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公开(公告)号：US20230399340A1
公开(公告)日：2023-12-14
申请号：US18046011
申请日：2022-10-12
发明人： Wilfried Braje , George Doherty , Katja Jantos , Cheng Ji , Andrew Judd , Aaron Kunzer , Anthony Mastracchio , Xiaohong Song , Andrew Souers , Gerard Sullivan , Zhi-Fu Tao , Chunqiu Lai , Andreas Kling , Frauke Pohlki , Jesse Teske , Michael Wendt , Patrick Brady , Xilu Wang , Thomas Penning , Michael Michaelides
IPC分类号： C07D495/16 , A61P35/00 , C07D519/00
CPC分类号： C07D495/16 , A61P35/00 , C07D519/00
摘要： The present disclosure provides for compounds of Formula (I)
wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).-
公开(公告)号：US09328112B2
公开(公告)日：2016-05-03
申请号：US14568153
申请日：2014-12-12
申请人： AbbVie Inc.
发明人： Robin Frey , Jane Gong , Zhiqin Ji , Chunqiu Lai , Thomas Penning , Xiaohong Song , Andrew Souers , Yunsong Tong , Gui-Dong Zhu
IPC分类号： A61K31/437 , A61K31/55 , C07D471/16 , C07D498/16 , C07D519/00
CPC分类号： C07D471/16 , A61K31/437 , A61K31/55 , C07D498/16 , C07D519/00
摘要： Disclosed are compounds of Formula (Ia), and pharmaceutically acceptable salts thereof, wherein X, Y, R1, R2, R3A, R3B, and R4 are as described herein. The compounds may be used as agents in the treatment of diseases, including cancer. Also disclosed are pharmaceutical compositions comprising one or more compounds of Formula (Ia).
摘要翻译： 公开了式（Ia）化合物及其药学上可接受的盐，其中X，Y，R 1，R 2，R 3A，R 3B和R 4如本文所述。 这些化合物可以用作治疗包括癌症在内的疾病的药剂。 还公开了包含一种或多种式（Ia）化合物的药物组合物。
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![Pyrrolo [2,3-B] pyridine CDK9 kinase inhibitors](/abs-image/US/2017/10/24/US09796708B2/abs.jpg.150x150.jpg)
公开(公告)号：US09796708B2
公开(公告)日：2017-10-24
申请号：US14780018
申请日：2014-03-13
申请人： AbbVie Inc.
发明人： Yunsong Tong , Milan Bruncko , Richard F. Clark , Michael Curtin , Alan S. Florjancic , Robin R. Frey , Jianchun Gong , Todd M. Hansen , Zhiqin Ji , Chunqiu Lai , Anthony Mastracchio , Michael Michaelides , Juliem Miyashiro , Roberto M. Risi , Xiaohong Song , Zhi-fu Tao , Keith W. Woods , Guidong Zhu , Thomas Penning , Andrew Souers , Rajeev Goswami , Omprakash Reddy Iguturi , Madhu Babu Dabbeeru
IPC分类号： C07D401/02 , C07D401/10 , A61K31/437 , A61K31/4353 , C07D471/04 , A61K45/06 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/5377
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： Disclosed are compounds of Formula (IIa), wherein R1, R2, R3A, R3B, R3C, R3D, R3E, and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (IIa).
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公开(公告)号：US20220259226A1
公开(公告)日：2022-08-18
申请号：US17660355
申请日：2022-04-22
发明人： Wilfried Braje , George Doherty , Katja Jantos , Cheng Ji , Andrew Judd , Aaron Kunzer , Anthony Mastracchio , Xiaohong Song , Andrew Souers , Gerard Sullivan , Zhi-Fu Tao , Chunqiu Lai , Jesse Teske , Michael Wendt , Patrick Brady , Xilu Wang , Thomas Penning , Yujia Dai , Jane Gong , Roberto Risi , Yiyun Yu , Guidong Zhu
IPC分类号： C07D498/18 , A61P35/00 , C07D519/00 , C07D495/18 , C07D495/16 , A61K31/519 , C07D491/16 , C07D498/16
摘要： The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
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公开(公告)号：US20150218165A1
公开(公告)日：2015-08-06
申请号：US14568153
申请日：2014-12-12
申请人： AbbVie Inc.
发明人： Robin Frey , Jianchun Gong , Zhiqin JI , Chunqiu Lai , Thomas Penning , Xiaohong Song , Andrew Souers , Yunsong Tong , Gui-Dong Zhu
IPC分类号： C07D471/16 , A61K31/437 , A61K31/55
CPC分类号： C07D471/16 , A61K31/437 , A61K31/55 , C07D498/16 , C07D519/00
摘要： Disclosed are compounds of Formula (Ia), and pharmaceutically acceptable salts thereof, wherein X, Y, R1, R2, R3A, R3B, and R4 are as described herein. The compounds may be used as agents in the treatment of diseases, including cancer. Also disclosed are pharmaceutical compositions comprising one or more compounds of Formula (Ia).
摘要翻译： 公开了式（Ia）化合物及其药学上可接受的盐，其中X，Y，R 1，R 2，R 3A，R 3B和R 4如本文所述。 这些化合物可以用作治疗包括癌症在内的疾病的药剂。 还公开了包含一种或多种式（Ia）化合物的药物组合物。
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公开(公告)号：US20240228509A1
公开(公告)日：2024-07-11
申请号：US18365044
申请日：2023-08-03
发明人： Wilfried Braje , George Doherty , Katja Jantos , Cheng Ji , Andrew Judd , Aaron Kunzer , Anthony Mastracchio , Xiaohong Song , Andrew Souers , Gerard Sullivan , Zhi-Fu Tao , Chunqiu Lai , Andreas Kling , Frauke Pohlki , Jessee Teske , Michael Wendt , Patrick Brady , Xilu Wang , Thomas Penning , Michael Michaelides
IPC分类号： C07D495/16 , A61P35/00 , C07D519/00
CPC分类号： C07D495/16 , A61P35/00 , C07D519/00
摘要： The present disclosure provides for compounds of Formula (I)
wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).-
![PYRROLO [2,3-B] PYRIDINE CDK9 KINASE INHIBITORS](/abs-image/US/2016/03/03/US20160060257A1/abs.jpg.150x150.jpg)
公开(公告)号：US20160060257A1
公开(公告)日：2016-03-03
申请号：US14780018
申请日：2014-03-13
申请人： ABBVIE INC.
发明人： Yunsong Tong , Milan Bruncko , Richard F. Clark , Michael Curtin , Alan S. Florjancic , Robin R. Frey , Jianchun Gong , Todd M. Hansen , Zhiqin Ji , Chunqiu Lai , Anthony Mastracchio , Michael Michaelides , Juliem Miyashiro , Roberto M. Risi , Xiaohong Song , Zhi-fu Tao , Keith W. Woods , Guidong Zhu , Thomas Penning , Andrew Souers , Rajeev Goswami , Omprakash Reddy Iquturi , Madhu Babu Dabbeeru
IPC分类号： C07D471/04 , A61K31/5377 , A61K31/437 , A61K31/4545
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： Disclosed are compounds of Formula (IIa), wherein R1, R2, R3A, R3B, R3C, R3D, R3E, and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (IIa).
摘要翻译： 公开了式（IIa）的化合物，其中R1，R2，R3A，R3B，R3C，R3D，R3E和R4如说明书中所定义，及其药学上可接受的盐。 这些化合物可以用作治疗包括癌症在内的疾病的药剂。 还提供了包含一种或多种式（IIa）化合物的药物组合物。
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