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    Method of making hydroxamic acid polymers from primary amide polymers
    2.
    发明授权
    Method of making hydroxamic acid polymers from primary amide polymers 失效
    由一级酰胺聚合物制备异羟肟酸聚合物的方法

    公开(公告)号：US5128420A

    公开(公告)日：1992-07-07

    申请号：US283594

    申请日：1988-12-13

    申请人： Abraham J. Domb ,  Robert S. Langer ,  Ernest G. Cravalho ,  Gershon Golomb ,  Edith Mathiowitz ,  Cato T. Laurencin

    发明人： Abraham J. Domb ,  Robert S. Langer ,  Ernest G. Cravalho ,  Gershon Golomb ,  Edith Mathiowitz ,  Cato T. Laurencin

    IPC分类号： C08F8/32

    CPC分类号： C08F8/32 ,  C08F2800/10 ,  C08F2810/20

    摘要： A method for preparing hydroxamic acid polymers from primary amide polymers wherein polyvinyl monomers such as polyacrylamide are reacted with hydroxyl amine in aqueous solution at room temperature. The low reaction temperature is crucial to producing a high yield (70%) of polymer with hydroxamic acid groups and having a low carboxylic acid content (less than 15%, preferably less than 3%). The polymers display high metal affinity over a broad pH range.The polymers are particularly useful for biomedical applications due to the low carboxylic acid content and for the removal and purification of metals due to the high binding constants and rapid reaction rates.

    摘要翻译： 由聚酰胺聚合物制备异羟肟酸聚合物的方法，其中聚乙烯基单体例如聚丙烯酰胺在室温下与羟胺在水溶液中反应。 低反应温度对于用异羟肟酸基团产生高产率（70％）的聚合物和低羧酸含量（小于15％，优选小于3％）是至关重要的。 聚合物在宽pH范围内显示出高的金属亲和力。 由于高的结合常数和快速的反应速率，由于羧酸含量低以及金属的去除和纯化，聚合物特别适用于生物医学应用。

    Controlled drug delivery high molecular weight polyanhydrides
    4.
    发明授权
    Controlled drug delivery high molecular weight polyanhydrides 失效
    受控药物递送高分子量聚酐

    公开(公告)号：US4888176A

    公开(公告)日：1989-12-19

    申请号：US61294

    申请日：1987-06-12

    申请人： Robert S. Langer ,  Abraham J. Domb ,  Cato T. Laurencin

    发明人： Robert S. Langer ,  Abraham J. Domb ,  Cato T. Laurencin

    IPC分类号： A61L17/10 ,  A61L27/18 ,  A61L27/58 ,  C08G67/04

    CPC分类号： C08G67/04 ,  A61L17/10 ,  A61L27/18 ,  A61L27/58

    摘要： A bioerodible controlled drug release device is produced as a homogeneous polymeric matrix from a high molecular weight polyanhydride and a suitable biologically active substance. The high molecular weight polyanhydride is defined by a molecular weight greater than 20,000 and an intrinsic viscosity greater than 0.3 dl/g. The controlled drug release device is preferrably formed by solvent casting with the biologically active substance and exhibits zero order release, improved correlation between the rate of release and polymer degradation, and an induction period between introduction to the eroding environment and the initial release of the biologically active substance. The controlled drug release devices are stable for extended periods of time, flexible and durable and not subject to fracture and disintegration.

    摘要翻译： 生物腐蚀控制药物释放装置由高分子量聚酐和合适的生物活性物质制成均匀的聚合物基质。 高分子量聚酐的分子量大于20,000，特性粘度大于0.3dl / g。 受控药物释放装置优选地通过与生物活性物质的溶剂流延形成并显示零级释放，改善释放速率和聚合物降解之间的相关性，以及引入到侵蚀环境和生物学上的初始释放之间的诱导期 活性物质。 受控药物释放装置长时间稳定，柔韧耐用，不会破裂和分解。