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    Sesquiterpene derivatives having anti-complementary activity
    2.
    发明授权
    Sesquiterpene derivatives having anti-complementary activity 失效
    倍半萜衍生物具有抗互补活性

    公开(公告)号：US4229466A

    公开(公告)日：1980-10-21

    申请号：US906300

    申请日：1978-05-15

    申请人： Wasei Miyazaki ,  Hirotsugu Kaise ,  Yoshimasa Nakano ,  Taketoshi Izawa ,  Yasuo Oshiro ,  Masanao Shinohara

    发明人： Wasei Miyazaki ,  Hirotsugu Kaise ,  Yoshimasa Nakano ,  Taketoshi Izawa ,  Yasuo Oshiro ,  Masanao Shinohara

    IPC分类号： C07D307/94 ,  C07D493/10 ,  C07D493/20 ,  C12P17/04 ,  A61K31/335 ,  A61K31/34 ,  C07D307/77 ,  C07D307/92

    CPC分类号： C07D307/94 ,  C07D493/10 ,  C12P17/04

    摘要： A sesquiterpene derivative expressed by the general formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or a lower alkanoyl group; R.sup.2 and R.sup.3, which may be the same or different, each represents a formyl group, a hydroxymethyl group, a hydroxyl group, a carboxyl group, a lower alkanoyloxymethyl group, or a group of the formula --CH.dbd.CR.sup.7 R.sup.8, wherein R.sup.7 and R.sup.8, which may be the same or different, each represents a hydrogen atom, a cyano group, a lower alkoxycarbonyl group or a carboxyl group, or R.sup.2 and R.sup.3 may combine to form a lactone ring of the formula ##STR2## in which R.sup.9 represents a hydrogen atom or a hydroxyl group; R.sup.4 and R.sup.6, which may be the same or different, each represents a hydroxyl group or a lower alkanoyloxy group; R.sup.5 represents a hydrogen atom; R.sup.4 and R.sup.5 may together form an oxo group (.dbd.O); and R.sup.4 and R.sup.6 may combine to form a lower alkylidenedioxy group, the pharmaceutically acceptable salts thereof, processes for the production of the compounds of the general formula (I) and the salts thereof, pharmaceutical composition containing the compounds of the general formula (I) and the salts thereof, and method of use of the compounds of the general formula (I) and the salts thereof.

    摘要翻译： 由通式（I）表示的倍半萜衍生物：其中R 1表示氢原子，低级烷基或低级烷酰基; R2和R3可以相同或不同，分别表示甲酰基，羟甲基，羟基，羧基，低级烷酰氧基甲基或式-CH = CR7R8的基团，其中R7和R8 可以相同或不同，各自表示氢原子，氰基，低级烷氧基羰基或羧基，或者R 2和R 3可以结合形成式“IMAGE”的内酯环，其中R 9表示 氢原子或羟基; R 4和R 6可以相同或不同，分别表示羟基或低级烷酰氧基; R5代表氢原子; R4和R5可以一起形成氧代基（= O）; 并且R4和R6可以结合形成低级亚烷基二氧基，其药学上可接受的盐，通式（I）化合物及其盐的制备方法，含有通式（I）化合物的药物组合物， 及其盐，以及通式（I）的化合物及其盐的使用方法。

    Anticomplementary agents comprising soyasapogenol B compounds
    4.
    发明授权
    Anticomplementary agents comprising soyasapogenol B compounds 失效
    包含大豆皂甙元B化合物的抗互补剂

    公开(公告)号：US4371524A

    公开(公告)日：1983-02-01

    申请号：US241294

    申请日：1981-03-06

    申请人： Masanao Shinohara ,  Yoshimasa Nakano ,  Hirotsugu Kaise ,  Taketoshi Izawa ,  Wasei Miyazaki

    发明人： Masanao Shinohara ,  Yoshimasa Nakano ,  Hirotsugu Kaise ,  Taketoshi Izawa ,  Wasei Miyazaki

    IPC分类号： C07H15/256 ,  A61K31/70

    CPC分类号： C07H15/256

    摘要： A pharmaceutical composition having an anticomplementary activity comprising a therapeutically effective amount of at least one soyasapogenol B compound represented by the general formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a group represented by the formula: ##STR2## wherein R.sup.2 represents a hydrogen atom or a hydroxymethyl group, R.sup.3 represents a hydrogen atom or a rhamnopyranosyl group, and R.sup.4 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier.

    摘要翻译： 一种具有抗补体活性的药物组合物，其包含治疗有效量的由通式（I）表示的至少一种大豆皂草酚B化合物：其中R 1表示氢原子或由下式表示的基团：其中R2表示氢原子或羟甲基，R3表示氢原子或鼠李糖吡喃糖基，R4表示氢原子或碳原子数1〜6的烷基或其药学上可接受的盐和药学上可接受的载体。