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    Esterase and methods for the production of optically active chroman compounds
    1.
    发明授权
    Esterase and methods for the production of optically active chroman compounds 失效
    酯酶和用于制备光学活性色满化合物的方法

    公开(公告)号：US6060290A

    公开(公告)日：2000-05-09

    申请号：US118275

    申请日：1998-07-17

    申请人： Toshihiro Oikawa ,  Nobuhiro Fukuhara ,  Yasuko Matsuba

    发明人： Toshihiro Oikawa ,  Nobuhiro Fukuhara ,  Yasuko Matsuba

    IPC分类号： C12N9/18 ,  C12N15/55 ,  C12P17/06 ,  C12P41/00

    CPC分类号： C12N9/18 ,  C12P17/06 ,  C12P41/005

    摘要： Optically active chroman-3-acetic acids and optically active chroman-3-acetic acid esters can be obtained by treating a mixture of (3R)- and (3S)-chroman-3-acetic esters of formula (I) ##STR1## [wherein R.sub.1 is a straight or branched alkyl group having 1-5 carbon atoms and R.sub.2 is a hydrogen atom or substituted or unsubstituted amino group]is treated with an esterase which has an optically selective hydrolyzing activity or microorganisms which carry said hydrolase, or a preparation therefrom. A novel esterase derived from bacteria of genus Pseudonocardia can also be used as said esterase.

    摘要翻译： 通过处理式（I）的（3R） - （3S） - 苯并二氢吡喃-3-乙酸酯的混合物[其中R 1是（R 3））和（3S） - 苯并二氢吡喃-3-乙酸酯的混合物可以获得光学活性色满-3-乙酸和光学活性色满-3-乙酸酯 具有1-5个碳原子的直链或支链烷基，R2是氢原子或取代或未取代的氨基]用具有光学选择性水解活性的酯酶或携带所述水解酶的微生物或其制备物进行处理。 也可以使用衍生自假诺卡氏菌属细菌的新型酯酶作为所述酯酶。

    Esterase and methods for the production of optically active chroman compounds
    2.
    发明授权
    Esterase and methods for the production of optically active chroman compounds 失效
    酯酶和用于制备光学活性色满化合物的方法

    公开(公告)号：US06303349B1

    公开(公告)日：2001-10-16

    申请号：US09524760

    申请日：2000-03-13

    申请人： Toshihiro Oikawa ,  Nobuhiro Fukuhara ,  Yasuko Matsuba

    发明人： Toshihiro Oikawa ,  Nobuhiro Fukuhara ,  Yasuko Matsuba

    IPC分类号： C12P1706

    CPC分类号： C12N9/18 ,  C12P17/06 ,  C12P41/005

    摘要： Optically active chroman-3-acetic acids and optically active chroman-3-acetic acid esters can be obtained by treating a mixture of (3R)- and (3S)-chroman-3-acetic esters of formula (I) [wherein R1 is a straight or branched alkyl group having 1-5 carbon atoms and R2 is a hydrogen atom or substituted or unsubstituted amino group] is treated with an esterase which has an optically selective hydrolyzing activity or microorganisms which carry said hydrolase, or a preparation therefrom. A novel esterase derived from bacteria of genus Pseudonocardia can also be used as said esterase.

    摘要翻译： 通过处理式（I）的（3R） - （3S） - 苯并二氢吡喃-3-乙酸酯的混合物[其中R 1是（R 3））和（3S） - 苯并二氢吡喃-3-乙酸酯的混合物可以获得光学活性色满-3-乙酸和光学活性色满-3-乙酸酯 具有1-5个碳原子的直链或支链烷基，R2是氢原子或取代或未取代的氨基]用具有光学选择性水解活性的酯酶或携带所述水解酶的微生物或其制备物进行处理。 也可以使用衍生自假诺卡氏菌属细菌的新型酯酶作为所述酯酶。

    Biocatalyst for production of D-lactic acid
    6.
    发明授权
    Biocatalyst for production of D-lactic acid 有权
    用于生产D-乳酸的生物催化剂

