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公开(公告)号：US20180057604A1
公开(公告)日：2018-03-01
申请号：US15525821
申请日：2015-11-18
申请人： Genentech, Inc. , Adimab LLC
发明人： Yichin Liu , Jasvinder Atwal , Cecilia Pui Chi Chiu , Ryan J. Watts , Yan WU , Eric Krauland , Michael Feldhaus , Yin Zhang , Joy Yu Zuchero , Jessica Couch , Mark S Dennis , James A Ernst , Gregory A Lazar
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/22 , C07K16/2881 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/41 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/528 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C12Y304/23046 , G01N33/6896 , G01N2333/70582 , G01N2333/96472 , G01N2800/28 , G01N2800/52
摘要： The present invention relates to bispecific antibodies that bind to transferrin receptor and BACE1 and methods of using the same.
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公开(公告)号：US20030224517A1
公开(公告)日：2003-12-04
申请号：US10163272
申请日：2002-06-04
发明人： Kenneth W. Dobie
IPC分类号： A61K048/00 , C07H021/04 , C12N005/00
CPC分类号： C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y304/23046 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of beta-site APP-cleaving enzyme 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding beta-site APP-cleaving enzyme 2. Methods of using these compounds for modulation of beta-site APP-cleaving enzyme 2 expression and for treatment of diseases associated with expression of beta-site APP-cleaving enzyme 2 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节β-位点APP切割酶2的表达。该组合物包含靶向编码β-位点APP切割酶的核酸的反义化合物，特别是反义寡核苷酸2.使用这些 提供了用于调节β位点APP切割酶2表达和用于治疗与β位点APP切割酶2的表达相关的疾病的化合物。
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公开(公告)号：US11746160B2
公开(公告)日：2023-09-05
申请号：US17113711
申请日：2020-12-07
申请人： Genentech, Inc. , Adimab LLC
发明人： Yichin Liu , Jasvinder Atwal , Cecilia Pui Chi Chiu , Ryan J. Watts , Yan Wu , Eric Krauland , Michael Feldhaus
IPC分类号： C12N15/52 , C07K16/40 , A61K47/68 , G01N33/573 , A61K39/00
CPC分类号： C07K16/40 , A61K47/6871 , C12N15/52 , C12Y304/23046 , G01N33/573 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/90 , C07K2317/92 , G01N2333/96472 , G01N2800/28 , G01N2800/52
摘要： The invention provides antagonistic antibodies to BACE1 and methods of using the same for the treatment of neurological disease and disorders.
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4.发明申请公开(公告)号：US20180038875A1
公开(公告)日：2018-02-08
申请号：US15552041
申请日：2016-02-18
发明人： Esther Oh , Constantine Lyketsos , Suzanne Craft
CPC分类号： G01N33/6896 , A61K38/488 , C07K16/18 , C07K2317/76 , C12Y304/23046 , G01N33/48 , G01N33/66 , G01N2333/4709 , G01N2333/605 , G01N2333/62 , G01N2800/2814 , G01N2800/2821 , G01N2800/50 , G01N2800/52
摘要： Described herein are methods of identifying a mammal having a neurological disease or disorder, such as AD or MCI, or at risk for developing a neurological disease or disorder, such as AD or MCI. Provided herein are also methods of monitoring the progression of a neurological disease or disorder in a patient or monitoring the effectiveness of therapeutic agent or treatment of a patient having a neurological disease or disorder.
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公开(公告)号：US20170362339A1
公开(公告)日：2017-12-21
申请号：US15525791
申请日：2015-11-18
申请人： Genentech, Inc. , Adimab LLC
发明人： Yichin Liu , Jasvinder Atwal , Cecilia Pui Chi Chiu , Ryan J. Watts , Yan WU , Eric Krauland , Michael Feldhaus
IPC分类号： C07K16/40 , G01N33/573 , A61K47/68 , A61K39/00
CPC分类号： C07K16/40 , A61K47/6871 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C12Y304/23046 , G01N33/573 , G01N2333/96472 , G01N2800/28 , G01N2800/52
摘要： The invention provides antagonistic antibodies to BACE1 and methods of using the same for the treatment of neurological disease and disorders.
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公开(公告)号：US07829303B1
公开(公告)日：2010-11-09
申请号：US12206421
申请日：2008-09-08
CPC分类号： C12N9/6421 , C07K2299/00 , C12Y304/23046
摘要： The x-ray crystal structure of BACE or BACE-like proteins is useful for solving the structure of other molecules or molecular complexes, and identifying and/or designing potential modifiers of BACE activity.
