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65 条记录 (耗时 0.021 秒)

    Air Valve
    2.
    发明申请
    Air Valve 有权

    公开(公告)号：US20230018901A1

    公开(公告)日：2023-01-19

    申请号：US17783838

    申请日：2020-12-08

    申请人： University of Pretoria

    发明人： Stefanus Johannes Van Vuuren ,  Marco Van Dijk

    IPC分类号： F16K24/04

    摘要： This invention relates to an air valve which includes a deflector positioned inside a float chamber in order to improve the flow of air through the air valve. Further, the air valve includes an upper opening leading from the float chamber and having a transverse cross-section which increases away from the float chamber in order to smooth air flow. The invention further relates to an air valve accessory whereby an air valve can be modified in order to improve air flow therethrough.

    Method and Kit for Identifying Gene Mutations
    3.
    发明申请
    Method and Kit for Identifying Gene Mutations 有权

    公开(公告)号：US20210340626A1

    公开(公告)日：2021-11-04

    申请号：US17374478

    申请日：2021-07-13

    申请人： UNIVERSITY OF PRETORIA

    发明人： Robin John GREEN ,  Refiloe MASEKELA ,  Cheryl STEWART ,  Michael Sean PEPPER

    IPC分类号： C12Q1/6883 ,  G16B30/00

    摘要： This invention relates to a method of identifying mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, a kit for performing the method, and furthermore to isolated nucleotide sequences being complementary to one or more mutations of the CFTR gene. According to a first aspect of the invention there is provided a method of identifying mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, including the steps of providing one or more nucleic acid sequences, fully complementary to one or more segments of the CFTR gene, wherein the one or more nucleic acid sequences correspond to the mutation to be identified; providing a biological sample of an individual to be tested for CF; isolating nucleic acids from the biological sample; and testing the biological sample for the presence of one or more of the nucleic acid sequences using a suitable detection method.

    Method and kit for identifying gene mutations
    4.
    发明授权
    Method and kit for identifying gene mutations 有权

    公开(公告)号：US11060146B2

    公开(公告)日：2021-07-13

    申请号：US15773800

    申请日：2016-11-03

    申请人： UNIVERSITY OF PRETORIA

    发明人： Robin John Green ,  Refiloe Masekela ,  Cheryl Stewart ,  Michael Sean Pepper

    IPC分类号： C12Q1/6883 ,  G16B30/00

    摘要： This invention relates to a method of identifying mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, a kit for performing the method, and furthermore to isolated nucleotide sequences being complementary to one or more mutations of the CFTR gene. According to a first aspect of the invention there is provided a method of identifying mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, including the steps of providing one or more nucleic acid sequences, fully complementary to one or more segments of the CFTR gene, wherein the one or more nucleic acid sequences correspond to the mutation to be identified; providing a biological sample of an individual to be tested for CF; isolating nucleic acids from the biological sample; and testing the biological sample for the presence of one or more of the nucleic acid sequences using a suitable detection method.

    MARKERS FOR DISEASE RESISTANCE IN MAIZE
    6.
    发明申请
    MARKERS FOR DISEASE RESISTANCE IN MAIZE 审中-公开
    玉米抗药性标记

    公开(公告)号：US20160340748A1

    公开(公告)日：2016-11-24

    申请号：US15106673

    申请日：2014-12-19

    申请人： UNIVERSITY OF PRETORIA ,  PANNAR SEED (PTY) LTD

    发明人： David K. Berger ,  Maryke Carstens ,  Fredrick J. Kloppers ,  Jacquline Meyer ,  Shane L. Murray ,  Alexander A. Myburg

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6895 ,  C12Q2600/156

    摘要： Methods and compositions for identifying maize plants that have newly conferred tolerance or enhanced tolerance to, or are susceptible to, Gray Leaf Spot (GLS) are provided. The methods use molecular genetic markers to identify, select and/or construct tolerant plants or identify and counter-select susceptible plants. Maize plants that display newly conferred tolerance or enhanced tolerance to GLS that are generated by the methods are also a feature of the invention.

    摘要翻译： 提供了用于鉴定新近赋予的对灰色斑点（GLS）的耐受性或增强的耐受性或易于受到影响的玉米植物的方法和组合物。 所述方法使用分子遗传标记来鉴定，选择和/或构建耐受性植物或识别并对抗敏感植物。 通过该方法产生的显示新赋予的耐受性或对GLS的增强的耐受性的玉米植物也是本发明的一个特征。

