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公开(公告)号：US20170042944A1
公开(公告)日：2017-02-16
申请号：US15305325
申请日：2015-04-20
申请人： Robert HARIRI , Jodi P. GURNEY , Xiaokui ZHANG , Stacy HERB , Cindy HARTUNG , ANTHROGENESIS CORPORATION
发明人： Robert J. HARIRI , Jodi P. GURNEY , Xiaokui ZHANG , Stacy Herb , Cindy HARTUNG
CPC分类号： A61K35/50 , A61K9/0019 , A61K9/0085 , A61K35/51 , C12N5/0605 , A61K2300/00
摘要： Provided herein are compositions and methods for treating one or more disorders or conditions in infants, including premature infants, by administering to such infants umbilical cord blood or cells obtained from umbilical cord blood and, optionally, cells obtained from placental perfusate, placental stem cells and/or blood additives. Also provided herein are methods for treating one or more disorders or conditions in infants, including premature infants, by administering to such infants cells obtained from placental perfusate alone or placental stem cells alone or in combination with umbilical cord blood or cells obtained from umbilical cord blood.
摘要翻译： 本文提供了通过对这些婴儿脐带血或从脐带血获得的细胞和任选地从胎盘灌注液，胎盘干细胞和胎盘干细胞获得的细胞施用来治疗婴儿包括早产儿的一种或多种病症或病症的组合物和方法 /或血液添加剂。 本文还提供了通过给予这样的婴儿从单独胎盘灌洗液获得的细胞或单独的胎盘干细胞或与脐带血或从脐带血获得的细胞组合来治疗婴儿（包括早产儿）的一种或多种病症或病症的方法 。
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2.发明授权公开(公告)号：US08969315B2
公开(公告)日：2015-03-03
申请号：US13340589
申请日：2011-12-29
IPC分类号： A61K48/00 , A61K35/50 , A61K31/7088 , A61K31/7105 , A61K31/713 , C12N5/073 , C12N5/0775 , C12N15/113 , A61K35/12
CPC分类号： A61K35/50 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K2035/122 , C12N5/0605 , C12N5/0668 , C12N15/1138 , C12N2310/141 , C12N2501/38 , C12N2501/65 , C12N2310/14 , C12N2310/531
摘要： Provided herein are methods of producing enhanced placental stem cells by modulatory RNA molecules. Also provided herein are methods of using enhanced placental stem cells, for example, to treat individuals having a disease, disorder or condition caused by, or relating to, an unwanted or harmful immune response. Further provided herein are compositions comprising said enhanced placental stem cells.
摘要翻译： 本文提供了通过调节性RNA分子生产增强的胎盘干细胞的方法。 本文还提供了使用增强的胎盘干细胞的方法，例如，治疗由不想要的或有害的免疫应答引起的疾病，病症或病状或与之相关的个体。 本文进一步提供包含所述增强胎盘干细胞的组合物。
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3.发明授权Methods for identifying modulators of transcriptional activator protein interactions 失效用于鉴定转录激活蛋白相互作用的调节剂的方法公开(公告)号：US06391572B1
公开(公告)日：2002-05-21
申请号：US09387418
申请日：1999-08-31
IPC分类号： G01N3353
CPC分类号： C07K14/4705 , C07K2319/00 , G01N33/5008 , G01N33/5011 , G01N33/5017 , G01N33/502 , G01N33/68 , G01N33/6845 , G01N2333/4715
摘要： The present invention relates to methods for identifying interacting regions of transcription factors, and methods for identifying agents which modulate the interactions, useful for affecting gene regulation, for example, cellular transformation. A site within residues 130-154 and within residues 343-358 in Stat3 were found to interact with the transcription factor c-Jun. On c-Jun, a site within residues 105 and 334, and more particularly, between 105 and 263, interact with Stat3. These sites of interactions permit methods for identifying agents which modulate the interaction between these transcription factors to modulate gene transcription.
