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    Multi-photon imaging installation
    2.
    发明授权
    Multi-photon imaging installation 失效
    多光子成像安装

    公开(公告)号：US06879394B2

    公开(公告)日：2005-04-12

    申请号：US10441027

    申请日：2003-05-20

    申请人： François Amblard ,  Xavier Sastre-Garau ,  Sylvie Robine

    发明人： François Amblard ,  Xavier Sastre-Garau ,  Sylvie Robine

    IPC分类号： A61B1/00 ,  A61B3/10 ,  A61B3/12 ,  A61N5/06 ,  G01N21/64 ,  G01N21/65 ,  G02B21/00 ,  G02B23/24

    CPC分类号： G01N21/6486 ,  G01N21/6458 ,  G02B21/0024 ,  G02B21/0076 ,  G02B21/0084

    摘要： An installation is provided for multi-dimensional non-linear imaging of a material comprising intrinsic chromophores, using laser scanning. This installation comprises i) at least one source (115) of time stamp pulses of synchronized photons, ii) means (12-14) for locally focusing the pulses on a material to cause its intrinsic chromophores to absorb groups of at least two synchronized photons to produce response photons, iii) means (22, 40, 53) for directing the response photons to at leat one collecting zone, iv) means (30-34) for collecting the response photons in the collecting zone(s) whatever their energy, v) processing means for converting the collected photons into data at least representative of their number and storing them in correspondence with at least the time stamp pulses that cause the material to produce the response photons, vi) means for scanning (11, 20) the pulses through a chosen area of the material, and vii) means for delivering from said data stored an image representative of said material chosen area, with a sub-millimeter resolution, and in function of the respective time stamp pulses of data.

    摘要翻译： 提供了一种用于使用激光扫描对包括内在发色团的材料进行多维非线性成像的装置。 该装置包括i）同步光子的时间戳脉冲的至少一个源（115），ii）用于将材料上的脉冲局部聚焦以使其内在发色团吸收至少两个同步光子的组的装置（12-14） 以产生响应光子，iii）用于将响应光子引导到一个收集区的装置（22,40,53），iv）用于收集收集区中的响应光子的装置（30-34），无论其能量如何 v）处理装置，用于将所收集的光子转换成至少代表其数量的数据，并且至少存储它们与至少引起材料产生响应光子的时间戳脉冲相对应; vi）扫描装置（11,20） 脉冲通过材料的选定区域，以及vii）用于从所述数据传送的装置，用于存储表示所述材料选择区域的图像，具有亚毫米分辨率，并且具有数据的相应时间戳脉冲的功能。

    Upregulation of rack-1 in melanoma and its use as a marker
    4.
    发明授权
    Upregulation of rack-1 in melanoma and its use as a marker 有权
    上调黑色素瘤中的架-1，并将其用作标记物

    公开(公告)号：US08247182B2

    公开(公告)日：2012-08-21

    申请号：US12830775

    申请日：2010-07-06

    申请人： Jean-Jacques Panthier ,  Giorgia Egidy ,  Xavier Sastre-Garau ,  Florence Bernex

    发明人： Jean-Jacques Panthier ,  Giorgia Egidy ,  Xavier Sastre-Garau ,  Florence Bernex

    IPC分类号： G01N33/53

    CPC分类号： G01N33/5743 ,  G01N2333/705

    摘要： The present invention concerns a method for diagnosing a melanoma in a mammal comprising the detection of the overexpression of RACK-1 protein in a melanocytic cell of said mammal, and the deduction of the presence of a melanoma from the overexpression of RACK-1 protein. The invention is also directed to a method for determining the tumoral status of a melanocytic cell of a mammal, comprising the detection of overexpression of RACK-1 protein in the melanocytic cell, and the deduction of the tumoral state of said cell from the overexpression of RACK-1 protein.

    摘要翻译： 本发明涉及一种用于诊断哺乳动物黑素瘤的方法，包括检测所述哺乳动物的黑素细胞中RACK-1蛋白的过表达，以及从RACK-1蛋白的过表达中减少黑素瘤的存在。 本发明还涉及一种用于确定哺乳动物黑素细胞细胞的肿瘤状态的方法，包括检测黑素细胞中RACK-1蛋白的过度表达，以及所述细胞的肿瘤状态从过表达 RACK-1蛋白。

    UPREGULATION OF RACK-1 IN MELANOMA AND ITS USE AS A MARKER
    6.
    发明申请
    UPREGULATION OF RACK-1 IN MELANOMA AND ITS USE AS A MARKER 审中-公开
    作为一个标记用于MELANOMA中的RACK-1和其使用的升级

    公开(公告)号：US20090098535A1

    公开(公告)日：2009-04-16

    申请号：US11831128

    申请日：2007-07-31

    申请人： Jean-Jacques Panthier ,  Giorgia Egidy ,  Xavier Sastre-Garau ,  Florence Bernex

