公开(公告)号：US11338019B2

公开(公告)日：2022-05-24

申请号：US16882508

申请日：2020-05-24

申请人： Yi-Hsun Huang ,  Hua-Lin Wu

发明人： Yi-Hsun Huang ,  Hua-Lin Wu

IPC分类号： A61K38/36 ,  A61K38/18 ,  A61P27/02 ,  A61K38/17 ,  A61K9/00 ,  A61K9/06

摘要： The present application relates to dual anti-angiogenic and anti-inflammatory effects of recombinant thrombomodulin domain 1 (TMD1). Specifically, an isolated recombinant polypeptide comprising an amino acid sequence that is at least 80% identical to TMD1 for use in treating an eye disease and/or an eye disorder associated with pathological ocular angiogenesis (POA) in a subject in need thereof is disclosed. The length of the recombinant polypeptide is no more than 200 amino acid residues. The eye disease and/or the eye disorder may be at least one selected from the group consisting of retinopathy of prematurity, diabetic retinopathy, and age-related macular degeneration. Use of TMD1 in the manufacture of a medicament for treating an eye disease and/or an eye disorder associated with vascular endothelial growth factor (VEGF)-induced ocular angiogenesis and/or hypoxia-inducible factor-1α (HIF-1α)-VEGF pathway is also disclosed.

公开(公告)号：US20070152217A1

公开(公告)日：2007-07-05

申请号：US11308015

申请日：2006-03-03

申请人： Chih-Ming Lai ,  Yung-Hui Yeh ,  Yi-Hsun Huang

发明人： Chih-Ming Lai ,  Yung-Hui Yeh ,  Yi-Hsun Huang

IPC分类号： H01L29/04

CPC分类号： H01L29/7869 ,  H01L27/1225 ,  H01L27/322 ,  H01L27/3265

摘要： A pixel structure of an active matrix organic light-emitting diode (AMOLED) includes an organic light-emitting diode (OLED), a data line, at least one scan line, at least one switch thin film transistor (TFT), at least one driving TFT and at least one storage capacitor with two transparent electrodes. Since both the electrodes of the transparent storage capacitor are formed by transparent material, the aperture ratio of the pixel and the area of the capacitor largely increase and can reach 50%˜95% of a pixel area. Thus, the display quality of an AMOLED panel can be improved.

摘要翻译： 有源矩阵有机发光二极管（AMOLED）的像素结构包括有机发光二极管（OLED），数据线，至少一条扫描线，至少一个开关薄膜晶体管（TFT），至少一个 驱动TFT和具有两个透明电极的至少一个存储电容器。 由于透明储能电容器的两个电极由透明材料形成，所以像素的开口率和电容器的面积大大增加，并且可以达到象素面积的50％〜95％。 因此，可以提高AMOLED面板的显示质量。

公开(公告)号：US20060243974A1

公开(公告)日：2006-11-02

申请号：US11175440

申请日：2005-07-07

申请人： Keng-Li Su ,  Chen-Pang Kung ,  Jan-Ruei Lin ,  Chia-Pao Chang ,  Yi-Hsun Huang

发明人： Keng-Li Su ,  Chen-Pang Kung ,  Jan-Ruei Lin ,  Chia-Pao Chang ,  Yi-Hsun Huang

IPC分类号： H01L29/04

CPC分类号： H01L29/78603 ,  H01L27/1296 ,  H01L29/41733

摘要： A thin-film transistor (TFT) is described to have a gate layer, an insulating layer, a semiconductor layer, and a source/drain layer formed on a flexible substrate. The source and the drain layers are separated by a channel with a special shape. This does not only increase the aspect ratio of the channel per unit area, the source and the drain also have multiple directions for transmitting carriers. The carrier mobility of the TFT is thus enhanced with uniform and stable circuit properties.