    A METHOD OF DIAGNOSING TUBERCULOSIS
    7.
    发明申请
    A METHOD OF DIAGNOSING TUBERCULOSIS 审中-公开
    诊断TUBCCOSOS的方法

    公开(公告)号：US20160169905A1

    公开(公告)日：2016-06-16

    申请号：US14891490

    申请日：2014-05-15

    申请人： UNIVERSITY OF PRETORIA

    发明人： Jan Adrianus VERSCHOOR ,  Carl BAUMEISTER

    IPC分类号： G01N33/68 ,  G01N33/543

    CPC分类号： G01N33/6854 ,  G01N33/5432 ,  G01N33/5438 ,  G01N33/5695 ,  G01N2333/35 ,  G01N2469/20 ,  G01N2800/12

    摘要： Mycolic acid antigen containing liposomes, and an electrode immobilised antigens of tuberculous mycobacterial origin are produced. A diagnostic sample from a human suspected of having tuberculosis is diluted and divided into first and second samples. A control sample comprising the first sample and a redox probe is exposed to the liposomes. A test sample comprising the second sample and a redox probe is exposed to liposomes not containing mycolic acid antigens. The control sample is contacted with the immobilised antigens to allow antibodies therein to bind to the antigens. The test sample is contacted with the immobilised antigens to allow any antibodies therein to bind to the antigens. The degree of binding in the samples is compared by electrochemical impedance spectroscopy. Any observed lesser binding by the control sample is an indicator of antibodies to the antigens in the diagnostic sample, indicating tuberculosis in the human.

    摘要翻译： 产生含有霉菌酸抗原的脂质体，以及结核菌分枝杆菌来源的电极固定抗原。 将疑似患有结核病的人的诊断样品稀释并分成第一和第二样品。 包含第一样品和氧化还原探针的对照样品暴露于脂质体。 将包含第二样品和氧化还原探针的测试样品暴露于不含霉菌酸抗原的脂质体。 将对照样品与固定的抗原接触，以使其中的抗体与抗原结合。 使测试样品与固定的抗原接触，以使其中的任何抗体与抗原结合。 通过电化学阻抗谱法比较样品中的结合度。 对照样品的任何观察到的较小的结合是诊断样品中抗原的抗体的指示剂，表明人类的结核病。

    EXTRACT OF GREYIA RADLKOFERI AND USE THEREOF
    8.
    发明申请
    EXTRACT OF GREYIA RADLKOFERI AND USE THEREOF 审中-公开
    GREYIA RADLKOFERI的提取及其使用

    公开(公告)号：US20150118337A1

    公开(公告)日：2015-04-30

    申请号：US14400645

    申请日：2013-05-17

    申请人： UNIVERSITY OF PRETORIA ,  UNIVERSITY OF KWAZULU-NATAL

    发明人： Marco Nuno De Canha ,  Namrita Lall ,  Ahmed Hussein ,  Elizabeth Mogapi ,  lndres Moodley

    IPC分类号： A61K8/97 ,  A61Q19/00

    CPC分类号： A61K8/97 ,  A61K36/77 ,  A61K2236/39 ,  A61Q19/00 ,  A61Q19/02

    摘要： This invention relates to the isolation, and use of a plant extract in the treatment of skin hyper-pigmentation. More particularly, this invention relates to the isolation of a tyrosinase inhibitor in an extract of plant material from the Greyia radlkoferi (G. radlkoferi) plant, the extract including 5,7-dihidroxyflavone[(2S)-pinocembrin]; 2′, 6′-dihydroxy-4′-methoxydihydrochalcone; 2′,4′,6′-trihydroxyhydrochalcone; 3,5,7-trihydroxyflavone and 4′,5′7-thhydroxyisoflavone.

    摘要翻译： 本发明涉及植物提取物在治疗皮肤色素沉着过程中的分离和使用。 更具体地说，本发明涉及从Greyia radlkoferi（G. radlkoferi）植物提取的植物材料的提取物中分离酪氨酸酶抑制剂，所述提取物包括5,7-二羟基黄酮[（2S） - 磷胆固醇]; 2'，6'-二羟基-4'-甲氧基二氢查耳酮; 2'，4'，6'-三羟基氢查尔酮; 3,5,7-三羟基黄酮和4'，5'-羟基异黄酮。

    AN IMMUNOGEN
    10.
    发明公开
    AN IMMUNOGEN 审中-公开

    公开(公告)号：US20240299511A1

    公开(公告)日：2024-09-12

    申请号：US18273087

    申请日：2022-01-26

    申请人： UNIVERSITY OF PRETORIA

    发明人： Robert Peter MILLAR

    IPC分类号： A61K39/00 ,  A61P15/16 ,  A61P15/18 ,  C07K14/005 ,  C07K14/475 ,  C07K14/59

    CPC分类号： A61K39/0006 ,  A61P15/16 ,  A61P15/18 ,  C07K14/005 ,  C07K14/475 ,  C07K14/59 ,  A61K2039/55566 ,  A61K2039/6075 ,  C07K2319/40 ,  C12N2730/10122

    摘要： This invention relates to an immunogen comprising a gonadotropin releasing hormone (GnRH) peptide sequence, a kisspeptin peptide sequence and a stimulant of raising an immune response, such an immunogen for use in a method to regulate the release of hormones in a vertebrate including modulation of reproductive hormones, to reduce fertility in a vertebrate and to treat hormone-dependent diseases including hormone-dependent tumours including prostate tumours, breast, ovary and endometrial tumours, benign hyperplasia including benign prostatic hyperplasia and uterine fibroids, endometriosis, polycystic ovarian disease, infertility, sexual dysfunction and any disorder that would benefit from an increased or decreased GnRH-dependent activity and a vaccine formulation comprising the immunogen. The invention also relates to the use of the immunogen in the preparation of a medicament for use in a method to regulate the release of hormones in a vertebrate.