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    Combined firework
    1.
    发明授权
    Combined firework 有权
    组合烟花

    公开(公告)号：US08322285B2

    公开(公告)日：2012-12-04

    申请号：US12840639

    申请日：2010-07-21

    申请人： Ziyou Zhong ,  Yongzhang Liu ,  Weimin Zhong ,  Liang Zhong ,  Binbo Gong

    发明人： Ziyou Zhong ,  Yongzhang Liu ,  Weimin Zhong ,  Liang Zhong ,  Binbo Gong

    IPC分类号： F42B4/00 ,  F42B4/20

    CPC分类号： F42B4/24 ,  F42B4/22

    摘要： A combined firework is disclosed. In the combined firework, several tubular holes whose central longitudinal axes are parallel to each other are uniformly distributed in a body, the tubular holes have openings upward and bottom ends closed. The closed end of the bottom of each tubular hole is provided with two small through holes penetrating through the bottom of the body and respectively provided with an inward fuse and an outward fuse in series connection. The body, the tubular holes and the small through holes thereof are an integrally molded structure. On the bottom in the tubular hole propellant powder is provided and connected with the outward fuse and the inward fuse. On the propellant powder an inner cylinder or effect powder is provided.

    摘要翻译： 披露了一个组合的烟火。 在组合的烟火中，其中心纵轴彼此平行的几个管状孔均匀地分布在主体中，管状孔具有向上且底端封闭的开口。 每个管孔的底部的封闭端设有穿过主体底部的两个小通孔，并分别设有一个串联连接的向内保险丝和一个向外的保险丝。 主体，管状孔及其小的通孔是整体模制的结构。 在管状孔的底部提供推进剂粉末并与外部保险丝和向内的保险丝相连。 在推进剂粉末上提供内筒或效果粉末。

    Liver enriched transcription factor
    2.
    发明授权
    Liver enriched transcription factor 失效
    肝脏丰富的转录因子

    公开(公告)号：US06500672B1

    公开(公告)日：2002-12-31

    申请号：US09447034

    申请日：1999-11-22

    申请人： Frances M. Sladek ,  Weimin Zhong ,  James E. Darnell, Jr.

    发明人： Frances M. Sladek ,  Weimin Zhong ,  James E. Darnell, Jr.

    IPC分类号： C01N3300

    CPC分类号： C07K14/4702 ,  A61K38/00 ,  C07K14/47 ,  C07K14/70571 ,  C07K14/721 ,  C07K16/4258 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/81 ,  C12N15/113 ,  C12N15/67 ,  G01N33/534

    摘要： HNF-4 (hepatocyte nuclear factor 4) is a protein enriched in liver extracts that binds to sites required for the transcription of the transthyretin (TTR) and apolipoprotein CIII (apoCIII) genes (Costa et al., 1989; Costa et al., 1990; Leff et al., 1989). We have purified HNF-4 protein (54 kD) and isolated a cDNA clone encoding the protein. HNF-4 is a member of the steroid hormone receptor superfamily with an unusual amino acid in the conserved “knuckle” of the first zinc finger (DGCKG). This and the fact that HNF-4 does not bind significantly to estrogen, thyroid hormone or glucocorticoid response elements indicate that HNF-4 may represent a new subfamily. HNF-4 binds to its recognition site as a dimer and activates transcription in a sequence-specific fashion in nonhepatic (HeLa) cells. HNF-4 mRNA is present in kidney and intestine as well as liver but is absent in other tissues. DNA binding data suggest that HNF-4 could be identical to liver factor A1 (LF-A1), a factor previously shown to regulate the transcription of the &agr;-1 antitrypsin, apolipoprotein A1 and pyruvate kinase genes.

    摘要翻译： HNF-4（肝细胞核因子4）是富含肝脏提取物的蛋白质，其结合转甲状腺素蛋白（TTR）和载脂蛋白CIII（apoCIII）基因转录所需的位点（Costa et al。，1989; Costa et al。 1990; Leff等人，1989）。 我们纯化HNF-4蛋白（54 kD），分离出一个编码蛋白质的cDNA克隆。 HNF-4是类固醇激素受体超家族的成员，在第一锌指（DGCKG）的保守“指关节”中具有不寻常的氨基酸。 这和HNF-4与雌激素，甲状腺激素或糖皮质激素反应元件不显着结合的事实表明，HNF-4可能代表一个新的亚家族。 HNF-4作为二聚体结合其识别位点，并以非特异性（HeLa）细胞中的序列特异性方式激活转录。 HNF-4 mRNA存在于肾和肠以及肝脏中，但在其他组织中不存在。 DNA结合数据表明HNF-4可以与肝脏因子A1（LF-A1）相同，这是以前显示的调节α-1抗胰蛋白酶，载脂蛋白A1和丙酮酸激酶基因转录的因子。

