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    METHOD AND KIT FOR DETECTING HEPCIDIN
    2.
    发明申请
    METHOD AND KIT FOR DETECTING HEPCIDIN 有权
    用于检测HEPCIDIN的方法和试剂盒

    公开(公告)号：US20140217277A1

    公开(公告)日：2014-08-07

    申请号：US14123679

    申请日：2012-06-01

    申请人： Guangjun Nie ,  Tony Hu ,  Jia Fan ,  Yuliang Zhao ,  Mauro Ferrari

    发明人： Guangjun Nie ,  Tony Hu ,  Jia Fan ,  Yuliang Zhao ,  Mauro Ferrari

    IPC分类号： H01J49/00 ,  G01N1/38

    CPC分类号： H01J49/0027 ,  G01N1/38 ,  G01N33/6848 ,  G01N33/74 ,  H01J49/00

    摘要： A method for detecting hepcidin. Having a sample liquid in contact with a nanochip having a specific surface coating structure of silicon oxide, so that hepcidin is enriched with specificity; eluting the nanochip with an eluent; by performing mass spectrometric detection on the elution product, determining the hepcidin content in the elution product. The enrichment method substantially enhances the sensitivity and accuracy of mass spectrometric detection. A kit for detecting hepcidin comprising a sample diluent and a nanochip, the sample diluent comprising water, trifluoroacetic acid, and acetonitrile.

    摘要翻译： 检测铁调素的方法。 使样品液体与具有氧化硅的比表面涂层结构的纳米芯片接触，使得铁调素富集特异性; 用洗脱剂洗脱纳米芯片; 通过对洗脱产物进行质谱检测，测定洗脱产物中的铁调素含量。 浓缩法大大提高了质谱检测的灵敏度和准确性。 用于检测包含样品稀释剂和纳米芯片的铁调素的试剂盒，所述样品稀释剂包含水，三氟乙酸和乙腈。

    Porous and non-porous nanostructures
    3.
    发明授权
    Porous and non-porous nanostructures 有权
    多孔和无孔纳米结构

    公开(公告)号：US08568877B2

    公开(公告)日：2013-10-29

    申请号：US13044250

    申请日：2011-03-09

    申请人： Mauro Ferrari ,  Xuewu Liu ,  Ciro Chiappini ,  Jean Raymond Fakhoury

    发明人： Mauro Ferrari ,  Xuewu Liu ,  Ciro Chiappini ,  Jean Raymond Fakhoury

    IPC分类号： H01L21/311

    CPC分类号： H01L29/0665 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  H01L2924/0002 ,  H01L2924/00

    摘要： Disclosed are a variety of porous and non-porous wire-like structures of microscopic and nanoscopic scale. For instance, disclosed are structures that comprise a porous object that comprises: (i) a first region; and (ii) a second region adjacent to the first region along an axis of the object, where the first region has at least one porous property different from that of the second region. Also disclosed are structures that include: (i) a high resistivity silicon; and (ii) a cross-section that is substantially perpendicular to an axis of the object. Also disclosed are methods of making and using such structures. For instance, the present invention provides methods of making a porous object by: (i) obtaining an etchable substrate; (ii) forming on a surface of the substrate a patterned porosification assisting metal layer that has at least one opening; and (iii) subsequently exposing the substrate to a first etching solution and a second etching solution to form respectively a first region and a second region of a porous object.

    摘要翻译： 公开了各种微观和纳米尺度的多孔和无孔线状结构。 例如，公开了包括多孔物体的结构，其包括：（i）第一区域; 和（ii）沿所述物体的轴线邻近所述第一区域的第二区域，其中所述第一区域具有与所述第二区域不同的至少一个多孔性质。 还公开了包括：（i）高电阻率硅; 和（ii）基本上垂直于物体轴线的横截面。 还公开了制造和使用这种结构的方法。 例如，本发明提供了制造多孔物体的方法：（i）获得可蚀刻的基底; （ii）在所述基材的表面上形成具有至少一个开口的图案化的赋形金属层; 和（iii）随后将衬底暴露于第一蚀刻溶液和第二蚀刻溶液以分别形成多孔物体的第一区域和第二区域。

    Particles for cell targeting
    4.
    发明授权
    Particles for cell targeting 有权
    用于细胞靶向的粒子

    公开(公告)号：US08563022B2

    公开(公告)日：2013-10-22

    申请号：US11870077

    申请日：2007-10-10

    申请人： Paolo Decuzzi ,  Mauro Ferrari

    发明人： Paolo Decuzzi ,  Mauro Ferrari

    IPC分类号： A01N25/26 ,  A01N25/28 ,  A61K49/00

    CPC分类号： A61K9/1611 ,  A61K9/143 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/0002

    摘要： Provided is a composition that includes oblate spheroidal particles comprising an active agent, such as a therapeutic or imaging agent, and a method for treating or monitoring a physiological condition, such as a disease, by administering the composition to a subject in need thereof. Also provided are methods for making particles that have a volume that can enhance the particles' adhesion to a target site in a subject's body for a pre-selected shape of the particles and methods for making particles that have a shape that can enhance particles' adhesion to a target site in a subject's body for a pre-selected volume of the particles.