    公开(公告)号：US08669093B2

    公开(公告)日：2014-03-11

    申请号：US10573813

    申请日：2004-09-17

    申请人： Mitsufumi Wade ,  Toshihiro Oikawa ,  Daisuke Mochizuki ,  Junko Tokuda ,  Miyuki Kawashima ,  Tadashi Araki ,  Reiko Abe ,  Hitoki Miyake ,  Hitoshi Takahashi ,  Hideki Sawai ,  Takashi Mimitsuka ,  Takashi Morishige ,  Yosuke Higashi

    发明人： Mitsufumi Wade ,  Toshihiro Oikawa ,  Daisuke Mochizuki ,  Junko Tokuda ,  Miyuki Kawashima ,  Tadashi Araki ,  Reiko Abe ,  Hitoki Miyake ,  Hitoshi Takahashi ,  Hideki Sawai ,  Takashi Mimitsuka ,  Takashi Morishige ,  Yosuke Higashi

    IPC分类号： C12N1/21 ,  C12P7/56 ,  C12N1/26

    CPC分类号： C12P7/56

    摘要： A method for producing D-lactic acid in high yield, and to provide a method for producing D-lactic acid with high selectivity, in which optical purity is high and a by-product organic acid is small. In one aspect, a microorganism, wherein activity of pyruvate formate-lyase (pfl) is inactivated or decreased, and further activity of Escherichia coli-derived NADH-dependent D-lactate dehydrogenase (ldhA) is enhanced, is cultured to efficiently produce D-lactic acid. With regard to a method for enhancing ldhA activity, by linking, on a genome, a gene encoding ldhA with a promoter of a gene which controls expression of a protein involved in a glycolytic pathway, a nucleic acid biosynthesis pathway or an amino acid biosynthesis pathway, suitable results are obtained compared to the method for enhancing expression of the gene using an expression vector. A microorganism in which a dld gene is substantially inactivated or decreased is cultured to produce high quality D-lactic acid with reduced concentration of pyruvic acid.

    摘要翻译： 提供高产率D-乳酸的制造方法，提供高纯度的高纯度D-副乳酸和副产物有机酸的生产方法。 在一个方面，培养其中丙酮酸甲酸裂合酶（pfl）的活性失活或降低，并且进一步增强大肠杆菌来源的NADH依赖性D-乳酸脱氢酶（ldhA）的活性的微生物，以有效地产生D- 乳酸。 关于增强ldhA活性的方法，通过在基因组上连接编码ldhA的基因与控制糖酵解途径参与蛋白质的表达的基因的启动子，核酸生物合成途径或氨基酸生物合成途径 与使用表达载体增强基因表达的方法相比，获得了合适的结果。 培养其中dld基因基本上失活或减少的微生物被培养以产生具有降低的丙酮酸浓度的高质量D-乳酸。

    Method for producing a rocker arm for use in an internal combustion engine
    8.
    发明授权
    Method for producing a rocker arm for use in an internal combustion engine 失效
    一种用于内燃机的摇臂的制造方法

    公开(公告)号：US4955121A

    公开(公告)日：1990-09-11

    申请号：US71652

    申请日：1987-07-09

    申请人： Masakazu Sato ,  Seiichi Koike ,  Toshihiro Oikawa ,  Keisuke Ban

    发明人： Masakazu Sato ,  Seiichi Koike ,  Toshihiro Oikawa ,  Keisuke Ban

    IPC分类号： B22D27/11

    CPC分类号： B21K1/205 ,  B22D27/11 ,  Y10T29/49295 ,  Y10T29/49989

    摘要： A method for casting a rocker arm made of light alloy for use in an overhead cam shaft type valve operating mechanism of an internal combustion engine, which rocker arm includes a thick-walled bearing section to be fitted on a rocker arm shaft and is integrally provided with a wear-resistive piece having a protrusion on its rear surface and adapted to abut a cam. After molten metal has been injected under pressure into a metallic mold for the rocker arm, a secondary pressurizing force directed in the direction of an imaginary center axis of a rocker arm shaft is exerted by means of a pressurizing rod. In the metallic mold for the rocker arm, a sprue is provided close to the position where the wear-resistive piece is disposed with respect to the position where the bearing section is formed, and the direction of the sprue is directed towards the position where the wear-resistive place is disposed.

