公开(公告)号：US20220249819A1

公开(公告)日：2022-08-11

申请号：US17617382

申请日：2020-06-16

申请人： UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK

发明人： Waleed FAISAL ,  Abina CREAN

IPC分类号： A61M37/00 ,  A61K31/4174 ,  A61K31/496 ,  A61K9/00 ,  A61P31/10 ,  A61K31/4196 ,  A61K31/415 ,  A61K31/196 ,  A61K31/192 ,  A61K31/519 ,  A61K31/4422

摘要： A microneedle with very high drug loading is described, and comprises a base and a penetrating tip, the tip having a dimension ranging from about 50 nm to about 50 μm, wherein at least 80% of the microneedle by volume consists of heat-meltable active pharmaceutical ingredient (v/v). The meltable active pharmaceutical ingredient is characterised by being heat-meltable (i.e. it can be heated to a molten form), is solid at 25° C., and has an ability to form a glassy, amorphous form following melting by heating and cooling with a glass transition temperature greater than 25° C. A method of fabricating a microneedle comprises the steps of providing a microneedle micromold comprising a micromold substrate and one or more holes in the upper surface of the micromold substrate, wherein the interior surface of the hole in the micromold substrate defines an exterior surface of the microneedle, moulding a meltable drug in the microneedle micromold to form a microneedle, and separating the microneedle from the microneedle micromold. Microneedles of the invention may incorporate up to 99% drug or more.

公开(公告)号：US20220249582A1

公开(公告)日：2022-08-11

申请号：US17614982

申请日：2020-05-30

申请人： University College Cork - National University of Ireland, Cork

发明人： Paul Ross ,  Catherine Stanton

IPC分类号： A61K35/747 ,  A61P3/10 ,  A61P3/04 ,  A61P25/24 ,  A23L33/00 ,  A23L33/135

摘要： A composition for use in a method of regulating or treating a metabolic disease or a symptom thereof, the composition comprising an isolated bacteria Lactobacillus brevis (DPC6108) deposited with the National Collection of Industrial and Marine Bacteria Limited (NCIMB) on 28 Nov. 2011 and accorded the accession number NCIMB 41903.

公开(公告)号：US20220184174A1

公开(公告)日：2022-06-16

申请号：US17436512

申请日：2020-03-04

申请人： UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK ,  TEAGASC, THE AGRICUL TURE AND FOOD DEVELOPMENT AUTHORITY

发明人： Reynolds Paul ROSS ,  Catherine Stanton ,  Colin Hill ,  Anthony Ryan ,  Julie O'Sullivan ,  Claire Watkins

IPC分类号： A61K38/16 ,  C12N1/20 ,  C12N15/74 ,  C07K14/31 ,  A61P31/04 ,  A61K35/00

摘要： An isolated lantibiotic is provided comprising amino acid sequence SEQ. ID No. 2 and at least one of amino acid sequences SEQ. ID No. 4 and SEQ. ID. No 6. Also provided is use of the lantibiotic in the treatment or prevention of infection by Group B Streptococcus or Corynebacterium xerosis. The invention further relates to isolated S. hominis strains and use of same in producing the lantibiotic. A vector is provided comprising nucleotides sequences for producing the lantibiotic.

公开(公告)号：US10813366B2

公开(公告)日：2020-10-27

申请号：US16794019

申请日：2020-02-18

申请人： PrecisionBiotics Group Limited ,  University College Cork—National University of Ireland, Cork

发明人： Eileen Frances Murphy ,  David Groeger ,  Timothy Dinan ,  John Cryan

IPC分类号： A61K35/745 ,  A23L33/135 ,  A23L33/00 ,  A23C9/123 ,  C12R1/01

摘要： Methods of treating a subject by administering Bifidobacterium longum strain NCIMB 41676 are discussed. The method may include orally administering a formulation comprising Bifidobacterium longum strain NCIMB 41676 to improve sleep.

公开(公告)号：US20200173927A1

公开(公告)日：2020-06-04

申请号：US16704587

申请日：2019-12-05

申请人： UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK

发明人： Dmitri Papkovsky ,  Andreas Fercher ,  Ingo Klimant ,  Sergey Borisov ,  Alexander Zhdanov

IPC分类号： G01N21/64 ,  G01N33/50 ,  B82Y30/00 ,  G01N33/84 ,  G01N33/58

摘要： A method of determining oxygen concentration, metabolic activity, and/or the effects of a test substance on the metabolic activity of a live cell sample by photoluminescence quenching technique employing a photoluminescent probe that self-loads sans any loading reagent into the cells of the cell sample. The probe comprises a plurality of polymeric particles each comprising an amphiphilic cationic polymer matrix having a hydrophobic core and a hydrophilic positively charged surface provided by quaternary amino groups, and a hydrophobic oxygen-sensitive photoluminescent dye embedded in the hydrophobic core.

