公开(公告)号：US20220095570A1

公开(公告)日：2022-03-31

申请号：US17488024

申请日：2021-09-28

Applicant: AMOREPACIFIC CORPORATION ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

Inventor： Young Gyu KANG ,  Moon Young KIM ,  Geum Ryong PARK ,  Seok Ha LEE ,  Hyun Ju JANG ,  Jeong Min HA ,  Myoyeon KIM ,  Dong Hyun KIM ,  Nok Hyun PARK ,  Yong Deog HONG

IPC: A01H6/54 ,  A01H5/10

Abstract: The present disclosure relates to a new soybean variety containing epicatechin with high content and having antioxidant and antiaging activities, a method for producing the new soybean variety, a composition containing an extract of the new soybean variety as an active ingredient, a functional health food containing the new soybean variety, a method for producing epicatechin from the new soybean variety, and a method for producing a commodity plant product. The seed of the new soybean (Glycine max) variety according to an aspect of the present disclosure contains epicatechin with a high content of 2 wt % or more based on the total weight of an 80 wt % ethanol aqueous solution of seed extract, exhibits 2 times or higher antioxidant activity confirmed by DPPH radical-scavenging ability than the mother plant IT109098, and exhibits superior collagenase (matrix metalloproteinase-1, MMP-1) expression inhibition as compared to EGCG, which is known as an antiaging substance.

公开(公告)号：US20190192413A1

公开(公告)日：2019-06-27

申请号：US16331452

申请日：2017-09-06

Applicant: AMOREPACIFIC CORPORATION

Inventor： Young-Gyu KANG ,  Nok Hyun PARK ,  Jun Seong PARK

IPC: A61K8/63 ,  A23L33/10 ,  A61Q19/08 ,  A61K8/36 ,  A61K31/704 ,  A61K31/192 ,  A61P17/18

CPC classification number: A61K8/63 ,  A23L33/10 ,  A23V2002/00 ,  A61K8/36 ,  A61K8/368 ,  A61K8/60 ,  A61K31/192 ,  A61K31/704 ,  A61P17/18 ,  A61Q19/00 ,  A61Q19/08

Abstract: The present specification provides a composition for preventing skin aging, containing, as active ingredients: dehydrogenated abietic acid, a stereoisomer thereof, a salt thereof, a hydrate thereof, or a solvate thereof; and compound K represented by chemical formula (2), a stereoisomer thereof, a salt thereof, a hydrate thereof, or a solvate thereof, thereby having excellent skin cell proliferation effects, collagen production promotion effects, and Lipofuscin accumulation inhibition effects, while not causing any skin side effects.

公开(公告)号：US20190142735A1

公开(公告)日：2019-05-16

申请号：US16308746

申请日：2017-06-26

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyeon Chung KIM ,  Min Jeong SONG ,  Eun Jung LEE ,  Nok Hyun PARK ,  Ji Yeong KIM

IPC: A61K8/9728 ,  A61Q19/08 ,  A61Q19/00 ,  A61K8/67 ,  A61K8/365 ,  A61K8/66 ,  A61K8/02

Abstract: The present invention relates to an antioxidant composition for the skin. More specifically, it relates to an antioxidant composition for the skin having: Saccharomyces ferment; and 60 -ketoglutaric acid or niacinamide alone or a mixture thereof. The antioxidant composition for the skin according to the present invention has not only an excellent antioxidant effect but also a high long lasting effect. Therefore, it provides an enhanced antioxidant effect when applied to the skin and it enables manufacture of various products such as cosmetics and medicines because it is not harmful to the human body.

