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公开(公告)号：US09580696B2
公开(公告)日：2017-02-28
申请号：US14243458
申请日：2014-04-02
Applicant: Ajinomoto Co., Inc.
Inventor： Hiroyuki Nozaki , Isao Abe , Jun Takakura , Rie Takeshita , Hideyuki Suzuki , Shunichi Suzuki
CPC classification number: C12P21/02 , C07K5/0215 , C07K5/0819 , C12N9/104 , C12N15/70 , C12Y203/02002 , Y02P20/52
Abstract: A method for producing γ-Glu-Val-Gly comprising the step of reacting Val-Gly with a γ-glutamyl group donor in the presence of a γ-glutamyltransferase, a microorganism containing the enzyme, or a processed product thereof to generate γ-Glu-Val-Gly, wherein the γ-glutamyltransferase consists of a large subunit and a small subunit, and the small subunit has a specific mutation.
Abstract translation: 一种γ-Glu-Val-Gly的制造方法，其特征在于，在γ-谷氨酰基转移酶，含有该微生物的微生物或其加工物的存在下，使Val-Gly与γ-谷氨酰供体反应， Glu-Val-Gly，其中γ-谷氨酰转移酶由大亚基和小亚基组成，小亚基具有特异性突变。
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公开(公告)号：US09677106B2
公开(公告)日：2017-06-13
申请号：US15235311
申请日：2016-08-12
Applicant: Ajinomoto Co., Inc.
Inventor： Hiroyuki Nozaki , Isao Abe , Jun Takakura , Rie Takeshita , Hideyuki Suzuki , Shunichi Suzuki
CPC classification number: C12P21/02 , C07K5/0215 , C07K5/0819 , C12N9/104 , C12N15/70 , C12Y203/02002 , Y02P20/52
Abstract: A method for producing γ-Glu-Val-Gly comprising the step of reacting Val-Gly with a γ-glutamyl group donor in the presence of a γ-glutamyltransferase, a microorganism containing the enzyme, or a processed product thereof to generate γ-Glu-Val-Gly, wherein the γ-glutamyltransferase consists of a large subunit and a small subunit, and the small subunit has a specific mutation.
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公开(公告)号：US20160355861A1
公开(公告)日：2016-12-08
申请号：US15235311
申请日：2016-08-12
Applicant: Ajinomoto Co., Inc.
Inventor： Hiroyuki NOZAKI , Isao Abe , Jun Takakura , Rie Takeshita , Hideyuki Suzuki , Shunichi Suzuki
CPC classification number: C12P21/02 , C07K5/0215 , C07K5/0819 , C12N9/104 , C12N15/70 , C12Y203/02002 , Y02P20/52
Abstract: A method for producing γ-Glu-Val-Gly comprising the step of reacting Val-Gly with a γ-glutamyl group donor in the presence of a γ-glutamyltransferase, a microorganism containing the enzyme, or a processed product thereof to generate γ-Glu-Val-Gly, wherein the γ-glutamyltransferase consists of a large subunit and a small subunit, and the small subunit has a specific mutation.
Abstract translation: 一种γ-Glu-Val-Gly的制造方法，其特征在于，在γ-谷氨酰基转移酶，含有该微生物的微生物或其加工物的存在下，使Val-Gly与γ-谷氨酰基供体反应， Glu-Val-Gly，其中γ-谷氨酰转移酶由大亚基和小亚基组成，小亚基具有特异性突变。
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Patent Agency Ranking
公开(公告)号：US12281340B2
公开(公告)日：2025-04-22
申请号：US17025173
申请日：2020-09-18
Applicant: AJINOMOTO CO., INC.
Inventor： Hidemi Nagata , Keiko Danjou , Jun Takakura , Hiroyuki Nozaki
Abstract: A method efficiently produces a compound containing an N-acyl-amino group by an enzymatic method. Specifically, a method of producing a compound containing an N-acyl-amino group includes producing the compound containing an N-acyl-amino group by reacting a compound containing an amino group with a compound containing a carboxyl group in the presence of an enzyme having an ability to bond a carboxyl group and an amino group in an ATP dependent manner to form an amide bond.
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公开(公告)号：US20210071214A1
公开(公告)日：2021-03-11
申请号：US17025173
申请日：2020-09-18
Applicant: AJINOMOTO CO., INC.