    COMBINED FIREWORK
    3.
    发明申请
    COMBINED FIREWORK 有权
    组合式烟火

    公开(公告)号：US20110017087A1

    公开(公告)日：2011-01-27

    申请号：US12840639

    申请日：2010-07-21

    申请人： Ziyou ZHONG ,  Yongzhang LIU ,  Weimin ZHONG ,  Liang ZHONG ,  Binbo GONG

    发明人： Ziyou ZHONG ,  Yongzhang LIU ,  Weimin ZHONG ,  Liang ZHONG ,  Binbo GONG

    IPC分类号： F42B4/00

    CPC分类号： F42B4/24 ,  F42B4/22

    摘要： A combined firework is disclosed in the invention. In the combined firework, several tubular holes whose central axes are parallel to each other are uniformly distributed in a body, the tubular holes have openings upward and bottom ends closed, the closed end of the bottom of each tubular hole is provided with two small through holes penetrating through the bottom of the body and respectively provided with an inward fuse and an outward fuse in series connection, the body, the tubular holes and the small through holes thereof are an integral structure moulded in one time; on the bottom in the tubular hole propellant powder is provided and connected with the outward fuse and the inward fuse, on the propellant powder an inner cylinder or effect powder is provided. The combined firework using the above solution has standard specification, firm structure and high production efficiency; moreover, the original fuse connection at the side of the cylinder body is changed into the fuse connection at the bottom, and the fuse connecting holes are mechanically moulded with a consistent size of the hole and precisely controlled distance between holes, therefore, the launching time is accurate and safety is good.

    摘要翻译： 在本发明中公开了组合的烟火。 在组合的烟花中，中心轴彼此平行的几个管状孔均匀地分布在主体中，管状孔具有向上和底端的开口，每个管状孔的底部的封闭端设有两个小通孔 贯穿本体底部的孔分别设置有一个向内的熔断体和一个串联的外部保险丝，主体，管状孔及其小的通孔是一次成型的整体结构; 在管状孔的底部，推进剂粉末设置并与外部保险丝和向内的保险丝连接，在推进剂粉末上提供内筒或效果粉末。 使用上述解决方案组合的烟花具有标准规格，结构牢固，生产效率高; 此外，在缸体侧的原来的保险丝连接改变为底部的保险丝连接，并且保险丝连接孔机械地模制成具有一致的孔尺寸和精确控制的孔之间的距离，因此，发射时间 准确，安全性好。

    Liver enriched transcription factor
    6.
    发明授权
    Liver enriched transcription factor 失效
    肝脏丰富的转录因子

    公开(公告)号：US5849485A

    公开(公告)日：1998-12-15

    申请号：US661330

    申请日：1996-06-14

    申请人： Frances M. Sladek ,  Weimin Zhong ,  James E. Darnell, Jr.

    发明人： Frances M. Sladek ,  Weimin Zhong ,  James E. Darnell, Jr.

    IPC分类号： A61K31/70 ,  A61K38/00 ,  A61K39/395 ,  A61P3/04 ,  A61P9/00 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/705 ,  C07K14/72 ,  C07K16/00 ,  C07K16/42 ,  C07K19/00 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/113 ,  C12N15/12 ,  C12N15/67 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/534 ,  G01N33/577 ,  C07H21/04

    CPC分类号： C07K14/4702 ,  C07K14/47 ,  C07K14/70571 ,  C07K14/721 ,  C07K16/4258 ,  C12N15/113 ,  C12N15/67 ,  G01N33/534 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/81