    摘要翻译： 本发明提供一种组合物，其包含包含活性剂的扁球形颗粒，例如治疗或显像剂，以及通过将该组合物施用于有需要的受试者来治疗或监测生理状况如疾病的方法。 还提供了制备具有体积的颗粒的方法，该体积可以增强颗粒对受试者体内的靶位置的粘附性，用于颗粒的预选形状，以及用于制备具有能够增强颗粒粘附性的形状的颗粒的方法 到受试者体内的预定体积的颗粒的靶位点。

    THERANOSTIC DELIVERY SYSTEMS WITH MODIFIED SURFACES
    5.
    发明申请
    THERANOSTIC DELIVERY SYSTEMS WITH MODIFIED SURFACES 审中-公开
    具有改性表面的传感器输送系统

    公开(公告)号：US20130071329A1

    公开(公告)日：2013-03-21

    申请号：US13635530

    申请日：2011-03-17

    申请人： Mauro Ferrari ,  Ennio Tasciotti ,  Nicoletta Quattrocchi

    发明人： Mauro Ferrari ,  Ennio Tasciotti ,  Nicoletta Quattrocchi

    IPC分类号： A61K9/14 ,  A61K49/00 ,  A61K9/127

    CPC分类号： A61K9/14 ,  A61K9/0019 ,  A61K9/1271 ,  A61K9/5068 ,  A61K9/5115 ,  A61K9/5123 ,  A61K9/5176 ,  A61K49/00 ,  Y02A50/423

    摘要： The present invention pertains to therapeutic compositions and delivery systems comprising at least one microparticle or nanoparticle. In various embodiments, the surface of the microparticle or nanoparticle is modified or functionalized with at least a portion of an isolated cellular membrane, such as an isolated plasma membrane. In addition, the microparticle or nanoparticle contains at least one active agent, such as a therapeutic and/or imaging agent. In additional embodiments, the compositions and delivery systems of the present invention may be used for targeted delivery of an active agent. Also provided are methods of making the therapeutic compositions and delivery systems of the present invention.

    摘要翻译： 本发明涉及包含至少一种微粒或纳米颗粒的治疗组合物和递送系统。 在各种实施方案中，微粒或纳米颗粒的表面被分离的细胞膜，例如分离的质膜的至少一部分修饰或官能化。 此外，微粒或纳米颗粒含有至少一种活性剂，例如治疗和/或成像剂。 在另外的实施方案中，本发明的组合物和递送系统可用于活性剂的靶向递送。 还提供了制备本发明的治疗组合物和递送系统的方法。

    DIFFUSION DELIVERY SYSTEMS AND METHODS OF FABRICATION
    6.
    发明申请
    DIFFUSION DELIVERY SYSTEMS AND METHODS OF FABRICATION 审中-公开
    扩散输送系统和制造方法

    公开(公告)号：US20120116307A1

    公开(公告)日：2012-05-10

    申请号：US13289177

    申请日：2011-11-04

    申请人： Mauro Ferrari ,  Xuewu Liu ,  Piyush Mohan Sinha ,  Bryan Smith ,  Sadhana Sharma

    发明人： Mauro Ferrari ,  Xuewu Liu ,  Piyush Mohan Sinha ,  Bryan Smith ,  Sadhana Sharma

    IPC分类号： A61M5/00

    CPC分类号： A61K9/0097 ,  A61F2/022 ,  A61M31/002 ,  A61N1/306 ,  B82Y30/00

    摘要： The invention generally relates to diffusion delivery systems and more particularly to high precision nanoengineered devices for therapeutic applications. The device contains diffusion areas that may be fabricated between bonded substrates, and the device can possess high mechanical strength. The invention further relates to capsules containing a diffusion delivery system. The present invention also relates to methods of fabricating the diffusion delivery systems.

