公开(公告)号：US06169815A

公开(公告)日：2001-01-02

申请号：US09077816

申请日：1998-05-22

申请人： Akira Aoki ,  Akihiko Tanioka

发明人： Akira Aoki ,  Akihiko Tanioka

IPC分类号： G06K900

CPC分类号： H04N1/60 ,  H04N1/6011

摘要： The image surface of an original photograph is covered with a transparent plastic film and the image is corrected by painting on the transparent film so that a combined image material is made. Then this combined image material is digitized with scanning equipment and the resulting digital data is stored in a computer. Thereafter, conventional computer image processing technology is applied to modify the digital image displayed on the monitor of the computer.

摘要翻译： 原始照片的图像表面被透明塑料膜覆盖，并且通过在透明膜上涂漆来校正图像，从而制成组合的图像材料。 然后将该组合的图像材料用扫描设备数字化，并将得到的数字数据存储在计算机中。 此后，应用传统的计算机图像处理技术来修改显示在计算机的监视器上的数字图像。

公开(公告)号：US20090304991A1

公开(公告)日：2009-12-10

申请号：US12065092

申请日：2005-09-02

申请人： Akihiko Tanioka ,  Mie Minagawa ,  Hidetoshi Matsumoto ,  Hirotaka Arai ,  Atsushi Obayashi ,  Ken Tashiro ,  Satoru Momohira

发明人： Akihiko Tanioka ,  Mie Minagawa ,  Hidetoshi Matsumoto ,  Hirotaka Arai ,  Atsushi Obayashi ,  Ken Tashiro ,  Satoru Momohira

IPC分类号： B32B3/24 ,  B32B27/00 ,  B32B5/16 ,  B05D1/12 ,  B32B7/02

CPC分类号： B32B27/08 ,  B32B3/266 ,  B32B27/16 ,  B32B27/18 ,  B32B27/283 ,  B32B27/286 ,  B32B27/302 ,  B32B27/304 ,  B32B27/306 ,  B32B27/308 ,  B32B27/32 ,  B32B27/34 ,  B32B27/36 ,  B32B27/365 ,  B32B27/40 ,  B32B2255/10 ,  B32B2255/20 ,  B32B2255/26 ,  B32B2270/00 ,  B32B2274/00 ,  B32B2307/206 ,  B32B2307/21 ,  B32B2307/7265 ,  B32B2307/728 ,  B32B2307/73 ,  B32B2410/00 ,  B32B2419/00 ,  B32B2451/00 ,  C08J7/042 ,  C08J7/047 ,  C08J7/06 ,  Y10T428/24331 ,  Y10T428/24942 ,  Y10T428/25 ,  Y10T428/31504

摘要： A surface-modified plastic film, comprising: a surface layer composed of minute filamentous forms and/or granular forms consisting of a composition containing a resin and/or inorganic microparticles, on at least one major surface of a substrate plastic film. Preferably, the surface-modified plastic film is characterized in that the minute filamentous forms have a diameter of 100 μm to 1 nm.

摘要翻译： 一种表面改性塑料膜，包括：在基材塑料膜的至少一个主表面上由微细丝状和/或由含有树脂和/或无机微粒的组合物组成的颗粒形式的表面层。 优选地，表面改性塑料膜的特征在于，微细丝状形式具有100μm至1nm的直径。

公开(公告)号：US20090299265A1

公开(公告)日：2009-12-03

申请号：US11992672

申请日：2006-10-02

申请人： Akihiko Tanioka ,  Mizuo Nakayama ,  Takehiko Matsumura ,  Hidero Akiyama ,  Akihiko Matsumura

发明人： Akihiko Tanioka ,  Mizuo Nakayama ,  Takehiko Matsumura ,  Hidero Akiyama ,  Akihiko Matsumura