    摘要： HNF-4 (hepatocyte nuclear factor 4) is a protein enriched in liver extracts that binds to sites required for the transcription of the transthyretin (TTR) and apolipoprotein CIII (apoCIII) genes (Costa et al., 1989; Costa et al., 1990; Leff et al., 1989). We have purified HNF-4 protein (54 kD) and isolated a cDNA clone encoding the protein. HNF-4 is a member of the steroid hormone receptor superfamily with an unusual amino acid in the conserved "knuckle" of the first zinc finger (DGCKG). This and the fact that HNF-4 does not bind significantly to estrogen, thyroid hormone or glucocorticoid response elements indicate that HNF-4 may represent a new subfamily. HNF-4 binds to its recognition site as a dimer and activates transcription in a sequence-specific fashion in nonhepatic (HeLa) cells. HNF-4 mRNA is present in kidney and intestine as well as liver but is absent in other tissues. DNA binding data suggest that HNF-4 could be identical to liver factor A1 (LF-A1), a factor previously shown to regulate the transcription of the .alpha.-1 antitrypsin, apolipoprotein A1 and pyruvate kinase genes.

    摘要翻译： HNF-4（肝细胞核因子4）是富含肝脏提取物的蛋白质，其结合转甲状腺素蛋白（TTR）和载脂蛋白CIII（apoCIII）基因转录所需的位点（Costa et al。，1989; Costa et al。 1990; Leff等人，1989）。 我们纯化HNF-4蛋白（54 kD），分离出一个编码蛋白质的cDNA克隆。 HNF-4是类固醇激素受体超家族的成员，其在第一锌指（DGCKG）的保守“指关节”中具有不寻常的氨基酸。 这和HNF-4与雌激素，甲状腺激素或糖皮质激素反应元件不显着结合的事实表明，HNF-4可能代表一个新的亚家族。 HNF-4作为二聚体结合其识别位点，并以非特异性（HeLa）细胞中的序列特异性方式激活转录。 HNF-4 mRNA存在于肾和肠以及肝脏中，但在其他组织中不存在。 DNA结合数据表明HNF-4可以与肝脏因子A1（LF-A1）相同，这是以前显示的调节α-1抗胰蛋白酶，载脂蛋白A1和丙酮酸激酶基因转录的因子。

    Integral-type combined firework
    7.
    发明授权
    Integral-type combined firework 有权
    整体型组合烟花

    公开(公告)号：US08286556B2

    公开(公告)日：2012-10-16

    申请号：US12839783

    申请日：2010-07-20

    申请人： Ziyou Zhong ,  Yongzhang Liu ,  Weimin Zhong ,  Liang Zhong ,  Binbo Gong

    发明人： Ziyou Zhong ,  Yongzhang Liu ,  Weimin Zhong ,  Liang Zhong ,  Binbo Gong

    IPC分类号： F42B4/00

    CPC分类号： F42B4/24

    摘要： The present invention discloses an integral-type combined firework, in which several tubular holes whose central longitudinal axes are parallel to each other are uniformly distributed on a body, the tubular holes have openings upward and bottom ends closed, the closed end of the bottom of each tubular hole is provided with one small through hole that penetrates through the bottom of the body and is provided with a spreading fuse, the body, the tubular holes and the small through holes thereof are an integrally molded structure; the bottom in each tubular holes is provided with propellant powder and connected with the spreading fuse, the propellant powder is provided with an inner cylinder or an effect powder on it. The integral-type combined firework using the above solution has standard specification, firm structure and results in high production efficiency; moreover, the original fuse connection at the side of the cylinder body is changed into the fuse connection at the bottom, and the fuse connecting holes are mechanically molded with a consistent size of the hole and precisely controlled distance between holes, therefore, the launching time is accurate and safety is good.

    摘要翻译： 本发明公开了一种整体型组合式烟火，其中心纵向彼此平行的几个管状孔均匀地分布在主体上，管状孔具有开口向上和底端封闭，底部的封闭端 每个管孔设有一个贯穿本体底部的小通孔，并设有扩展保险丝，其主体，管状孔及其小通孔为整体模制的结构; 在每个管状孔中的底部设置有推进剂粉末并与扩展保险丝相连，推进剂粉末上设置有内筒或效果粉末。 采用上述解决方案的整体式烟花拼装具有标准规格，结构坚固，生产效率高; 此外，在缸体侧的原来的保险丝连接改变为底部的保险丝连接，并且保险丝连接孔机械地模制成具有一致的孔尺寸和精确控制的孔之间的距离，因此，发射时间 准确，安全性好。

    Integral-type Combined Firework
    8.
    发明申请
    Integral-type Combined Firework 有权
    整体型组合烟花

