公开(公告)号：US11166458B2

公开(公告)日：2021-11-09

申请号：US15968586

申请日：2018-05-01

申请人： ALLIED BIOSCIENCE, INC.

发明人： Craig Grossman ,  Gavri Grossman ,  Jie Fang ,  Misagh Alipour

IPC分类号： A01N25/34 ,  B05D7/00 ,  B05D1/04 ,  D06M23/00 ,  D06M11/46 ,  D06M15/423 ,  D06M13/513 ,  A61Q19/10 ,  A61K8/41 ,  A61K8/898 ,  A61K8/58 ,  A61K8/02 ,  A61Q17/00 ,  A01N33/12 ,  A01N55/00

摘要： A wet wipe is disclosed that provides both contact sanitization of a surface and application of a residual antimicrobial coating on the surface through the same wiping. The wet wipe comprises a substrate such as an absorbent nonwoven fabric and a liquid composition impregnated therein, the liquid composition comprising an organosilane such as the antimicrobial dimethyloctadecyl[3-(trimethoxysilyl)propyl] ammonium chloride, a non-silane quaternary disinfectant, an organic amine, and a solvent. The non-silane quaternary actives comprise a mixture of actives, and the solvent comprises 60 wt. % isopropanol or more.

公开(公告)号：US20210251810A1

公开(公告)日：2021-08-19

申请号：US17246181

申请日：2021-04-30

申请人： Allied Bioscience, Inc.

发明人： Craig Grossman ,  Gavri Grossman ,  Daniel Moros ,  Misagh Alipour ,  Jie Fang

IPC分类号： A61F13/00 ,  A61K31/695 ,  A61F13/84

摘要： Antimicrobial coating compositions are used to form dried residual antimicrobial coatings on medical dressings including gauze, bandages, gowns, and dry wipers. Antimicrobial coating compositions comprise at least one of an organosilane (R1O)3Si—R2—Z, an organic amine R9R10R11N, a titanium (IV) species, a 1,2-diol, an α-hydroxy acid, a β-hydroxy acid, and an organosilane grafted parylene polymer, wherein R1 is H, alkyl, substituted alkyl, aryl or substituted aryl, R2 is a bivalent linker, Z is a nucleophile, leaving group, or quaternary nitrogen substituent and R9, R10, and R11 are independently H, alkyl, substituted alkyl, aryl, substituted aryl or cyclic.

公开(公告)号：US10993441B2

公开(公告)日：2021-05-04

申请号：US16591785

申请日：2019-10-03

申请人： ALLIED BIOSCIENCE, INC.

发明人： Gavri Grossman ,  Jie Fang ,  Parham Asgari ,  Maha El-Sayed ,  Craig Grossman ,  Daniel Moros

IPC分类号： C08G77/26 ,  A01N55/00 ,  B05D1/04 ,  C23C26/00 ,  C09D179/02 ,  B05D7/00 ,  B05D7/14 ,  B05D1/02 ,  A01N33/08 ,  A01N25/02 ,  C09D5/14 ,  A61L2/00 ,  A01N59/16 ,  C09D183/08 ,  C09D183/00 ,  C08K3/22 ,  C09D183/06 ,  C07F7/08

摘要： Aqueous antimicrobial coating compositions are disclosed comprising at least one organosilane homopolymer, present as a distribution of polymer chain lengths, and optionally at least one amine. A method of preparing an antimicrobial coating comprises coating a surface with the aqueous antimicrobial coating composition and allowing the composition to dry into a film that exhibits residual antimicrobial efficacy against microorganisms even after mechanical abrasion of the coating. The organosilane homopolymer may comprise only 3-aminopropylsilanetriol homopolymer, mixtures of 3-aminopropylsilanetriol homopolymer, 3-chloropropylsilanetriol homopolymer and 3-(trihydroxysilyl)propyl dimethyloctadecyl ammonium chloride homopolymer, or any one of various unique organosilane homopolymers having multiple amine functionality.

公开(公告)号：US11442032B2

公开(公告)日：2022-09-13

申请号：US17234330

申请日：2021-04-19

申请人： Allied Bioscience, Inc.

