PYRROLOPYRIDINE INHIBITORS OF KINASES
    4.
    发明申请
    PYRROLOPYRIDINE INHIBITORS OF KINASES 有权
    金刚烷吡咯啉抑制剂

    公开(公告)号:US20140357616A1

    公开(公告)日:2014-12-04

    申请号:US14444540

    申请日:2014-07-28

    申请人: AbbVie Inc.

    IPC分类号: C07D471/04

    CPC分类号: C07D471/04

    摘要: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, R1c, X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.

    摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,其中R1a,R1b,R1c,X和Y在说明书中定义。 本发明还涉及含有所述化合物的组合物,其可用于抑制诸如Cdc7的激酶和治疗诸如癌症的疾病的方法。

    PYRROLOPYRIMINDINE CDK9 KINASE INHIBITORS
    5.
    发明申请
    PYRROLOPYRIMINDINE CDK9 KINASE INHIBITORS 有权
    吡咯烷酮CDK9激酶抑制剂

    公开(公告)号:US20140275004A1

    公开(公告)日:2014-09-18

    申请号:US14207868

    申请日:2014-03-13

    申请人: AbbVie Inc.

    IPC分类号: C07D487/04 A61K31/519

    摘要: Disclosed are compound of Formula (Ia), wherein R1, R2, and R3 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions, comprising one or more compounds of Formula (Ia).

    摘要翻译: 公开了式(Ia)的化合物,其中R 1,R 2和R 3如说明书中所定义,及其药学上可接受的盐。 这些化合物可以用作治疗包括癌症在内的疾病的药剂。 还提供了包含一种或多种式(Ia)化合物的药物组合物。