    摘要翻译： 本发明一般涉及扩散递送系统，更具体地涉及用于治疗应用的高精度纳米工程设备。 该器件包含可在接合的衬底之间制造的扩散区域，该器件可以具有高的机械强度。 本发明还涉及含有扩散递送系统的胶囊。 本发明还涉及制造扩散递送系统的方法。

    QUALITY CONTROL METHOD AND MICRO/NANO-CHANNELED DEVICES
    8.
    发明申请
    QUALITY CONTROL METHOD AND MICRO/NANO-CHANNELED DEVICES 审中-公开
    质量控制方法和微/纳米通道设备

    公开(公告)号：US20110137596A1

    公开(公告)日：2011-06-09

    申请号：US12990411

    申请日：2009-04-28

    申请人： Alessandro Grattoni ,  Mauro Ferrari ,  Xeuwu Liu

    发明人： Alessandro Grattoni ,  Mauro Ferrari ,  Xeuwu Liu

    IPC分类号： G06F19/00

    CPC分类号： B81C99/005 ,  B81B2201/058 ,  B81B2203/0338 ,  G01N11/08 ,  G01N35/00663

    摘要： Embodiments of the present invention comprise a quality control system and method for testing micro- or nano-channeled devices. The system and method can utilize a pressure-driven gas flow for the detection and quantification of structural defects. The test method and system are non-destructive and allow defects to be detected and classified quickly based on measured factors, such as mass flow rate for a given pressure differential.

    摘要翻译： 本发明的实施例包括用于测试微通道或纳米通道器件的质量控制系统和方法。 该系统和方法可以利用压力驱动气流来检测和定量结构缺陷。 测试方法和系统是非破坏性的，并且基于测量因素（例如给定压力差的质量流率）来快速检测和分类缺陷。

    COMBINATORIAL MULTIDOMAIN MESOPOROUS CHIPS AND A METHOD FOR FRACTIONATION, STABILIZATION, AND STORAGE OF BIOMOLECULES
    9.
    发明申请
    COMBINATORIAL MULTIDOMAIN MESOPOROUS CHIPS AND A METHOD FOR FRACTIONATION, STABILIZATION, AND STORAGE OF BIOMOLECULES 有权
    组合多元醇多糖和一种分解，稳定和储存生物分子的方法

    公开(公告)号：US20110065207A1

    公开(公告)日：2011-03-17

    申请号：US12839606

    申请日：2010-07-20

    申请人： Mauro Ferrari ,  Xuewu Liu ,  Ennio Tasciotti ,  Ali Bouamrani ,  Ye Hu

    发明人： Mauro Ferrari ,  Xuewu Liu ,  Ennio Tasciotti ,  Ali Bouamrani ,  Ye Hu

    IPC分类号： G01N33/53 ,  G01N33/00 ,  G01N33/68 ,  H01J49/26 ,  G01N30/02

    CPC分类号： G01N1/405 ,  G01N33/552

    摘要： A new fractionation device shows desirable features for exploratory screening and biomarker discovery. The constituent MSCs may be tailored for desired pore sizes and surface properties and for the sequestration and enrichment of extremely low abundant protein and peptides in desired ranges of the mass/charge spectrum. The MSCs are effective in yielding reproducible extracts from complex biological samples as small as 10 μl in a time as short as 30 minutes. They are inexpensive to manufacture, and allow for scaled up production to attain the simultaneous processing of a large number of samples. The MSCs are multiplexed, label-free diagnostic tools with the potential of biological recognition moiety modification for enhanced specificity. The MSCs may store, protect and stabilize biological fluids, enabling the simplified and cost-effective collection and transportation of clinical samples. The MSC-based device may serve as a diagnostic tool to complement histopathology, imaging, and other conventional clinical techniques. The MSCs mediated identification of disease-specific protein signatures may help in the selection of personalized therapeutic combinations, in the real-time assessment of therapeutic efficacy and toxicity, and in the rational modulation of therapy based on the changes in the protein networks associated with the prognosis and the drug resistance of the disease.

    摘要翻译： 新的分馏装置显示出探索性筛选和生物标志物发现的理想特征。 组成的MSC可以针对所需的孔径和表面性质以及在质量/电荷谱的期望范围内极低的丰富蛋白质和肽的螯合和富集而定制。 MSCs有效地从短至30分钟的时间内将复杂的生物样品中的可重复提取物产生少至10μl。 它们制造成本便宜，并且允许放大生产以获得大量样品的同时处理。 MSCs是复合的，无标记的诊断工具，具有生物识别部分修饰的潜力，以增强特异性。 MSC可以存储，保护和稳定生物液体，从而简化和成本有效地收集和运输临床样品。 基于MSC的装置可以用作补充组织病理学，成像和其他常规临床技术的诊断工具。 MSCs介导的疾病特异性蛋白质特征的鉴定可能有助于个性化治疗组合的选择，治疗功效和毒性的实时评估，以及基于与蛋白质网络相关联的蛋白质网络的变化的合理调节治疗 预后和耐药性的疾病。