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公开(公告)号：US08754564B2
公开(公告)日：2014-06-17
申请号：US13222812
申请日：2011-08-31
申请人： Steven Bennett , Nathaniel Mast , Kevin Lavigne , Walter Skalla , Timothy Sargeant , Joshua Stopek
发明人： Steven Bennett , Nathaniel Mast , Kevin Lavigne , Walter Skalla , Timothy Sargeant , Joshua Stopek
IPC分类号： H02K1/06
CPC分类号： A61K41/00 , A61K9/0024 , A61K9/06 , A61K31/00 , A61K47/34 , A61L24/0015 , A61L24/0031 , A61L26/0066 , A61L26/008 , A61L27/52 , A61L27/54 , A61L29/145 , A61L29/16 , A61L31/145 , A61L31/16 , A61L2300/622 , A61L2300/626 , C08J3/075 , C08J3/246 , C08J2371/02
摘要： The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.
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公开(公告)号：US20120049689A1
公开(公告)日：2012-03-01
申请号：US13222812
申请日：2011-08-31
申请人： Steven Bennett , Nathaniel Mast , Kevin Lavigne , Walter Skalla , Timothy Sargeant , Joshua Stopek , Saumya Banerjee , Arpan Desai
发明人： Steven Bennett , Nathaniel Mast , Kevin Lavigne , Walter Skalla , Timothy Sargeant , Joshua Stopek , Saumya Banerjee , Arpan Desai
IPC分类号： H02K1/06
CPC分类号： A61K41/00 , A61K9/0024 , A61K9/06 , A61K31/00 , A61K47/34 , A61L24/0015 , A61L24/0031 , A61L26/0066 , A61L26/008 , A61L27/52 , A61L27/54 , A61L29/145 , A61L29/16 , A61L31/145 , A61L31/16 , A61L2300/622 , A61L2300/626 , C08J3/075 , C08J3/246 , C08J2371/02
摘要： The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.
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公开(公告)号：US20110293692A1
公开(公告)日：2011-12-01
申请号：US13115066
申请日：2011-05-24
申请人： Steven Bennett , Nathaniel Mast , Kevin Lavigne , Walter Skalla
发明人： Steven Bennett , Nathaniel Mast , Kevin Lavigne , Walter Skalla
CPC分类号： A61K31/00 , A61L31/145 , A61L31/16 , A61L2300/00
摘要： The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.
摘要翻译： 本公开涉及水凝胶组合物及其使用方法。 水凝胶组合物可包括在接触时彼此反应的前体以及与引发剂接触时反应的前体。 在实施方案中，所得到的水凝胶可具有不同密度和较不致密区域的交联水平。
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公开(公告)号：US08044234B2
公开(公告)日：2011-10-25
申请号：US11123690
申请日：2005-05-05
申请人： Ahmad R. Hadba , Walter Skalla , Nadya Belcheva
发明人： Ahmad R. Hadba , Walter Skalla , Nadya Belcheva
IPC分类号： C07C273/00 , A61F13/15 , A61K47/30
CPC分类号： C08G18/4252 , A61L24/0042 , A61L24/046 , C08G18/12 , C08G63/672 , C08G63/6856 , C08G63/916 , C08G2190/00 , C08G2230/00 , C09J175/06 , C08L71/02 , C08G18/42
摘要： Compounds are provided which can form bioabsorbable compositions useful as adhesives or sealants for medical/surgical applications. In embodiments, suitable compositions may possess various functional groups, including groups derived from multifunctional compounds, aliphatic or aromatic groups, groups derived from aliphatic diacids, groups derived from a dihydroxy compound, and combinations thereof. Methods for forming these compositions, as well as uses thereof, are also provided.
摘要翻译： 可以提供可形成用作医疗/外科应用的粘合剂或密封剂的生物可吸收组合物的化合物。 在实施方案中，合适的组合物可以具有各种官能团，包括衍生自多官能化合物的基团，脂族或芳族基团，衍生自脂族二酸的基团，衍生自二羟基化合物的基团及其组合。 还提供了形成这些组合物的方法及其用途。
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公开(公告)号：US20090312572A1
公开(公告)日：2009-12-17
申请号：US12544469
申请日：2009-08-20
申请人： Ahmad R. Hadba , Walter Skalla , Nadya Belcheva
发明人： Ahmad R. Hadba , Walter Skalla , Nadya Belcheva
IPC分类号： C07C271/22
CPC分类号： C08G18/4252 , A61L24/0042 , A61L24/046 , C08G18/12 , C08G63/672 , C08G63/6856 , C08G63/916 , C08G2190/00 , C08G2230/00 , C09J175/06 , C08L71/02 , C08G18/42
摘要： Compounds are provided which can form bioabsorbable compositions useful as adhesives or sealants for medical/surgical applications.
