公开(公告)号：US20190083476A1

公开(公告)日：2019-03-21

申请号：US16085372

申请日：2017-03-17

Applicant: XENIOPRO GmbH

Inventor： Viktoria REINMUELLER ,  Jieping ZHU

IPC: A61K31/44 ,  A61K31/192 ,  A61K31/216 ,  A61P17/06 ,  A61P21/00 ,  A61P35/00

Abstract: The present invention relates to the use for enhancing Notch signaling in an individual, of a compound showing the general formula (I) and/or a pharmaceutically acceptable salt or ester thereof, for the treatment of a disease selected from the group of dermatological disorders including atopic dermatitis, psoriasis, immune related disorders, cancer, squamous cell carcinoma, cutaneous and lung squamous cell carcinoma, head and neck cancer, non-melanoma skin cancer, basal cell carcinoma and actinic keratosis, neuroendocrine tumors, neuroendocrine small cell carcinoma and carcinoid tumors, thyroid carcinomas, muscular disorders muscular dystrophy and impaired regeneration capacity after injury; use in immunotherapy for cancer.

公开(公告)号：US20240140895A1

公开(公告)日：2024-05-02

申请号：US17270646

申请日：2019-08-23

Applicant: XENIOPRO GmbH

Inventor： Viktoria REINMÜLLER ,  Roman MARTY ,  Olivier WAGNIÈRES ,  Jean-Baptiste GUALTIEROTTI ,  Verena KÜPPERS

IPC: C07C43/21 ,  A61P35/00 ,  C07C43/215 ,  C07C43/225 ,  C07C47/575 ,  C07C65/26 ,  C07C217/60 ,  C07C217/62 ,  C07D205/04 ,  C07D213/643 ,  C07D239/34 ,  C07D303/22 ,  C07D305/08

CPC classification number: C07C43/21 ,  A61P35/00 ,  C07C43/215 ,  C07C43/225 ,  C07C47/575 ,  C07C65/26 ,  C07C217/60 ,  C07C217/62 ,  C07D205/04 ,  C07D213/643 ,  C07D239/34 ,  C07D303/22 ,  C07D305/08

Abstract: The present invention comprises novel aromatic molecules, which can be used in the treatment of pathological conditions, such as cancer, skin diseases, muscle disorders, and immune system-related disorders such as disorders of the haematopoietic system including the haematologic system in human and veterinary medicine.

公开(公告)号：US20230150923A1

公开(公告)日：2023-05-18

申请号：US18064576

申请日：2022-12-12

Applicant: XENIOPRO GMBH

Inventor： Viktoria REINMÜLLER

IPC: C07C233/65 ,  C07C65/24 ,  C07C69/94 ,  C07D213/80

CPC classification number: C07C233/65 ,  C07C65/24 ,  C07C69/94 ,  C07D213/80 ,  A61K31/44

Abstract: The present invention comprises novel aromatic molecules, which can be used in the treatment of pathological conditions, such as cancer, skin diseases, muscle disorders, and immune system-related disorders such as disorders of the hematopoietic system including the hematologic system in human and veterinary medicine.

公开(公告)号：US20220354949A1

公开(公告)日：2022-11-10

申请号：US17270665

申请日：2019-08-23

Applicant: XENIOPRO GmbH

Inventor： Viktoria REINMÜLLER ,  Roman MARTY ,  Olivier WAGNIÈRES ,  Jean-Baptiste GUALTIEROTTI ,  Verena KÜPPERS

IPC: A61K39/39 ,  C07C311/51 ,  C07D213/89 ,  C07C261/04 ,  C07C259/10 ,  C07C325/02 ,  C07D405/04 ,  C07C217/58 ,  C07C239/12 ,  C07C255/43 ,  C07D309/06 ,  C07D211/22 ,  C07D295/092 ,  C07D453/02 ,  C07D205/04 ,  C07D491/107 ,  C07D401/12 ,  C07D405/12 ,  C07D519/00 ,  C07D407/12 ,  C07D331/04 ,  C07D409/12 ,  C07D211/28 ,  C07D305/04 ,  C07C69/78 ,  C07C47/198 ,  C07D213/80 ,  C07D213/643 ,  C07D237/04 ,  C07D239/47 ,  C07D239/52

Abstract: The present invention comprises novel aromatic molecules, which can be used in the treatment of pathological conditions, such as cancer, skin diseases, muscle disorders, and immune system-related disorders such as disorders of the haematopoietic system including the haematologic system in human and veterinary medicine.

公开(公告)号：US20210107863A2

公开(公告)日：2021-04-15

申请号：US16488458

申请日：2018-02-26

Applicant: XENIOPRO GMBH

Inventor： Viktoria REINMÜLLER

IPC: C07C233/65 ,  C07C65/24 ,  C07C69/94 ,  C07D213/80

Abstract: The present invention comprises novel aromatic molecules, which can be used in the treatment of pathological conditions, such as cancer, skin diseases, muscle disorders, and immune system-related disorders such as disorders of the hematopoietic system including the hematologic system in human and veterinary medicine.

