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    DNA molecules having human BCL-2 gene sequences
    4.
    发明授权
    DNA molecules having human BCL-2 gene sequences 失效
    具有人BCL-2基因序列的DNA分子

    公开(公告)号：US5202429A

    公开(公告)日：1993-04-13

    申请号：US663010

    申请日：1991-03-19

    申请人： Yoshihide Tsujimoto ,  Carlo A. Croce

    发明人： Yoshihide Tsujimoto ,  Carlo A. Croce

    IPC分类号： C07K14/82 ,  C12Q1/68 ,  G01N33/574

    CPC分类号： C12Q1/6827 ,  C07K14/82 ,  C12Q1/6886 ,  G01N33/5748 ,  C12Q2600/158 ,  Y10S436/813 ,  Y10S530/806 ,  Y10S530/828

    摘要： The sequence of the protein coding regions of the bcl-2 gene are provided as well as bacterial clones which produce the proteins. Assays are provided for detecting a class of B-cell neoplasms associated with a chromosome translocation between chromosomes 14 and 18. The translocation is involved in the majority of cases of human follicular lymphomas. One assay employs an antibody which is immunoreactive with a human protein which is over-expressed due to the chromosome translocation. Another assay involves measurement of the amount of mRNA which hybridizes to the gene proximal to the translocation break-point.

    摘要翻译： 提供bcl-2基因的蛋白质编码区的序列以及产生蛋白质的细菌克隆。 提供了用于检测与染色体14和18之间的染色体易位相关联的一类B细胞赘生物的测定。在大多数人类滤泡性淋巴瘤的病例中涉及易位。 一种测定采用与由于染色体易位而过表达的人蛋白质免疫反应的抗体。 另一种测定法包括测量与易位断裂点相近的基因杂交的mRNA的量。

    Screening method for apoptosis-suppressing or-promoting substance
    5.
    发明授权
    Screening method for apoptosis-suppressing or-promoting substance 失效
    凋亡抑制或促进物质的筛选方法

    公开(公告)号：US07229773B1

    公开(公告)日：2007-06-12

    申请号：US09958215

    申请日：2000-04-05

    申请人： Yoshihide Tsujimoto ,  Shigeomi Shimizu

    发明人： Yoshihide Tsujimoto ,  Shigeomi Shimizu

    IPC分类号： G01N33/53

    CPC分类号： G01N33/5076 ,  G01N33/6872 ,  G01N2500/00 ,  G01N2510/00

    摘要： To provide a screening method for an apoptosis-suppressing substance or an apoptosis-promoting substance, the application of which substances to pharmaceuticals or diagnostic drugs are expected, also to provide an apoptosis-suppressing substance or an apoptosis-promoting substance, since Bcl-2 family having apoptosis-suppressing or -promoting activities is deeply involved in many diseases.To attain the above object, VDAC-liposomes, an indicator substance such as fluorescent-labeled cytochrome c or isotope-labeled sucrose etc. capable of passing through VDAC (voltage-dependent anion channel), and a subject substance are incubated, and then concentration changes in the indicator substance, inside and outside the VDAC-liposomes before and after the incubation, are detected in order to estimate presence or absence of the apoptosis-suppressing activity or -promoting activity of the subject substance.

    摘要翻译： 为了提供细胞凋亡抑制物质或细胞凋亡促进物质的筛选方法，由于Bcl-2可以提供抑制物质或细胞凋亡促进物质的作用，因此预期使用药物或诊断药物的物质 具有细胞凋亡抑制或促进活性的家族深深地涉及许多疾病。 为了达到上述目的，将VDAC-脂质体，能够通过VDAC（电压依赖性阴离子通道）的荧光标记的细胞色素c或同位素标记的蔗糖等指示物质和受试物质孵育，然后浓缩 检测VDAC-脂质体内外指示物质的变化，以便估计存在或不存在目标物质的凋亡抑制活性或促进活性。

    Apoptosis-associated gene
    7.
    发明授权
    Apoptosis-associated gene 失效
    凋亡相关基因

    公开(公告)号：US07011951B1

    公开(公告)日：2006-03-14

    申请号：US09958346

    申请日：2000-04-07

    申请人： Setsuko Sahara ,  Yutaka Eguchi ,  Yoshihide Tsujimoto

    发明人： Setsuko Sahara ,  Yutaka Eguchi ,  Yoshihide Tsujimoto

    IPC分类号： G01N33/53

    CPC分类号： C07K14/4747 ,  A61K38/00

    摘要： A polypeptide possessing an action of causing chromatin condensation; a sense nucleic acid encoding the polypeptide; an antisense nucleic acid thereof, a probe or primer capable of specifically binding to the nucleic acid; an antibody or a fragment thereof against the polypeptide; an agent for controlling apoptosis, comprising the nucleic acid, the polypeptide, or the antibody or a fragment thereof; a screening method for a substance for controlling chromatin condensation, comprising evaluating an activity of causing chromatin condensation exhibited by the polypeptide; and a substance for controlling chromatin condensation. The present invention is useful for screening a substance controlling apoptosis, its use for controlling apoptosis and its applications to various diseases accompanying apoptosis.

    摘要翻译： 具有引起染色质凝集作用的多肽; 编码该多肽的正义核酸; 其反义核酸，能够特异性结合核酸的探针或引物; 针对多肽的抗体或其片段; 包含核酸，多肽或抗体或其片段的用于控制凋亡的试剂; 一种用于控制染色质缩合的物质的筛选方法，包括评估多肽所表现的引起染色质缩合的活性; 和用于控制染色质凝聚的物质。 本发明可用于筛选控制细胞凋亡的物质，其控​​制细胞凋亡的用途及其与凋亡相关的各种疾病的应用。