摘要翻译： BACE或BACE样蛋白的x射线晶体结构可用于解决其他分子或分子复合物的结构，以及鉴定和/或设计BACE活性的潜在修饰剂。
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公开(公告)号：US20240075047A1
公开(公告)日：2024-03-07
申请号：US18506916
申请日：2023-11-10
申请人： UNIVERSITY OF SOUTH FLORIDA , THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
IPC分类号： A61K31/675 , A61K31/122 , A61K33/242 , A61P25/28
CPC分类号： A61K31/675 , A61K31/122 , A61K33/242 , A61P25/28 , C12Y304/23046
摘要： Provided herein are formulations effective for and methods of treating or preventing a neurodegenerative disorder in a subject in need thereof that can include administering an amount of an aPKC inhibitor to a subject in need thereof.
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8.发明申请METHOD FOR TREATMENT OF DEGENERATIVE BRAIN DISORDERS COMPRISING INHIBITOR OF SUM01 AND BACE1 INTERACTION AS AN ACTIVE INGREDIENT 审中-公开用于治疗包含SUM01和BACE1抑制剂的变应性脑疾病的方法作为活性成分公开(公告)号：US20140186357A1
公开(公告)日：2014-07-03
申请号：US14021210
申请日：2013-09-09
发明人： Young Ho Koh , Sang Moon Yun , Sun-Jung Cho , Chulman Jo , Sangmee Ahn , Jae Chun Song , Sung Yeon Song
IPC分类号： C12N15/113 , G01N33/50 , G01N33/68 , C12Q1/68 , A61K38/02 , A61K39/395
CPC分类号： C12N15/1138 , A61K38/43 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/16 , C12N2310/531 , C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , C12Y304/23046 , G01N33/6896 , G01N2500/10
摘要： A treatment method for degenerative brain disorders using a pharmaceutically effective dose of the inhibitor of SUMO1 (small ubiquitin-like modifier 1) and BACE1 (β-secretase) interaction, or the inhibitor of SUMO1 expression or activation is provided. More specifically, it was confirmed that SUMO1 increased BACE1 accumulation and Aβ generation, that is SUMO1 regulated BACE1 accumulation by interacting with BACE1, and BACE1 dileucine motif was involved in SUMO1-mediated BACE1 accumulation. In addition, SUMO1 protein induced autophagy in H4 cells, while SUMO1 depletion reduced LC3-II level. It was further confirmed that SUMO1 and LC3 were co-localized in the cortex of APP transgenic mice. As shown herein, a pharmaceutically effective dose of the inhibitor of SUMO1 and BACE1 interaction or the inhibitor of SUMO1 expression can be effectively used for the treatment of degenerative brain disorders.
摘要翻译： 提供了使用药学有效剂量的SUMO1抑制剂（小泛素样修饰物1）和BACE1（＆amp;分泌酶）相互作用或SUMO1表达或激活抑制剂的退行性脑病的治疗方法。 更具体地说，证实了SUMO1增加了BACE1的积累和A＆bgr; 一代，即SUMO1通过与BACE1相互作用调节BACE1的积累，BACE1二亚氨酸基序参与SUMO1介导的BACE1积累。 此外，SUMO1蛋白在H4细胞中诱导自噬，而SUMO1消耗降低LC3-II水平。 进一步证实，SUMO1和LC3共定位于APP转基因小鼠的皮质中。 如本文所示，药物有效剂量的SUMO1和BACE1相互作用的抑制剂或SUMO1表达的抑制剂可以有效地用于治疗退行性脑病。
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公开(公告)号：US20130108645A1
公开(公告)日：2013-05-02
申请号：US13640984
申请日：2011-04-13
申请人： Mohamed H. Farah
发明人： Mohamed H. Farah
IPC分类号： A61K31/7088 , A61K39/395
CPC分类号： A61K31/7088 , A61K31/18 , A61K39/3955 , C12N9/6478 , C12Y304/23046
摘要： The invention provides novel methods of enhancing axonal regeneration. The methods of the invention are suitable for use in treating a subject suffering from a nerve injury.
摘要翻译： 本发明提供增强轴索再生的新方法。 本发明的方法适用于治疗患有神经损伤的受试者。
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10.发明申请公开(公告)号：US20100204309A1
公开(公告)日：2010-08-12
申请号：US12450698
申请日：2008-04-21
IPC分类号： A61K31/7088 , C12Q1/68 , C07H21/04 , A61P25/28
CPC分类号： C12N15/1137 , A61K31/7105 , C12N15/113 , C12N2310/11 , C12N2310/113 , C12N2310/141 , C12N2310/321 , C12N2310/3513 , C12Y304/23046 , C12N2310/3521
摘要： The invention relates to the identification of microRNAs whose expression is diminished in neurodegenerative disorders. In particular, the identified microRNAs can be used for the downregulation of the beta-secretase (BACE1) in mammalian brain and hence for the treatment of Alzheimer's disease.
摘要翻译： 本发明涉及在神经变性疾病中表达减弱的微小RNA的鉴定。 特别地，鉴定的微小RNA可用于哺乳动物脑中的β-分泌酶（BACE1）的下调，因此用于治疗阿尔茨海默病。
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