发明人： Parham Asgari ,  Jie Fang ,  Gavri Grossman ,  Maha El-Sayed

IPC分类号： G01N23/223 ,  G01B15/02

摘要： A method of quantifying an antimicrobial coatings using a handheld XRF analyzer is disclosed. The method provides an estimate of the expected level of antimicrobial efficacy for a thin film comprising silicon and/or titanium by obtaining a 14Si or 22Ti peak intensity using XRF spectroscopy and converting the obtained 14Si or 22Ti peak intensity to the expected level of efficacy using a calibration curve. A properly calibrated handheld XRF analyzer allows a user to assess the viability of antimicrobial coatings in the field, such as in a hospital where various fomites may be coated with silane and/or titanium compositions.

公开(公告)号：US20210308339A1

公开(公告)日：2021-10-07

申请号：US17351453

申请日：2021-06-18

申请人： Allied Bioscience, Inc.

发明人： Craig Grossman ,  Gavri Grossman ,  Daniel Moros ,  Misagh Alipour ,  Jie Fang

IPC分类号： A61L29/16 ,  A01N55/00 ,  A61L29/02 ,  A61L29/08 ,  A61L29/06 ,  A61L31/08 ,  A61L31/16

摘要： The present disclosure provides antimicrobial coating compositions that are used to form residual antimicrobial coatings on medical implements and medical devices including the components of medical equipment such as CPAP/BiPAP machines. Antimicrobial coating compositions comprise at least one of an organosilane (R1O)3Si—R2—Z, an organic amine R9R10R11N, a titanium (IV) species, a 1,2-diol, an α-hydroxy acid, a β-hydroxy acid, and an organosilane grafted parylene polymer, wherein R1 is H, alkyl, substituted alkyl, aryl or substituted aryl, R2 is a bivalent linker, Z is a nucleophile, leaving group, or quaternary nitrogen substituent, and R9, R10 and R11 are independently H, alkyl, substituted alkyl, aryl, substituted aryl or cyclic.

公开(公告)号：US11033031B1

公开(公告)日：2021-06-15

申请号：US17200245

申请日：2021-03-12

申请人： ALLIED BIOSCIENCE, INC.

发明人： Gavri Grossman ,  Jie Fang ,  Parham Asgari ,  Maha El-Sayed ,  Valerie Beck ,  Elias Shaheen

IPC分类号： C09D183/08 ,  A01N55/00 ,  A01N59/16 ,  A61L2/00 ,  C09D5/14 ,  A01N25/02 ,  A01N33/08 ,  B05D1/02 ,  B05D7/14 ,  B05D7/00 ,  C09D179/02 ,  C23C26/00 ,  B05D1/04 ,  C08G77/26 ,  C08K3/22 ,  C09D183/00

摘要： An aqueous antimicrobial coating composition capable of forming an antimicrobial coating on a surface comprises at least two organosilanes, each of the at least two organosilanes having a structure, R—Si(OR′)3 wherein R=—(CH2)3—Y; Y=+—N(CH3)2(C18H37)X−; +—N(CH3)2(C14H29)X−; +—N(C10H21)2(CH3)X−; —Cl or —NH2; X−=halide, sulfate, nitrate, phosphate, carbonate, organic sulfonate, organic carbonate, BF4−, or ClO4−; and R′=H, methyl or ethyl, or a C3-C6 straight-chained, branched or cyclic alkyl group, with the proviso that the organosilane R—Si(OR′)3 having the C3-C6 straight-chained, branched or cyclic alkyl group hydrolyzes in the aqueous antimicrobial coating composition to R—Si(OH)3.

公开(公告)号：US11020278B2

公开(公告)日：2021-06-01

申请号：US15938314

申请日：2018-03-28

申请人： Allied Bioscience, Inc.

发明人： Craig Grossman ,  Gavri Grossman ,  Daniel Moros ,  Misagh Alipour ,  Jie Fang

IPC分类号： A61F13/00 ,  A61K31/695 ,  A61F13/84

摘要： Antimicrobial coating compositions are used to form dried residual antimicrobial coatings on medical dressings including gauze, bandages, gowns and dry wipers. Antimicrobial coating compositions comprise at least one of an organosilane (R1O)3Si—R2—Z, an organic amine R9R10R11N a titanium (IV) species, a 1,2-diol, an α-hydroxy acid, a β-hydroxy acid, and an organosilane grafted parylene polymer, wherein R1 is H, alkyl, substituted alkyl, aryl or substituted aryl, R2 is a bivalent linker, Z is a nucleophile, leaving group, or quaternary nitrogen substituent and R9, R10, and R11 are independently H, alkyl, substituted alkyl, aryl, substituted aryl or cyclic.

