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公开(公告)号：US10684199B2
公开(公告)日：2020-06-16
申请号：US15995755
申请日：2018-06-01
Applicant: Agilent Technologies, Inc.
Inventor： Kyle Schleifer , Kristin Briana Bernick , Adrienne Mccampbell , Nicholas M Sampas , Victor Lim
Abstract: The present disclosure is directed to an improved method for distinguishing tissue from an embedding medium, such as paraffin in a formalin-fixed paraffin-embedded sample. The method involves the use of fluorescence of naturally-occurring species in tissue to determine the location of the tissue in the embedded sample. An embedded sample is generally excited by light of a selected wavelength, and the fluorescence emission at an emitted wavelength is used to locate the boundary or location of the tissue in the embedded sample.
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公开(公告)号：US11982606B2
公开(公告)日：2024-05-14
申请号：US16803503
申请日：2020-02-27
Applicant: Agilent Technologies, Inc.
Inventor： Victor Lim , Carol T. Schembri , Adrienne Mccampbell , Nazumi Alice Yama-Dang
CPC classification number: G01N1/44 , G01N1/30 , G01N1/31 , G01N1/312 , G01N1/36 , G01N1/40 , G01N2001/366 , G01N2001/4038
Abstract: Paraffin-embedded tissue, which may be disposed on a solid substrate, is prepared by a dry technique that removes paraffin from tissue without adding any liquid to the tissue, thereby rendering the tissue substantially free of paraffin. The dry technique may entail applying heat energy to the tissue effective to melt the paraffin and thereby render it flowable, and applying an electric field. The electric field is effective to impart electrical charge to the paraffin and to move the paraffin out from the tissue due to electrical charge repulsion or attraction, which may be assisted by moving an electrode utilized to generate the electric field relative to the paraffin. The electric field, or both the electric field and the heat energy, may be applied until the tissue is substantially free of paraffin.
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公开(公告)号：US11940359B2
公开(公告)日：2024-03-26
申请号：US17564447
申请日：2021-12-29
Applicant: AGILENT TECHNOLOGIES, INC.
Inventor： Kyle Schleifer , Kristin Briana Bernick , Adrienne Mccampbell , Nicholas M. Sampas , Victor Lim
CPC classification number: G01N1/30 , G01N1/06 , G01N1/286 , G01N35/00594 , G06T7/0012 , G01N2001/068 , G01N2001/2873 , G06T2207/10064 , G06T2207/10152 , G06T2207/30024
Abstract: The present disclosure is directed to an improved method for distinguishing tissue from an embedding medium, such as paraffin in a formalin-fixed paraffin-embedded sample. The method involves the use of fluorescence of naturally-occurring species in tissue to determine the location of the tissue in the embedded sample. An embedded sample is generally excited by light of a selected wavelength, and the fluorescence emission at an emitted wavelength is used to locate the boundary or location of the tissue in the embedded sample.
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公开(公告)号：US20230053368A1
公开(公告)日：2023-02-23
申请号：US17976610
申请日：2022-10-28
Applicant: Agilent Technologies, Inc.
Inventor： Adrienne Mccampbell , Victor Lim
Abstract: Paraffin-embedded tissue is prepared removing paraffin from the tissue. The paraffin is removed by generating an electric field effective to produce plasma and direct charged species of the plasma to the paraffin, thereby rendering the paraffin responsive to the electric field. The electric field may move the paraffin out from the tissue due to electrostatic force. Movement of the paraffin may be assisted by moving an electrode utilized to generate the electric field relative to the paraffin. Movement of the paraffin also may be assisted by applying a solvent and/or heat energy to the tissue.
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公开(公告)号：US12050163B2
公开(公告)日：2024-07-30
申请号：US17976610
申请日：2022-10-28
Applicant: Agilent Technologies, Inc.
Inventor： Adrienne Mccampbell , Victor Lim
CPC classification number: G01N1/40 , G01N1/4022 , G01N1/44 , G01N2001/4038 , G02B21/34
Abstract: Paraffin-embedded tissue is prepared removing paraffin from the tissue. The paraffin is removed by generating an electric field effective to produce plasma and direct charged species of the plasma to the paraffin, thereby rendering the paraffin responsive to the electric field. The electric field may move the paraffin out from the tissue due to electrostatic force. Movement of the paraffin may be assisted by moving an electrode utilized to generate the electric field relative to the paraffin. Movement of the paraffin also may be assisted by applying a solvent and/or heat energy to the tissue.
