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    Medical devices for use in the surgical treatment of hyperproliferative diseases affecting the spinal cord
    1.
    发明授权
    Medical devices for use in the surgical treatment of hyperproliferative diseases affecting the spinal cord 有权
    用于手术治疗影响脊髓的过度增生性疾病的医疗装置

    公开(公告)号：US09173732B2

    公开(公告)日：2015-11-03

    申请号：US12186346

    申请日：2008-08-05

    申请人： Robert S. Langer ,  Rajiv Saigal ,  Yang Teng ,  Eric Woodard

    发明人： Robert S. Langer ,  Rajiv Saigal ,  Yang Teng ,  Eric Woodard

    IPC分类号： A61F2/02 ,  A61L27/50 ,  A61L27/58 ,  A61L27/18

    CPC分类号： A61F2/02 ,  A61F2210/0004 ,  A61L27/18 ,  A61L27/50 ,  A61L27/58 ,  A61L2430/38 ,  C08L67/04

    摘要： Provided herein are new methods for the treatment of hyperproliferative diseases affecting the spinal cord, including the use of biodegradable polymers to treat spinal cord tumor recessing, i.e., to patch open zones left by spinal tumor removal. Biocompatible polymeric materials are tailored to fill areas previously occupied by tumors, e.g., materials in the form of tubular articles configured for insertion into the spinal column after surgical removal of a tumor. These protective articles may also include medicinal agents that stimulate spinal column neural regeneration, such as medicines or donor neuronal cells such as human neural stem cells, thus assisting patients to recover motorsensory function after spinal tumor surgery.

    摘要翻译： 本文提供了用于治疗影响脊髓的过度增生性疾病的新方法，包括使用可生物降解的聚合物来治疗脊髓肿瘤凹陷，即通过脊髓肿瘤去除留下的开放区域。 生物相容的聚合物材料被调整以填补先前由肿瘤占据的区域，例如被构造成在手术切除肿瘤后插入到脊柱中的管状制品形式的材料。 这些保护制品还可以包括刺激脊柱神经再生的药剂，例如药物或供体神经元细胞例如人神经干细胞，从而帮助患者恢复脊髓肿瘤手术后的感觉功能。

    Gas flow guiding device for use in crystal-growing furnace
    4.
    发明授权
    Gas flow guiding device for use in crystal-growing furnace 有权
    用于晶体生长炉的气流引导装置

    公开(公告)号：US08926751B2

    公开(公告)日：2015-01-06

    申请号：US12958469

    申请日：2010-12-02

    申请人： Jyh-Chen Chen ,  Ying-Yang Teng ,  Chung-Wei Lu ,  Hsueh-I Chen

    发明人： Jyh-Chen Chen ,  Ying-Yang Teng ,  Chung-Wei Lu ,  Hsueh-I Chen

    IPC分类号： C30B15/02 ,  C30B11/00 ,  C30B28/06

    CPC分类号： C30B11/006 ,  C30B28/06 ,  Y10T117/108

    摘要： The present invention relates to a gas flow guiding device for use in a crystal-growing furnace. The gas flow guiding device has an insulation layer enclosing a crucible, a gas inlet mounted in the upper insulation layer, and a gas exit formed in the lateral insulation layer. A plurality of guide plates are radially arranged around the opening of the gas inlet, so that the free surface of the melt is blown by the guided gas flow in such a manner that the gas flow takes the impurity away from the free surface efficiently. As a result, the crystal ingot obtained by solidifying the melt will exhibit a reduced concentration of impurities and an improved crystal quality.

    摘要翻译： 本发明涉及一种用于晶体生长炉的气流引导装置。 气体流动引导装置具有包围坩埚的绝缘层，安装在上部绝缘层中的气体入口和形成在侧面绝缘层中的气体出口。 多个引导板围绕气体入口的开口径向布置，使得熔体的自由表面被引导气流吹送，使得气流使杂质从自由表面高效地离开。 结果，通过使熔体固化而获得的晶锭将显示出降低的杂质浓度和改善的晶体质量。

    Compositions and methods for enhancing structural and functional nervous system reorganization and recovery
    6.
    发明申请
    Compositions and methods for enhancing structural and functional nervous system reorganization and recovery 审中-公开
    用于增强结构和功能性神经系统重组和恢复的组合物和方法

    公开(公告)号：US20060104969A1

    公开(公告)日：2006-05-18

    申请号：US11205501

    申请日：2005-08-16

    申请人： Serkan Oray ,  Ania Majewska ,  Mriganka Sur ,  Yang Teng

    发明人： Serkan Oray ,  Ania Majewska ,  Mriganka Sur ,  Yang Teng

    IPC分类号： A61K38/48

    CPC分类号： A61K38/49 ,  A61K33/14 ,  A61K33/30 ,  A61K33/42 ,  A61K38/484 ,  A61K45/06 ,  A61L27/54 ,  A61L2300/254 ,  A61L2300/412 ,  A61K2300/00

