公开(公告)号：US20140067082A1

公开(公告)日：2014-03-06

申请号：US13832455

申请日：2013-03-15

申请人： Xinyin Liu ,  Mark Fulmer ,  Peter Schaut ,  Kevin Joye

发明人： Xinyin Liu ,  Mark Fulmer ,  Peter Schaut ,  Kevin Joye

IPC分类号： A61L27/56 ,  A61L27/10

CPC分类号： A61L24/0042 ,  A61L24/001 ,  A61L24/02 ,  A61L27/10 ,  A61L27/12 ,  A61L27/32 ,  A61L27/50 ,  A61L27/56 ,  A61L27/58 ,  A61L2400/06 ,  A61L2420/02 ,  A61L2420/08 ,  A61L2430/02 ,  B05D1/12 ,  B05D3/007 ,  C04B28/14 ,  C04B28/344 ,  C04B2111/00836

摘要： The present disclosure is directed to a bioresorbable ceramic composition having a plurality of biocompatible ceramic granules, each of the granules having a coating of a plurality of calcium containing particles, where at least a portion of the particles are bound to at least a portion of an outer surface of each of the granules, and further where the composition is flowable in a dry state. The present disclosure is also directed to a three dimensional scaffold for bone repair that includes the bioresorbable composition, which upon implantation to a locus of repair defines an interconnected pore network between outer walls of the coated granules of the composition. Finally, the present disclosure is directed to methods of forming both the bioresorbable ceramic composition and the three-dimensional ceramic scaffold.

摘要翻译： 本公开涉及具有多个生物相容性陶瓷颗粒的生物可吸收陶瓷组合物，每个颗粒具有多个含钙颗粒的涂层，其中至少一部分颗粒与至少一部分 每个颗粒的外表面，并且其中组合物在干燥状态下可流动。 本公开还涉及用于骨修复的三维支架，其包括生物可再吸收组合物，其在植入修复位点时限定组合物的包衣颗粒的外壁之间的互连孔网络。 最后，本公开涉及形成生物可吸收陶瓷组合物和三维陶瓷支架的方法。

公开(公告)号：US20100041770A1

公开(公告)日：2010-02-18

申请号：US12447959

申请日：2007-10-31

申请人： Xinyin Liu ,  Mark Thomas Fulmer ,  Elliott Gruskin ,  Milvia Lepre

发明人： Xinyin Liu ,  Mark Thomas Fulmer ,  Elliott Gruskin ,  Milvia Lepre

IPC分类号： A61F2/28

CPC分类号： A61L27/46 ,  A61L27/446 ,  A61L27/58 ,  C08J3/212 ,  C08J2367/04 ,  C08K3/01 ,  C08L67/04 ,  C08L67/00

摘要： Methods and devices are shown for a composite material that is easily applied to a surface such as a bone defect in need of filling or reinforcement, etc. The composite material provides good mechanical properties such as compressive strength upon curing in the presence of water. Selected materials and methods as described are further bioabsorbable with absorption rates that are controllable to provide desired morphology over time. In selected embodiments a pharmaceutical agent further provides benefits such as bone growth, infection resistance, pain management, etc.

摘要翻译： 显示了易于应用于诸如需要填充或加强等的骨缺损的表面的复合材料的方法和装置。复合材料提供良好的机械性能，例如在水存在下固化时的抗压强度。 所描述的所选择的材料和方法进一步具有生物吸收性，吸收速率可控制以随时间提供期望的形态。 在选择的实施方案中，药剂还提供益处，例如骨生长，感染抵抗，疼痛管理等。