公开(公告)号：US5751373A

公开(公告)日：1998-05-12

申请号：US623112

申请日：1996-03-28

申请人： Tomoko Ohyama ,  Yukiko Ohkura ,  Masaharu Fukumoto ,  Shigeyuki Sano ,  Yasuko Rokukawa ,  Shiro Endo ,  Kyosuke Oda ,  Yumiko Minakawa ,  Chifumi Matsuura

发明人： Tomoko Ohyama ,  Yukiko Ohkura ,  Masaharu Fukumoto ,  Shigeyuki Sano ,  Yasuko Rokukawa ,  Shiro Endo ,  Kyosuke Oda ,  Yumiko Minakawa ,  Chifumi Matsuura

IPC分类号： G06F3/033 ,  G06F3/048 ,  H01H9/02 ,  H03J1/00 ,  H04N5/00 ,  H04N5/445 ,  H04N5/57 ,  H04Q9/00

CPC分类号： H04N5/44513 ,  G06F3/0482 ,  H03J1/0025 ,  H04N21/4221 ,  H04N21/4312 ,  H01H9/0235 ,  H04N5/57

摘要： A method and apparatus by which function as of a television receiver can be selected simply. A main menu displays the highest level of a hierarchical menu which includes items corresponding to functions of a television receiver is displayed on a left side portion of a screen of the television receiver. When a cursor is moved to the first item of the main menu, while the main menu remains displayed on the screen, a sub menu corresponding to the first item is displayed on a right side portion of the screen. When the cursor is subsequently moved to one of the items forming the sub menu and then a predetermined operation is performed.

摘要翻译： 可以简单地选择与电视接收机相关的功能的方法和装置。 主菜单显示包括与电视接收机的功能对应的项目的分级菜单的最高级别显示在电视接收机的屏幕的左侧部分。 当光标移动到主菜单的第一项目时，当主菜单保持显示在屏幕上时，与第一项目对应的子菜单显示在屏幕的右侧部分。 当光标随后移动到形成子菜单的其中一个项目然后执行预定的操作时。

公开(公告)号：US20080090254A1

公开(公告)日：2008-04-17

申请号：US11905027

申请日：2007-09-27

申请人： Michitaka Notoya ,  Jun Sato ,  Tomoko Ohyama ,  Tomokazu Yoshida ,  Hideki Ishihara

发明人： Michitaka Notoya ,  Jun Sato ,  Tomoko Ohyama ,  Tomokazu Yoshida ,  Hideki Ishihara

IPC分类号： G01N33/53

CPC分类号： C12Q1/485 ,  G01N2333/9121 ,  G01N2500/00

摘要： A method for assessing the proliferation inhibiting effect of a receptor tyrosine kinase inhibitor is described. In the method, a cytoplasm is separated from a tumor cell to prepare a sample containing various receptor tyrosine kinases. The prepared sample is treated with the inhibitor. The receptor tyrosine kinases in the treated sample, and a substrate for at least two kinds of receptor tyrosine kinases are contacted. The phosphorylated substrate is detected, and the activity value of the receptor tyrosine kinases is measured based on the detection result. The proliferation inhibiting effect is assessed based on the resulting activity value.

摘要翻译： 描述了用于评估受体酪氨酸激酶抑制剂的增殖抑制作用的方法。 在该方法中，从肿瘤细胞分离细胞质以制备含有各种受体酪氨酸激酶的样品。 制备的样品用抑制剂处理。 处理的样品中的受体酪氨酸激酶和至少两种受体酪氨酸激酶的底物接触。 检测磷酸化底物，并根据检测结果测定受体酪氨酸激酶的活性值。 基于得到的活性值评估增殖抑制作用。

公开(公告)号：US20070238141A1

公开(公告)日：2007-10-11

申请号：US11729901

申请日：2007-03-30

申请人： Michitaka Notoya ,  Tomoko Ohyama ,  Shigeyuki Tamura ,  Tomokazu Yoshida ,  Hideki Ishihara

发明人： Michitaka Notoya ,  Tomoko Ohyama ,  Shigeyuki Tamura ,  Tomokazu Yoshida ,  Hideki Ishihara

IPC分类号： C12Q1/48 ,  G01N33/53

CPC分类号： C12Q1/485 ,  G01N33/573

摘要： A method for measuring the activity of a receptor kinase present in a cell membrane of a cell is described. The method comprises steps of preparing a sample containing the receptor kinase by separating a cytoplasm from the cell, contacting the receptor kinase in the sample with a substrate to phosphorylate the substrate with the activity of the receptor kinase, binding a labeling substance to the phosphorylated substrate, and measuring the activity of the receptor kinase based on a result of detection of the labeling substance bound to the phosphorylated substrate.

摘要翻译： 描述了测定存在于细胞的细胞膜中的受体激酶的活性的方法。 该方法包括以下步骤：通过从细胞分离细胞质来制备含有受体激酶的样品，使样品中的受体激酶与底物接触，以使受体激酶活性磷酸化底物，将标记物质结合到磷酸化底物 ，并且基于与磷酸化底物结合的标记物质的检测结果测量受体激酶的活性。

公开(公告)号：US20110244497A1

公开(公告)日：2011-10-06

申请号：US13075673

申请日：2011-03-30

申请人： Tomoko Ohyama ,  Masaki Shibayama ,  Hideki Ishihara ,  Tomokazu Yoshida ,  Keigo Gohda

发明人： Tomoko Ohyama ,  Masaki Shibayama ,  Hideki Ishihara ,  Tomokazu Yoshida ,  Keigo Gohda

IPC分类号： C12Q1/48

CPC分类号： G01N33/57415 ,  G01N2333/91177 ,  G01N2333/9121 ,  G01N2800/44 ,  G01N2800/52

摘要： The present invention provides a method for judging susceptibility of cancer cells contained in a biological sample to an anthracycline anticancer agent comprising steps of: measuring expression levels of GST-π of cancer cells contained in a biological sample; and judging the susceptibility of cancer cells contained in a biological sample to an anthracycline anticancer agent as high when the expression level of GST-π obtained by the measuring process is high, and a computer program which makes a computer execute the method.