    摘要： The present invention provides methods and compositions for enhancing recovery in a subject suffering from damage to the nervous system. In particular, the invention includes a method for promoting recovery and/or reorganization in the nervous system of a subject in need of enhancement of recovery and/or reorganization of the nervous system as a result of ischemic, hemorrhagic, neoplastic, degenerative, or traumatic damage by focally administering a composition comprising a proteolysis-enhancing agent such as tissue plasminogen activator (tPA), plasmin, or a PAI inhibitor to the nervous system of the subject. In some embodiments an additional active agent is also administered. The composition can be delivered using a variety of techniques including injection, via infusion pump, from an implantable microchip, or using a polymeric delivery vehicle. The composition can be administered, for example, to one or more subdivisions or areas of the brain, the spinal cord, or to one or more nerves or nerve tracts innervating diverse regions of the body. The invention also includes a drug delivery device for implantation into the nervous system to promote nervous system reorganization and/or recovery following ischemic, hemorrhagic, neoplastic, traumatic or degenerative damage, the drug delivery device comprising a biocompatible polymer and a proteolysis-enhancing agent such as tissue plasminogen activator (tPA), plasmin, or a PAI inhibitor, wherein the proteolysis-enhancing agent is released from the polymer in an amount effective to promote structural reorganization of the nervous system. In some embodiments the biocompatible polymer is a hydrogel.

    摘要翻译： 本发明提供用于增强患有神经系统损伤的受试者的恢复的方法和组合物。 特别地，本发明包括促进需要增强神经系统的恢复和/或重组作为缺血性，出血性，肿瘤性，退行性或外伤性的结果的神经系统中的恢复和/或重组的方法。 通过向受试者的神经系统照射施用包含蛋白水解增强剂如组织纤溶酶原激活剂（tPA），纤溶酶或PAI抑制剂的组合物的损伤。 在一些实施方案中，还施用另外的活性剂。 组合物可以使用各种技术递送，包括注射，通过输注泵，可植入微芯片，或使用聚合物递送载体。 组合物可以例如施用于脑，脊髓的一个或多个细分或区域，或者一个或多个神经或神经束，其支配身体的不同区域。 本发明还包括用于植入神经系统以促进缺血性，出血性，肿瘤性，创伤性或退行性损伤后的神经系统重组和/或恢复的药物递送装置，药物递送装置包含生物相容性聚合物和蛋白水解增强剂，例如 作为组织纤溶酶原激活剂（tPA），纤溶酶或PAI抑制剂，其中蛋白水解增强剂以有效促进神经系统结构重组的量从聚合物中释放。 在一些实施方案中，生物相容性聚合物是水凝胶。

    HOT ZONE DEVICE
    7.
    发明申请
    HOT ZONE DEVICE 审中-公开
    热区设备

    公开(公告)号：US20120137976A1

    公开(公告)日：2012-06-07

    申请号：US12958475

    申请日：2010-12-02

    申请人： Jyh-Chen Chen ,  Ying-Yang Teng ,  Chung-Wei Lu ,  Hsueh-I Chen

    发明人： Jyh-Chen Chen ,  Ying-Yang Teng ,  Chung-Wei Lu ,  Hsueh-I Chen

    IPC分类号： C23C16/455

    CPC分类号： C30B28/06 ,  C30B11/006

    摘要： The present invention relates to a hot zone device for use in a crystal-growing furnace. The hot zone device has a gas inlet. The gas inlet is mounted in an insulation layer at a position above the crucible in a manner protruding into an interior of the crucible. The insulation layer is formed with a gas exit. The gas inlet is positioned such that the opening thereof is spaced apart from the free surface of the melt contained in the crucible by a distance substantially equal to or shorter than 10 cm, so as to allow the free surface of the melt to be blown by the guided gas flow in such a manner that the gas flow takes the impurity away from the free surface efficiently. As a result, the crystal ingot obtained by solidifying the melt will exhibit a reduced concentration of impurities and an improved crystal quality.

    摘要翻译： 本发明涉及一种用于晶体生长炉的热区装置。 热区装置具有气体入口。 气体入口以突出到坩埚内部的方式安装在坩埚上方位置的绝缘层中。 绝缘层形成有气体出口。 气体入口被定位成使得其开口与坩埚中包含的熔体的自由表面间隔开大致等于或小于10cm的距离，从而允许熔体的自由表面被 引导气体流以这样一种方式使气流有效地将杂质从自由表面离开。 结果，通过使熔体固化而获得的晶锭将显示出降低的杂质浓度和改善的晶体质量。

    Gas supply device for use in crystal-growing furnace
    8.
    发明申请
    Gas supply device for use in crystal-growing furnace 审中-公开
    用于晶体生长炉的气体供应装置

    公开(公告)号：US20120137962A1

    公开(公告)日：2012-06-07

    申请号：US12960045

    申请日：2010-12-03

    申请人： Jyh-Chen Chen ,  Ying-Yang Teng ,  Chung-Wei Lu ,  Hsueh-I Chen

    发明人： Jyh-Chen Chen ,  Ying-Yang Teng ,  Chung-Wei Lu ,  Hsueh-I Chen

    IPC分类号： C30B11/00

    CPC分类号： C30B28/06 ,  C30B11/006 ,  Y10T117/1024

    摘要： The present invention relates to a gas supply device for use in a crystal-growing furnace. The gas supply device has an insulation layer enclosing a crucible, a gas inlet mounted in the insulation layer, and a gas exit formed in the insulation layer. A gas flow guide shield with an adjustable angle is disposed at the opening of the gas inlet, so that the free surface of the melt is blown by the guided gas flow in such a manner that the gas flow takes the impurity away from the free surface efficiently. As a result, the crystal ingot obtained by solidifying the melt will exhibit a reduced concentration of impurities and an improved crystal quality.

