METHODS OF TREATING HEARING DISORDERS
    3.
    发明申请

    公开(公告)号:US20180021315A1

    公开(公告)日:2018-01-25

    申请号:US15655222

    申请日:2017-07-20

    CPC classification number: A61K31/437 A61K31/454 A61K38/1793

    Abstract: The present disclosure provides methods for treating a hearing disorder associated with maladaptive neuroplasticity, reduction of inhibition, shift of excitation-to-inhibition balance, changes in central gain, and/or changes in neural sensitivity in a subject by inhibiting the function and/or production of tumor necrosis factor alpha (TNF-α) in the subject. The present disclosure provides methods of administering to the subject a TNF-α inhibitory agent in an amount effective to treat the subject for a hearing disorder associated with maladaptive neuroplasticity, reduction of inhibition, shift of excitation-to-inhibition balance, changes in central gain, and/or changes in neural sensitivity. TNF-α inhibitory agents of the subject disclosure include agents that inhibit the function TNF-α, inhibit the production of TNF-α, inhibit TNF-α signaling, inhibit TNF-α expression, or inhibit TNF-α signaling pathway genes in the subject. The present disclosure also provides methods for treating a hearing disorder associated with maladaptive neuroplasticity, reduction of inhibition, shift of excitation-to-inhibition balance, changes in central gain, and/or changes in neural sensitivity in a subject by disrupting one or more alleles of a TNF-α signaling pathway gene in a cell of the subject.

    HEARING AID FITTING PROCEDURE AND PROCESSING BASED ON SUBJECTIVE SPACE REPRESENTATION
    4.
    发明申请
    HEARING AID FITTING PROCEDURE AND PROCESSING BASED ON SUBJECTIVE SPACE REPRESENTATION 有权
    基于主观空间表示的听力辅助配套程序和处理

    公开(公告)号:US20150281862A1

    公开(公告)日:2015-10-01

    申请号:US14611701

    申请日:2015-02-02

    CPC classification number: H04R25/70 H04R25/507 H04R29/008 H04R2225/41

    Abstract: A system for hearing assistance devices to assist hearing aid fitting applied to individual differences in hearing impairment. The system is also usable for assisting fitting and use of hearing assistance devices for listeners of music. The method uses a subjective space approach to reduce the dimensionality of the fitting problem and a non-linear regression technology to interpolate among hearing aid parameter settings. This listener-driven method provides not only a technique for preferred aid fitting, but also information on individual differences and the effects of gain compensation on different musical styles.

    Abstract translation: 用于听力辅助设备的系统,用于辅助助听器配件应用于听力障碍的个体差异。 该系统还可用于辅助音乐听众的听力辅助装置的装配和使用。 该方法使用主观空间法来减少拟合问题的维数和非线性回归技术,以在助听器参数设置之间进行插值。 这种听众驱动的方法不仅提供了优先援助适应的技术,还提供了个人差异的信息以及增益补偿对不同音乐风格的影响。

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