    公开(公告)号：US20110017086A1

    公开(公告)日：2011-01-27

    申请号：US12839783

    申请日：2010-07-20

    申请人： Ziyou ZHONG ,  Yongzhang LIU ,  Weimin ZHONG ,  Liang ZHONG ,  Binbo GONG

    发明人： Ziyou ZHONG ,  Yongzhang LIU ,  Weimin ZHONG ,  Liang ZHONG ,  Binbo GONG

    IPC分类号： F42B4/00

    CPC分类号： F42B4/24

    摘要： The present invention discloses an integral-type combined firework, in which several tubular holes whose central axes are parallel to each other are uniformly distributed on a body, the tubular holes have openings upward and bottom ends closed, the closed end of the bottom of each tubular hole is provided with one small through hole that penetrates through the bottom of the body and is provided with a spreading fuse, the body, the tubular holes and the small through holes thereof are an integral structure moulded in one time; the bottom in the tubular holes is provided with propellant powder and connected with the spreading fuse, the propellant powder is provided with an inner cylinder or an effect powder on it. The integral-type combined firework using the above solution has standard specification, firm structure and results in high production efficiency; moreover, the original fuse connection at the side of the cylinder body is changed into the fuse connection at the bottom, and the fuse connecting holes are mechanically moulded with a consistent size of the hole and precisely controlled distance between holes, therefore, the launching time is accurate and safety is good.

    摘要翻译： 本发明公开了一种整体式组合式烟火，其中心轴线彼此平行的多个管状孔均匀分布在主体上，管状孔具有开口向上和底端封闭，每个底部的封闭端 管状孔设有穿过本体底部的一个小通孔，并设置有扩展保险丝，主体，管状孔及其小通孔是一次成型的整体结构; 在管状孔中的底部设置有推进剂粉末并与扩展保险丝相连，推进剂粉末上设置有内筒或效果粉末。 采用上述解决方案的整体式烟花拼装具有标准规格，结构坚固，生产效率高; 此外，在缸体侧的原来的保险丝连接改变为底部的保险丝连接，并且保险丝连接孔机械地模制成具有一致的孔尺寸和精确控制的孔之间的距离，因此，发射时间 准确，安全性好。

    Liver enriched transcription factor
    9.
    发明授权
    Liver enriched transcription factor 失效
    肝脏丰富的转录因子

    公开(公告)号：US07368293B2

    公开(公告)日：2008-05-06

    申请号：US10215597

    申请日：2002-08-09

    申请人： Frances M. Sladek ,  Weimin Zhong ,  James E. Darnell, Jr.

    发明人： Frances M. Sladek ,  Weimin Zhong ,  James E. Darnell, Jr.

    IPC分类号： C01N33/00 ,  C01N33/566

    CPC分类号： C07K14/4702 ,  A61K38/00

    摘要： HNF-4 (hepatocyte nuclear factor 4) is a protein enriched in liver extracts that binds to sites required for the transcription of the transthyretin (TTR) and apolipoprotein CIII (apoCIII) genes (Costa et al., 1989; Costa et al., 1990; Leff et al., 1989). We have purified HNF-4 protein (54 kD) and isolated a cDNA clone encoding the protein. HNF-4 is a member of the steroid hormone receptor superfamily with an unusual amino acid in the conserved “knuckle” of the first zinc finger (DGCKG). This and the fact that HNF-4 does not bind significantly to estrogen, thyroid hormone or glucocorticoid response elements indicate that HNF-4 may represent a new subfamily. HNF-4 binds to its recognition site as a dimer and activates transcription in a sequence-specific fashion in nonhepatic (HeLa) cells. HNF-4 mRNA is present in kidney and intestine as well as liver but is absent in other tissues. DNA binding data suggest that HNF-4 could be identical to liver factor A1 (LF-A1), a factor previously shown to regulate the transcription of the α-1 antitrypsin, apolipoprotein A1 and pyruvate kinase genes.