    摘要翻译： 本发明涉及一种用于晶体生长炉中的气体供应装置。 气体供给装置具有封闭坩埚的绝缘层，安装在绝缘层中的气体入口和形成在绝缘层中的气体出口。 具有可调角度的气体流动导向屏蔽件设置在气体入口的开口处，使得熔体的自由表面被引导气流吹送，使得气流使杂质远离自由表面 有效率的。 结果，通过使熔体固化而获得的晶锭将显示出降低的杂质浓度和改善的晶体质量。

    MEDICAL DEVICES FOR USE IN THE SURGICAL TREATMENT OF HYPERPROLIFERATIVE DISEASES AFFECTING THE SPINAL CORD
    9.
    发明申请
    MEDICAL DEVICES FOR USE IN THE SURGICAL TREATMENT OF HYPERPROLIFERATIVE DISEASES AFFECTING THE SPINAL CORD 有权
    用于影响脊髓的高增殖性疾病的手术治疗的医疗装置

    公开(公告)号：US20090053284A1

    公开(公告)日：2009-02-26

    申请号：US12186346

    申请日：2008-08-05

    申请人： Robert S. LANGER ,  Rajiv SAIGAL ,  Yang TENG ,  Eric WOODARD

    发明人： Robert S. LANGER ,  Rajiv SAIGAL ,  Yang TENG ,  Eric WOODARD

    IPC分类号： A61L27/58 ,  A61F2/02 ,  A61L27/54

    CPC分类号： A61F2/02 ,  A61F2210/0004 ,  A61L27/18 ,  A61L27/50 ,  A61L27/58 ,  A61L2430/38 ,  C08L67/04

    摘要： Provided herein are new methods for the treatment of hyperproliferative diseases affecting the spinal cord, including the use of biodegradable polymers to treat spinal cord tumor recessing, i.e., to patch open zones left by spinal tumor removal. Biocompatible polymeric materials are tailored to fill areas previously occupied by tumors, e.g., materials in the form of tubular articles configured for insertion into the spinal column after surgical removal of a tumor. These protective articles may also include medicinal agents that stimulate spinal column neural regeneration, such as medicines or donor neuronal cells such as human neural stem cells, thus assisting patients to recover motorsensory function after spinal tumor surgery.

    摘要翻译： 本文提供了用于治疗影响脊髓的过度增生性疾病的新方法，包括使用可生物降解的聚合物来治疗脊髓肿瘤凹陷，即通过脊髓肿瘤去除留下的开放区域。 生物相容的聚合物材料被调整以填补先前由肿瘤占据的区域，例如被构造成在手术切除肿瘤后插入到脊柱中的管状制品形式的材料。 这些保护制品还可以包括刺激脊柱神经再生的药剂，例如药物或供体神经元细胞例如人神经干细胞，从而帮助患者恢复脊髓肿瘤手术后的感觉功能。

    User's database in networks and method of constructing the same
    10.
    发明授权
    User's database in networks and method of constructing the same 失效
    网络用户数据库及其构建方法

    公开(公告)号：US06295537B1

    公开(公告)日：2001-09-25

    申请号：US09120200

    申请日：1998-07-22

    申请人： Wei-Yang Teng

    发明人： Wei-Yang Teng

    IPC分类号： G06F700

    CPC分类号： H04L29/12009 ,  H04L29/12783 ,  H04L45/745 ,  H04L61/35 ,  H04L67/00 ,  H04L69/329 ,  Y10S707/959 ,  Y10S707/99942 ,  Y10S707/99943 ,  Y10S707/99953

    摘要： The present invention relates to a user's database structure in the network and a method of constructing the same, in particular, to a user's database structure and a method of constructing the same in Ethernet. The structure comprises a set of bytes having a plurality of fields, a main storage layer having the set of bytes, a plurality of sub-storage layers having the set of bytes, a plurality of main connection lines and sub-connection lines, to form a database of tree structure. For retrieval of the user's address data, only the main storage layer, the main connection line and sub-connection lines, and the last sub-storage layer are required to retrieve a user's address data so as to save the storage space occupied by the database.

    摘要翻译： 本发明涉及网络中的用户数据库结构及其构造方法，特别涉及用户的数据库结构及其以太网中的构造方法。 该结构包括具有多个字段的字节集合，具有该字节集合的主存储层，具有字节集合的多个子存储层，多个主连接线和子连接线，以形成 树结构数据库。 为了检索用户的地址数据，仅需要主存储层，主连接线和子连接线以及最后一个子存储层来检索用户的地址数据，以便节省数据库占用的存储空间 。