公开(公告)号：US20240269204A1

公开(公告)日：2024-08-15

申请号：US18436603

申请日：2024-02-08

Applicant: AMOREPACIFIC CORPORATION

Inventor： Eunmi KIM ,  Nok Hyun PARK

IPC: A61K36/064 ,  A61K8/9728 ,  A61K36/82 ,  A61P17/00 ,  A61Q19/08 ,  C12N1/18 ,  C12R1/865

CPC classification number: A61K36/064 ,  A61K8/9728 ,  A61K36/82 ,  A61P17/00 ,  A61Q19/08 ,  C12N1/185 ,  A61K2236/333 ,  C12R2001/865

Abstract: The present specification relates to a composition for alleviating skin damage due to hypoxia, which contains one or more selected from the group consisting of a Saccharomyces cerevisiae strain; its lysate; its culture; and an extract of the strain, lysate, or culture as an active ingredient, and a novel Saccharomyces cerevisiae strain, and the composition, which contains one or more selected from the group consisting of a Saccharomyces cerevisiae strain; its lysate; its culture; and an extract of the strain, lysate, or culture as an active ingredient, according to an aspect of the present invention is effective in inhibiting the expression of MMP1 and COX2 overexpressed in skin in a hypoxic environment, and is thus excellently effective in improving skin damaged by exposure to a hypoxic environment for a long period of time or repeatedly or alleviating skin damage due to hypoxia.

公开(公告)号：US20210338565A1

公开(公告)日：2021-11-04

申请号：US17271790

申请日：2019-08-26

Applicant: AMOREPACIFIC CORPORATION

Inventor： Gayoung CHO ,  Lee Kyoung KWON ,  Sowoong CHOI ,  Nok Hyun PARK ,  Eun Soo LEE ,  Byungfhy SUH ,  Seonga CHO

IPC: A61K8/9789 ,  A61K8/9767 ,  A61Q19/02

Abstract: In the present specification, a composition for improving skin transparency and a composition for reducing skin dullness are disclosed. The composition contains a mixed extract of Rosa Multiflorae Fructus, black sesame, plum, quince, and pine nut as an active ingredient, wherein the Rosa Multiflorae Fructus and black sesame may be germinated. Also, the composition has the effect of improving skin that has become dull due to the effects of aging, the external environment, stress, etc., so that the skin is made clear and transparent.

公开(公告)号：US20200253859A1

公开(公告)日：2020-08-13

申请号：US16651966

申请日：2018-09-20

Applicant: AMOREPACIFIC CORPORATION

Inventor： Jin Sup SHIM ,  Eun Jung LEE ,  Nok Hyun PARK ,  So Woong CHOI ,  Yong Jin KIM

IPC: A61K8/9728 ,  A61K8/73 ,  A61K8/31 ,  A61Q19/08

Abstract: A method for preparing Ganoderma lucidum extract using an eco-friendly extraction technique is disclosed. A Ganoderma lucidum extract prepared thereby and a cosmetic composition containing the extract, and their uses are disclosed. The extraction technique use an aqueous cyclodextrin solution alone or in combination with ultrasonic extraction to afford a Ganoderma lucidum extract containing a high concentration of the effective ingredient triterpenoid.

公开(公告)号：US20160106864A1

公开(公告)日：2016-04-21

申请号：US14883327

申请日：2015-10-14

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyung Jun LIM ,  Nok Hyun PARK ,  Yuri CHOI ,  Il-Hong BAE ,  Myeong Jin GOH ,  Jae Won YOU ,  Song Seok SHIN ,  Jon Hwan LEE

IPC: A61K47/48 ,  A61K8/64 ,  A61K9/107 ,  A61Q19/00 ,  A61K9/127 ,  A61K8/06 ,  A61K9/00 ,  A61K8/14

CPC classification number: A61K9/1075 ,  A61K8/0241 ,  A61K8/042 ,  A61K8/062 ,  A61K8/14 ,  A61K8/64 ,  A61K9/0014 ,  A61K9/1271 ,  A61K9/1275 ,  A61K47/62 ,  A61K47/6911 ,  A61K2800/654 ,  A61Q1/02 ,  A61Q19/00 ,  A61Q19/10

Abstract: The present disclosure relates to a drug delivery carrier containing a lipid structure or a polymer particle which is covalently bonded to a cell-penetrating AP-GRR peptide (SEQ ID NO 1) or is modified with the peptide chain containing the peptide. The present disclosure also relates to a composition containing the drug delivery carrier and a physiologically active ingredient encapsulated in the carrier. The drug delivery carrier of the present disclosure can effectively deliver macromolecules that are difficult to be delivered into cells, thereby improving the bioavailability of the macromolecules.

