公开(公告)号：US11166458B2

公开(公告)日：2021-11-09

申请号：US15968586

申请日：2018-05-01

申请人： ALLIED BIOSCIENCE, INC.

发明人： Craig Grossman ,  Gavri Grossman ,  Jie Fang ,  Misagh Alipour

IPC分类号： A01N25/34 ,  B05D7/00 ,  B05D1/04 ,  D06M23/00 ,  D06M11/46 ,  D06M15/423 ,  D06M13/513 ,  A61Q19/10 ,  A61K8/41 ,  A61K8/898 ,  A61K8/58 ,  A61K8/02 ,  A61Q17/00 ,  A01N33/12 ,  A01N55/00

摘要： A wet wipe is disclosed that provides both contact sanitization of a surface and application of a residual antimicrobial coating on the surface through the same wiping. The wet wipe comprises a substrate such as an absorbent nonwoven fabric and a liquid composition impregnated therein, the liquid composition comprising an organosilane such as the antimicrobial dimethyloctadecyl[3-(trimethoxysilyl)propyl] ammonium chloride, a non-silane quaternary disinfectant, an organic amine, and a solvent. The non-silane quaternary actives comprise a mixture of actives, and the solvent comprises 60 wt. % isopropanol or more.

公开(公告)号：US20210251810A1

公开(公告)日：2021-08-19

申请号：US17246181

申请日：2021-04-30

申请人： Allied Bioscience, Inc.

发明人： Craig Grossman ,  Gavri Grossman ,  Daniel Moros ,  Misagh Alipour ,  Jie Fang

IPC分类号： A61F13/00 ,  A61K31/695 ,  A61F13/84

摘要： Antimicrobial coating compositions are used to form dried residual antimicrobial coatings on medical dressings including gauze, bandages, gowns, and dry wipers. Antimicrobial coating compositions comprise at least one of an organosilane (R1O)3Si—R2—Z, an organic amine R9R10R11N, a titanium (IV) species, a 1,2-diol, an α-hydroxy acid, a β-hydroxy acid, and an organosilane grafted parylene polymer, wherein R1 is H, alkyl, substituted alkyl, aryl or substituted aryl, R2 is a bivalent linker, Z is a nucleophile, leaving group, or quaternary nitrogen substituent and R9, R10, and R11 are independently H, alkyl, substituted alkyl, aryl, substituted aryl or cyclic.

公开(公告)号：US10993441B2

公开(公告)日：2021-05-04

申请号：US16591785

申请日：2019-10-03

申请人： ALLIED BIOSCIENCE, INC.

发明人： Gavri Grossman ,  Jie Fang ,  Parham Asgari ,  Maha El-Sayed ,  Craig Grossman ,  Daniel Moros

IPC分类号： C08G77/26 ,  A01N55/00 ,  B05D1/04 ,  C23C26/00 ,  C09D179/02 ,  B05D7/00 ,  B05D7/14 ,  B05D1/02 ,  A01N33/08 ,  A01N25/02 ,  C09D5/14 ,  A61L2/00 ,  A01N59/16 ,  C09D183/08 ,  C09D183/00 ,  C08K3/22 ,  C09D183/06 ,  C07F7/08

摘要： Aqueous antimicrobial coating compositions are disclosed comprising at least one organosilane homopolymer, present as a distribution of polymer chain lengths, and optionally at least one amine. A method of preparing an antimicrobial coating comprises coating a surface with the aqueous antimicrobial coating composition and allowing the composition to dry into a film that exhibits residual antimicrobial efficacy against microorganisms even after mechanical abrasion of the coating. The organosilane homopolymer may comprise only 3-aminopropylsilanetriol homopolymer, mixtures of 3-aminopropylsilanetriol homopolymer, 3-chloropropylsilanetriol homopolymer and 3-(trihydroxysilyl)propyl dimethyloctadecyl ammonium chloride homopolymer, or any one of various unique organosilane homopolymers having multiple amine functionality.