Inventor： Hidemi Nagata , Keiko Danjou , Jun Takakura , Hiroyuki Nozaki
Abstract: A method efficiently produces a compound containing an N-acyl-amino group by an enzymatic method. Specifically, a method of producing a compound containing an N-acyl-amino group includes producing the compound containing an N-acyl-amino group by reacting a compound containing an amino group with a compound containing a carboxyl group in the presence of an enzyme having an ability to bond a carboxyl group and an amino group in an ATP dependent manner to form an amide bond.
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公开(公告)号：US10266857B2
公开(公告)日：2019-04-23
申请号：US15955267
申请日：2018-04-17
Applicant: AJINOMOTO CO., INC.
Inventor： Jun Takakura , Hiroyuki Nozaki
Abstract: The present invention provides a method for producing Nε-dodecanoyl-L-lysine using an enzyme having properties suitable for the industrial production of Nε-dodecanoyl-L-lysine. More specifically, the present invention provides a method for producing Nε-acyl-L-lysine including reacting a carboxylic acid or a salt thereof and L-lysine or a salt thereof in the presence of a protein having an amino acid sequence of SEQ ID NO: 1; a protein having an amino acid sequence in which one or several amino acid residues are inserted, added, deleted, or substituted in the amino acid sequence of SEQ ID NO: 1 and having Nε-acyl-L-lysine-specific aminoacylase activity; and a protein which has 90% or higher homology with the amino acid sequence of SEQ ID NO: 1 and having Nε-acyl-L-lysine-specific aminoacylase activity.
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公开(公告)号：US20180230502A1
公开(公告)日：2018-08-16
申请号：US15955267
申请日：2018-04-17
Applicant: AJINOMOTO CO., INC.
Inventor： Jun Takakura , Hiroyuki Nozaki
IPC: C12P13/08
CPC classification number: C12P13/08 , C12N9/80 , C12Y305/01014
Abstract: The present invention provides a method for producing Nε-dodecanoyl-L-lysine using an enzyme having properties suitable for the industrial production of Nε-dodecanoyl-L-lysine. More specifically, the present invention provides a method for producing Nε-acyl-L-lysine including reacting a carboxylic acid or a salt thereof and L-lysine or a salt thereof in the presence of a protein having an amino acid sequence of SEQ ID NO: 1; a protein having an amino acid sequence in which one or several amino acid residues are inserted, added, deleted, or substituted in the amino acid sequence of SEQ ID NO: 1 and having Nε-acyl-L-lysine-specific aminoacylase activity; and a protein which has 90% or higher homology with the amino acid sequence of SEQ ID NO: 1 and having Nε-acyl-L-lysine-specific aminoacylase activity.
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8.发明申请MUTANT GAMMA-GLUTAMYLTRANSFERASE, AND A METHOD FOR PRODUCING GAMMA-GLUTAMYLVALYLGLYCINE OR A SALT THEREOF 有权突变GAMMA-GLUTAMYLTRANSFERASE，以及一种生产GAMMA-谷氨酰乙酰胆碱或其盐的方法公开(公告)号：US20140212920A1
公开(公告)日：2014-07-31
申请号：US14243458
申请日：2014-04-02
Applicant: Ajinomoto Co., Inc.
Inventor： Hiroyuki NOZAKI , Isao Abe , Jun Takakura , Rie Takeshita , Hideyuki Suzuki , Shunichi Suzuki
CPC classification number: C12P21/02 , C07K5/0215 , C07K5/0819 , C12N9/104 , C12N15/70 , C12Y203/02002 , Y02P20/52
Abstract: A method for producing γ-Glu-Val-Gly comprising the step of reacting Val-Gly with a γ-glutamyl group donor in the presence of a γ-glutamyltransferase, a microorganism containing the enzyme, or a processed product thereof to generate γ-Glu-Val-Gly, wherein the γ-glutamyltransferase consists of a large subunit and a small subunit, and the small subunit has a specific mutation.
Abstract translation: 一种γ-Glu-Val-Gly的制造方法，其特征在于，在γ-谷氨酰基转移酶，含有该微生物的微生物或其加工物的存在下，使Val-Gly与γ-谷氨酰基供体反应， Glu-Val-Gly，其中γ-谷氨酰转移酶由大亚基和小亚基组成，小亚基具有特异性突变。
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