    发明人： Jean-Jacques Panthier ,  Giorgia Egidy ,  Xavier Sastre-Garau ,  Florence Bernex

    IPC分类号： C12Q1/68 ,  C12Q1/02 ,  G01N33/574

    CPC分类号： G01N33/5743 ,  G01N2333/705

    摘要： The present invention concerns a method for diagnosing a melanoma in a mammal comprising the detection of the overexpression of RACK-1 protein in a melanocytic cell of said mammal, and the deduction of the presence of a melanoma from the overexpression of RACK-1 protein. The invention is also directed to a method for determining the tumoral status of a melanocytic cell of a mammal, comprising the detection of overexpression of RACK-1 protein in the melanocytic cell, and the deduction of the tumoral state of said cell from the overexpression of RACK-1 protein.

    摘要翻译： 本发明涉及一种用于诊断哺乳动物黑素瘤的方法，包括检测所述哺乳动物的黑素细胞中RACK-1蛋白的过表达，以及从RACK-1蛋白的过表达中减少黑素瘤的存在。 本发明还涉及一种用于确定哺乳动物黑素细胞细胞的肿瘤状态的方法，包括检测黑素细胞中RACK-1蛋白的过度表达，以及所述细胞的肿瘤状态从过表达 RACK-1蛋白。

    Upregulation of RACK-1 in melanoma and its use as a marker
    7.
    发明授权
    Upregulation of RACK-1 in melanoma and its use as a marker 失效
    黑色素瘤中RACK-1的上调及其作为标记

    公开(公告)号：US08367348B2

    公开(公告)日：2013-02-05

    申请号：US12671415

    申请日：2008-07-28

    申请人： Jean-Jacques Panthier ,  Giorgia Egidy ,  Xavier Sastre-Garau ,  Florence Bernex

    发明人： Jean-Jacques Panthier ,  Giorgia Egidy ,  Xavier Sastre-Garau ,  Florence Bernex

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6893 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/5743 ,  G01N2333/705 ,  G01N2333/9121

    摘要： The present invention concerns a method for diagnosing a melanoma in a mammal comprising the detection of the overexpression of RACK-1 protein in a melanocyte cell of said mammal, and the deduction of the presence of a melanoma from the overexpression of RACK-1 protein. The invention is also directed to a method for determining the tumoral status of a melanocyte cell of a mammal, comprising the detection of overexpression of RACK-1 protein in the melanocyte cell, and the deduction of the tumoral state of said cell from the overexpression of RACK-1 protein.

    摘要翻译： 本发明涉及用于诊断哺乳动物黑素瘤的方法，包括检测所述哺乳动物的黑素细胞细胞中RACK-1蛋白的过表达，以及从RACK-1蛋白的过表达中减少黑素瘤的存在。 本发明还涉及一种用于确定哺乳动物黑素细胞细胞的肿瘤状态的方法，其包括检测黑素细胞细胞中RACK-1蛋白的过度表达，以及所述细胞的肿瘤状态从过表达 RACK-1蛋白。

    UPREGULATION OF RACK-1 IN MELANOMA AND ITS USE AS A MARKER
    8.
    发明申请
    UPREGULATION OF RACK-1 IN MELANOMA AND ITS USE AS A MARKER 有权
    作为一个标记用于MELANOMA中的RACK-1和其使用的升级

    公开(公告)号：US20110045475A1

    公开(公告)日：2011-02-24

    申请号：US12830775

    申请日：2010-07-06

    申请人： Jean-Jacques PANTHIER ,  Giorgia Egidy ,  Xavier Sastre-Garau ,  Florence Bernex

    发明人： Jean-Jacques PANTHIER ,  Giorgia Egidy ,  Xavier Sastre-Garau ,  Florence Bernex

    IPC分类号： C12Q1/68 ,  C12Q1/02 ,  G01N33/53

    CPC分类号： G01N33/5743 ,  G01N2333/705

    摘要： The present invention concerns a method for diagnosing a melanoma in a mammal comprising the detection of the overexpression of RACK-1 protein in a melanocytic cell of said mammal, and the deduction of the presence of a melanoma from the overexpression of RACK-1 protein. The invention is also directed to a method for determining the tumoral status of a melanocytic cell of a mammal, comprising the detection of overexpression of RACK-1 protein in the melanocytic cell, and the deduction of the tumoral state of said cell from the overexpression of RACK-1 protein.

    摘要翻译： 本发明涉及一种用于诊断哺乳动物黑素瘤的方法，包括检测所述哺乳动物的黑素细胞中RACK-1蛋白的过表达，以及从RACK-1蛋白的过表达中减少黑素瘤的存在。 本发明还涉及一种用于确定哺乳动物黑素细胞细胞的肿瘤状态的方法，包括检测黑素细胞中RACK-1蛋白的过度表达，以及所述细胞的肿瘤状态从过表达 RACK-1蛋白。