公开(公告)号：US12070452B2

公开(公告)日：2024-08-27

申请号：US17265716

申请日：2019-08-05

申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) ,  Université de Caen Normandie ,  Université de Bourgogne

发明人： Carmen Garrido Fleury ,  Gaetan Jego ,  Daniel Gonzalez ,  Anne-Sophie Voisin-Chiret

IPC分类号： A61K31/444 ,  A61K31/519 ,  A61K45/06 ,  A61P35/04

CPC分类号： A61K31/444 ,  A61K31/519 ,  A61K45/06 ,  A61P35/04

摘要： HSP110 inhibitors bind directly to the nucleotide binding domain of HSP110 and then block the phosphorylation of STAT3, cancer cell growth or MyD88 stability. Aspects involve a compound of formula (I) for use in the treatment of a HSP110-associated cancer, for example colorectal cancer and lymphoma. An examplary compound was tested on a syngeneic model for which mouse colon cancer CT-26 cells were injected into Balb/c mice and on a NOD/SCID model in which mice were implanted with human colorectal cancer HCT116 cells. In those animals bearing a tumor, the compound induced tumor regression that was associated with the inhibition of other HSP110 reported tumorigenic functions (resistance to apoptosis, induction of pro-tumor macrophages). Further, the compound was tested on large B cell lymphoma cell lines (DLBCL) and it was able to alter the interaction between HSP110 and MyD88, which induces a degradation of the oncogene MyD88. Additionally, it has been shown that the compound acts synergistically with other anti-cancer agents, including with tyrosine kinase inhibitors like Ibrutinib.

公开(公告)号：US20210346449A1

公开(公告)日：2021-11-11

申请号：US17272739

申请日：2019-09-10

申请人： UNIVERSITÉ DE BOURGOGNE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT NATIONAL DE LA RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT ,  UNIVERSITÉ DE MONASTIR

发明人： Basma ABED ,  Corinne LELOUP

IPC分类号： A61K36/31 ,  A61K36/481 ,  A23L33/18 ,  A61P3/10

摘要： A composition including an extract of Moricandia for the use thereof in the prevention and/or treatment of metabolic diseases related to impaired glucose tolerance and/or insulin resistance. Also a composition including an extract of Moricandia for the use thereof in the prevention of weight gain, in particular of body fat.

公开(公告)号：US20180230189A1

公开(公告)日：2018-08-16

申请号：US15761828

申请日：2016-09-21

申请人： INSERM (Institut National de la Sante et de la Recherche Medicale) ,  Fondation Imagine ,  Assistance Publique-Hopitaux de Paris (APHP) ,  Universite Paris Descartes ,  Centre National de la Recherche Scientifique (CNRS) ,  Université de Bourgogne ,  CNAM - Conservatoire National des Arts et Metiers

发明人： Zakia Belaid-Choucair ,  Olivier Hermine ,  Matthieu Montes ,  Carmen Garrido-Fleury ,  Renaud Seigneuric ,  Guillaume Marcion

IPC分类号： C07K14/475 ,  A61K38/18 ,  C07K16/22 ,  A61K39/395 ,  A61P35/00

CPC分类号： C07K14/475 ,  A61K38/1866 ,  A61K39/3955 ,  A61K2039/505 ,  A61P35/00 ,  C07K14/5759 ,  C07K14/705 ,  C07K14/72 ,  C07K16/22 ,  C07K2317/76

摘要： The present invention relates to agents capable of inhibiting the binding between Leptin and Neuropilin-1 (NRP1) and uses thereof in the therapeutic field.

公开(公告)号：US09863048B2

公开(公告)日：2018-01-09

申请号：US14323950

申请日：2014-07-03

申请人： UNIVERSITÉ DE BOURGOGNE

发明人： Jacques Andrieu ,  Charles Devillers ,  Guillaume de Robillard

IPC分类号： C25B3/00 ,  C25B3/04 ,  C01B31/20 ,  C07D233/90 ,  C07D233/58 ,  C07D233/54

CPC分类号： C25B3/04 ,  C01B32/50 ,  C07D233/54 ,  C07D233/58 ,  C07D233/90

摘要： The present invention relates to a new method for preparation of biobased imidazolium salts and derivatives thereof; in particular, for the preparation of imidazolium hydrogenooxalate. The present invention also relates to uses of imidazolium hydrogenooxalate salts, especially as a precursor of imidazolium carboxylate compounds. The present invention also refers to a green electrochemical process providing imidazolium compounds, especially imidazolium carboxylate compounds. Especially, the invention refers to a one-compartment electrochemical cell and its use for the preparation of imidazolium carboxylate compounds of formula (II):

公开(公告)号：US11242359B2

公开(公告)日：2022-02-08

申请号：US16496387

申请日：2018-03-23

申请人： Centre national de la recherche scientifique ,  Université de Bourgogne

发明人： Victor Goncalves ,  Franck Denat ,  Claire Bernhard ,  Coline Canovas

IPC分类号： C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  A61K39/00 ,  C07F5/02 ,  C07D405/12

摘要： A modular tetrazine platform, can be used as diagnostic, theragnostic agent and/or medicinal product. An inverse electron demand Diels-Alder reaction can be used for synthesizing bifunctionalized tetrazines, which can be obtained from monofunctionalised tetrazines.

