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公开(公告)号：US10882920B2
公开(公告)日：2021-01-05
申请号：US15525791
申请日：2015-11-18
申请人： Genentech, Inc. , Adimab LLC
发明人： Yichin Liu , Jasvinder Atwal , Cecilia Pui Chi Chiu , Ryan J. Watts , Yan Wu , Eric Krauland , Michael Feldhaus
IPC分类号： C07K16/40 , A61K47/68 , A61K39/00 , G01N33/573
摘要： The invention provides antagonistic antibodies to BACE1 and methods of using the same for the treatment of neurological disease and disorders.
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公开(公告)号：US20180057604A1
公开(公告)日：2018-03-01
申请号：US15525821
申请日：2015-11-18
申请人： Genentech, Inc. , Adimab LLC
发明人： Yichin Liu , Jasvinder Atwal , Cecilia Pui Chi Chiu , Ryan J. Watts , Yan WU , Eric Krauland , Michael Feldhaus , Yin Zhang , Joy Yu Zuchero , Jessica Couch , Mark S Dennis , James A Ernst , Gregory A Lazar
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/22 , C07K16/2881 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/41 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/528 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C12Y304/23046 , G01N33/6896 , G01N2333/70582 , G01N2333/96472 , G01N2800/28 , G01N2800/52
摘要： The present invention relates to bispecific antibodies that bind to transferrin receptor and BACE1 and methods of using the same.
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公开(公告)号：US20170362339A1
公开(公告)日：2017-12-21
申请号：US15525791
申请日：2015-11-18
申请人： Genentech, Inc. , Adimab LLC
发明人： Yichin Liu , Jasvinder Atwal , Cecilia Pui Chi Chiu , Ryan J. Watts , Yan WU , Eric Krauland , Michael Feldhaus
IPC分类号： C07K16/40 , G01N33/573 , A61K47/68 , A61K39/00
CPC分类号： C07K16/40 , A61K47/6871 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C12Y304/23046 , G01N33/573 , G01N2333/96472 , G01N2800/28 , G01N2800/52
摘要： The invention provides antagonistic antibodies to BACE1 and methods of using the same for the treatment of neurological disease and disorders.
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公开(公告)号：US11008403B2
公开(公告)日：2021-05-18
申请号：US15525821
申请日：2015-11-18
申请人： Genentech, Inc. , Adimab LLC
发明人： Yichin Liu , Jasvinder Atwal , Cecilia Pui Chi Chiu , Ryan J. Watts , Yan Wu , Eric Krauland , Michael Feldhaus , Yin Zhang , Joy Yu Zuchero , Jessica Couch , Mark S Dennis , James A Ernst , Gregory A Lazar
摘要： The present invention relates to bispecific antibodies that bind to transferrin receptor and BACE1 and methods of using the same.
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公开(公告)号：US20210206877A1
公开(公告)日：2021-07-08
申请号：US17113711
申请日：2020-12-07
申请人： Genentech, Inc. , Adimab LLC
发明人： Yichin Liu , Jasvinder Atwal , Cecilia Pui Chi Chiu , Ryan J. Watts , Yan Wu , Eric Krauland , Michael Feldhaus
IPC分类号： C07K16/40 , A61K47/68 , G01N33/573
摘要： The invention provides antagonistic antibodies to BACE1 and methods of using the same for the treatment of neurological disease and disorders
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公开(公告)号：US09879094B2
公开(公告)日：2018-01-30
申请号：US15234649
申请日：2016-08-11
申请人： Genentech, Inc.
发明人： Jasvinder Atwal , Yongmei Chen , Cecilia Pui Chi Chiu , Robert A. Lazarus , Weiru Wang , Ryan J. Watts , Yan Wu , Yingnan Zhang
IPC分类号： C07H21/04 , C07K16/18 , C12P21/08 , C07K16/40 , A61K39/395 , G01N33/573 , C12P21/00 , A61K47/68 , A61K39/00
CPC分类号： C07K16/40 , A61K39/3955 , A61K47/6871 , A61K2039/505 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12P21/005 , G01N33/573
摘要： The invention provides antibodies to specific neural proteins and methods of using the same.
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公开(公告)号：US20180000964A1
公开(公告)日：2018-01-04
申请号：US15618467
申请日：2017-06-09
申请人： Genentech, Inc.
发明人： Christine Tan , Ryan J. Watts , Joy Yu Zuchero , Xiaocheng Chen , Mark S. Dennis
CPC分类号： A61K47/6849 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K16/18 , C07K16/26 , C07K16/2803 , C07K16/2896 , C07K16/40 , C07K2317/31 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/92 , C12Y304/23046
摘要： The present invention relates to antibodies that bind to receptors expressed on the blood brain barrier and methods of using the same.
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公开(公告)号：US20170058049A1
公开(公告)日：2017-03-02
申请号：US15234649
申请日：2016-08-11
申请人： Genentech, Inc.
发明人： Jasvinder Atwal , Yongmei Chen , Cecilia Pui Chi Chiu , Robert A. Lazarus , Weiru Wang , Ryan J. Watts , Yan Wu , Yingnan Zhang
CPC分类号： C07K16/40 , A61K39/3955 , A61K47/6871 , A61K2039/505 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12P21/005 , G01N33/573
摘要： The invention provides antibodies to specific neural proteins and methods of using the same.
摘要翻译： 本发明提供了针对特定神经蛋白的抗体及其使用方法。
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公开(公告)号：US08795660B2
公开(公告)日：2014-08-05
申请号：US13740080
申请日：2013-01-11
申请人： Genentech, Inc.
发明人： Ryan J. Watts , Yan Wu
IPC分类号： A61K39/395
CPC分类号： C07K16/2863 , A61K31/404 , A61K31/502 , A61K31/506 , A61K31/517 , A61K31/661 , A61K31/69 , A61K39/3955 , A61K39/39558 , A61K45/06 , C07K16/22 , C07K16/3023 , C07K2317/31 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Novel anti-NRP1 antibodies and variants thereof having unique structural and functional characteristics are disclosed. Also provided are uses of the antibodies in research, diagnostic and therapeutic applications.
摘要翻译： 公开了具有独特结构和功能特征的新型NRP1抗体及其变体。 还提供了抗体在研究，诊断和治疗应用中的用途。
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公开(公告)号：US20130115214A1
公开(公告)日：2013-05-09
申请号：US13740080
申请日：2013-01-11
申请人： GENENTECH, INC.
发明人： Ryan J. Watts , Yan WU
IPC分类号： C07K16/28 , A61K31/69 , A61K31/506 , A61K31/517 , A61K31/404 , A61K31/661 , A61K39/395 , A61K31/502
CPC分类号： C07K16/2863 , A61K31/404 , A61K31/502 , A61K31/506 , A61K31/517 , A61K31/661 , A61K31/69 , A61K39/3955 , A61K39/39558 , A61K45/06 , C07K16/22 , C07K16/3023 , C07K2317/31 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Novel anti-NRP1 antibodies and variants thereof having unique structural and functional characteristics are disclosed. Also provided are uses of the antibodies in research, diagnostic and therapeutic applications.
摘要翻译： 公开了具有独特结构和功能特征的新型NRP1抗体及其变体。 还提供了抗体在研究，诊断和治疗应用中的用途。
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