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公开(公告)号:US08573150B2
公开(公告)日:2013-11-05
申请号:US12742591
申请日:2008-11-14
申请人: Ivan Vecerina , Vinh Pham
发明人: Ivan Vecerina , Vinh Pham
CPC分类号: B05D1/02 , A61F2/915 , A61F2002/91575 , A61F2002/91583 , A61L31/00 , B05B12/02 , B05B12/122 , B05B12/126 , B05B13/0235 , B05C5/0216 , B05C11/1021 , B05C11/1023 , B05C13/025
摘要: An automated apparatus and method for coating medical devices such as an intravascular stent, are disclosed in the method, a 2-D image of a stent is processed to determine (1) paths along the stent skeletal elements by which a stent secured to a rotating support element can be traversed by a dispenser head whose relative motion with respect to the support element is along the support-element axis, such that some or all of the stent skeletal elements will be traversed (2) the relative speeds of the dispenser head and support element as the dispenser head travels along the paths, and (3), and positions of the dispenser head with respect to a centerline of the stent elements as the dispenser head travels along such paths The rotational speed of the support and relative linear speed of the dispenser are controlled to achieve the desired coating thickness and coating coverage on the upper surfaces, and optionally, the side surfaces, of the stent elements.
摘要翻译: 在该方法中公开了用于涂覆诸如血管内支架的医疗装置的自动化装置和方法,处理支架的2-D图像以确定(1)沿支架骨架元件的路径,支架固定在旋转 支撑元件可以通过相对于支撑元件的相对运动沿着支撑元件轴线的分配器头部移动,使得一些或全部支架骨架元件将被穿过(2)分配器头部的相对速度 当分配器头沿着路径行进时的支撑元件,和(3)以及分配器头部相对于支架元件的中心线的位置,因为分配器头沿着这样的路径行进。支撑件的旋转速度和相对线速度 控制分配器以在支架元件的上表面和任选的侧表面上实现期望的涂层厚度和涂层覆盖。
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公开(公告)号:US20120077781A1
公开(公告)日:2012-03-29
申请号:US12737781
申请日:2009-08-11
申请人: Robert Gadwood , Harpreet Kaur , Kevin Kells , Jeffrey A. Leiby , David Moon , Vinh Pham , Philip D.G. Coish , Kenneth F. Blount , Brian R. Dixon , Jayhyuk Myung , David Osterman , Stephanie Avola , Nick Baboulas , Angelica Bello , Judd Berman , Bruce R. Evans , Tan Quach , Heinrich J. Schostarez , Frank C. Sciavolino , Dennis Underwood , Phil Wickens , Jeffrey Wilson , Justin Wu
发明人: Robert Gadwood , Harpreet Kaur , Kevin Kells , Jeffrey A. Leiby , David Moon , Vinh Pham , Philip D.G. Coish , Kenneth F. Blount , Brian R. Dixon , Jayhyuk Myung , David Osterman , Stephanie Avola , Nick Baboulas , Angelica Bello , Judd Berman , Bruce R. Evans , Tan Quach , Heinrich J. Schostarez , Frank C. Sciavolino , Dennis Underwood , Phil Wickens , Jeffrey Wilson , Justin Wu
IPC分类号: A61K31/675 , A61P31/04 , C07D487/04 , C07F9/6561 , A61K31/525 , A61K31/5377
CPC分类号: A61K31/495 , A61K31/505 , C07D475/02 , Y02A50/401 , Y02A50/471 , Y02A50/473 , Y02A50/481
摘要: The present invention relates novel flavin derivatives and other flavin derivatives, their use and compositions for use as riboswitch ligands and/or anti-infectives. The invention also provides method of making novel flavin derivatives.
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公开(公告)号:US07812037B2
公开(公告)日:2010-10-12
申请号:US11262509
申请日:2005-10-28
申请人: Wasimul Haque , James Diakur , Vinh Pham , Atiq Rehman , Tara Whitney , Mohammed Omar , Seng Yi , A. Qasim Khan
发明人: Wasimul Haque , James Diakur , Vinh Pham , Atiq Rehman , Tara Whitney , Mohammed Omar , Seng Yi , A. Qasim Khan
IPC分类号: A61K31/4425 , C07D213/65
CPC分类号: C07D213/65 , C07D213/66 , C07D213/74 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/89 , C07D491/04 , C07D498/04
摘要: Compounds with antiplatelet aggregation and anticoagulant characteristics for the treatment of cardiovascular, cerebrovascular, and cardiovascular related diseases and symptoms, are described. The methods are directed to administering pharmaceutical compositions comprising aryl sulfonic pyridoxine and/or substituted pyridoxine analogs.
