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公开(公告)号：US10684199B2
公开(公告)日：2020-06-16
申请号：US15995755
申请日：2018-06-01
Applicant: Agilent Technologies, Inc.
Inventor： Kyle Schleifer , Kristin Briana Bernick , Adrienne Mccampbell , Nicholas M Sampas , Victor Lim
Abstract: The present disclosure is directed to an improved method for distinguishing tissue from an embedding medium, such as paraffin in a formalin-fixed paraffin-embedded sample. The method involves the use of fluorescence of naturally-occurring species in tissue to determine the location of the tissue in the embedded sample. An embedded sample is generally excited by light of a selected wavelength, and the fluorescence emission at an emitted wavelength is used to locate the boundary or location of the tissue in the embedded sample.
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公开(公告)号：US11940359B2
公开(公告)日：2024-03-26
申请号：US17564447
申请日：2021-12-29
Applicant: AGILENT TECHNOLOGIES, INC.
Inventor： Kyle Schleifer , Kristin Briana Bernick , Adrienne Mccampbell , Nicholas M. Sampas , Victor Lim
CPC classification number: G01N1/30 , G01N1/06 , G01N1/286 , G01N35/00594 , G06T7/0012 , G01N2001/068 , G01N2001/2873 , G06T2207/10064 , G06T2207/10152 , G06T2207/30024
Abstract: The present disclosure is directed to an improved method for distinguishing tissue from an embedding medium, such as paraffin in a formalin-fixed paraffin-embedded sample. The method involves the use of fluorescence of naturally-occurring species in tissue to determine the location of the tissue in the embedded sample. An embedded sample is generally excited by light of a selected wavelength, and the fluorescence emission at an emitted wavelength is used to locate the boundary or location of the tissue in the embedded sample.
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3.发明申请METHODS AND COMPOSITIONS FOR MULTIPLEX TISSUE SECTION ANALYSES USING VISIBLE AND NON-VISIBLE LABELS 审中-公开使用可见和不可见标签的多组织组织分析方法和组合物公开(公告)号：US20160258848A1
公开(公告)日：2016-09-08
申请号：US14987256
申请日：2016-01-04
Applicant: Agilent Technologies, Inc.
Inventor： Brian Phillip Smart , Kristin Briana Bernick
IPC: G01N1/30 , G01N21/78 , G01N33/483
Abstract: Provided in this disclosure are methods and compositions that find use in a variety of multiplex cellular/tissue section analyses. In certain aspects, a tissue section (or planar cellular slide) is stained with a combination of “visible” labels and “invisible” labels for specific targets of interest. The visible labels are observed to obtain a result and then, based on the result, one or more of the invisible labels are detected, e.g., using digital microscopy.
Abstract translation: 在本公开中提供了可用于多种细胞/组织切片分析的方法和组合物。 在某些方面，组织部分（或平面细胞载玻片）用特定目的靶标的“可见”标签和“不可见”标签的组合染色。 观察可见标签以获得结果，然后基于结果，检测一个或多个不可见标签，例如使用数字显微镜。
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公开(公告)号：US20240183763A1
公开(公告)日：2024-06-06
申请号：US18443049
申请日：2024-02-15
Applicant: Agilent Technologies, Inc.
Inventor： Kyle Schleifer , Kristin Briana Bernick , Adrienne Mccampbell , Nicholas M. Sampas , Victor Lim
CPC classification number: G01N1/30 , G01N1/06 , G01N1/286 , G01N35/00594 , G06T7/0012 , G01N2001/068 , G01N2001/2873 , G06T2207/10064 , G06T2207/10152 , G06T2207/30024
Abstract: The present disclosure is directed to an improved method for distinguishing tissue from an embedding medium, such as paraffin in a formalin-fixed paraffin-embedded sample. The method involves the use of fluorescence of naturally-occurring species in tissue to determine the location of the tissue in the embedded sample. An embedded sample is generally excited by light of a selected wavelength, and the fluorescence emission at an emitted wavelength is used to locate the boundary or location of the tissue in the embedded sample.
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公开(公告)号：US20220120646A1
公开(公告)日：2022-04-21
申请号：US17564447
申请日：2021-12-29
Applicant: AGILENT TECHNOLOGIES, INC.
