公开(公告)号：US20160213787A1

公开(公告)日：2016-07-28

申请号：US14916559

申请日：2014-09-01

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Motoichi KURISAWA ,  Ki Hyun BAE

IPC: A61K47/48 ,  A61K9/06 ,  A61Q19/00 ,  A61K8/73 ,  A61K8/49 ,  A61K9/00 ,  A61K31/353 ,  A61K8/04

Abstract: There is provided polymer-flavonoid conjugates. Flavonoid-grafted and flavonoid-terminated polymer conjugates are disclosed according to the invention. The linkage of flavonoids to the polymers has been achieved via thiol linkages. The inventive processes allow for making of the conjugates in high yield avoiding complex purification steps. The conjugates can be easily autoxidized to hydrogels with uses in many biomedical applications where a higher stability of the flavonoid is necessary. The hydrogels can be potentially used as viscosupplement, anti-adhesion film or dermal filler.

Abstract translation: 提供了聚合物 - 类黄酮轭合物。 根据本发明公开了类黄酮接枝和类黄酮封端的聚合物缀合物。 黄酮与聚合物的连接已经通过硫醇键实现。 本发明的方法允许以高产率制备缀合物，避免了复杂的纯化步骤。 缀合物可以容易地自动氧化成水凝胶，其用途在许多生物医学应用中，其中黄酮类化合物的稳定性更高。 水凝胶可以用作粘合补充剂，抗粘连膜或真皮填料。

公开(公告)号：US20170258926A1

公开(公告)日：2017-09-14

申请号：US15309675

申请日：2015-05-08

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Motoichi KURISAWA ,  Yongvongsoontorn NUNNARPAS ,  Jackie Y. YING ,  Joo Eun CHUNG ,  Ki Hyun BAE ,  Min-han TAN ,  Esther LEE

IPC: A61K9/127 ,  A61K31/704 ,  A61K31/353 ,  C08G65/332 ,  A61K9/107 ,  A61K31/404 ,  C07D405/14

CPC classification number: A61K31/404 ,  A61K9/107 ,  A61K31/353 ,  A61K31/704 ,  A61K47/10 ,  A61K47/48215 ,  A61K47/60 ,  B82Y5/00 ,  C08G65/331 ,  C08G65/3315 ,  C08G65/3317 ,  C08G65/3318 ,  C08G65/332 ,  C08G65/3326 ,  C08G65/3328 ,  C08G65/33396 ,  C08L1/02 ,  C08L3/02 ,  C08L5/00 ,  C08L5/02 ,  C08L5/16 ,  C08L89/00 ,  C08L2203/02

Abstract: The present invention relates to micellar nanocomplexes and a method of forming the same. The micellar nanocomplex comprises a micelle and an agent encapsulated within said micelle, where the micelle comprises a polymer-flavonoid conjugate, wherein said polymer is bonded to the B ring of said flavonoid. The micellar nanocomplex may have useful applications as a drug-delivery system.

公开(公告)号：US20190008830A1

公开(公告)日：2019-01-10

申请号：US16039098

申请日：2018-07-18

Applicant: Agency for Science, Technology and Research

Inventor： Motoichi Kurisawa ,  Yongvongsoontorn Nunnarpas ,  Jackie Y. YING ,  Joo Eun CHUNG ,  Ki Hyun BAE ,  Min-Han TAN ,  Esther LEE

IPC: A61K31/404 ,  C08G65/332 ,  C08G65/331 ,  A61K31/704 ,  A61K47/60 ,  C08L89/00 ,  C08L5/16 ,  C08L5/02 ,  C08L5/00 ,  C08L3/02 ,  C08L1/02

Abstract: The present invention relates to micellar nanocomplexes and a method of forming the same. The micellar nanocomplex comprises a micelle and an agent encapsulated within said micelle, where the micelle comprises a polymer-flavonoid conjugate, wherein said polymer is bonded to the B ring of said flavonoid. The micellar nanocomplex may have useful applications as a drug-delivery system.