公开(公告)号：US20180368648A1

公开(公告)日：2018-12-27

申请号：US16013750

申请日：2018-06-20

申请人： Allied Bioscience, Inc.

发明人： Craig Grossman ,  Gavri Grossman ,  Daniel Moros

IPC分类号： A47L13/16 ,  A01N55/00 ,  A01N33/08 ,  A01N25/34

摘要： The disclosure provides an antimicrobial sponge comprising: a porous sponge substrate; and an antimicrobial coating composition dried therein, the composition comprising: at least one organosilane of formula (R1O)3Si—R2—Z; and an organic amine of formula R9R10R11N, wherein each R1 is independently H, alkyl, substituted alkyl, aryl, or substituted aryl, R2 is a bivalent linker, and Z is a nucleophile, a leaving group or a quaternary nitrogen substituent, and wherein R9, R10, and R11 are independently H, alkyl, substituted alkyl, aryl, substituted aryl or cyclic.

公开(公告)号：US09963596B2

公开(公告)日：2018-05-08

申请号：US15432567

申请日：2017-02-14

申请人： Allied Bioscience, Inc.

发明人： Daniel Moros ,  Craig Grossman ,  Gavri Grossman

IPC分类号： C09D183/08 ,  C09D5/14 ,  C08G77/26 ,  B05D1/02

CPC分类号： C09D5/14 ,  B05D1/02 ,  C08G73/0246 ,  C08G77/26 ,  C08G77/62 ,  C08K3/22 ,  C08K2003/2241 ,  C09D183/08 ,  C09D183/16 ,  C08L83/14

摘要： The invention relates to an antimicrobial coating composition formed by admixing choline bitartrate or choline chloride, an aminopropyltrialkoxysilane and water. This coating composition is preferably sprayed onto a surface and allowed to dry. Preferably the surface is a stainless steel surface. The coating reduces the amount of E. Coli on the surface of the substrate.

公开(公告)号：US09855584B2

公开(公告)日：2018-01-02

申请号：US15432334

申请日：2017-02-14

申请人： Allied Bioscience, Inc.

发明人： Craig Grossman ,  Mai Ngo ,  Ronald Wysocki

IPC分类号： B05D7/00 ,  B05D1/04 ,  D06M23/00 ,  D06M11/46 ,  D06M13/513 ,  D06M15/423

CPC分类号： C09D5/14 ,  A01N55/00 ,  A01N55/02 ,  B05D1/02 ,  B05D1/04 ,  B05D5/00 ,  B05D7/52 ,  B05D2425/01 ,  B05D2601/24 ,  C07F7/28 ,  C08G77/26 ,  C08G79/00 ,  C09D5/00 ,  C09D7/63 ,  C09D183/08 ,  C09D185/00 ,  D06M11/46 ,  D06M13/51 ,  D06M13/513 ,  D06M15/423 ,  D06M23/005

摘要： A method to prepare a self-decontaminating surface, where that method includes disposing a first coating on a surface, where that first coating comprises an organosilane, and disposing a second coating over the first coating, where the second coating comprises TiO2.

公开(公告)号：US20170166754A1

公开(公告)日：2017-06-15

申请号：US15432443

申请日：2017-02-14

申请人： Allied Bioscience, Inc.

发明人： Daniel Moros ,  Craig Grossman

IPC分类号： C09D5/14 ,  C23C26/00 ,  B05D1/02 ,  B05D7/14 ,  A01N55/00 ,  A01N25/02

CPC分类号： A01N55/00 ,  A01N25/02 ,  A01N33/08 ,  A01N59/16 ,  A61L2/00 ,  B05D1/02 ,  B05D1/04 ,  B05D7/14 ,  B05D7/544 ,  C08G77/26 ,  C08K3/22 ,  C08K2003/2241 ,  C09D5/14 ,  C09D179/02 ,  C09D183/00 ,  C09D183/08 ,  C23C26/00 ,  A01N2300/00

摘要： An anti-microbial coating formulation consisting essentially of triethanolamine and a silane.

公开(公告)号：US20200068897A1

公开(公告)日：2020-03-05

申请号：US16591785

申请日：2019-10-03

申请人： ALLIED BIOSCIENCE, INC.

