公开(公告)号：US09796708B2

公开(公告)日：2017-10-24

申请号：US14780018

申请日：2014-03-13

Applicant: AbbVie Inc.

Inventor： Yunsong Tong ,  Milan Bruncko ,  Richard F. Clark ,  Michael Curtin ,  Alan S. Florjancic ,  Robin R. Frey ,  Jianchun Gong ,  Todd M. Hansen ,  Zhiqin Ji ,  Chunqiu Lai ,  Anthony Mastracchio ,  Michael Michaelides ,  Juliem Miyashiro ,  Roberto M. Risi ,  Xiaohong Song ,  Zhi-fu Tao ,  Keith W. Woods ,  Guidong Zhu ,  Thomas Penning ,  Andrew Souers ,  Rajeev Goswami ,  Omprakash Reddy Iguturi ,  Madhu Babu Dabbeeru

IPC: C07D401/02 ,  C07D401/10 ,  A61K31/437 ,  A61K31/4353 ,  C07D471/04 ,  A61K45/06 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/5377

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/5377 ,  A61K45/06 ,  A61K2300/00

Abstract: Disclosed are compounds of Formula (IIa), wherein R1, R2, R3A, R3B, R3C, R3D, R3E, and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (IIa).

公开(公告)号：US09181239B2

公开(公告)日：2015-11-10

申请号：US13655164

申请日：2012-10-18

Applicant: AbbVie Inc.

Inventor： Anthony Mastracchio ,  Chunqiu Lai ,  Thomas D. Penning

IPC: C07D471/04 ,  A61K31/519 ,  A61P35/00

CPC classification number: C07D471/04

Abstract: Compounds of formula (I), and pharmaceutical acceptable salts thereof, which inhibit the activity of kinases such as Wee-1 kinase are described. Also described are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Abstract translation: 描述抑制激酶例如Wee-1激酶活性的式（I）化合物及其药学上可接受的盐。 还描述了制备化合物，含有该化合物的组合物和使用该化合物的处理方法的方法。

公开(公告)号：US20140357616A1

公开(公告)日：2014-12-04

申请号：US14444540

申请日：2014-07-28

Applicant: AbbVie Inc.

Inventor： Thomas D. Penning ,  Keith W. Woods ,  Chunqiu Lai ,  Alan S. Florjancic ,  Yunsong Tong

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, R1c, X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，其中R1a，R1b，R1c，X和Y在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如Cdc7的激酶和治疗诸如癌症的疾病的方法。

公开(公告)号：US20140296220A1

公开(公告)日：2014-10-02

申请号：US14307680

申请日：2014-06-18

Applicant: AbbVie Inc.

Inventor： Gui-Dong Zhu ,  Jane Gong ,  Andrew S. Judd ,  Virajkumar B. Ghandi ,  Alexander R. Shoemaker ,  Thomas D. Penning ,  Michael R. Michaelides ,  Chunqiu Lai ,  Keith W. Woods

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein B, R1, R2, R4, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，其中B，R 1，R 2，R 4和m在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如wee-1的激酶和治疗诸如癌症的疾病的方法。

公开(公告)号：US20220259226A1

公开(公告)日：2022-08-18

申请号：US17660355

申请日：2022-04-22

Applicant: AbbVie Inc. ,  AbbVie Deutschland GmbH & Co. KG

Inventor： Wilfried Braje ,  George Doherty ,  Katja Jantos ,  Cheng Ji ,  Andrew Judd ,  Aaron Kunzer ,  Anthony Mastracchio ,  Xiaohong Song ,  Andrew Souers ,  Gerard Sullivan ,  Zhi-Fu Tao ,  Chunqiu Lai ,  Jesse Teske ,  Michael Wendt ,  Patrick Brady ,  Xilu Wang ,  Thomas Penning ,  Yujia Dai ,  Jane Gong ,  Roberto Risi ,  Yiyun Yu ,  Guidong Zhu

IPC: C07D498/18 ,  A61P35/00 ,  C07D519/00 ,  C07D495/18 ,  C07D495/16 ,  A61K31/519 ,  C07D491/16 ,  C07D498/16

Abstract: The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).