IPC分类号： A61N1/30

CPC分类号： A61N1/0444 ,  A61N1/044 ,  A61N1/0448

摘要： An electrode assembly for iontophoresis including an electrode coupled to an electric power source device having a same polarity as that of the ionic drug in the electrode assembly, an electrolyte solution holding portion holding an electrolyte solution by being impregnated with the electrolyte solution, the electrolyte solution holding portion being placed adjacent to the electrode, a first ion exchange membrane operable to substantially pass ions having a polarity that is same as a polarity of the ionic drug and substantially block ions having a polarity that is opposite the polarity of the ionic drug, the first ion exchange membrane being placed adjacent to the electrolyte solution holding portion, a drug solution holding portion holding the ionic drug by being impregnated with the ionic drug, the drug solution holding portion being placed adjacent to the first ion exchange membrane, a second ion exchange membrane operable to substantially pass ions having a polarity that is opposite the polarity of the ionic drug and substantially block ions having a polarity that is the same as the polarity of the ionic drug, the second ion exchange membrane being placed adjacent to the drug solution holding portion, and a shape-memory separator capable of being transformed between a first and a second configuration to respectively allow passage of a substance and blocking of the substance, the shape-memory separator placed adjacent to at least one surface of the first ion exchange membrane.

摘要翻译： 一种用于离子电渗疗法的电极组件，其包括与电极组件中的离子药物极性相同的电源装置的电极，通过浸渍电解质溶液保持电解质溶液的电解液保持部分， 保持部分被放置成与电极相邻，第一离子交换膜可操作以基本上通过具有与离子药物的极性相同的极性的离子，并且基本上阻挡具有与离子药物的极性相反的极性的离子， 第一离子交换膜与电解质溶液保持部相邻配置，通过浸渍离子性药物而保持离子性药物的药液保持部，药液保持部与第一离子交换膜相邻配置，第二离子交换 膜可操作以基本上通过具有相反极性的离子 e离子药物的极性，并且基本上阻挡具有与离子药物的极性相同的极性的离子，第二离子交换膜邻近药物溶液保持部分放置，以及形状记忆分离器，其能够 在第一和第二构型之间转换以分别允许物质的通过和物质的阻塞，所述形状记忆隔离物与第一离子交换膜的至少一个表面相邻放置。

公开(公告)号：US20070066930A1

公开(公告)日：2007-03-22

申请号：US11471973

申请日：2006-06-20

申请人： Akihiko Tanioka ,  Akihiko Matsumura ,  Takehiko Matsumura ,  Mizuo Nakayama ,  Hidero Akiyama

发明人： Akihiko Tanioka ,  Akihiko Matsumura ,  Takehiko Matsumura ,  Mizuo Nakayama ,  Hidero Akiyama

IPC分类号： A61N1/30 ,  A61L33/00 ,  B32B18/00

CPC分类号： A61N1/0444 ,  A61N1/044 ,  A61N1/0448

摘要： An iontophoresis device and method of producing the same may reduce material loss during the course of production of a conventional iontophoresis device, and may allow for easy automation of production processes and increases in production scale. The iontophoresis device may be used for administering drug ions of a first polarity generated by dissociation of a drug to a living body, and may comprise: a first conductive layer formed on a surface of a first substrate; a drug layer made of a drug coating containing the drug, the drug layer being laminated on the first conductive layer; and a first ion exchange layer made of an ion exchange coating containing an ion exchange resin having an exchange group introduced thereto, the ion exchange group having a counter ion to the first polarity ions, the first ion exchange layer being laminated on the drug layer.

摘要翻译： 离子电渗装置及其制造方法可以在常规离子电渗装置的制造过程中减少材料损失，并且可以容易地实现生产方法的自动化和生产规模的增加。 离子电渗装置可以用于施用通过将药物解离为活体而产生的第一极性的药物离子，并且可以包括：形成在第一基底的表面上的第一导电层; 由含有药物的药物涂层制成的药物层，所述药物层被层压在所述第一导电层上; 以及第一离子交换层，其由含有引入了交换基团的离子交换树脂的离子交换涂层构成，所述离子交换基团与所述第一极性离子具有抗衡离子，所述第一离子交换层层叠在所述药物层上。