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Patent Agency Ranking
公开(公告)号：US11525759B2
公开(公告)日：2022-12-13
申请号：US16392532
申请日：2019-04-23
Applicant: Agilent Technologies, Inc.
Inventor： Adrienne Mccampbell , Victor Lim
Abstract: Paraffin-embedded tissue is prepared removing paraffin from the tissue. The paraffin is removed by generating an electric field effective to produce plasma and direct charged species of the plasma to the paraffin, thereby rendering the paraffin responsive to the electric field. The electric field may move the paraffin out from the tissue due to electrostatic force. Movement of the paraffin may be assisted by moving an electrode utilized to generate the electric field relative to the paraffin. Movement of the paraffin also may be assisted by applying a solvent and/or heat energy to the tissue.
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公开(公告)号：US10914658B2
公开(公告)日：2021-02-09
申请号：US16868715
申请日：2020-05-07
Applicant: Agilent Technologies, Inc.
Inventor： Kyle Schleifer , Kristin Briana Bernick , Adrienne Mccampbell , Nicholas M. Sampas , Victor Lim
Abstract: The present disclosure is directed to an improved method for distinguishing tissue from an embedding medium, such as paraffin in a formalin-fixed paraffin-embedded sample. The method involves the use of fluorescence of naturally-occurring species in tissue to determine the location of the tissue in the embedded sample. An embedded sample is generally excited by light of a selected wavelength, and the fluorescence emission at an emitted wavelength is used to locate the boundary or location of the tissue in the embedded sample.
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公开(公告)号：US20240272051A1
公开(公告)日：2024-08-15
申请号：US18632030
申请日：2024-04-10
Applicant: Agilent Technologies, Inc.
Inventor： Victor Lim , Carol T. Schembri , Adrienne Mccampbell , Nazumi Alice Yama-Dang
CPC classification number: G01N1/44 , G01N1/30 , G01N1/31 , G01N1/312 , G01N1/36 , G01N1/40 , G01N2001/366 , G01N2001/4038
Abstract: Paraffin-embedded tissue, which may be disposed on a solid substrate, is prepared by a dry technique that removes paraffin from tissue without adding any liquid to the tissue, thereby rendering the tissue substantially free of paraffin. The dry technique may entail applying heat energy to the tissue effective to melt the paraffin and thereby render it flowable, and applying an electric field. The electric field is effective to impart electrical charge to the paraffin and to move the paraffin out from the tissue due to electrical charge repulsion or attraction, which may be assisted by moving an electrode utilized to generate the electric field relative to the paraffin. The electric field, or both the electric field and the heat energy, may be applied until the tissue is substantially free of paraffin.
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公开(公告)号：US20240183763A1
公开(公告)日：2024-06-06
申请号：US18443049
申请日：2024-02-15
Applicant: Agilent Technologies, Inc.
Inventor： Kyle Schleifer , Kristin Briana Bernick , Adrienne Mccampbell , Nicholas M. Sampas , Victor Lim
CPC classification number: G01N1/30 , G01N1/06 , G01N1/286 , G01N35/00594 , G06T7/0012 , G01N2001/068 , G01N2001/2873 , G06T2207/10064 , G06T2207/10152 , G06T2207/30024
Abstract: The present disclosure is directed to an improved method for distinguishing tissue from an embedding medium, such as paraffin in a formalin-fixed paraffin-embedded sample. The method involves the use of fluorescence of naturally-occurring species in tissue to determine the location of the tissue in the embedded sample. An embedded sample is generally excited by light of a selected wavelength, and the fluorescence emission at an emitted wavelength is used to locate the boundary or location of the tissue in the embedded sample.
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公开(公告)号：US20220120646A1
公开(公告)日：2022-04-21
申请号：US17564447
申请日：2021-12-29
Applicant: AGILENT TECHNOLOGIES, INC.
Inventor： Kyle Schleifer , Kristin Briana Bernick , Adrienne Mccampbell , Nicholas M. Sampas , Victor Lim
Abstract: The present disclosure is directed to an improved method for distinguishing tissue from an embedding medium, such as paraffin in a formalin-fixed paraffin-embedded sample. The method involves the use of fluorescence of naturally-occurring species in tissue to determine the location of the tissue in the embedded sample. An embedded sample is generally excited by light of a selected wavelength, and the fluorescence emission at an emitted wavelength is used to locate the boundary or location of the tissue in the embedded sample.
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