Abstract translation: 本公开内容涉及含有脂质结构或聚合物颗粒的药物递送载体，其共价结合到细胞穿透性AP-GRR肽（SEQ ID NO 1）或用含有肽的肽链进行修饰。 本公开还涉及包含药物递送载体和包封在载体中的生理活性成分的组合物。 本公开的药物递送载体可以有效地递送难以递送到细胞中的大分子，从而提高大分子的生物利用度。

公开(公告)号：US20210275435A1

公开(公告)日：2021-09-09

申请号：US16321782

申请日：2017-07-25

Applicant: AMOREPACIFIC CORPORATION

Inventor： Se Jin YOO ,  Nok Hyun PARK ,  Yu Jin OH ,  Hyunwoo LEE ,  Yong-Jin KIM

IPC: A61K8/9789 ,  A61K36/736 ,  A61K36/65 ,  A61Q19/00

Abstract: Disclosed herein are a composition for inhibiting sebum secretion comprising a peach sprout extract as an active ingredient, and a composition for inhibiting sebum secretion comprising a mixed extract of peach sprout and peony as an active ingredient. The extract can inhibit an overproduction of sebum and regulates secretion of sebum, thereby not only imparting elasticity to the pores but also suppressing the aging of the pores and exhibiting a pore-contraction effect.

公开(公告)号：US20200297601A1

公开(公告)日：2020-09-24

申请号：US16089161

申请日：2017-03-29

Applicant: AMOREPACIFIC CORPORATION

Inventor： Sejin YOO ,  Nok Hyun PARK ,  Jeong AH ,  Hyunwoo LEE ,  Yongjin KIM

IPC: A61K8/37 ,  A61K8/42 ,  A61Q19/00 ,  A61Q19/02

Abstract: The present specification relates to a composition for skin moisturizing or skin whitening, containing, as an active ingredient: 3β,23,28-trihydroxy-12-oleanene 23-caffeate, a salt thereof, an isomer thereof, a hydrate thereof or a solvate thereof; and/or 3β,23,28-trihydroxy-12-oleanene 3β-caffeate, an isomer thereof, a hydrate thereof or a solvate thereof, wherein the composition can be used as a composition for external application to the skin or as a cosmetic composition, and the composition has a skin moisturization or skin whitening effect.

公开(公告)号：US20200069566A1

公开(公告)日：2020-03-05

申请号：US16550758

申请日：2019-08-26

Applicant: AMOREPACIFIC CORPORATION

Inventor： Eunjung LEE ,  Nok Hyun PARK ,  Hyangtae CHOI ,  Young Gyu KANG ,  Dong Hyun KIM ,  Yong Jin KIM

IPC: A61K8/9789 ,  A61K8/34 ,  A61Q19/08

Abstract: Disclosed is to provide a composition for enhancing skin elasticity or improving skin wrinkles, which comprises a polyol as a dispersion medium, and a ginseng cell lysate dispersed in the polyol as an active ingredient. Specifically, the composition according to the present disclosure contains a polyol and all useful substances in ginseng cells dispersed in a polyol as an active ingredient, thereby exhibiting excellent skin elasticity enhancement or skin winkle improvement effects. In addition, the preparing method according to the present disclosure can effectively disperse useful substances in ginseng cells in the polyol by using a micro fluidizer, and thus can exhibit synergistic effects of useful substances in ginseng cells.