公开(公告)号：US20060148958A1

公开(公告)日：2006-07-06

申请号：US10545311

申请日：2004-01-07

Applicant: Kazutoshi Haraguchi ,  Tooru Takehisa

Inventor： Kazutoshi Haraguchi ,  Tooru Takehisa

IPC: C08K9/04 ,  C08K3/00 ,  A61K33/00

CPC classification number: C08K3/346

Abstract: The polymer gel obtained from the method for incorporating hydroxyapatite in a polymer hydrogel by impregnating an aqueous phosphoric acid alkali metal salt solution and an aqueous carbonate solution alternately one or more times with a polymer gel consisting of a polymer of a water-soluble organic monomer and a water-swelling clay mineral, contains finely dispersed biocompatible substances, and the polymer gel excels in dynamic physical property and stability and can exhibit the performance of the biocompatible substance efficiently. The dried biocompatible substance-containing polymer gel is obtained by drying the above polymer gel.

Abstract translation: 将聚羟基磷灰石在聚合物水凝胶中掺入的方法得到的聚合物凝胶通过用水溶性有机单体的聚合物和聚合物凝胶交替浸渍磷酸碱金属盐溶液和碳酸水溶液一次或多次， 水溶性粘土矿物，含有细分散的生物相容性物质，聚合物凝胶具有优异的动态物理性能和稳定性，可有效显示生物相容性物质的性能。 通过干燥上述聚合物凝胶获得干燥的含生物相容性物质的聚合物凝胶。

公开(公告)号：US09474835B2

公开(公告)日：2016-10-25

申请号：US14237664

申请日：2012-08-10

Applicant: Kazutoshi Haraguchi ,  Kazuomi Kubota ,  Tooru Takehisa ,  Tetsuo Takada ,  Noriko Santou

Inventor： Kazutoshi Haraguchi ,  Kazuomi Kubota ,  Tooru Takehisa ,  Tetsuo Takada ,  Noriko Santou

IPC: C08F220/56 ,  C08F220/58 ,  C09D133/26 ,  C09D153/00 ,  A61L33/06 ,  C08F293/00

CPC classification number: A61L33/064 ,  A61L33/06 ,  C08F220/56 ,  C08F293/005 ,  C08F2438/03 ,  C09D133/26 ,  C09D153/00 ,  C08F2220/281 ,  C08F220/58

Abstract: The object of the present invention is achieved by providing a copolymer, in particular, a block copolymer which has excellent coating formation ability, adhesive properties to a substrate, and does not adsorb protein; an antithrombotic coating agent which has superior antithrombotic properties and adhesive properties to a substrate to those of the conventional antithrombotic coating agent; and a medical instrument which is obtained by coating the antithrombotic coating agent, and the block copolymer includes a polymer (A) containing a (meth)acrylic ester monomer and a polymer (B) containing a (meth)acrylamide monomer and has excellent coating formation ability and high adhesive properties to a substrate.

Abstract translation: 本发明的目的是通过提供共聚物，特别是具有优异的涂层形成能力，对基材的粘合性能并且不吸附蛋白质的嵌段共聚物来实现的; 一种抗血栓形成剂，其具有优异的抗血栓形成性能和对基质的粘合性能，与常规抗凝血剂的抗凝血性能和粘合性能相当; 以及通过涂布抗血栓形成剂而得到的医疗器械，嵌段共聚物包含含有（甲基）丙烯酸酯单体的聚合物（A）和含有（甲基）丙烯酰胺单体的聚合物（B），并且具有优异的涂布形成 能力和高粘合性能。

公开(公告)号：US20140235748A1

公开(公告)日：2014-08-21

申请号：US14237664

申请日：2012-08-10

Applicant: Kazutoshi Haraguchi ,  Kazuomi Kubota ,  Tooru Takehisa ,  Tetsuo Takada ,  Noriko Santou

Inventor： Kazutoshi Haraguchi ,  Kazuomi Kubota ,  Tooru Takehisa ,  Tetsuo Takada ,  Noriko Santou

IPC: A61L33/06

CPC classification number: A61L33/064 ,  A61L33/06 ,  C08F220/56 ,  C08F293/005 ,  C08F2438/03 ,  C09D133/26 ,  C09D153/00 ,  C08F2220/281 ,  C08F220/58

Abstract: The object of the present invention is achieved by providing a copolymer, in particular, a block copolymer which has excellent coating formation ability, adhesive properties to a substrate, and does not adsorb protein; an antithrombotic coating agent which has superior antithrombotic properties and adhesive properties to a substrate to those of the conventional antithrombotic coating agent; and a medical instrument which is obtained by coating the antithrombotic coating agent, and the block copolymer includes a polymer (A) containing a (meth)acrylic ester monomer and a polymer (B) containing a (meth)acrylamide monomer and has excellent coating formation ability and high adhesive properties to a substrate.