摘要翻译： 薄膜晶体管（TFT）被描述为具有形成在柔性基板上的栅极层，绝缘层，半导体层和源极/漏极层。 源极和漏极层由具有特殊形状的通道分开。 这不仅增加了每单位面积通道的纵横比，而且源和漏还具有用于传输载体的多个方向。 因此，TFT的载流子迁移率增强，具有均匀且稳定的电路特性。

公开(公告)号：US20210361747A1

公开(公告)日：2021-11-25

申请号：US16882508

申请日：2020-05-24

申请人： Yi-Hsun HUANG ,  Hua-Lin Wu

发明人： Yi-Hsun HUANG ,  Hua-Lin Wu

IPC分类号： A61K38/36 ,  A61K38/18 ,  A61K38/17 ,  A61P27/02

摘要： The present application relates to dual anti-angiogenic and anti-inflammatory effects of recombinant thrombomodulin domain 1 (TMD1). Specifically, an isolated recombinant polypeptide comprising an amino acid sequence that is at least 80% identical to TMD1 for use in treating an eye disease and/or an eye disorder associated with pathological ocular angiogenesis (POA) in a subject in need thereof is disclosed. The length of the recombinant polypeptide is no more than 200 amino acid residues. The eye disease and/or the eye disorder may be at least one selected from the group consisting of retinopathy of prematurity, diabetic retinopathy, and age-related macular degeneration. Use of TMD1 in the manufacture of a medicament for treating an eye disease and/or an eye disorder associated with vascular endothelial growth factor (VEGF)-induced ocular angiogenesis and/or hypoxia-inducible factor-1α (HIF-1α)-VEGF pathway is also disclosed.

公开(公告)号：US20090068773A1

公开(公告)日：2009-03-12

申请号：US12254820

申请日：2008-10-20

申请人： Chih-Ming Lai ,  Yung-Hui Yeh ,  Yi-Hsun Huang

发明人： Chih-Ming Lai ,  Yung-Hui Yeh ,  Yi-Hsun Huang

IPC分类号： H01L21/04

CPC分类号： H01L29/7869 ,  H01L27/1225 ,  H01L27/322 ,  H01L27/3265

摘要： A method for fabricating an AMOLED pixel includes forming a transparent semiconductor layer on a substrate and forming a first channel layer of the switch TFT, a lower electrode of a storage capacitor and a second channel layer of a driving TFT. A first dielectric layer is formed over the substrate. A first opaque metal gate of the switch TFT, a second opaque metal gate of the driving TFT and a scan line are formed on the first dielectric layer. A first source and a first drain of the switch TFT are formed in the first channel layer and a second source and a second drain of the switch TFT are formed in the second channel layer. A patterned transparent metal layer is formed on the first dielectric layer. A data line is formed over the substrate. An OLED is formed over the substrate.

摘要翻译： 一种制造AMOLED像素的方法包括在衬底上形成透明半导体层并形成开关TFT的第一沟道层，存储电容器的下电极和驱动TFT的第二沟道层。 第一电介质层形成在衬底上。 开关TFT的第一不透明金属栅极，驱动TFT的第二不透明金属栅极和扫描线形成在第一介电层上。 开关TFT的第一源极和第一漏极形成在第一沟道层中，并且开关TFT的第二源极和第二漏极形成在第二沟道层中。 在第一电介质层上形成有图案的透明金属层。 数据线形成在衬底上。 在衬底上形成OLED。

公开(公告)号：US20110184696A1

公开(公告)日：2011-07-28

申请号：US12718117

申请日：2010-03-05

申请人： Kuo-Lun Tung ,  Yu-Ling Li ,  Nien-Jung Lin ,  Shih-Chieh Lai ,  Yi-Hsun Huang

发明人： Kuo-Lun Tung ,  Yu-Ling Li ,  Nien-Jung Lin ,  Shih-Chieh Lai ,  Yi-Hsun Huang

IPC分类号： G01B11/06 ,  G06F15/00

CPC分类号： G01B11/06

摘要： The present invention discloses a detection and analysis apparatus, comprising a photo sensing device, comprising a plurality of sensing elements linearly arranged to form a first array, for detecting a signal of the thickness change of the cake at a linear position of the filter medium; a driving device, for driving the photo sensing device to move relatively parallel to the filter medium on the top of the cake so that the photo sensing device detects the thickness change of the cake on at least one local plane of the filter medium; and a data processing device, coupling to the photo sensing device, for continuously processing and analyzing the signal detected by the photo sensing device to thereby in-situ estimate the thickness change of the cake on the at least one local plane of the filter medium during the filtration process.