摘要翻译： 本发明涉及用于鉴定转录因子的相互作用区域的方法，以及用于鉴定调节相互作用的试剂的方法，其用于影响基因调控，例如细胞转化。 发现Stat3中残基130-154和343-358位残基内的位点与转录因子c-Jun相互作用。 在c-Jun上，残基105和334内的位点，特别是105和263之间的位点与Stat3相互作用。 这些相互作用的位点允许用于鉴定调节这些转录因子之间的相互作用以调节基因转录的试剂的方法。
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公开(公告)号：US08926964B2
公开(公告)日：2015-01-06
申请号：US13182250
申请日：2011-07-13
申请人： Robert J. Hariri , Mohammad A. Heidaran , Stephen Jasko , Lin Kang , Eric Law , Ajai Pal , Bhavani Stout , Vanessa Voskinarian-Berse , Andrew Zeitlin , Xiaokui Zhang
发明人： Robert J. Hariri , Mohammad A. Heidaran , Stephen Jasko , Lin Kang , Eric Law , Ajai Pal , Bhavani Stout , Vanessa Voskinarian-Berse , Andrew Zeitlin , Xiaokui Zhang
IPC分类号： A01N63/00 , C12N5/00 , C12N5/0783 , A61K35/12
CPC分类号： C12N5/0646 , A61K35/17 , A61K2035/124 , C12N2500/05 , C12N2500/25 , C12N2500/33 , C12N2500/36 , C12N2500/38 , C12N2500/44 , C12N2500/46 , C12N2500/84 , C12N2501/125 , C12N2501/145 , C12N2501/2302 , C12N2501/2303 , C12N2501/2307 , C12N2501/2315 , C12N2501/26 , C12N2501/59 , C12N2501/91 , C12N2501/998 , C12N2506/11
摘要： Provided herein are methods of producing natural killer cells using a two-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation, of treating individuals having cancer or a viral infection, comprising administering the NK cells produced by the method to an individual having the cancer or viral infection.
摘要翻译： 本文提供了使用两步膨胀和分化方法生产天然杀伤细胞的方法。 本文还提供了抑制肿瘤细胞增殖，治疗患有癌症或病毒感染的个体的方法，包括将通过该方法产生的NK细胞施用于具有癌症或病毒感染的个体。
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公开(公告)号：US08586360B2
公开(公告)日：2013-11-19
申请号：US12829326
申请日：2010-07-01
CPC分类号： C12N5/0641 , C12N5/0018 , C12N2500/36 , C12N2500/90 , C12N2501/105 , C12N2501/125 , C12N2501/14 , C12N2501/145 , C12N2501/2303 , C12N2501/2311 , C12N2501/26 , C12N2501/90 , C12N2501/998 , C12N2501/999 , C12N2506/03
摘要： Provided herein are methods of producing erythrocytes from hematopoietic cells, particularly hematopoietic cells from placental perfusate in combination with hematopoietic cells from umbilical cord blood, wherein the method results in accelerated expansion and differentiation of the hematopoietic cells to more efficiently produce administrable erythrocytes. Further provided herein is a bioreactor in which hematopoietic cell expansion and differentiation takes place.
摘要翻译： 本文提供了从造血细胞产生红细胞的方法，特别是来自胎盘灌洗液的造血细胞与来自脐带血的造血细胞结合，其中该方法导致造血细胞的加速扩增和分化，以更有效地产生可施用的红细胞。 本文进一步提供的是其中发生造血细胞扩增和分化的生物反应器。
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6.发明申请公开(公告)号：US20120230959A1
公开(公告)日：2012-09-13
申请号：US13340589
申请日：2011-12-29
CPC分类号： A61K35/50 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K2035/122 , C12N5/0605 , C12N5/0668 , C12N15/1138 , C12N2310/141 , C12N2501/38 , C12N2501/65 , C12N2310/14 , C12N2310/531
摘要： Provided herein are methods of producing enhanced placental stem cells by modulatory RNA molecules. Also provided herein are methods of using enhanced placental stem cells, for example, to treat individuals having a disease, disorder or condition caused by, or relating to, an unwanted or harmful immune response. Further provided herein are compositions comprising said enhanced placental stem cells.
摘要翻译： 本文提供了通过调节性RNA分子生产增强的胎盘干细胞的方法。 本文还提供了使用增强的胎盘干细胞的方法，例如，治疗由不想要的或有害的免疫应答引起的疾病，病症或病状或与之相关的个体。 本文进一步提供包含所述增强胎盘干细胞的组合物。
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公开(公告)号：US20110003387A1
公开(公告)日：2011-01-06
申请号：US12829326
申请日：2010-07-01
IPC分类号： C12N5/078
CPC分类号： C12N5/0641 , C12N5/0018 , C12N2500/36 , C12N2500/90 , C12N2501/105 , C12N2501/125 , C12N2501/14 , C12N2501/145 , C12N2501/2303 , C12N2501/2311 , C12N2501/26 , C12N2501/90 , C12N2501/998 , C12N2501/999 , C12N2506/03
摘要： Provided herein are methods of producing erythrocytes from hematopoietic cells, particularly hematopoietic cells from placental perfusate in combination with hematopoietic cells from umbilical cord blood, wherein the method results in accelerated expansion and differentiation of the hematopoietic cells to more efficiently produce administrable erythrocytes. Further provided herein is a bioreactor in which hematopoietic cell expansion and differentiation takes place.
