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6 条记录 (耗时 0.073 秒)

    Method for purifying protected 2′-deoxycytidines and hydrated crystals thereof
    1.
    发明授权
    Method for purifying protected 2′-deoxycytidines and hydrated crystals thereof 失效
    保护的2'-脱氧胞苷及其水合晶体的纯化方法

    公开(公告)号：US06936709B2

    公开(公告)日：2005-08-30

    申请号：US10453481

    申请日：2003-06-04

    申请人： Hiroki Ishibashi ,  Kiyoteru Nagahara ,  Yasushi Fukuiri ,  Yasuko Matsuba

    发明人： Hiroki Ishibashi ,  Kiyoteru Nagahara ,  Yasushi Fukuiri ,  Yasuko Matsuba

    IPC分类号： C07H19/073 ,  B01D9/02 ,  C07H1/06 ,  C07H19/06 ,  C07H19/048

    CPC分类号： C07H19/06 ,  C07H1/06

    摘要： A protected 2′-deoxycytidine is purified by precipitating the protected 2′-deoxycytidine represented by general formula (3) in the form of a hydrated crystal from a solution containing the protected 2′-deoxycytidine and water, and by recovering the protected 2′-deoxycytidine: wherein R1 represents a 4-methoxytrityl, 4, 4′-dimethoxytrityl, or triphenylmethyl group; and B1 represents a cytosine group having a protected amino group. The compound represented by general formula (3) is, in particular, a protected 2′-deoxycytidine represented by formula (4): The 2′-deoxycytidine is used as a raw material for antisense DNA.

    摘要翻译： 通过从含有保护的2'-脱氧胞苷和水的溶液中沉淀出水合晶体形式的由通式（3）表示的受保护的2'-脱氧胞苷，并通过回收受保护的2'-脱氧胞苷来保护受保护的2'-脱氧胞苷， 脱氧胞苷：其中R1表示4-甲氧基三苯甲基，4,4'-二甲氧基三苯甲基或三苯基甲基; B1表示具有被保护的氨基的胞嘧啶基。 由通式（3）表示的化合物特别是由式（4）表示的保护的2'-脱氧胞苷：2'-脱氧胞苷用作反义DNA的原料。

    Esterase and methods for the production of optically active chroman compounds
    2.
    发明授权
    Esterase and methods for the production of optically active chroman compounds 失效
    酯酶和用于制备光学活性色满化合物的方法

    公开(公告)号：US6060290A

    公开(公告)日：2000-05-09

    申请号：US118275

    申请日：1998-07-17

    申请人： Toshihiro Oikawa ,  Nobuhiro Fukuhara ,  Yasuko Matsuba

    发明人： Toshihiro Oikawa ,  Nobuhiro Fukuhara ,  Yasuko Matsuba

    IPC分类号： C12N9/18 ,  C12N15/55 ,  C12P17/06 ,  C12P41/00

    CPC分类号： C12N9/18 ,  C12P17/06 ,  C12P41/005

    摘要： Optically active chroman-3-acetic acids and optically active chroman-3-acetic acid esters can be obtained by treating a mixture of (3R)- and (3S)-chroman-3-acetic esters of formula (I) ##STR1## [wherein R.sub.1 is a straight or branched alkyl group having 1-5 carbon atoms and R.sub.2 is a hydrogen atom or substituted or unsubstituted amino group]is treated with an esterase which has an optically selective hydrolyzing activity or microorganisms which carry said hydrolase, or a preparation therefrom. A novel esterase derived from bacteria of genus Pseudonocardia can also be used as said esterase.

    摘要翻译： 通过处理式（I）的（3R） - （3S） - 苯并二氢吡喃-3-乙酸酯的混合物[其中R 1是（R 3））和（3S） - 苯并二氢吡喃-3-乙酸酯的混合物可以获得光学活性色满-3-乙酸和光学活性色满-3-乙酸酯 具有1-5个碳原子的直链或支链烷基，R2是氢原子或取代或未取代的氨基]用具有光学选择性水解活性的酯酶或携带所述水解酶的微生物或其制备物进行处理。 也可以使用衍生自假诺卡氏菌属细菌的新型酯酶作为所述酯酶。

    Esterase and methods for the production of optically active chroman compounds
    6.
    发明授权
    Esterase and methods for the production of optically active chroman compounds 失效
    酯酶和用于制备光学活性色满化合物的方法

    公开(公告)号：US06303349B1

    公开(公告)日：2001-10-16

    申请号：US09524760

    申请日：2000-03-13

    申请人： Toshihiro Oikawa ,  Nobuhiro Fukuhara ,  Yasuko Matsuba

    发明人： Toshihiro Oikawa ,  Nobuhiro Fukuhara ,  Yasuko Matsuba

    IPC分类号： C12P1706

    CPC分类号： C12N9/18 ,  C12P17/06 ,  C12P41/005

    摘要： Optically active chroman-3-acetic acids and optically active chroman-3-acetic acid esters can be obtained by treating a mixture of (3R)- and (3S)-chroman-3-acetic esters of formula (I) [wherein R1 is a straight or branched alkyl group having 1-5 carbon atoms and R2 is a hydrogen atom or substituted or unsubstituted amino group] is treated with an esterase which has an optically selective hydrolyzing activity or microorganisms which carry said hydrolase, or a preparation therefrom. A novel esterase derived from bacteria of genus Pseudonocardia can also be used as said esterase.

    摘要翻译： 通过处理式（I）的（3R） - （3S） - 苯并二氢吡喃-3-乙酸酯的混合物[其中R 1是（R 3））和（3S） - 苯并二氢吡喃-3-乙酸酯的混合物可以获得光学活性色满-3-乙酸和光学活性色满-3-乙酸酯 具有1-5个碳原子的直链或支链烷基，R2是氢原子或取代或未取代的氨基]用具有光学选择性水解活性的酯酶或携带所述水解酶的微生物或其制备物进行处理。 也可以使用衍生自假诺卡氏菌属细菌的新型酯酶作为所述酯酶。