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公开(公告)号：US20150211036A1
公开(公告)日：2015-07-30
申请号：US14421872
申请日：2013-08-13
发明人： Michael Naesby , Christophe Folly , Curt Aimé Friis Nielsen , Anaelle Hatsch , Markus Schwab , Oskar Zelder , Stefan Haefner , Hartwig Schroeder , Birgit Hoff , Andrea Molt , Klaus Ditrich , Michael Breuer , Holger Hartmann , Karsten Koerber
IPC分类号： C12P17/12 , C12N9/02 , C07D209/90 , C12P17/10 , C07K16/40 , C07D487/06 , C12N9/10 , C12N9/90
CPC分类号： C12P17/12 , C07D209/90 , C07D487/06 , C07K16/40 , C12N9/0004 , C12N9/001 , C12N9/1007 , C12N9/1085 , C12N9/90 , C12N15/52 , C12P17/10 , C12P17/182 , C12Y205/01
摘要： Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.
摘要翻译： 用于重组生产角鲨烯型生物碱如环圈子，festuclavine，agroclavine，chanoclavine和chanoclavine醛的微生物和方法，以及多肽，多核苷酸和包含这样的多核苷酸的载体，其可以用于制造棒状的方法 提供生物碱。
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公开(公告)号：US09828617B2
公开(公告)日：2017-11-28
申请号：US14421872
申请日：2013-08-13
发明人： Michael Naesby , Christophe Folly , Curt Aimé Friis Nielsen , Anaelle Hatsch , Markus Schwab , Oskar Zelder , Stefan Haefner , Hartwig Schroeder , Birgit Hoff , Andrea Molt , Klaus Ditrich , Michael Breuer , Holger Hartmann , Karsten Koerber
IPC分类号： C12N15/53 , C12P17/12 , C12N9/02 , C12N9/90 , C12N15/52 , C12P17/10 , C12P17/18 , C07D209/90 , C07D487/06 , C07K16/40 , C12N9/10
CPC分类号： C12P17/12 , C07D209/90 , C07D487/06 , C07K16/40 , C12N9/0004 , C12N9/001 , C12N9/1007 , C12N9/1085 , C12N9/90 , C12N15/52 , C12P17/10 , C12P17/182 , C12Y205/01
摘要： Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.
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公开(公告)号：US20210340518A1
公开(公告)日：2021-11-04
申请号：US17286328
申请日：2019-10-09
申请人： BASF SE
发明人： Diego Ghislieri , Tobias Joachim Zimmermann , Stefan Seemayer , Michael Breuer , Doreen Schactschabel
摘要： Described herein are methods for the production of ammonium acrylate or salts thereof from acrylonitrile using nitrilase as a catalyst.
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4.发明授权公开(公告)号：US11136611B2
公开(公告)日：2021-10-05
申请号：US16487978
申请日：2018-02-23
申请人： BASF SE
摘要： The invention provides an improved method of isolating the 3-(E)-isomer of an unsaturated carboxylic acid from a mixture of corresponding (E/Z)isomers. More particularly, the present invention relates to an improved method for the biocatalytic preparation of (3E,7E)-homofarnesylic acid; as well as a novel biocatalytic method for the improved preparation of homofarnesol, in particular of (3E,7E)-homofarnesol and homofarnesol preparations having an increased content of (3E,7E)-homofarnesol. The present invention also relates to methods of preparing(−)-ambroxby applying (3E,7E)-homofarnesylic acid or (3E,7E)-homofarnesol as obtained according to the invention as starting material.
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5.发明授权公开(公告)号：US10179923B2
公开(公告)日：2019-01-15
申请号：US15514706
申请日：2015-09-28
申请人： BASF SE
发明人： Michael Breuer , Ralf Pelzer
摘要： The present invention relates to a novel process for cyclizing geranyllinalool using the squalene-hopene cyclase from Zymomonas mobilis (Zm-SHC) or a cyclase with at least 80% sequence identity to the Zm-SHC, and cyclization products obtained in this process.
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公开(公告)号：US09796992B2
公开(公告)日：2017-10-24
申请号：US14084030
申请日：2013-11-19
申请人： BASF SE
发明人： Oskar Zelder , Birgit Hoff , Hartwig Schröder , Andrea Molt , Holger Hartmann , Klaus Ditrich , Michael Breuer , Rüdiger Reingruber , Jakob Weber
摘要： The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polypeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.