摘要翻译： 本文提供了从造血细胞产生红细胞的方法，特别是来自胎盘灌洗液的造血细胞与来自脐带血的造血细胞结合，其中该方法导致造血细胞的加速扩增和分化，以更有效地产生可施用的红细胞。 本文进一步提供的是其中发生造血细胞扩增和分化的生物反应器。
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公开(公告)号：US20090104164A1
公开(公告)日：2009-04-23
申请号：US12239679
申请日：2008-09-26
申请人： Xiaokui Zhang , Mohammad A. Heidaran , Vanessa R. Voskinarian-Berse , Lin Kang , Henry Rendon Barragan
发明人： Xiaokui Zhang , Mohammad A. Heidaran , Vanessa R. Voskinarian-Berse , Lin Kang , Henry Rendon Barragan
CPC分类号： C12N5/0692 , C12N2501/115 , C12N2501/15 , C12N2501/70
摘要： Provided herein are the production of vasculogenic or angiogenic cells from placental perfusate. Also provided are methods of treating an individual having a cardiac or vascular insufficiency, disease, disorder or condition comprising administering to said individual placental perfusate, placental perfusate cells, or combinations of placental perfusate or perfusate cells with placental or non-placental hematopoietic stem cells or adherent placental stem cells.
摘要翻译： 本文提供了从胎盘灌注液产生血管生成或血管生成细胞。 还提供了治疗患有心脏或血管功能不全，疾病，障碍或病症的个体的方法，包括向所述个体胎盘灌洗液，胎盘灌洗液细胞或胎盘灌注液或灌注液细胞与胎盘或非胎盘造血干细胞或 贴壁胎盘干细胞。
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公开(公告)号：US09200253B1
公开(公告)日：2015-12-01
申请号：US12187337
申请日：2008-08-06
申请人： Mohammad A. Heidaran , Xiaokui Zhang , Lin Kang , Andrew Zeitlin , Vanessa R. Voskinarian-Berse , Stewart Ernest Abbott
发明人： Mohammad A. Heidaran , Xiaokui Zhang , Lin Kang , Andrew Zeitlin , Vanessa R. Voskinarian-Berse , Stewart Ernest Abbott
CPC分类号： C12N5/0641 , C12N2500/99 , C12N2501/105 , C12N2501/11 , C12N2501/125 , C12N2501/135 , C12N2501/14 , C12N2501/145 , C12N2501/22 , C12N2501/2303 , C12N2501/2306 , C12N2501/2311 , C12N2501/26 , C12N2501/999
摘要： Provided herein are methods of producing erythrocytes from hematopoietic cells, particularly hematopoietic cells from placental perfusate in combination with hematopoietic cells from umbilical cord blood, wherein the method results in accelerated expansion and differentiation of the hematopoietic cells to more efficiently produce administrable erythrocytes. Further provided herein is a bioreactor in which hematopoietic cell expansion and differentiation takes place.
摘要翻译： 本文提供了从造血细胞产生红细胞的方法，特别是来自胎盘灌洗液的造血细胞与来自脐带血的造血细胞结合，其中该方法导致造血细胞的加速扩增和分化，以更有效地产生可施用的红细胞。 本文进一步提供的是其中发生造血细胞扩增和分化的生物反应器。
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公开(公告)号：US08562973B2
公开(公告)日：2013-10-22
申请号：US13081422
申请日：2011-04-06
申请人： James W. Edinger , Steven Alan Fischkoff , Aleksandar Francki , Vladimir Jankovic , Bitao Liang , Philippe Martin , Cynthia Ray , Xiaokui Zhang
发明人： James W. Edinger , Steven Alan Fischkoff , Aleksandar Francki , Vladimir Jankovic , Bitao Liang , Philippe Martin , Cynthia Ray , Xiaokui Zhang
IPC分类号： C12C7/04
摘要： Methods of treating individuals having sarcoidosis or a sarcoidosis-related disease or disorder using placental cells are described. Also describe are kits comprising placental stem cells or a composition thereof that can be used in methods of treating sarcoidosis or a sarcoidosis-related disease or disorder.
摘要翻译： 描述了使用胎盘细胞治疗患有结节病或结节病相关疾病或病症的个体的方法。 还描述了可用于治疗结节病或结节病相关疾病或病症的方法中的胎盘干细胞或其组合物的试剂盒。
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