公开(公告)号：US20200010480A1

公开(公告)日：2020-01-09

申请号：US16575114

申请日：2019-09-18

Applicant: AbbVie Inc. ,  AbbVie Deutschland GmbH & Co. KG

Inventor： Patrick B. Brady ,  Wilfried Braje ,  Yujia Dai ,  George A. Doherty ,  Jane Gong ,  Katja Jantos ,  Cheng Ji ,  Andrew S. Judd ,  Aaron R. Kunzer ,  Chunqiu Lai ,  Anthony Mastracchio ,  Roberto M. Risi ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Jesse A. Teske ,  Xilu Wang ,  Michael D. Wendt ,  Yiyun Yu ,  Guidong Zhu ,  Thomas D. Penning

IPC: C07D498/18 ,  A61P35/00 ,  C07D519/00 ,  C07D495/18 ,  C07D495/16

Abstract: The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).

公开(公告)号：US20190055264A1

公开(公告)日：2019-02-21

申请号：US15998688

申请日：2018-08-15

Applicant: AbbVie Inc. ,  AbbVie Deutschland GmbH & Co. KG

Inventor： Patrick B. Brady ,  Wilfried Braje ,  Yujia Dai ,  George A. Doherty ,  Jane Gong ,  Katja Jantos ,  Cheng Ji ,  Andrew S. Judd ,  Aaron R. Kunzer ,  Chunqiu Lai ,  Anthony Mastracchio ,  Roberto M. Risi ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Jesse A. Teske ,  Xilu Wang ,  Michael D. Wendt ,  Yiyun Yu ,  Guidong Zhu ,  Thomas D. Penning

IPC: C07D498/18 ,  C07D495/18 ,  C07D519/00 ,  A61P35/00

Abstract: The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).

公开(公告)号：US20150218165A1

公开(公告)日：2015-08-06

申请号：US14568153

申请日：2014-12-12

Applicant: AbbVie Inc.

Inventor： Robin Frey ,  Jianchun Gong ,  Zhiqin JI ,  Chunqiu Lai ,  Thomas Penning ,  Xiaohong Song ,  Andrew Souers ,  Yunsong Tong ,  Gui-Dong Zhu

IPC: C07D471/16 ,  A61K31/437 ,  A61K31/55

CPC classification number: C07D471/16 ,  A61K31/437 ,  A61K31/55 ,  C07D498/16 ,  C07D519/00

Abstract: Disclosed are compounds of Formula (Ia), and pharmaceutically acceptable salts thereof, wherein X, Y, R1, R2, R3A, R3B, and R4 are as described herein. The compounds may be used as agents in the treatment of diseases, including cancer. Also disclosed are pharmaceutical compositions comprising one or more compounds of Formula (Ia).

Abstract translation: 公开了式（Ia）化合物及其药学上可接受的盐，其中X，Y，R 1，R 2，R 3A，R 3B和R 4如本文所述。 这些化合物可以用作治疗包括癌症在内的疾病的药剂。 还公开了包含一种或多种式（Ia）化合物的药物组合物。

公开(公告)号：US09051327B2

公开(公告)日：2015-06-09

申请号：US14307680

申请日：2014-06-18

Applicant: AbbVie Inc.

Inventor： Gui-Dong Zhu ,  Jane Gong ,  Andrew S. Judd ,  Virajkumar B. Gandhi ,  Alexander R. Shoemaker ,  Thomas D. Penning ,  Michael R. Michaelides ,  Chunqiu Lai ,  Keith W. Woods

IPC: A01N43/90 ,  A61K31/519 ,  C07D487/02 ,  C07D487/04

CPC classification number: C07D487/04

Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein B, R1, R2, R4, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，其中B，R 1，R 2，R 4和m在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如wee-1的激酶和治疗诸如癌症的疾病的方法。

公开(公告)号：US20200325153A1

公开(公告)日：2020-10-15

申请号：US16872279

申请日：2020-05-11

Applicant: AbbVie Inc. ,  AbbVie Deutschland GmbH & Co. KG

Inventor： Andrew S. Judd ,  Aaron R. Kunzer ,  Chunqiu Lai ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Jesse A. Teske ,  Anthony Mastracchio ,  Xilu Wang ,  Cheng Ji ,  Michael D. Wendt ,  Xiaohong Song ,  George A. Doherty ,  Katja Jantos ,  Wilfried Braje ,  Andreas Kling ,  Frauke Pohlki ,  Thomas D. Penning

IPC: C07D495/16 ,  C07D495/18 ,  A61K45/06 ,  C07D495/22 ,  C07D491/18 ,  A61K31/519 ,  C07D491/22 ,  A61P35/00 ,  A61P35/02

Abstract: The present disclosure provides for compounds of formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of formula (I).