摘要翻译: 描述了用于治疗心血管,脑血管和心血管相关疾病和症状的具有抗血小板聚集和抗凝血特征的化合物。 该方法涉及给予包含芳基磺酸吡哆醇和/或取代的吡哆醛类似物的药物组合物。
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公开(公告)号:US20080306108A1
公开(公告)日:2008-12-11
申请号:US12134622
申请日:2008-06-06
申请人: Wasimul Haque , James Diakur , Vinh Pham , Wenlian Zhang
发明人: Wasimul Haque , James Diakur , Vinh Pham , Wenlian Zhang
IPC分类号: A61K31/4412 , A61P9/00 , C07D491/056 , C07D213/65 , C07D401/12 , A61K31/436 , A61K31/444
CPC分类号: C07D213/66 , C07D213/65 , C07D213/79 , C07D491/04
摘要: Compounds with antiplatelet aggregation characteristics for the treatment of cardiovascular and cardiovascular related disease, are described. The methods are directed to administering pharmaceutical compositions comprising a pyridoxine analogue.
摘要翻译: 描述了具有用于治疗心血管和心血管相关疾病的抗血小板聚集特性的化合物。 所述方法涉及给予包含吡哆醇类似物的药物组合物。
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公开(公告)号:US20060094761A1
公开(公告)日:2006-05-04
申请号:US11262509
申请日:2005-10-28
申请人: Wasimul Haque , James Diakur , Vinh Pham , Atiq Rehman , Tara Whitney , Mohammed Omar , Seng Yi , A. Khan
发明人: Wasimul Haque , James Diakur , Vinh Pham , Atiq Rehman , Tara Whitney , Mohammed Omar , Seng Yi , A. Khan
IPC分类号: C07D401/02 , C07D213/63 , A61K31/444 , A61K31/44
CPC分类号: C07D213/65 , C07D213/66 , C07D213/74 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/89 , C07D491/04 , C07D498/04
摘要: Compounds with antiplatelet aggregation and anticoagulant characteristics for the treatment of cardiovascular, cerebrovascular, and cardiovascular related diseases and symptoms, are described. The methods are directed to administering pharmaceutical compositions comprising aryl sulfonic pyridoxine and/or substituted pyridoxine analogs.
摘要翻译: 描述了用于治疗心血管,脑血管和心血管相关疾病和症状的具有抗血小板聚集和抗凝血特征的化合物。 该方法涉及给予包含芳基磺酸吡哆醇和/或取代的吡哆醛类似物的药物组合物。
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公开(公告)号:US20060094749A1
公开(公告)日:2006-05-04
申请号:US10974718
申请日:2004-10-28
申请人: Wasimul Haque , James Diakur , Vinh Pham , Wenlian Zhang
发明人: Wasimul Haque , James Diakur , Vinh Pham , Wenlian Zhang
IPC分类号: C07D491/02 , C07D213/63 , A61K31/44 , A61K31/4741
CPC分类号: C07D213/66 , C07D213/65 , C07D213/79 , C07D491/04
摘要: Compounds with antiplatelet aggregation characteristics for the treatment of cardiovascular and cardiovascular related disease, are described. The methods are directed to administering pharmaceutical compositions comprising a pyridoxine analogue.
摘要翻译: 描述了具有用于治疗心血管和心血管相关疾病的抗血小板聚集特性的化合物。 所述方法涉及给予包含吡哆醇类似物的药物组合物。
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公开(公告)号:US20130029980A1
公开(公告)日:2013-01-31
申请号:US13640054
申请日:2011-04-06
申请人: Philip D. G. Coish , Brian R. Dixon , David Osterman , Paul Adrian Aristoff , Manuel Navia , Frank Sciavolino , Stephanie Avola , Nick Baboulas , Thomas R. Belliotti , Angelica Bello , Judd Berman , Robert A. Chrusciel , Bruce R. Evans , Harpreet Kaur , David Moon , Vinh Pham , Andrew Roughton , Phil Wickens , Jeffrey Wilson , Heinrich J. Schostarez
发明人: Philip D. G. Coish , Brian R. Dixon , David Osterman , Paul Adrian Aristoff , Manuel Navia , Frank Sciavolino , Stephanie Avola , Nick Baboulas , Thomas R. Belliotti , Angelica Bello , Judd Berman , Robert A. Chrusciel , Bruce R. Evans , Harpreet Kaur , David Moon , Vinh Pham , Andrew Roughton , Phil Wickens , Jeffrey Wilson , Heinrich J. Schostarez
IPC分类号: C07D487/04 , A61P31/04 , A61K31/5377 , A61K31/519 , C07D491/147
CPC分类号: A01N43/90 , C07D475/14
摘要: The present invention relates novel flavin derivatives, their use and compositions for use as riboswitch ligands and/or anti-infectives.
