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公开(公告)号:US20120077781A1
公开(公告)日:2012-03-29
申请号:US12737781
申请日:2009-08-11
申请人: Robert Gadwood , Harpreet Kaur , Kevin Kells , Jeffrey A. Leiby , David Moon , Vinh Pham , Philip D.G. Coish , Kenneth F. Blount , Brian R. Dixon , Jayhyuk Myung , David Osterman , Stephanie Avola , Nick Baboulas , Angelica Bello , Judd Berman , Bruce R. Evans , Tan Quach , Heinrich J. Schostarez , Frank C. Sciavolino , Dennis Underwood , Phil Wickens , Jeffrey Wilson , Justin Wu
发明人: Robert Gadwood , Harpreet Kaur , Kevin Kells , Jeffrey A. Leiby , David Moon , Vinh Pham , Philip D.G. Coish , Kenneth F. Blount , Brian R. Dixon , Jayhyuk Myung , David Osterman , Stephanie Avola , Nick Baboulas , Angelica Bello , Judd Berman , Bruce R. Evans , Tan Quach , Heinrich J. Schostarez , Frank C. Sciavolino , Dennis Underwood , Phil Wickens , Jeffrey Wilson , Justin Wu
IPC分类号: A61K31/675 , A61P31/04 , C07D487/04 , C07F9/6561 , A61K31/525 , A61K31/5377
CPC分类号: A61K31/495 , A61K31/505 , C07D475/02 , Y02A50/401 , Y02A50/471 , Y02A50/473 , Y02A50/481
摘要: The present invention relates novel flavin derivatives and other flavin derivatives, their use and compositions for use as riboswitch ligands and/or anti-infectives. The invention also provides method of making novel flavin derivatives.
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公开(公告)号:US20120295903A1
公开(公告)日:2012-11-22
申请号:US13381809
申请日:2010-06-30
申请人: Kenneth F. Blount , Philip D.G. Coish , Brian R. Dixon , Jayhyuk Myung , David Osterman , Phil Wickens , Stephanie Avola , Nick Baboulas , Angelica Bello , Judd Berman , Harpreet Kaur , David Moon , Vinh Pham , Andrew Roughton , Jeffrey Wilson , Jeffrey A. Leiby , Dennis Underwood , Paul Adrian Aristoff , Heinrich J. Schostarez , Robert A. Chrusciel , Thomas R. Belliotti , Bruce R. Evans , Frank C. Sciavolino , Manuel A. Navia
发明人: Kenneth F. Blount , Philip D.G. Coish , Brian R. Dixon , Jayhyuk Myung , David Osterman , Phil Wickens , Stephanie Avola , Nick Baboulas , Angelica Bello , Judd Berman , Harpreet Kaur , David Moon , Vinh Pham , Andrew Roughton , Jeffrey Wilson , Jeffrey A. Leiby , Dennis Underwood , Paul Adrian Aristoff , Heinrich J. Schostarez , Robert A. Chrusciel , Thomas R. Belliotti , Bruce R. Evans , Frank C. Sciavolino , Manuel A. Navia
IPC分类号: C07D487/04 , A01P1/00 , A61K31/5377 , A61P31/04 , A61K31/525 , A01N43/90
CPC分类号: C07D487/04
摘要: The present invention relates novel flavin derivatives and other flavin derivatives, their use and compositions for use as riboswitch ligands and/or anti-infectives. The invention also provides method of making novel flavin derivatives.
摘要翻译: 本发明涉及新的黄素衍生物和其它黄素衍生物,其用途和用作核糖开关配体和/或抗感染剂的组合物。 本发明还提供了制备新型黄素衍生物的方法。
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公开(公告)号:US20120283219A1
公开(公告)日:2012-11-08
申请号:US13257325
申请日:2010-03-25
申请人: Philip D.G. Coish , Phil Wickens , Brian R. Dixon , David Osterman , Uday R. Khire , Manuel Navia , Judd Berman , Harpreet Kaur , Jeffrey Wilson , Dennis Underwood
发明人: Philip D.G. Coish , Phil Wickens , Brian R. Dixon , David Osterman , Uday R. Khire , Manuel Navia , Judd Berman , Harpreet Kaur , Jeffrey Wilson , Dennis Underwood
IPC分类号: A61K31/519 , C07F9/6561 , C07D403/12 , C07F9/6512 , A61P1/12 , A61P31/00 , A61P31/04 , A61P31/10 , A61P13/02 , C07D475/08 , A61K31/675
CPC分类号: C07D475/08
摘要: The present invention relates novel diaminopteridine derivatives, their compositions and method of treatment comprising the same for use as anti-infectives.
摘要翻译: 本发明涉及新型的二氨基脒衍生物,其组合物和包含其的治疗方法用作抗感染剂。
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公开(公告)号:US20080140616A1
公开(公告)日:2008-06-12
申请号:US11525245
申请日:2006-09-21
申请人: Nicolas Encina , Kevin Gilpin , Dennis Underwood
发明人: Nicolas Encina , Kevin Gilpin , Dennis Underwood
IPC分类号: G06F17/30
CPC分类号: G06F17/30613 , G06F17/30864
摘要: A search system and method are disclosed. In one general aspect the method features fingerprinting digitally stored documents and queries based on one or more topic models. Similarities between document and query fingerprints can be detected to search for documents. Topic summaries can also be derived from the documents and queries based on the topic models.
