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    MICROFLUIDIC SYSTEMS AND METHODS OF USE
    2.
    发明申请
    MICROFLUIDIC SYSTEMS AND METHODS OF USE 有权

    公开(公告)号：US20210362157A1

    公开(公告)日：2021-11-25

    申请号：US17397146

    申请日：2021-08-09

    Applicant: 10x Genomics, Inc.

    Inventor： Rajiv BHARADWAJ ,  Kevin NESS ,  Tobias Daniel WHEELER

    IPC: B01L3/00 ,  G01N1/28 ,  G01N33/487

    Abstract: Microfluidic channels networks and systems are provided. One network includes a first fluid channel having a first depth dimension; at least a second channel intersecting the first channel at a first intersection; at least a third channel in fluid communication with the first intersection, at least one of the first intersection and the third channel having a depth dimension that is greater than the first depth dimension. Also provided is a flow control system for directing fluids in the network. Systems are additionally provided for flowing disrupted particles into a droplet formation junction, whereby a portion of the disrupted particles or the contents thereof are encapsulated into one or more droplets. Further provided is a method for controlling filling of a microfluidic network by controlling passive valving microfluidic channel network features.

    INSTRUMENT SYSTEMS FOR INTEGRATED SAMPLE PROCESSING
    5.
    发明申请
    INSTRUMENT SYSTEMS FOR INTEGRATED SAMPLE PROCESSING 有权

    公开(公告)号：US20220097045A1

    公开(公告)日：2022-03-31

    申请号：US17471603

    申请日：2021-09-10

    Applicant: 10x Genomics, Inc.

    Inventor： Donald A. MASQUELIER ,  Benjamin HINDSON ,  Kevin NESS ,  Rajiv BHARADWAJ

    IPC: B01L3/00 ,  F16K99/00 ,  B01L9/00 ,  C12Q1/6874

    Abstract: An integrated system for processing and preparing samples for analysis may include a microfluidic device including a plurality of parallel channel networks for partitioning the samples including various fluids, and connected to a plurality of inlet and outlet reservoirs, at least a portion of the fluids comprising reagents, a holder including a closeable lid hingedly coupled thereto, in which in a closed configuration, the lid secures the microfluidic device in the holder, and in an open configuration, the lid is a stand orienting the microfluidic device at a desired angle to facilitate recovery of partitions or droplets from the partitioned samples generated within the microfluidic device, and an instrument configured to receive the holder and apply a pressure differential between the plurality of inlet and outlet reservoirs to drive fluid movement within the channel networks.

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