公开(公告)号：US20190331833A1

公开(公告)日：2019-10-31

申请号：US16070445

申请日：2017-01-13

申请人： UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK

发明人： Parvaneh Mokarian-Tabari ,  Michael Morris ,  Ramsankar Senthamaraikannan

IPC分类号： G02B1/113 ,  H01L33/20 ,  H01L31/0216

摘要： The invention provides a solution based process based on high molecular weight block copolymer (BCP) nanolithography for fabrication of periodic structures on large areas of optical surfaces. In one embodiment there is provided method of fabricating a nano-patterned surface for application in a photonic, optical or other related device, said method comprising the steps of: providing a substrate material; depositing a block copolymer (BCP) material on the substrate material; and phase separating the BCPs using at least one solvent selected to facilitate polymer chain mobilisation and lead to phase separation to fabricate said nano-patterned surface; wherein the nano-patterned surface comprises an ordered array of structures and having a domain or diameter of 100 nm or greater. A new photonic device and optical device is also described.

公开(公告)号：US20190321487A1

公开(公告)日：2019-10-24

申请号：US16469248

申请日：2017-12-14

申请人： UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK

发明人： Raphael DARCY ,  Caitriona O'DRISCOLL ,  Meenakshi MALHOTRA

IPC分类号： A61K47/69 ,  A61K47/62 ,  A61K47/61 ,  A61K31/7105

摘要： A cyclodextrin-RNA conjugate is described in which the cyclodextrin molecule is conjugated at its glucosyl 6-, 2- or 3-positions, optionally via a linker, to at least one RNA molecule at the RNA 3′ terminal base. The at least one RNA molecule may be an siRNA molecule.

公开(公告)号：US10279083B2

公开(公告)日：2019-05-07

申请号：US15498860

申请日：2017-04-27

申请人： UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK

发明人： Noel Caplice

IPC分类号： A61F2/06 ,  A61L29/04 ,  A61L29/16

摘要： Provided herein are methods for treating an individual having (suffering from) an acute myocardial infarction and drug eluting stents useful for treating such individuals. These methods include treating an individual by introducing, such as by surgically inserting, at a site of an acute coronary artery occlusion upstream of the site of acute myocardial infarction, a drug eluting stent (DES) that is capable of eluting from 25 pg to 950 pg of IGF-1 directly into the coronary circulation. The treatment is specifically directed to stimulation of repair or survival of damaged cardiac muscle or left ventricular remodeling.

公开(公告)号：US10184127B2

公开(公告)日：2019-01-22

申请号：US15101078

申请日：2013-12-02

申请人： Compagnie Gervais Danone ,  University College Cork—National University of Ireland, Cork

发明人： Douwe van Sinderen ,  Mary O'Connell Motherway ,  Debbie Watson ,  Tamara Smokvina ,  Peggy Garault

IPC分类号： C12P21/06 ,  A61K39/00 ,  A61K39/38 ,  C12N15/74 ,  C12N1/20 ,  C12N9/10

摘要： The present invention concerns a method for genetically transforming a Bifidobacterium strain comprising a step of methylation of a shuttle vector in an E. coli or a Gram-positive bacterium strain by two type II DNA methyltransferases from a Bifidobacterium: a methyltransferase enzyme that methylates the adenine base at position 4 of the nucleotide sequence RTCAGG and a methyltransferase enzyme that methylates the cytosine base at position 4 of the nucleotide sequence GGWCC. The present invention also concerns genetic tools and culture media useful for carrying out said method.

公开(公告)号：US20180191231A1

公开(公告)日：2018-07-05

申请号：US15737275

申请日：2016-06-16

申请人： UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK

发明人： Roy Saibal ,  Pranay Podder ,  Dhiman Mallick ,  Andreas Amann

IPC分类号： H02K35/02 ,  H01L41/113 ,  G01H11/08 ,  G01H11/02 ,  H02N2/18 ,  G01R17/00

CPC分类号： H02K35/02 ,  G01H11/02 ,  G01H11/08 ,  G01R17/00 ,  H01L41/1132 ,  H01L41/1136 ,  H02N2/186

摘要： A vibrational energy harvesting device is disclosed, which comprises first and second assemblies mounted on a base at a distance one from the other. The first assembly comprises vibrational means adapted to stretch under a straining force, whereby the device exhibits monostable quartic nonlinearity. The first and second assemblies comprise respective magnetised means in opposite polarity to one another, so that the second assembly exerts a repulsive magnetic force upon the vibrational means, whereby the device exhibits bistability. Both the monostable quartic and bistable nonlinearities can be independently controlled. A method of harvesting energy with the vibrational energy harvesting device is also disclosed.