-
公开(公告)号：US20140303003A1
公开(公告)日：2014-10-09
申请号：US14229663
申请日：2014-03-28
Applicant: APPLIED BIOSYSTEMS, LLC
Inventor： Ronald Graham , Ruiming Zou , Krishna Upadhya , Scott Benson
CPC classification number: C07H21/00 , C07D219/06 , C09B15/00 , C09K11/06 , C09K2211/1011 , C09K2211/1029 , C12Q1/6816 , C12Q1/6869 , G01N33/582 , Y10S436/80 , Y10T436/143333
Abstract: The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof.
Abstract translation: 本教导通常涉及荧光染料，荧光染料的可连接形式，能量转移染料，用荧光染料标记的试剂及其用途。
-
公开(公告)号：US08637658B2
公开(公告)日：2014-01-28
申请号：US13629021
申请日：2012-09-27
Applicant: Debra Kay Ewing-Fieri , Applied Biosystems, LLC
Inventor： Gregory J. Ewing , Khairuzzaman Bashar Mullah , Ronald Graham
IPC: C07H19/04 , C07D221/18 , C12Q1/00 , A61K38/00
CPC classification number: C07C245/08 , C07C245/10 , C07C255/67 , C07C317/32 , C07D207/46 , C07D241/16 , C07F7/1804 , C07F9/1411 , C07F9/2404 , C12Q1/68 , G01N21/6486 , G01N33/533 , C12Q2563/107
Abstract: Bis-diazo, triaryl and aryldiazo-N-arylphenazonium quencher moieties, substituted with electron-withdrawing and electron-donating substituents which induce polarity in the delocalized aryl/diazo ring systems, are useful as labels when attached to biomolecules such as polynucleotides, nucleosides, nucleotides and polypeptides. The quencher moieties are non-fluorescent and accept energy transfer from fluorescent reporter labels by any energy-transfer mechanism, such as FRET.Fluorescence quencher compositions are useful in preparing quencher labeled biomolecules for various molecular biology assays based on fluorescence detection.
Abstract translation: 由引发极性的离域芳基/重氮环体系中的吸电子取代基和给电子取代基取代的双重氮，三芳基和芳基二偶氮-N-芳基吩唑猝灭剂部分可用作生物分子如多核苷酸，核苷， 核苷酸和多肽。 猝灭剂部分是非荧光的，并且通过任何能量转移机制（例如FRET）接受来自荧光报告物标记物的能量转移。 荧光猝灭剂组合物可用于制备猝灭标记的生物分子，用于基于荧光检测的各种分子生物学测定。
-
3.发明申请公开(公告)号：US20150038368A1
公开(公告)日：2015-02-05
申请号：US14457014
申请日：2014-08-11
Applicant: APPLIED BIOSYSTEMS, LLC
Inventor： Timothy Z. LIU , Jer-Kang Chen , Ronald Graham
CPC classification number: C12Q1/686 , B01J19/0046 , B01J2219/00387 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/00619 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , B01L3/50851 , B01L3/5088 , B01L7/52 , B01L2300/0636 , B01L2300/0819 , C12N15/1093 , C40B50/18 , C40B80/00
Abstract: A method, apparatus, or system for generating a pattern of polynucleotides on a substrate. The method includes providing a substrate having a hydrophobic surface. The method further includes conjugating a polystyrene moiety to a polynucleotide and applying a polystyrene-polynucleotide conjugate to create a plurality of reaction spots on the hydrophobic surface of the substrate. An apparatus includes a substrate with at least one polystyrene-polynucleotide conjugate on a surface of the substrate. A system can analyze a polystyrene-polynucleotide conjugate and the system may perform PCR.
Abstract translation: 一种用于在衬底上产生多核苷酸图案的方法，装置或系统。 该方法包括提供具有疏水表面的基底。 该方法还包括将聚苯乙烯部分与多核苷酸缀合并施加聚苯乙烯 - 多核苷酸缀合物，以在基底的疏水性表面上产生多个反应点。 一种装置包括在基底表面上具有至少一个聚苯乙烯 - 多核苷酸缀合物的底物。 系统可以分析聚苯乙烯 - 多核苷酸缀合物，并且系统可以进行PCR。
-
公开(公告)号：US09745336B2
公开(公告)日：2017-08-29
申请号：US14229663
申请日：2014-03-28
Applicant: APPLIED BIOSYSTEMS, LLC
Inventor： Ronald Graham , Ruiming Zou , Krishna Upadhya , Scott Benson
CPC classification number: C07H21/00 , C07D219/06 , C09B15/00 , C09K11/06 , C09K2211/1011 , C09K2211/1029 , C12Q1/6816 , C12Q1/6869 , G01N33/582 , Y10S436/80 , Y10T436/143333
Abstract: The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof.
-
-
-
Search Results
4
records
(took 0.014 seconds)