    摘要翻译： 一种用于铸造用于内燃机的顶部凸轮轴型阀操作机构的由轻合金制成的摇臂的方法，所述摇臂包括将被安装在摇臂轴上的厚壁轴承部分并且一体地设置 具有在其后表面上具有凸起并且适于邻接凸轮的耐磨件。 在压力下将熔融金属注入到用于摇臂的金属模具中之后，通过加压杆来施加沿摇臂轴的假想中心轴方向的二次加压力。 在用于摇臂的金属模具中，相对于形成有轴承部的位置，在耐磨件设置的位置附近设有浇道，并且浇道的方向被引导到 设置耐磨地点。

    SOHC type internal combustion engine
    9.
    发明授权
    SOHC type internal combustion engine 失效
    SOHC型内燃机

    公开(公告)号：US4748946A

    公开(公告)日：1988-06-07

    申请号：US70987

    申请日：1987-07-08

    申请人： Noriaki Fujii ,  Takeshi Iwata ,  Toshihiro Oikawa

    发明人： Noriaki Fujii ,  Takeshi Iwata ,  Toshihiro Oikawa

    IPC分类号： F01L1/04 ,  B23K26/06 ,  F01L1/053 ,  F01L1/12 ,  F01L1/18 ,  F01L1/26 ,  F02B1/04 ,  F02F1/24 ,  F02F1/38 ,  F02F1/42 ,  F02P13/00 ,  F02P15/00

    CPC分类号： F02F1/4214 ,  F01L1/053 ,  F01L1/26 ,  F02B1/04 ,  F02B2275/20 ,  F02F2001/245

    摘要： An SOHC type internal combustion engine having a cam shaft for opening and closing intake and exhaust valves via rocker arms, the cam shaft being held between a cam shaft receiving wall of a cylinder head and a cam shaft holder which is secured to the cam shaft receiving wall, wherein a hole for allowing insertion of an ignition plug into a plug mounting hole is formed in the cam shaft receiving wall and opens to the surface of the wall against which a cam shaft holder abuts, and a hole for guiding a high power cord for an ignition plug is formed between the mutually abutting surfaces of the cam shaft receiving wall and the cam shaft holder.

    摘要翻译： 一种SOHC型内燃机，其具有用于通过摇臂打开和关闭进气和排气阀的凸轮轴，所述凸轮轴保持在气缸盖的凸轮轴接收壁和凸轮轴保持器之间，所述凸轮轴保持器固定到所述凸轮轴接收 壁，其中，用于允许将火花塞插入插头安装孔的孔形成在凸轮轴接收壁中，并且通向凸轮轴保持器邻接的壁的表面，以及用于引导高功率线的孔 因为在凸轮轴接收壁和凸轮轴保持器的相互抵接的表面之间形成火花塞。

    Spark plug cap apparatus
    10.
    发明授权
    Spark plug cap apparatus 失效
    火花塞帽装置

    公开(公告)号：US4637358A

    公开(公告)日：1987-01-20

    申请号：US781247

    申请日：1985-09-27

    申请人： Yoshiki Yano ,  Toshihiro Oikawa

    发明人： Yoshiki Yano ,  Toshihiro Oikawa

    IPC分类号： F02B1/04 ,  F02F1/24 ,  H01T13/04 ,  F02P1/00

    CPC分类号： F02F1/242 ,  H01T13/04 ,  F02B1/04

    摘要： A spark plug cap apparatus for an internal combustion engine having relatively deep and generally vertical spark plug receiving bores. The upper end of the bore is provided with an annular protrusion. A resilient head cover has a bent flange for extending over and sealably engaging the annular protrusion. The head cover has a downwardly extending seal lip for engaging the inside of the bore. A pipe is molded to the head cover and extends downwardly to engage the top of the spark plug. The spark wire extends through the head cover and pipe. A vent hole is provided in the head cover.

    摘要翻译： 一种用于内燃机的火花塞盖设备，其具有相对较深且基本垂直的火花塞接收孔。 孔的上端设置有环形突起。 弹性头盖具有弯曲的凸缘，用于延伸并密封地接合环形突起。 头盖具有用于接合孔内部的向下延伸的密封唇。 管道被模制到头盖并向下延伸以接合火花塞的顶部。 火花线延伸穿过头盖和管道。 头盖上设有通气孔。