摘要翻译： 可以提供可形成用作医疗/外科应用的粘合剂或密封剂的生物可吸收组合物的化合物。
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公开(公告)号：US08748558B2
公开(公告)日：2014-06-10
申请号：US12594608
申请日：2008-04-21
CPC分类号： C08G18/712 , A61L27/18 , A61L27/58 , C08G18/10 , C08G18/4252 , C08G18/7614 , C08G63/672 , C08G63/78 , C09J175/04 , C08G18/3206 , C08L75/04
摘要： Methods for producing biocompatible compositions are provided. The biocompatible compositions include an aliphatic polyester macromer produced without the use of solvents or catalysts. The resulting aliphatic polyester macromer may be reacted with a polyisocyanate to form an end-capped aliphatic polyester macromer which, in turn, may be reacted with a polyol to produce a polyurethane. The polyurethane, in turn, may be reacted with a second polyisocyanate to produce an isocyanate-functional polyurethane. The compositions prepared by the methods of the present disclosure may be used as adhesives or sealants for medical/surgical uses.
摘要翻译： 提供生产生物相容性组合物的方法。 生物相容性组合物包括不使用溶剂或催化剂制备的脂族聚酯大分子单体。 所得到的脂族聚酯大分子单体可以与多异氰酸酯反应以形成端封脂肪族聚酯大分子单体，其又可以与多元醇反应以制备聚氨酯。 聚氨酯又可以与第二多异氰酸酯反应以产生异氰酸酯官能的聚氨酯。 通过本公开的方法制备的组合物可以用作医疗/外科用途的粘合剂或密封剂。
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公开(公告)号：US08734930B2
公开(公告)日：2014-05-27
申请号：US13222801
申请日：2011-08-31
申请人： Steven Bennett , Nathaniel Mast , Kevin Lavigne , Walter Skalla , Timothy Sargeant , Joshua Stopek , Saumya Banerjee , Arpan Desai
发明人： Steven Bennett , Nathaniel Mast , Kevin Lavigne , Walter Skalla , Timothy Sargeant , Joshua Stopek , Saumya Banerjee , Arpan Desai
IPC分类号： B32B3/00
摘要： The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.
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公开(公告)号：US20110293688A1
公开(公告)日：2011-12-01
申请号：US13115060
申请日：2011-05-24
申请人： Steven Bennett , Nathaniel Mast , Kevin Lavigne , Walter Skalla
发明人： Steven Bennett , Nathaniel Mast , Kevin Lavigne , Walter Skalla
CPC分类号： A61L24/0031 , A61K31/00 , A61L24/046 , A61L26/0014 , A61L31/10 , A61L31/14 , A61L31/145
摘要： The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.
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公开(公告)号：US20090127195A1
公开(公告)日：2009-05-21
申请号：US12261505
申请日：2008-10-30
IPC分类号： B01D15/04
CPC分类号： C07C263/20 , C08G18/10 , C08G18/4887 , C08G2190/00 , C08G2230/00 , C08G18/302 , C07C265/14
摘要： Methods are provided for isolating and purifying components useful, either alone or in combination with other components, as adhesives or sealants for medical/surgical applications.
摘要翻译： 提供了用于分离和纯化作为医疗/外科应用的粘合剂或密封剂的单独或与其它组分组合有用的组分的方法。
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公开(公告)号：US5641502A
公开(公告)日：1997-06-24
申请号：US480084
申请日：1995-06-07
申请人： Walter Skalla , Steven L. Bennett , Ying Jiang
发明人： Walter Skalla , Steven L. Bennett , Ying Jiang
IPC分类号： A61L24/00 , A61L24/04 , A61L27/18 , A61L27/26 , A61L27/56 , A61L31/04 , A61L31/06 , A61F2/00 , A61L15/64
CPC分类号： A61L31/041 , A61L24/0036 , A61L24/043 , A61L24/046 , A61L27/18 , A61L27/26 , A61L27/56 , A61L31/06
摘要： A moldable biodegradable surgical material is made of a bioabsorbable polymer derived from hydroxyacids, tactones, carbonates, etheresters, anhydrides, orthoesters and copolymers, terpolymers and/or blends thereof, the polymer blended with at least one surface active agent selected from the group consisting of fatty acid ester and poly(oxypropylene)/poly(oxyethylene) block copolymer. In one embodiment, a leaching agent is blended with the above-mentioned surgical material. Methods of making moldable biodegradable surgical material are provided. The surgical material may be used as a moldable bone wax in connection with repair of wounds and is an adaptable aid for any appropriate surgical use, e.g., hemostat, anchor, patch etc.
摘要翻译： 可成型的可生物降解手术材料由衍生自羟基酸，触媒，碳酸酯，醚类，酸酐，原酸酯和共聚物的生物可吸收聚合物，三聚物和/或其共混物制成，所述聚合物与至少一种选自以下的表面活性剂共混 脂肪酸酯和聚（氧丙烯）/聚（氧乙烯）嵌段共聚物。 在一个实施方案中，将浸出剂与上述手术材料混合。 提供可模制生物降解外科手术材料的制备方法。 外科手术材料可以用作与伤口修复相关的可模制骨蜡，并且是用于任何合适手术用途的适应性辅助，例如止血剂，锚固剂，贴剂等。
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