摘要翻译： 本发明公开了一种检测和分析装置，包括一个感光装置，其包括多个传感元件，其被直线地布置成形成第一阵列，用于检测滤饼在过滤介质的线性位置处的厚度变化的信号; 驱动装置，用于驱动光感测装置相对平行于滤饼顶部的过滤介质移动，使得感光装置检测滤饼在至少一个局部平面上的厚度变化; 以及耦合到光感测装置的数据处理装置，用于连续地处理和分析由感光装置检测到的信号，从而在滤纸的至少一个局部平面上原位估计滤饼的厚度变化， 过滤过程。

公开(公告)号：US07632694B2

公开(公告)日：2009-12-15

申请号：US11375336

申请日：2006-03-15

申请人： Cheng-Chung Chen ,  Yu-Chang Sun ,  Yi-Hsun Huang ,  Chien-Wei Wu ,  Shuo-Wei Liang ,  Chia-Hsiang Chen ,  Chi-Shen Lee ,  Chai-Yuan Sheu ,  Yu-Chi Lee ,  Te-Ming Chu ,  Cheng-Hsing Chen

发明人： Cheng-Chung Chen ,  Yu-Chang Sun ,  Yi-Hsun Huang ,  Chien-Wei Wu ,  Shuo-Wei Liang ,  Chia-Hsiang Chen ,  Chi-Shen Lee ,  Chai-Yuan Sheu ,  Yu-Chi Lee ,  Te-Ming Chu ,  Cheng-Hsing Chen

IPC分类号： H01L21/00

CPC分类号： H01L29/78669 ,  H01L27/124 ,  H01L29/42384 ,  H01L29/4908 ,  H01L29/66765

摘要： A manufacturing method for a TFT electrode which is implemented to prevent metal ion diffusion to an adjacent insulating layer during fabrication. The method includes, in the order recited, providing a substrate; forming a first metal layer on the substrate which is comprised of one of a single metal layer structure or a multiple metal layer structure; performing a photolithography and etching process on the first metal layer to form a gate electrode of the TFT electrode; forming a transparent conducting electrode on the first metal layer to cover at least the gate electrode and prevent metal ion diffusion during fabrication, the transparent conducting electrode being comprised of one of indium tin oxide, indium zinc oxide, ZnO or an organic material; and forming a pixel electrode which functions as a barrier to prevent metal ion diffusion during fabrication by performing a photolithography and etching process on the transparent conducting electrode.

摘要翻译： 一种用于在制造期间防止金属离子扩散到相邻绝缘层的TFT电极的制造方法。 该方法按照所述的顺序包括提供衬底; 在所述基板上形成由单金属层结构或多金属层结构中的一个构成的第一金属层; 对所述第一金属层进行光刻和蚀刻处理以形成所述TFT电极的栅电极; 在所述第一金属层上形成透明导电电极以至少覆盖所述栅电极，并且在制造期间防止金属离子扩散，所述透明导电电极由铟锡氧化物，氧化铟锌，Zn​​O或有机材料中的一种构成; 并且通过对透明导电电极进行光刻和蚀刻处理，形成用作阻挡层的像素电极，以防止在制造期间的金属离子扩散。

公开(公告)号：US20070194677A1

公开(公告)日：2007-08-23

申请号：US11651448

申请日：2007-01-10

申请人： Yu-Jung Liu ,  Yi-Hsun Huang ,  Yung-Hui Yeh

发明人： Yu-Jung Liu ,  Yi-Hsun Huang ,  Yung-Hui Yeh

IPC分类号： H01L51/52 ,  H01L51/56

CPC分类号： H01L27/322 ,  H01L27/1248 ,  H01L29/458

摘要： A structure and method for improving contact resistance in an organic light emitting diode integrated with a color filter, the structure and method mainly utilize a metal to be filled in a contact well on a source/drain metal layer or in a contact well corresponding to the position of the source/drain metal layer on a poly-silicon island to effectively reduce the contact resistance between pixel electrode and thin film transistor, therefore color display quality of the organic light emitting diode is improved.

