timothy Tully ,  Gert M. Bolwig

    Inventor： Timothy Tully ,  Gert M. Bolwig

    IPC: C07K14/435 ,  C12N15/12

    CPC classification number: C07K14/43581

    Abstract: The invention pertains to a novel gene present in cytological region 37D of the second chromosome which functions in associative learning and/or memory. Disruption of the gene, such as by P element transposon-tagged insertion, results in decreased associative learning and/or memory. The invention also pertains to a novel protein encoded by the gene, antibodies which bind the encoded protein, and homologs of the novel gene which function in associative learning and hybridize to the DNA sequence of the novel gene.

    Abstract translation: 本发明涉及存在于第二染色体的细胞学区域37D中的新基因，其在缔合学习和/或记忆中起作用。 基因的破坏，例如通过P元件转座子标记的插入导致关联学习和/或记忆的减少。 本发明还涉及由该基因编码的新型蛋白质，结合编码蛋白的抗体，以及在关联学习中起作用并与新基因的DNA序列杂交的新基因的同源物。

    METHODS FOR REMOVING A CONTAMINANT USING INDIGENOUS PROTEIN DISPLACEMENT ION EXCHANGE MEMBRANE CHROMATOGRAPHY
    10.
    发明申请
    METHODS FOR REMOVING A CONTAMINANT USING INDIGENOUS PROTEIN DISPLACEMENT ION EXCHANGE MEMBRANE CHROMATOGRAPHY 审中-公开
    使用酸性蛋白质离子离子交换色谱法去除污染物的方法

    公开(公告)号：US20120122759A1

    公开(公告)日：2012-05-17

    申请号：US13058796

    申请日：2008-08-14

    Applicant: Arick Brown ,  Jerome Bill, JR. ,  Timothy Tully ,  Christopher Dowd

    Inventor： Arick Brown ,  Jerome Bill, JR. ,  Timothy Tully ,  Christopher Dowd

    IPC: A61K38/00 ,  C07K16/00 ,  C07K1/36 ,  C07K1/18

    CPC classification number: C07K1/18 ,  C07K1/34 ,  C07K1/36

    Abstract: Methods for purifying a polypeptide from a composition comprising the polypeptide and at least one contaminant are described, which methods comprise the sequential steps of: (a) passing the composition through an ion exchange membrane, where the polypeptide and the membrane have opposite charge, at operating conditions comprised of a buffer having a pH sufficiently distinct from the pI of the polypeptide to enhance the charge of the polypeptide and a low ionic strength effective to prevent the shielding of charges by buffer ions, which cause the membrane to bind the polypeptide and the at least one contaminant, and (b) recovering the purified polypeptide from the effluent.

    Abstract translation: 描述了从包含多肽和至少一种污染物的组合物中纯化多肽的方法，哪些方法包括以下顺序步骤：（a）使组合物通过离子交换膜，其中多肽和膜具有相反的电荷， 操作条件由具有与多肽的pI充分不同的pH的缓冲液组成，以增强多肽的电荷，以及有效地防止由缓冲离子屏蔽电荷的低离子强度，其导致膜结合多肽和 至少一种污染物，和（b）从流出物中回收纯化的多肽。

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