摘要翻译： 本发明提供了一种用于判断生物样品中包含的癌细胞对蒽环类抗癌剂的敏感性的方法，包括以下步骤：测量GST-和pgr的表达水平; 包含在生物样品中的癌细胞; 并且当GST-＆pgr的表达水平，判断生物样品中包含的癌细胞对蒽环类抗癌剂的敏感性高。 通过测量过程获得的计算机程序高，并且使计算机执行该方法。

公开(公告)号：US20080003630A1

公开(公告)日：2008-01-03

申请号：US11819236

申请日：2007-06-26

申请人： Michitaka Notoya ,  Tomoko Ohyama ,  Tomokazu Yoshida ,  Hideki Ishihara

发明人： Michitaka Notoya ,  Tomoko Ohyama ,  Tomokazu Yoshida ,  Hideki Ishihara

IPC分类号： C12Q1/48 ,  C07K14/00

CPC分类号： C07K14/71 ,  C07K1/13 ,  C07K2319/00 ,  C12Q1/485

摘要： A tyrosine kinase substrate is described. The tyrosine kinase substrate comprises a fusion protein which comprises a protein for labeling and a specific peptide fused with the protein for labeling. The specific peptide has an amino acid sequence including a glutamic acid residue and a tyrosine residue. The tyrosine kinase substrate is capable of being phosphorylated by a plurality of kinds of tyrosine kinases.

摘要翻译： 描述了酪氨酸激酶底物。 酪氨酸激酶底物包含融合蛋白，其包含用于标记的蛋白质和与用于标记的蛋白质融合的特异性肽。 特定肽具有包含谷氨酸残基和酪氨酸残基的氨基酸序列。 酪氨酸激酶底物能够被多种酪氨酸激酶磷酸化。

公开(公告)号：US20120278000A1

公开(公告)日：2012-11-01

申请号：US13457081

申请日：2012-04-26

申请人： Chihiro SUMINAKA ,  Amame HARADA ,  Tomoko OHYAMA ,  Yasuhiro TORIKOSHI

发明人： Chihiro SUMINAKA ,  Amame HARADA ,  Tomoko OHYAMA ,  Yasuhiro TORIKOSHI

IPC分类号： G06F19/00

CPC分类号： C12Q1/485 ,  G01N33/573 ,  G01N33/57415 ,  G01N2333/91177 ,  G01N2800/52 ,  G16B20/00

摘要： A method for assessing an efficacy of combination chemotherapy, comprising: a first obtaining process for obtaining a specific activity value of Cyclin Dependent Kinase (CDK) 1 and a specific activity value of CDK2 in a biological sample including a carcinoma cell collected from a cancer patient; a second obtaining process for obtaining a GSTπ expression level in the biological sample; and an assessment process for assessing the efficacy of the combination chemotherapy on the cancer patient based on the specific activity values of CDK1 and CDK2 obtained in the first obtaining process and the GSTπ expression level obtained in the second obtaining process.

摘要翻译： 一种评估联合化疗疗效的方法，包括：获得细胞周期蛋白依赖性激酶（CDK）1的比活性值的第一获得方法和包含从癌症患者收集的癌细胞的生物样品中CDK2的比活性值 ; 获得GST＆pgr的第二获取过程 生物样品中的表达水平; 以及基于在第一获得方法和GST＆pgr中获得的CDK1和CDK2的比活性值来评估联合化疗对癌症患者的功效的评估过程。 在第二获得过程中获得的表达水平。

公开(公告)号：US20100250483A1

公开(公告)日：2010-09-30

申请号：US12569130

申请日：2009-09-29

申请人： Tomoko Ohyama ,  Masaki Shibayama ,  Hideki Ishihara ,  Tomokazu Yoshida ,  Keigo Gohda

发明人： Tomoko Ohyama ,  Masaki Shibayama ,  Hideki Ishihara ,  Tomokazu Yoshida ,  Keigo Gohda

IPC分类号： G06N5/02

CPC分类号： G16C20/30 ,  G16B25/00

摘要： An effect predicting apparatus for predicting an effect of anthracycline anticancer drugs, comprising: a display, a processor, and a memory, under control of said processor, including software instructions adapted to enable the processor to perform operations, comprising: acquiring a CDK parameter based on a first CDK parameter and a second CDK parameter; acquiring an expression level of glutathione; comparing the CDK parameter with a CDK threshold value, and the expression level of glutathione with a glutathione threshold value; predicting an effect of anthracycline anticancer drugs based on the result of the comparison; and displaying the result of the prediction. A computer program product and a method for predicting an effect are also disclosed.

摘要翻译： 一种用于预测蒽环类抗癌药物的效果的效果预测装置，包括：在所述处理器的控制下的显示器，处理器和存储器，包括适于使处理器执行操作的软件指令，包括：基于CDK参数获取 第一个CDK参数和第二个CDK参数; 获得谷胱甘肽的表达水平; 将CDK参数与CDK阈值进行比较，以及谷胱甘肽阈值的谷胱甘肽的表达水平; 基于比较结果预测蒽环类抗癌药物的作用; 并显示预测结果。 还公开了一种用于预测效果的计算机程序产品和方法。