公开(公告)号：US20200240935A1

公开(公告)日：2020-07-30

申请号：US16749343

申请日：2020-01-22

申请人： Allied Bioscience, Inc.

发明人： Parham Asgari ,  Jie Fang ,  Gavri Grossman ,  Maha El-Sayed

IPC分类号： G01N23/223 ,  G01B15/02

摘要： A method of quantifying an antimicrobial coatings using a handheld XRF analyzer is disclosed. The method provides an estimate of the expected level of antimicrobial efficacy for a thin film comprising silicon and/or titanium by obtaining a 14Si or 22Ti peak intensity using XRF spectroscopy and converting the obtained 14Si or 22Ti peak intensity to the expected level of efficacy using a calibration curve. A properly calibrated handheld XRF analyzer allows a user to assess the viability of antimicrobial coatings in the field, such as in a hospital where various fomites may be coated with silane and/or titanium compositions.

公开(公告)号：US20210267208A1

公开(公告)日：2021-09-02

申请号：US17315559

申请日：2021-05-10

申请人： ALLIED BIOSCIENCE, INC.

发明人： Gavri Grossman ,  Jie Fang ,  Parham Asgari ,  Maha El-Sayed ,  Valerie Beck ,  Elias Shaheen

IPC分类号： A01N55/00 ,  C23C26/00 ,  A01N33/08 ,  C09D5/14 ,  C09D179/02 ,  B05D1/04 ,  A01N25/02 ,  B05D1/02 ,  C09D183/08 ,  A01N59/16 ,  B05D7/00 ,  A61L2/00 ,  B05D7/14 ,  C08G77/26

摘要： An aqueous antimicrobial coating composition capable of forming an antimicrobial coating on a surface comprises at least two organosilanes, each of the at least two organosilanes having a structure, R—Si(OR′)3 wherein R=—(CH2)3—Y; Y=+—N(CH3)2(C18H37)X−; +—N(CH3)2(C14H29)X−; +—N(C10H21)2(CH3)X−; —Cl or —NH2; X−=halide, sulfate, nitrate, phosphate, carbonate, organic sulfonate, organic carbonate, BF4−, or ClO4−; and R′=H, methyl or ethyl, or a C3-C6 straight-chained, branched or cyclic alkyl group, with the proviso that the organosilane R—Si(OR′)3 having the C3-C6 straight-chained, branched or cyclic alkyl group hydrolyzes in the aqueous antimicrobial coating composition to R—Si(OH)3.

公开(公告)号：US11077234B2

公开(公告)日：2021-08-03

申请号：US15938417

申请日：2018-03-28

申请人： Allied Bioscience, Inc.

发明人： Craig Grossman ,  Gavri Grossman ,  Daniel Moros ,  Misagh Alipour ,  Jie Fang

IPC分类号： A61L29/16 ,  A01N55/00 ,  A61L29/02 ,  A61L29/08 ,  A61L29/06 ,  A61L31/08 ,  A61L31/16

摘要： The present disclosure provides antimicrobial coating compositions that are used to form residual antimicrobial coatings on medical implements and medical devices including the components of medical equipment such as CPAP/BiPAP machines. Antimicrobial coating compositions comprise at least one of an organosilane (R1O)3Si—R2—Z, an organic amine R9R10R11N, a titanium (IV) species, a 1,2-diol, an α-hydroxy acid, β-hydroxy acid, and an organosilane grafted parylene polymer, wherein R1 is H, alkyl, substituted alkyl, aryl or substituted aryl, R2 is a bivalent linker, Z is a nucleophile, leaving group, or quaternary nitrogen substituent, and R9, R10, and R11 are independently H, alkyl, substituted alkyl, aryl, substituted aryl or cyclic.