公开(公告)号：US20210186941A1

公开(公告)日：2021-06-24

申请号：US17265716

申请日：2019-08-05

申请人： INSERM (Institut National De La Santé et de la Recherche Médicale) ,  Université de Caen Normandie ,  Université de Bourgogne

发明人： Carmen GARRIDO FLEURY ,  Gaetam JEGO ,  Daniel GONZALEZ ,  Anne-Sophie VOISIN-CHIRET

IPC分类号： A61K31/444 ,  A61K45/06 ,  A61K31/519 ,  A61P35/04

摘要： HSP110 is involved in multiple tumorigenic processes but no inhibitor was known to date. The inventors have identified for the first time HSP110 inhibitors. These inhibitors bind directly to the nucleotide binding domain of HSP110 and then blocks the phosphorylation of STAT3, cancer cell growth or MyD88 stability. The present invention relates to a compound of general formula (I) for use in the treatment of a HSP 110-associated cancer, for example colorectal cancer and lymphoma. Especially the inventors tested the compound on two different colorectal mice models, a syngeneic model for which mouse colon cancer CT-26 cells were injected into Balb/c mice and a NOD/SCID model in which mice were implanted with human colorectal cancer HCT116 cells. In those animals bearing a tumor, the compound induced tumor regression that was associated with the inhibition of other HSP110 reported tumorigenic functions (resistance to apoptosis, induction of pro-tumor macrophages). Further, the inventors also tested the compound on large B cell lymphoma cell lines (DLBCL). Specifically, the compound is able to alter the interaction between HSP110 and MyD88, which induces a degradation of the oncogene MyD88. Additionally, is has been showed that the compound act synergistically with other anticancer agents, including with tyrosine kinase inhibitors like Ibmtinib.

公开(公告)号：US20210155640A1

公开(公告)日：2021-05-27

申请号：US17059361

申请日：2019-05-27

申请人： UNIVERSITÉ DE BOURGOGNE ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE

发明人： Naim KHAN ,  Sylvain JUGE ,  Aziz HICHAMI ,  Jérôme BAYARDON ,  Marie-Laure LOUILLAT-HABERMEYER ,  Baptiste RUGERI

IPC分类号： C07F9/40 ,  A61P3/04 ,  C07C233/47 ,  C07D305/06 ,  C07D263/16 ,  C07D307/12 ,  C07D303/16 ,  C07D319/06 ,  A23L33/12 ,  A23L33/00 ,  A23K20/158

摘要： Disclosed is a linoleic acid derivative of Formula (I) below including a hydrophobic part C17H31 linked to a polar head part “A”: wherein the polar head part A is selected from A1 to A4 below: or a pharmaceutically/food quality acceptable salt thereof.

公开(公告)号：US10924687B2

公开(公告)日：2021-02-16

申请号：US16478404

申请日：2017-12-22

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  SORBONNE UNIVERSITÉ ,  Université Paris Diderot—Paris 7 DIDEROT VALORISATION ,  ECOLE NORMALE SUPERIEURE DE PARIS ,  UNIVERSITÉ DE BOURGOGNE

发明人： David Darson ,  Julien Dubois ,  Barthélémy Heyrman ,  Dominique Ginhac ,  Mustapha Bouderbane

IPC分类号： H04N5/232 ,  H04N5/272 ,  H04N5/355 ,  H01L27/146 ,  H04N5/235 ,  H04N5/378

摘要： High dynamic range (HDR) images are generated on the basis of a plurality of images obtained by non-destructive reading of an image sensor, called NDRO images. An HDR image generation method includes: the determination of a criterion of desired quality for the HDR image; at least two non-destructive readings of the sensor delivering at least two successive NDRO images; the selection, as a function of the criterion of desired quality, of the first and of the last NDRO image to be used to generate the HDR image; the generation of the HDR image on the basis of information extracted from a series of successive NDRO images starting with the first and terminating with the last NDRO image to be used; the storage of a single image at one and the same time throughout the entire HDR generation phase.

公开(公告)号：US20180370842A1

公开(公告)日：2018-12-27

申请号：US15574354

申请日：2016-05-12

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  Université de Bourgogne ,  Université de Bordeaux

发明人： Sylvain Danto ,  Thierry Cardinal ,  Yannick Petit ,  Lionel Canioni ,  Frédéric Desevedavy ,  Frédéric Smektala

IPC分类号： C03B37/027 ,  G01T1/20 ,  G02B6/44 ,  G02B6/02

摘要： Optical fiber (1) made of a photosensitive glass and with a rectangular cross section, wherein the radius of curvature of a corner of the rectangular cross section is smaller than 100 microns.

公开(公告)号：US20240251172A1

公开(公告)日：2024-07-25

申请号：US18565698

申请日：2022-06-01

申请人： UNIVERSITÉ DE BOURGOGNE

发明人： Dominique GINHAC ,  Barthélémy HEYRMAN ,  Steven TEL

IPC分类号： H04N23/741

CPC分类号： H04N23/741

摘要： The invention relates to a method for generating a video stream comprising a set of high dynamic range images, called HDR video stream, from a plurality of standard dynamic range images that are obtained by reading at least two image sensors each having an image production rate, each sensor comprising a plurality of pixels arranged in a matrix, and each associated with a photoelectric conversion element for converting received light into electric charge and accumulating said electric charge over a light exposure time, said method comprising a plurality of iterations of creating high dynamic range images comprising determining exposure times, reading optical sensors and combining the data from these sensors in an iterative operating mode involving temporary memory area management.