    摘要翻译： HNF-4（肝细胞核因子4）是富含肝脏提取物的蛋白质，其结合转甲状腺素蛋白（TTR）和载脂蛋白CIII（apoCIII）基因转录所需的位点（Costa et al。，1989; Costa et al。 1990; Leff等人，1989）。 我们纯化HNF-4蛋白（54 kD），分离出一个编码蛋白质的cDNA克隆。 HNF-4是类固醇激素受体超家族的成员，其在第一锌指（DGCKG）的保守“指关节”中具有不寻常的氨基酸。 这和HNF-4与雌激素，甲状腺激素或糖皮质激素反应元件不显着结合的事实表明，HNF-4可能代表一个新的亚家族。 HNF-4作为二聚体结合其识别位点，并以非特异性（HeLa）细胞中的序列特异性方式激活转录。 HNF-4 mRNA存在于肾和肠以及肝脏中，但在其他组织中不存在。 DNA结合数据表明HNF-4可以与肝脏因子A1（LF-A1）相同，这是以前显示的调节α-1抗胰蛋白酶，载脂蛋白A1和丙酮酸激酶基因转录的因子。

    Liver enriched transcription factor
    10.
    发明授权
    Liver enriched transcription factor 失效
    肝脏丰富的转录因子

    公开(公告)号：US5604115A

    公开(公告)日：1997-02-18

    申请号：US078222

    申请日：1993-10-28

    申请人： Frances M. Sladek ,  Weimin Zhong ,  James E. Darnell, Jr.

    发明人： Frances M. Sladek ,  Weimin Zhong ,  James E. Darnell, Jr.

    IPC分类号： A61K31/70 ,  A61K38/00 ,  A61K39/395 ,  A61P3/04 ,  A61P9/00 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/705 ,  C07K14/72 ,  C07K16/00 ,  C07K16/42 ,  C07K19/00 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/113 ,  C12N15/12 ,  C12N15/67 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/534 ,  G01N33/577 ,  C12P21/06 ,  C12N15/63

    CPC分类号： C07K14/4702 ,  C07K14/47 ,  C07K14/70571 ,  C07K14/721 ,  C07K16/4258 ,  C12N15/113 ,  C12N15/67 ,  G01N33/534 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/81

    摘要： HNF-4 (hepatocyte nuclear factor 4) is a protein enriched in liver extracts that binds to sites required for the transcription of the transthyretin (TTR) and apolipoprotein CIII (apoCIII) genes (Costa et al., 1989; Costa et al., 1990; Leff et al., 1989). We have purified HNF-4 protein (54 kD) and isolated a cDNA clone encoding the protein. HNF-4 is a member of the steroid hormone receptor superfamily with an unusual amino acid in the conserved "knuckle" of the first zinc finger (DGCKG). This and the fact that HNF-4 does not bind significantly to estrogen, thyroid hormone or glucocorticoid response elements indicate that HNF-4 may represent a new subfamily. HNF-4 binds to its recognition site as a dimer and activates transcription in a sequence-specific fashion in nonhepatic (HeLa) cells. HNF-4 mRNA is present in kidney and intestine as well as liver but is absent in other tissues. DNA binding data suggest that HNF-4 could be identical to liver factor A1 (LF-A1), a factor previously shown to regulate the transcription of the .alpha.-1 antitrypsin, apolipoprotein A1 and pyruvate kinase genes.

    摘要翻译： PCT No.PCT / US91 / 09733 Sec。 371日期：1993年10月28日 102（e）日期1993年10月28日PCT 1991年12月23日PCT公布。 第WO92 / 11365号PCT公告 日期1992年9月7日HNF-4（肝细胞核因子4）是富含肝提取物的蛋白质，其结合转甲状腺素蛋白（TTR）和载脂蛋白CIII（apoCIII）基因转录所需的位点（Costa et al。，1989; Costa et al。，1990; Leff et al。，1989）。 我们纯化HNF-4蛋白（54 kD），分离出一个编码蛋白质的cDNA克隆。 HNF-4是类固醇激素受体超家族的成员，其在第一锌指（DGCKG）的保守“指关节”中具有不寻常的氨基酸。 这和HNF-4与雌激素，甲状腺激素或糖皮质激素反应元件不显着结合的事实表明，HNF-4可能代表一个新的亚家族。 HNF-4作为二聚体结合其识别位点，并以非特异性（HeLa）细胞的序列特异性方式激活转录。 HNF-4 mRNA存在于肾和肠以及肝脏中，但在其他组织中不存在。 DNA结合数据表明HNF-4可以与肝脏因子A1（LF-A1）相同，这是以前显示的调节α-1抗胰蛋白酶，载脂蛋白A1和丙酮酸激酶基因转录的因子。