摘要翻译: 公开了一种搜索系统和方法。 在一个一般方面,该方法特征是基于一个或多个主题模型对数字存储的文档和查询进行指纹识别。 可以检测文档和查询指纹之间的相似性来搜索文档。 主题摘要也可以从基于主题模型的文档和查询中导出。
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公开(公告)号:US20070213321A1
公开(公告)日:2007-09-13
申请号:US11600514
申请日:2006-11-15
申请人: Jayhong Chong , Christopher Fanger , Glenn Larsen , William Lumma , Magdalene Moran , Amy Ripka , Dennis Underwood , Manfred Weigele , Xiaoguang Zhen
发明人: Jayhong Chong , Christopher Fanger , Glenn Larsen , William Lumma , Magdalene Moran , Amy Ripka , Dennis Underwood , Manfred Weigele , Xiaoguang Zhen
IPC分类号: A61K31/55 , A61K31/4709
CPC分类号: C07D513/04 , A61K8/49 , A61K8/4906 , A61K8/4926 , A61K31/428 , A61K31/47 , A61K31/4709 , A61K31/498 , A61K31/538 , A61K31/55 , A61Q7/02 , C07D215/08 , C07D223/16 , C07D277/70 , C07D401/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要: The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
摘要翻译: 本申请涉及用于治疗与TRPV3相关的疼痛和其它病症的化合物和方法。
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公开(公告)号:USD950334S1
公开(公告)日:2022-05-03
申请号:US29700716
申请日:2019-08-05
申请人: Dennis Underwood
设计人: Dennis Underwood
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公开(公告)号:US20060270688A1
公开(公告)日:2006-11-30
申请号:US11431942
申请日:2006-05-09
申请人: Jayhong Chong , Christopher Fanger , Glenn Larsen , William Lumma , Magdalene Moran , Amy Ripka , Dennis Underwood , Manfred Weigele , Xiaoguang Zhen
发明人: Jayhong Chong , Christopher Fanger , Glenn Larsen , William Lumma , Magdalene Moran , Amy Ripka , Dennis Underwood , Manfred Weigele , Xiaoguang Zhen
IPC分类号: A61K31/506 , A61K31/4709
CPC分类号: A61K31/4709 , A61K9/0014 , A61K9/0053 , A61K31/427 , A61K31/47 , A61K31/498 , A61K31/506 , A61K31/538 , A61K31/55 , C07D215/54 , C07D409/04 , C07D495/04
摘要: The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
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公开(公告)号:US07707206B2
公开(公告)日:2010-04-27
申请号:US11525245
申请日:2006-09-21
申请人: Nicolas Encina , Kevin Gilpin , Dennis Underwood
发明人: Nicolas Encina , Kevin Gilpin , Dennis Underwood
CPC分类号: G06F17/30613 , G06F17/30864
摘要: A search system and method are disclosed. In one general aspect the method features fingerprinting digitally stored documents and queries based on one or more topic models. Similarities between document and query fingerprints can be detected to search for documents. Topic summaries can also be derived from the documents and queries based on the topic models.
摘要翻译: 公开了一种搜索系统和方法。 在一个一般方面,该方法特征是基于一个或多个主题模型对数字存储的文档和查询进行指纹识别。 可以检测文档和查询指纹之间的相似性来搜索文档。 主题摘要也可以从基于主题模型的文档和查询中导出。
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公开(公告)号:US20070179164A1
公开(公告)日:2007-08-02
申请号:US11592783
申请日:2006-11-03
申请人: Jayhong Chong , Christopher Fanger , Glenn Larsen , William Lumma , Magdalene Moran , Amy Ripka , Dennis Underwood , Manfred Weigele , Xiaoguang Zhen
发明人: Jayhong Chong , Christopher Fanger , Glenn Larsen , William Lumma , Magdalene Moran , Amy Ripka , Dennis Underwood , Manfred Weigele , Xiaoguang Zhen
IPC分类号: A61K31/517 , C07D239/91
CPC分类号: C07D487/04 , A61K31/517 , C07D239/91 , C07D401/06 , C07D471/04
摘要: The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
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10.
公开(公告)号:US20060025460A1
公开(公告)日:2006-02-02
申请号:US11156364
申请日:2005-06-17
申请人: Alfredo Castro , Wei Deng , Kristopher Depew , Michael Foley , Christian Fritz , Asimina Georges Evangelinos , Michael Grogan , Nafeeza Hafeez , Edward Holson , Brian Hopkins , Nii Koney , Tao Liu , David Mann , Lisa Marcaurelle , Daniel Snyder , Dennis Underwood , Andrew Wylie , Lin-Chen Yu , Linping Zhang
发明人: Alfredo Castro , Wei Deng , Kristopher Depew , Michael Foley , Christian Fritz , Asimina Georges Evangelinos , Michael Grogan , Nafeeza Hafeez , Edward Holson , Brian Hopkins , Nii Koney , Tao Liu , David Mann , Lisa Marcaurelle , Daniel Snyder , Dennis Underwood , Andrew Wylie , Lin-Chen Yu , Linping Zhang
IPC分类号: C07D261/02 , A61K31/42
CPC分类号: C07D261/02 , C07D261/18 , C07D413/10 , C07D413/12 , C07D417/12 , C07D498/04
摘要: One aspect of the present invention relates to heterocyclic compounds that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising a heterocyclic compound of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer.
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