公开(公告)号：US20230141913A2

公开(公告)日：2023-05-11

申请号：US17270652

申请日：2019-08-23

Applicant: XENIOPRO GmbH

Inventor： Viktoria REINMÜLLER ,  Roman MARTY ,  Olivier WAGNIÉRES ,  Jean-Baptiste GUALTIEROTTI ,  Verena KÜPPERS

IPC: A61K31/5375 ,  C07C43/275 ,  C07D213/647 ,  A61K31/09 ,  A61K31/44 ,  A61P35/02 ,  A61P35/00 ,  C07D295/096 ,  C07D453/02 ,  A61K31/351 ,  A61K31/451 ,  A61K31/495 ,  A61K31/439 ,  C07D305/06 ,  C07D331/04 ,  C07D205/04 ,  A61K31/337 ,  A61K31/38 ,  A61K31/397 ,  C07D407/12 ,  C07D411/12 ,  C07D405/12 ,  C07D409/12 ,  C07D401/12 ,  A61K31/5377 ,  A61K31/496 ,  C07D309/04 ,  A61K31/12 ,  A61K31/085 ,  C07C49/255 ,  C07C43/295 ,  C07C205/04 ,  C07C251/20 ,  C07C251/48 ,  A61K31/04 ,  A61K31/15 ,  A61K39/39

CPC classification number: A61K31/5375 ,  C07C43/275 ,  C07D213/647 ,  A61K31/09 ,  A61K31/44 ,  A61P35/02 ,  A61P35/00 ,  C07D295/096 ,  C07D453/02 ,  A61K31/351 ,  A61K31/451 ,  A61K31/495 ,  A61K31/439 ,  C07D305/06 ,  C07D331/04 ,  C07D205/04 ,  A61K31/337 ,  A61K31/38 ,  A61K31/397 ,  C07D407/12 ,  C07D411/12 ,  C07D405/12 ,  C07D409/12 ,  C07D401/12 ,  A61K31/5377 ,  A61K31/496 ,  C07D309/04 ,  A61K31/12 ,  A61K31/085 ,  C07C49/255 ,  C07C43/295 ,  C07C205/04 ,  C07C251/20 ,  C07C251/48 ,  A61K31/04 ,  A61K31/15 ,  A61K39/39

Abstract: The present invention comprises novel aromatic molecules, which can be used in the treatment of pathological conditions, such as cancer, skin diseases, muscle disorders, and immune system-related disorders such as disorders of the haematopoietic system including the haematologic system in human and veterinary medicine.

公开(公告)号：US20220249500A1

公开(公告)日：2022-08-11

申请号：US17270652

申请日：2019-08-23

Applicant: XENIOPRO GmbH

Inventor： Viktoria REINMÜLLER ,  Roman MARTY ,  Olivier WAGNIÈRES ,  Jean-Baptiste GUALTIEROTTI ,  Verena KÜPPERS

IPC: A61K31/5375 ,  C07C43/275 ,  C07D213/647 ,  A61K31/09 ,  A61K31/44 ,  A61P35/02 ,  A61P35/00 ,  C07D295/096 ,  C07D453/02 ,  A61K31/351 ,  A61K31/451 ,  A61K31/495 ,  A61K31/439 ,  C07D305/06 ,  C07D331/04 ,  C07D205/04 ,  A61K31/337 ,  A61K31/38 ,  A61K31/397 ,  C07D407/12 ,  C07D411/12 ,  C07D405/12 ,  C07D409/12 ,  C07D401/12 ,  A61K31/5377 ,  A61K31/496 ,  C07D309/04 ,  A61K31/12 ,  A61K31/085 ,  C07C49/255 ,  C07C43/295 ,  C07C205/04 ,  C07C251/20 ,  C07C251/48 ,  A61K31/04 ,  A61K31/15 ,  A61K39/39

Abstract: The present invention comprises novel aromatic molecules, which can be used in the treatment of pathological conditions, such as cancer, skin diseases, muscle disorders, and immune system-related disorders such as disorders of the haematopoietic system including the haematologic system in human and veterinary medicine.

公开(公告)号：US20200031763A1

公开(公告)日：2020-01-30

申请号：US16488458

申请日：2018-02-26

Applicant: XENIOPRO GMBH

Inventor： Viktoria REINMÜLLER

IPC: C07C233/65 ,  C07C65/24 ,  C07C69/94 ,  C07D213/80

Abstract: The present invention comprises novel aromatic molecules, which can be used in the treatment of pathological conditions, such as cancer, skin diseases, muscle disorders, and immune system-related disorders such as disorders of the hematopoietic system including the hematologic system in human and veterinary medicine.

公开(公告)号：US20230406814A2

公开(公告)日：2023-12-21

申请号：US18064576

申请日：2022-12-12

Applicant: XENIOPRO GMBH

Inventor： Viktoria REINMÜLLER

IPC: C07C233/65 ,  C07C65/24 ,  C07C69/94 ,  C07D213/80

CPC classification number: C07C233/65 ,  C07C65/24 ,  C07C69/94 ,  C07D213/80 ,  A61K31/44

Abstract: The present invention comprises novel aromatic molecules, which can be used in the treatment of pathological conditions, such as cancer, skin diseases, muscle disorders, and immune system-related disorders such as disorders of the hematopoietic system including the hematologic system in human and veterinary medicine.

公开(公告)号：US11591289B2

公开(公告)日：2023-02-28

申请号：US16488458

申请日：2018-02-26

Applicant: XENIOPRO GMBH

Inventor： Viktoria Reinmüller

IPC: C07C233/65 ,  C07C65/24 ,  C07C69/94 ,  C07D213/80 ,  A61K31/44

Abstract: The present invention comprises novel aromatic molecules, which can be used in the treatment of pathological conditions, such as cancer, skin diseases, muscle disorders, and immune system-related disorders such as disorders of the hematopoietic system including the hematologic system in human and veterinary medicine.