Inventor： Kyle Schleifer , Kristin Briana Bernick , Adrienne Mccampbell , Nicholas M. Sampas , Victor Lim
Abstract: The present disclosure is directed to an improved method for distinguishing tissue from an embedding medium, such as paraffin in a formalin-fixed paraffin-embedded sample. The method involves the use of fluorescence of naturally-occurring species in tissue to determine the location of the tissue in the embedded sample. An embedded sample is generally excited by light of a selected wavelength, and the fluorescence emission at an emitted wavelength is used to locate the boundary or location of the tissue in the embedded sample.
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Patent Agency Ranking
公开(公告)号：US20210108995A1
公开(公告)日：2021-04-15
申请号：US17129209
申请日：2020-12-21
Applicant: AGILENT TECHNOLOGIES, INC.
Inventor： Kyle Schleifer , Kristin Briana Bernick , Adrienne Mccampbell , Nicholas M. Sampas , Victor Lim
Abstract: The present disclosure is directed to an improved method for distinguishing tissue from an embedding medium, such as paraffin in a formalin-fixed paraffin-embedded sample. The method involves the use of fluorescence of naturally-occurring species in tissue to determine the location of the tissue in the embedded sample. An embedded sample is generally excited by light of a selected wavelength, and the fluorescence emission at an emitted wavelength is used to locate the boundary or location of the tissue in the embedded sample.
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公开(公告)号：US11808675B2
公开(公告)日：2023-11-07
申请号：US16874499
申请日：2020-05-14
Applicant: Agilent Technologies, Inc.
Inventor： Genevieve Van de Bittner , James Alexander Apffel , Steven M. Fischer , Christine A. Miller , Kristin Briana Bernick
CPC classification number: G01N1/28 , B01D11/0288 , B01D15/00 , C07K1/145 , C12N1/06 , C12N15/1006
Abstract: Reagents and methods for extracting and stabilizing metabolites at room temperature and methods in which metabolites and one or more of proteins, lipids and nucleic acids are extracted from a single sample in a unified workflow.
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公开(公告)号：US10914658B2
公开(公告)日：2021-02-09
申请号：US16868715
申请日：2020-05-07
Applicant: Agilent Technologies, Inc.
Inventor： Kyle Schleifer , Kristin Briana Bernick , Adrienne Mccampbell , Nicholas M. Sampas , Victor Lim
Abstract: The present disclosure is directed to an improved method for distinguishing tissue from an embedding medium, such as paraffin in a formalin-fixed paraffin-embedded sample. The method involves the use of fluorescence of naturally-occurring species in tissue to determine the location of the tissue in the embedded sample. An embedded sample is generally excited by light of a selected wavelength, and the fluorescence emission at an emitted wavelength is used to locate the boundary or location of the tissue in the embedded sample.
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公开(公告)号：US11243148B2
公开(公告)日：2022-02-08
申请号：US17129209
申请日：2020-12-21
Applicant: AGILENT TECHNOLOGIES, INC.
Inventor： Kyle Schleifer , Kristin Briana Bernick , Adrienne Mccampbell , Nicholas M. Sampas , Victor Lim
Abstract: The present disclosure is directed to an improved method for distinguishing tissue from an embedding medium, such as paraffin in a formalin-fixed paraffin-embedded sample. The method involves the use of fluorescence of naturally-occurring species in tissue to determine the location of the tissue in the embedded sample. An embedded sample is generally excited by light of a selected wavelength, and the fluorescence emission at an emitted wavelength is used to locate the boundary or location of the tissue in the embedded sample.
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公开(公告)号：US20200264077A1
公开(公告)日：2020-08-20
申请号：US16868715
申请日：2020-05-07
Applicant: Agilent Technologies, Inc.
Inventor： Kyle Schleifer , Kristin Briana Bernick , Adrienne Mccampbell , Nicholas M. Sampas , Victor Lim
Abstract: The present disclosure is directed to an improved method for distinguishing tissue from an embedding medium, such as paraffin in a formalin-fixed paraffin-embedded sample. The method involves the use of fluorescence of naturally-occurring species in tissue to determine the location of the tissue in the embedded sample. An embedded sample is generally excited by light of a selected wavelength, and the fluorescence emission at an emitted wavelength is used to locate the boundary or location of the tissue in the embedded sample.
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