发明人： Gavri Grossman ,  Jie Fang ,  Parham Asgari ,  Maha El-Sayed ,  Craig Grossman

IPC分类号： A01N55/00 ,  C08G77/26 ,  B05D1/04 ,  C23C26/00 ,  C09D179/02 ,  B05D7/00 ,  B05D7/14 ,  B05D1/02 ,  A01N33/08 ,  A01N25/02 ,  C09D5/14 ,  A61L2/00 ,  A01N59/16 ,  C09D183/08

摘要： Aqueous antimicrobial coating compositions are disclosed comprising at least one organosilane homopolymer, present as a distribution of polymer chain lengths, and optionally at least one amine. A method of preparing an antimicrobial coating comprises coating a surface with the aqueous antimicrobial coating composition and allowing the composition to dry into a film that exhibits residual antimicrobial efficacy against microorganisms even after mechanical abrasion of the coating. The organosilane homopolymer may comprise only 3-aminopropylsilanetriol homopolymer, mixtures of 3-aminopropylsilanetriol homopolymer, 3-chloropropylsilanetriol homopolymer and 3-(trihydroxysilyl)propyl dimethyloctadecyl ammonium chloride homopolymer, or any one of various unique organosilane homopolymers having multiple amine functionality.

公开(公告)号：US10258046B2

公开(公告)日：2019-04-16

申请号：US15969576

申请日：2018-05-02

申请人： ALLIED BIOSCIENCE, INC.

发明人： Craig Grossman ,  Gavri Grossman ,  Daniel Moros ,  Jie Fang

IPC分类号： C09D183/08 ,  A01N55/00 ,  A01N33/08 ,  A61L2/00 ,  B05D1/02 ,  B05D7/14 ,  B05D7/00 ,  C09D5/14 ,  C09D179/02 ,  C23C26/00 ,  A01N59/16 ,  A01N25/02 ,  C09D7/61 ,  B05B5/025 ,  A61L2/08 ,  A61L2/232 ,  C08K3/22 ,  C09D183/00 ,  C08G77/26

摘要： A method of preparing an antimicrobial coating comprises coating a surface with an aqueous mixture of 3-(trihydroxysilyl)propyl dimethyloctadecyl ammonium chloride, 3-chloropropyltrimethoxysilane, and triethanolamine and then coating the surface with an aqueous titanyl sol-gel solution comprising an aqueous mixture of peroxotitanium acid and peroxo-modified anatase sol overtop of the silane to form the antimicrobial coating. The antimicrobial coating exhibits residual antimicrobial efficacy against E. coli and S. epidermidis after water rinsing or after abrasion. The use of 3-chloropropyltrimethoxysilane was found to improve storage stability of the quaternary silane composition and the durability of the antimicrobial coating.

公开(公告)号：US20180280582A1

公开(公告)日：2018-10-04

申请号：US15938417

申请日：2018-03-28

申请人： Allied Bioscience, Inc.

发明人： Craig Grossman ,  Gavri Grossman ,  Daniel Moros ,  Misagh Alipour ,  Jie Fang

IPC分类号： A61L29/16 ,  A01N55/00 ,  A61L29/02 ,  A61L29/06 ,  A61L29/08

摘要： The present disclosure provides antimicrobial coating compositions that are used to form residual antimicrobial coatings on medical implements and medical devices including the components of medical equipment such as CPAP/BiPAP machines. Antimicrobial coating compositions comprise at least one of an organosilane (R1O)3Si—R2—Z, an organic amine R9R10R11N, a titanium (IV) species, a 1,2-diol, an α-hydroxy acid, β-hydroxy acid, and an organosilane grafted parylene polymer, wherein R1 is H, alkyl, substituted alkyl, aryl or substituted aryl, R2 is a bivalent linker, Z is a nucleophile, leaving group, or quaternary nitrogen substituent, and R9, R10, and R11 are independently H, alkyl, substituted alkyl, aryl, substituted aryl or cyclic.