公开(公告)号：US09828617B2

公开(公告)日：2017-11-28

申请号：US14421872

申请日：2013-08-13

申请人： BASF SE ,  Evolva SA

发明人： Michael Naesby ,  Christophe Folly ,  Curt Aimé Friis Nielsen ,  Anaelle Hatsch ,  Markus Schwab ,  Oskar Zelder ,  Stefan Haefner ,  Hartwig Schroeder ,  Birgit Hoff ,  Andrea Molt ,  Klaus Ditrich ,  Michael Breuer ,  Holger Hartmann ,  Karsten Koerber

IPC分类号： C12N15/53 ,  C12P17/12 ,  C12N9/02 ,  C12N9/90 ,  C12N15/52 ,  C12P17/10 ,  C12P17/18 ,  C07D209/90 ,  C07D487/06 ,  C07K16/40 ,  C12N9/10

CPC分类号： C12P17/12 ,  C07D209/90 ,  C07D487/06 ,  C07K16/40 ,  C12N9/0004 ,  C12N9/001 ,  C12N9/1007 ,  C12N9/1085 ,  C12N9/90 ,  C12N15/52 ,  C12P17/10 ,  C12P17/182 ,  C12Y205/01

摘要： Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.

公开(公告)号：US20150211036A1

公开(公告)日：2015-07-30

申请号：US14421872

申请日：2013-08-13

申请人： BASF SE ,  Evolva SA

发明人： Michael Naesby ,  Christophe Folly ,  Curt Aimé Friis Nielsen ,  Anaelle Hatsch ,  Markus Schwab ,  Oskar Zelder ,  Stefan Haefner ,  Hartwig Schroeder ,  Birgit Hoff ,  Andrea Molt ,  Klaus Ditrich ,  Michael Breuer ,  Holger Hartmann ,  Karsten Koerber

IPC分类号： C12P17/12 ,  C12N9/02 ,  C07D209/90 ,  C12P17/10 ,  C07K16/40 ,  C07D487/06 ,  C12N9/10 ,  C12N9/90

CPC分类号： C12P17/12 ,  C07D209/90 ,  C07D487/06 ,  C07K16/40 ,  C12N9/0004 ,  C12N9/001 ,  C12N9/1007 ,  C12N9/1085 ,  C12N9/90 ,  C12N15/52 ,  C12P17/10 ,  C12P17/182 ,  C12Y205/01

摘要： Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.

摘要翻译： 用于重组生产角鲨烯型生物碱如环圈子，festuclavine，agroclavine，chanoclavine和chanoclavine醛的微生物和方法，以及多肽，多核苷酸和包含这样的多核苷酸的载体，其可以用于制造棒状的方法 提供生物碱。

公开(公告)号：US10731188B2

公开(公告)日：2020-08-04

申请号：US16235511

申请日：2018-12-28

申请人： BASF SE

发明人： Hartwig Schröder ,  Holger Hartmann ,  Qingzhao Wang ,  Shakir Siraj Ratani ,  Zheyuan Guo ,  Markus Pompejus

IPC分类号： C12P13/06 ,  C07K14/245 ,  C12N1/20 ,  C12N9/06 ,  C12P7/04 ,  C12P7/46 ,  C12P7/56 ,  C12P13/08 ,  C12P13/20

摘要： The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.

公开(公告)号：US10519474B2

公开(公告)日：2019-12-31

申请号：US15579291

申请日：2016-06-02

申请人： BASF SE

发明人： Qingzhao Wang ,  Shakir Siraj Ratani ,  Zheyuan Guo ,  Hartwig Schroeder ,  Holger Hartmann ,  Markus Pompejus

IPC分类号： C12P13/06 ,  C07K14/245 ,  C12N1/20 ,  C12N15/70

摘要： Recombinant microorganism for improved production of fine chemicals The present invention relates to a recombinant nucleic acid molecule, a recombinant micro-organism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.

公开(公告)号：US20140141440A1

公开(公告)日：2014-05-22

申请号：US14084030

申请日：2013-11-19

申请人： BASF SE

发明人： Oskar Zelder ,  Birgit Hoff ,  Hartwig Schröder ,  Andrea Molt ,  Holger Hartmann ,  Klaus Ditrich ,  Michael Breuer ,  Rüdiger Reingruber ,  Jakob Weber

IPC分类号： C12P17/04

CPC分类号： C12P17/04 ,  C12N15/52 ,  C12P7/50

摘要： The invention pertains to/the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.