摘要翻译: 本发明涉及新的黄素衍生物,其用途和用作核糖开关配体和/或抗感染剂的组合物。
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公开(公告)号:US20120295903A1
公开(公告)日:2012-11-22
申请号:US13381809
申请日:2010-06-30
申请人: Kenneth F. Blount , Philip D.G. Coish , Brian R. Dixon , Jayhyuk Myung , David Osterman , Phil Wickens , Stephanie Avola , Nick Baboulas , Angelica Bello , Judd Berman , Harpreet Kaur , David Moon , Vinh Pham , Andrew Roughton , Jeffrey Wilson , Jeffrey A. Leiby , Dennis Underwood , Paul Adrian Aristoff , Heinrich J. Schostarez , Robert A. Chrusciel , Thomas R. Belliotti , Bruce R. Evans , Frank C. Sciavolino , Manuel A. Navia
发明人: Kenneth F. Blount , Philip D.G. Coish , Brian R. Dixon , Jayhyuk Myung , David Osterman , Phil Wickens , Stephanie Avola , Nick Baboulas , Angelica Bello , Judd Berman , Harpreet Kaur , David Moon , Vinh Pham , Andrew Roughton , Jeffrey Wilson , Jeffrey A. Leiby , Dennis Underwood , Paul Adrian Aristoff , Heinrich J. Schostarez , Robert A. Chrusciel , Thomas R. Belliotti , Bruce R. Evans , Frank C. Sciavolino , Manuel A. Navia
IPC分类号: C07D487/04 , A01P1/00 , A61K31/5377 , A61P31/04 , A61K31/525 , A01N43/90
CPC分类号: C07D487/04
摘要: The present invention relates novel flavin derivatives and other flavin derivatives, their use and compositions for use as riboswitch ligands and/or anti-infectives. The invention also provides method of making novel flavin derivatives.
摘要翻译: 本发明涉及新的黄素衍生物和其它黄素衍生物,其用途和用作核糖开关配体和/或抗感染剂的组合物。 本发明还提供了制备新型黄素衍生物的方法。
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公开(公告)号:US20100262230A1
公开(公告)日:2010-10-14
申请号:US12742591
申请日:2008-11-14
申请人: Ivan Vecerina , Vinh Pham
发明人: Ivan Vecerina , Vinh Pham
CPC分类号: B05D1/02 , A61F2/915 , A61F2002/91575 , A61F2002/91583 , A61L31/00 , B05B12/02 , B05B12/122 , B05B12/126 , B05B13/0235 , B05C5/0216 , B05C11/1021 , B05C11/1023 , B05C13/025
摘要: An automated apparatus and method for coating medical devices such as an intravascular stent, are disclosed in the method, a 2-D image of a stent is processed to determine (1) paths along the stent skeletal elements by which a stent secured to a rotating support element can be traversed by a dispenser head whose relative motion with respect to the support element is along the support-element axis, such that some or all of the stent skeletal elements will be traversed (2) the relative speeds of the dispenser head and support element as the dispenser head travels along the paths, and (3), and positions of the dispenser head with respect to a centerline of the stent elements as the dispenser head travels along such paths The rotational speed of the support and relative linear speed of the dispenser are controlled to achieve the desired coating thickness and coating coverage on the upper surfaces, and optionally, the side surfaces, of the stent elements
摘要翻译: 在该方法中公开了用于涂覆诸如血管内支架的医疗装置的自动化装置和方法,处理支架的2-D图像以确定(1)沿支架骨架元件的路径,支架固定在旋转 支撑元件可以通过相对于支撑元件的相对运动沿着支撑元件轴线的分配器头部移动,使得一些或全部支架骨架元件将被穿过(2)分配器头部的相对速度 当分配器头沿着路径行进时的支撑元件,和(3)以及分配器头部相对于支架元件的中心线的位置,因为分配器头沿着这样的路径行进。支撑件的旋转速度和相对线速度 控制分配器以在支架元件的上表面和任选的侧表面上实现期望的涂层厚度和涂层覆盖
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公开(公告)号:US20060241083A1
公开(公告)日:2006-10-26
申请号:US10549505
申请日:2004-03-15
申请人: James Diakur , Wasimul Haque , Wenlian Zhang , Junzhi Yao , Vinh Pham
发明人: James Diakur , Wasimul Haque , Wenlian Zhang , Junzhi Yao , Vinh Pham
IPC分类号: A61K31/675 , C07F9/58
CPC分类号: C07F9/58
摘要: This invention teaches a-substituted phosphonates, their preparation, pharmaceutical compositions thereof, biologically acceptable salts thereof, and methods for treating various disorders using such compositions.
摘要翻译: 本发明教导了α-取代的膦酸酯,其制备方法,其药物组合物,其生物可接受的盐,以及使用这些组合物治疗各种病症的方法。
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