Abstract translation: 本发明的目的是通过提供共聚物，特别是具有优异的涂层形成能力，对基材的粘合性能并且不吸附蛋白质的嵌段共聚物来实现的; 一种抗血栓形成剂，其具有优异的抗血栓形成性能和对基质的粘合性能，与常规抗凝血剂的抗凝血性能和粘合性能相当; 以及通过涂布抗血栓形成剂而得到的医疗器械，嵌段共聚物包含含有（甲基）丙烯酸酯单体的聚合物（A）和含有（甲基）丙烯酰胺单体的聚合物（B），并且具有优异的涂布形成 能力和高粘合性能。

公开(公告)号：US20090291500A1

公开(公告)日：2009-11-26

申请号：US11721519

申请日：2005-12-13

Applicant: Tetsuo Takada ,  Kazutoshi Haraguchi ,  Tooru Takehisa

Inventor： Tetsuo Takada ,  Kazutoshi Haraguchi ,  Tooru Takehisa

IPC: C12N5/00 ,  C09K3/18

CPC classification number: C08F2/44 ,  C08F2/18 ,  C08F2/20 ,  C08F220/28 ,  C08F220/54 ,  C08F220/56 ,  C08F220/58

Abstract: The present invention provides a production process of an organic/inorganic composite hydrogel, which demonstrates superior mechanical properties, by uniformly dispersing a clay mineral in an organic polymer over a wide range of clay mineral content, and a dried form thereof, to be produced easily in a short period of time. The production process of an organic/inorganic composite hydrogel of the present invention comprises reacting a water-soluble organic monomer (a) in the presence of a water-swellable clay mineral (b) by irradiating with an energy beam in a solution in which a non-water-soluble polymerization initiator (d) is dispersed in an aqueous medium (c).

Abstract translation: 本发明提供了一种有机/无机复合水凝胶的制造方法，其通过在粘土矿物质的宽范围内将粘土矿物均匀地分散在有机聚合物及其干燥形式中而显示出优异的机械性能，容易制造 在短时间内。 本发明的有机/无机复合水凝胶的制造方法包括使水溶性有机单体（a）在水溶胀性粘土矿物（b）的存在下，在溶液中照射能量束， 非水溶性聚合引发剂（d）分散在水性介质（c）中。

公开(公告)号：US07993892B2

公开(公告)日：2011-08-09

申请号：US11721519

申请日：2005-12-13

Applicant: Tetsuo Takada ,  Kazutoshi Haraguchi ,  Tooru Takehisa

Inventor： Tetsuo Takada ,  Kazutoshi Haraguchi ,  Tooru Takehisa

IPC: C12N11/14 ,  C12N11/02 ,  C12N11/08 ,  C12N5/00

CPC classification number: C08F2/44 ,  C08F2/18 ,  C08F2/20 ,  C08F220/28 ,  C08F220/54 ,  C08F220/56 ,  C08F220/58

Abstract: The present invention provides a production process of an organic/inorganic composite hydrogel, which demonstrates superior mechanical properties, by uniformly dispersing a clay mineral in an organic polymer over a wide range of clay mineral content, and a dried form thereof, to be produced easily in a short period of time. The production process of an organic/inorganic composite hydrogel of the present invention comprises reacting a water-soluble organic monomer (a) in the presence of a water-swellable clay mineral (b) by irradiating with an energy beam in a solution in which a non-water-soluble polymerization initiator (d) is dispersed in an aqueous medium (c).

Abstract translation: 本发明提供了一种有机/无机复合水凝胶的制造方法，其通过在粘土矿物质的宽范围内将粘土矿物均匀地分散在有机聚合物及其干燥形式中而显示出优异的机械性能，容易制造 在短时间内。 本发明的有机/无机复合水凝胶的制造方法包括使水溶性有机单体（a）在水溶胀性粘土矿物（b）的存在下，在溶液中照射能量束， 非水溶性聚合引发剂（d）分散在水性介质（c）中。