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公开(公告)号：US20150275248A1
公开(公告)日：2015-10-01
申请号：US14441215
申请日：2013-11-13
申请人： BASF SE
发明人： Oskar Zelder , Birgit Hoff , Hartwig Schroeder , Andrea Molt , Holger Hartmann , Klaus Ditrich , Michael Breuer , Rüdiger Reingrubber , Jakob Weber
CPC分类号： C12P17/04 , A01N37/42 , A01N37/46 , A01N63/04 , C07D307/93 , C07K14/37 , C12N15/52 , C12N15/67 , C12N15/80
摘要： The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.
摘要翻译： 本发明涉及天然产物的生产领域，尤其涉及在玉米corn霉素和羟基角质素的生产领域。 它提供了编码涉及Cornexistin和羟基角质素的生物合成的多肽的多核苷酸以及包含这种多核苷酸的载体和重组微生物。 还提供了生产天然产物的方法，特别是使用这样的多核苷酸和其中编码的多肽以及包含这种多核苷酸和多肽的载体和重组微生物来生产玉米corn霉素和羟基角质柔比星的方法。
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公开(公告)号：US10315975B2
公开(公告)日：2019-06-11
申请号：US15743153
申请日：2016-07-08
发明人： Julia Strautmann , Stefan Rüdenauer , Christian Rein , Melanie Weingarten , Rocco Paciello , Wolfgang Siegel , Michael Breuer , Peter Hofmann , Sebastian Schmidt
IPC分类号： C07C45/50 , B01J31/00 , C07C47/21 , C07D307/92 , C07C29/141 , C07C29/56 , B01J31/18 , C07C33/025
摘要： The present invention relates to a method for the regioselective hydroformylation of polyunsaturated acyclic hydrocarbons, which are 1, 3 butadienes, which, in the 2 position, bear a saturated or monounsaturated or polyunsaturated acyclic hydrocarbon radical. The present invention also relates to the production of secondary products of these hydroformylation products, especially of ambrox.
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9.发明申请Process for the Bioconversion of C3-C13 Alkanes to C3-C13 Primary Alcohols 审中-公开将C3-C13烷烃生物转化为C3-C13伯醇的方法公开(公告)号：US20160201093A1
公开(公告)日：2016-07-14
申请号：US14908293
申请日：2014-07-21
申请人： BASF SE
发明人： Michael Breuer , Boris Breitscheidel , Hans-Günter Wagner , Detlef Kratz , Bernhard Hauer , Daniel Scheps , Bernd Nebel
CPC分类号： C12P7/16 , C12P7/04 , C12Y114/15003 , C12Y118/01001 , Y02E50/10
摘要： A process for preparing linear or branched primary alcohols with 3 to 13 carbon atoms from linear or branched alkanes with 3 to 13 carbon atoms by incubating a host organism having a functional P153 enzyme under elevated pressure in the presence of oxygen.
摘要翻译： 通过在氧气存在下在升高的压力下孵育具有功能性P153酶的宿主生物体，从具有3至13个碳原子的直链或支链烷烃制备具有3至13个碳原子的直链或支链伯醇的方法。
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10.发明申请METHOD FOR THE BIOCATALYTIC CYCLIZATION OF TERPENES AND CYCLASE MUTANTS EMPLOYABLE THEREIN 有权用于生物化学循环的方法和可用于其的环状基因突变体公开(公告)号：US20150104851A1
公开(公告)日：2015-04-16
申请号：US14560263
申请日：2014-12-04
申请人： BASF SE
发明人： Michael Breuer , Bernhard Hauer , Dieter Jendrossek , Gabrielle Siedenburg , Juergen Pleiss , Demet Sirim , Silvia Racolta
IPC分类号： C12N9/90
CPC分类号： C12N9/88 , C12N9/90 , C12P5/007 , C12P7/02 , C12P7/22 , C12Y406/01 , C12Y504/99017 , Y02P20/52
摘要： The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.
摘要翻译： 本发明涉及具有环化酶活性的新颖突变体及其在萜烯生物催化环化方法中的应用，特别是通过香茅醛环化生产异胡胆糖; 用于制备薄荷醇的方法和用于生物催化转化具有类似于萜烯的结构基序的其它化合物的方法。
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