摘要翻译： 一种用于改善与滤色器集成的有机发光二极管中的接触电阻的结构和方法，该结构和方法主要利用金属填充在源极/漏极金属层或接触阱中的接触阱中 源极/漏极金属层在多晶硅岛上的位置，以有效降低像素电极和薄膜晶体管之间的接触电阻，从而提高了有机发光二极管的彩色显示质量。

公开(公告)号：US20070040953A1

公开(公告)日：2007-02-22

申请号：US11236612

申请日：2005-09-28

申请人： Yi-Hsun Huang ,  Chih-Ming Lai ,  Yung-Hui Yeh

发明人： Yi-Hsun Huang ,  Chih-Ming Lai ,  Yung-Hui Yeh

IPC分类号： G02F1/136

CPC分类号： G02F1/13624 ,  G02F1/133305

摘要： A pixel structure utilized for flexible displays, which is suitably disposed on a flexible substrate and is driven by a data line and a scan line, is characterized in that the pixel structure comprises a plurality of thin film transistors. In the pixel structure, the plural thin film transistors are connected by various connection layouts so as to solve the prior-art problem that the pixel structure can't functional normally since the single transistor contained in the pixel structure is damaged by alignment error caused by the deformation in the manufacturing process of the flexible substrate or the buckling of the flexible display while it is being used, and further to improve the reliability of the pixel structure disposed on the flexible substrate.

摘要翻译： 用于柔性显示器的像素结构，其适当地设置在柔性基板上并且由数据线和扫描线驱动，其特征在于，像素结构包括多个薄膜晶体管。 在像素结构中，通过各种连接布局连接多个薄膜晶体管，以解决像素结构不能正常工作的现有技术问题，因为像素结构中包含的单个晶体管被由于 柔性基板的制造过程中的变形或柔性显示器的使用时的弯曲，并进一步提高设置在柔性基板上的像素结构的可靠性。

公开(公告)号：US08332183B2

公开(公告)日：2012-12-11

申请号：US12718117

申请日：2010-03-05

申请人： Kuo-Lun Tung ,  Yu-Ling Li ,  Nien-Jung Lin ,  Shih-Chieh Lai ,  Yi-Hsun Huang

发明人： Kuo-Lun Tung ,  Yu-Ling Li ,  Nien-Jung Lin ,  Shih-Chieh Lai ,  Yi-Hsun Huang

IPC分类号： G01B11/06

CPC分类号： G01B11/06

摘要： The present invention discloses a detection and analysis apparatus, comprising a photo sensing device, comprising a plurality of sensing elements linearly arranged to form a first array, for detecting a signal of the thickness change of the cake at a linear position of the filter medium; a driving device, for driving the photo sensing device to move relatively parallel to the filter medium on the top of the cake so that the photo sensing device detects the thickness change of the cake on at least one local plane of the filter medium; and a data processing device, coupling to the photo sensing device, for continuously processing and analyzing the signal detected by the photo sensing device to thereby in-situ estimate the thickness change of the cake on the at least one local plane of the filter medium during the filtration process.

摘要翻译： 本发明公开了一种检测和分析装置，包括一个感光装置，其包括多个传感元件，其被直线地布置成形成第一阵列，用于检测滤饼在过滤介质的线性位置处的厚度变化的信号; 驱动装置，用于驱动光感测装置相对平行于滤饼顶部的过滤介质移动，使得感光装置检测滤饼在至少一个局部平面上的厚度变化; 以及耦合到光感测装置的数据处理装置，用于连续地处理和分析由感光装置检测到的信号，从而在滤纸的至少一个局部平面上原位估计滤饼的厚度变化， 过滤过程。