公开(公告)号：US20020187288A1

公开(公告)日：2002-12-12

申请号：US09879023

申请日：2001-06-11

申请人： Advanced Cardiovascular Systems, Inc.

发明人： Florencia Lim ,  Christopher J. Buchko ,  Ashok A. Shah ,  Murthy V. Simhambhatla

IPC分类号： B32B001/08

CPC分类号： A61L31/146 ,  A61F2/07 ,  A61F2002/072 ,  A61L27/18 ,  A61L27/56 ,  A61L29/06 ,  A61L29/146 ,  A61L31/06 ,  Y10T428/1334 ,  Y10T428/139 ,  C08L75/04

摘要： A medical device, and particularly an intracorporeal device for therapeutic or diagnostic use, comprising a silicone polyurethane. One embodiment of the invention is a medical device having a body formed of melt process extruded, porous silicone polyurethane material. In a method of the invention, the silicone polyurethane is combined with a porogen and then melt process extruded into a desired shape such as a tubular body. The porogen is then extracted from the extrudate, to form the extruded, melt processed, porous silicone polyurethane tubular body. The medical device, such as a stent cover, vascular graft, or catheter balloon, formed of the silicone polyurethane has excellent biostability, strength, and flexibility.

摘要翻译： 医疗装置，特别是用于治疗或诊断用途的体内器械，其包含硅氧烷聚氨酯。 本发明的一个实施方案是具有由熔融加工挤出的多孔硅氧烷聚氨酯材料形成的主体的医疗装置。 在本发明的方法中，将硅氧烷聚氨酯与致孔剂组合，然后熔融加工成挤出成所需形状如管状体。 然后从挤出物中提取致孔剂，以形成挤出的熔融加工的多孔硅氧烷聚氨酯管体。 由硅氧烷聚氨酯形成的医疗装置，例如支架盖，血管移植物或导管球囊具有优异的生物稳定性，强度和柔韧性。

公开(公告)号：US20010027329A1

公开(公告)日：2001-10-04

申请号：US09880983

申请日：2001-06-13

申请人： Advanced Cardiovascular Systems, Inc.

发明人： Murthy V. Simhambhatla ,  Venu Ghanta ,  Timoteo Tomas

IPC分类号： A61M029/00

CPC分类号： B29C49/18 ,  A61L29/06 ,  A61L29/14 ,  A61M25/1029 ,  B29C49/6481 ,  B29C2049/0089 ,  B29K2105/258 ,  B29L2022/022 ,  B29L2031/7542 ,  C08L67/02

摘要： A balloon formed of a single layer of polybutylene terephthalate and polytetramethylene ether glycol terephthalate copolymer in a substantially unblended form. The copolymer has a flexural modulus of greater than about 150,000 psi. The presently preferred copolymer is Hytrelnull 8238 by DuPont. The balloon of the invention would be substantially unblended, defined as greater than about 60% by weight to about 100% by weight of the copolymer. The balloon is formed in a series of molds. The balloon of the invention exhibits high rupture pressure and low compliance coupled with good lesion cross and recross ability.

摘要翻译： 由单层聚对苯二甲酸丁二醇酯和聚四亚甲基醚二醇对苯二甲酸乙二醇酯共聚物形成的气囊，基本上是非混合形式。 共聚物的挠曲模量大于约150,000psi。 目前优选的共聚物是DuPont的Hytrel 8238。 本发明的气囊将基本上未共混，定义为大于约60重量％至约100重量％的共聚物。 气球形成一系列模具。 本发明的气囊显示出高的破裂压力和低顺应性，同时具有良好的病变交叉和回交能力。

公开(公告)号：US20020171180A1

公开(公告)日：2002-11-21

申请号：US09862223

申请日：2001-05-21

申请人： Advanced Cardiovascular Systems, Inc

发明人： Murthy V. Simhambhatla

IPC分类号： B29C049/18

CPC分类号： B29C49/00 ,  B29C49/0015 ,  B29C49/18 ,  B29K2067/00 ,  B29K2105/0085 ,  B29L2022/022 ,  B29L2031/7542

摘要： A method of forming an expandable member for a medical device, and particularly a balloon for a catheter, in which extruded tubing is first expanded in a continuous or a semi-continuous process to form expanded tubing, and then the expanded tubing is further expanded in a balloon mold to form the catheter balloon. The method generally includes expanding a long length of tubing from a first inner and outer diameter to a second larger inner and outer diameter, to form expanded tubing having an expanded intermediate diameter, and processing the expanded tubing to form a plurality of expanded intermediate diameter tube segments, each segment having a length significantly shorter than the length of the expanded tubing. One of the segments is then placed in an inner chamber of a balloon mold, and expanded in the balloon mold to form a balloon for a catheter.

摘要翻译： 一种形成用于医疗装置的可膨胀构件的方法，特别是用于导管的气囊，其中挤压管首先在连续或半连续过程中膨胀以形成扩张管，然后将膨胀管进一步扩大 气球模具形成导管气囊。 该方法通常包括将长度长的管道从第一内部和外部直径扩大到第二较大的内部和外部直径，以形成具有膨胀的中间直径的膨胀管，并且处理膨胀管以形成多个膨胀的中间直径管 每个段具有明显短于膨胀管长度的长度。 然后将其中一个片段放置在球囊模具的内腔中，并在气囊模具中膨胀以形成用于导管的气囊。