摘要翻译： 本发明涉及天然产物的生产领域，尤其涉及在玉米corn霉素和羟基角质素的生产领域。 它提供了编码涉及Cornexistin和羟基角质素的生物合成的多肽的多核苷酸以及包含这种多核苷酸的载体和重组微生物。 还提供了生产天然产物的方法，特别是使用这样的多核苷酸和其中编码的多肽以及包含这种多核苷酸和多肽的载体和重组微生物来生产玉米corn霉素和羟基角质柔比星的方法。

公开(公告)号：US20240093211A1

公开(公告)日：2024-03-21

申请号：US18463923

申请日：2023-09-08

申请人： BASF SE

发明人： Max Fabian Felle ,  Stefan Jenewein ,  Kerstin Hage ,  Holger Hartmann

IPC分类号： C12N15/75 ,  C12N9/08 ,  C12N15/63 ,  C12P1/04

CPC分类号： C12N15/75 ,  C12N9/0065 ,  C12N15/63 ,  C12P1/04 ,  C12Y111/01006

摘要： The present invention generally relates to the field of fermentation technology and microorganisms useful for such fermentations. The invention also relates to materials including nucleic acids and proteins useful for altering fermentation characteristics of microorganisms, and to microorganisms comprising such nucleic acids and/or proteins.

公开(公告)号：US20230059334A1

公开(公告)日：2023-02-23

申请号：US17785762

申请日：2020-12-17

申请人： BASF SE

发明人： Stefan Seemayer ,  Holger Hartmann

IPC分类号： C12Q1/6827 ,  C12N15/10

摘要： The present invention is concerned with materials and methods for nucleic acid and/or protein analysis, including materials and methods for creating and/or analysing mutant libraries. The invention in particular relates to materials and methods for correlating a property of mutants of a target nucleic acid to the respective sequences of the mutants. The invention is particularly useful for analysing saturation mutagenesis libraries and the analysis of sensitivities to chemical or physical conditions, for example temperature stability and solvent stability, and for the analysis of production properties, for example yield or cellular localisation.

公开(公告)号：US10597429B2

公开(公告)日：2020-03-24

申请号：US15779646

申请日：2016-12-02

申请人： BASF SE

发明人： Stefan Haefner ,  Andreas Thywissen ,  Holger Hartmann ,  Nico Boehmer

IPC分类号： C12P21/00 ,  C12P21/02 ,  C12Q1/34 ,  C12N1/14 ,  C12N15/01 ,  C12N15/80 ,  C12P19/14 ,  C07K14/37 ,  C12N9/42

摘要： The present invention relates to a method of producing a recombinant polypeptide in a filamentous fungus which is genetically modified to decrease or eliminate the activity of cellulase regulator 1 (CLR1) and to express the recombinant polypeptide. The method further relates to a filamentous fungus Myceliophthora thermophila, which is genetically modified to decrease or eliminate the activity of CLR1 and to the use of this filamentous fungus in the production of a recombinant polypeptide.

公开(公告)号：US20190112612A1

公开(公告)日：2019-04-18

申请号：US16062291

申请日：2016-12-08

申请人： BASF SE

发明人： Max Fabian Felle ,  Stefan Jenewein ,  Kerstin Hage ,  Holger Hartmann

IPC分类号： C12N15/75 ,  C12N9/08 ,  C12P1/04

摘要： The present invention generally relates to the field of fermentation technology and microorganisms useful for such fermentations. The invention also relates to materials including nucleic acids and proteins useful for altering fermentation characteristics of microorganisms, and to microorganisms comprising such nucleic acids and/or proteins.

公开(公告)号：US11299522B2

公开(公告)日：2022-04-12

申请号：US15779595

申请日：2016-12-02

申请人： BASF SE

发明人： Stefan Haefner ,  Andreas Thywissen ,  Holger Hartmann ,  Nico Boehmer

IPC分类号： C12P21/00 ,  C12N9/14 ,  C12N1/15 ,  C07K14/37 ,  C12N9/16 ,  C12N9/24 ,  C12N15/80

摘要： The present invention relates to a method of producing a recombinant polypeptide a filamentous fungus which is genetically modified to decrease or eliminate the activity of cellulase regulator 2 (CLR2) and to express said recombinant polypeptide. The method further relates to a filamentous fungus Myceliophthora thermophila, which is genetically modified to decrease or eliminate the activity of CLR2 and the use of this filamentous fungus in the production of a recombinant polypeptide.