公开(公告)号：US08544410B2

公开(公告)日：2013-10-01

申请号：US12734516

申请日：2008-11-06

申请人： Akihiko Tanioka ,  Kozo Inoue ,  Kazuya Nitta ,  Masaru Tamaru

发明人： Akihiko Tanioka ,  Kozo Inoue ,  Kazuya Nitta ,  Masaru Tamaru

IPC分类号： B05B5/025 ,  B05C11/00

CPC分类号： B05B5/032 ,  B05B5/001 ,  B05B5/03 ,  B05B5/087 ,  B05B7/0075 ,  B05B7/0807

摘要： The invention is an immobilization apparatus comprising: a container (1) having a nozzle (4) formed for exhausting a solution; a charging means (PS, 5, 4) for charging the sample solution within the container; and an airflow generating means for generating airflow (Af) crashing into the sample solution. The immobilization apparatus is configured to operate the charging means and the airflow generating means simultaneously, atomize the solution into microparticulate substances charged while maintaining its activity and functionality by the electrostatic force due to the charge of the sample solution charged by the charging means and the crash energy due to the crash of the airflow generated by the airflow generating means into the sample solution, and exhaust it from the exhaust outlet (4), and the charged microparticulate substances are deposited on a substrate (7) by the electrostatic force.

摘要翻译： 本发明是一种固定装置，包括：具有形成用于排出溶液的喷嘴（4）的容器（1） 用于对容器内的样品溶液充电的充电装置（PS，5,4） 以及用于产生流入样品溶液的气流（Af）的气流产生装置。 固定装置被配置为同时操作充气装置和气流发生装置，由于由充电装置充电的样品溶液的充电和崩溃，通过静电力保持其活性和功能性，将溶液雾化成微粒状物质 由气流产生装置产生的气流撞击到样品溶液中并从排气口（4）排出的能量，并且带电的微粒物质通过静电力沉积在基板（7）上。

公开(公告)号：US20110017134A1

公开(公告)日：2011-01-27

申请号：US12734516

申请日：2008-11-06

申请人： Akihiko Tanioka ,  Kozo Inoue ,  Kazuya Nitta ,  Masaru Tamaru

发明人： Akihiko Tanioka ,  Kozo Inoue ,  Kazuya Nitta ,  Masaru Tamaru

IPC分类号： B05B5/03

CPC分类号： B05B5/032 ,  B05B5/001 ,  B05B5/03 ,  B05B5/087 ,  B05B7/0075 ,  B05B7/0807

摘要： The invention is an immobilization apparatus comprising: a container (1) having a nozzle (4) formed for exhausting a solution; a charging means (PS, 5, 4) for charging the sample solution within the container; and an airflow generating means for generating airflow (Af) crashing into the sample solution. The immobilization apparatus is configured to operate the charging means and the airflow generating means simultaneously, atomize the solution into microparticulate substances charged while maintaining its activity and functionality by the electrostatic force due to the charge of the sample solution charged by the charging means and the crash energy due to the crash of the airflow generated by the airflow generating means into the sample solution, and exhaust it from the exhaust outlet (4), and the charged microparticulate substances are deposited on a substrate (7) by the electrostatic force.

摘要翻译： 本发明是一种固定装置，包括：具有形成用于排出溶液的喷嘴（4）的容器（1） 用于对容器内的样品溶液充电的充电装置（PS，5,4） 以及用于产生流入样品溶液的气流（Af）的气流产生装置。 固定装置被配置为同时操作充气装置和气流发生装置，由于由充电装置充电的样品溶液的充电和崩溃，通过静电力保持其活性和功能性，将溶液雾化成微粒状物质 由气流产生装置产生的气流撞击到样品溶液中并从排气口（4）排出的能量，并且带电的微粒物质通过静电力沉积在基板（7）上。

公开(公告)号：US07590444B2

公开(公告)日：2009-09-15

申请号：US11172372

申请日：2005-06-30

申请人： Akihiko Tanioka ,  Akihiko Matsumura ,  Takehiko Matsumura ,  Mizuo Nakayama ,  Hidero Akiyama

发明人： Akihiko Tanioka ,  Akihiko Matsumura ,  Takehiko Matsumura ,  Mizuo Nakayama ,  Hidero Akiyama

IPC分类号： A61N1/30

CPC分类号： A61N1/044 ,  A61N1/0436 ,  A61N1/0444

摘要： An iontophoresis device for administering drug ions via the first ion-exchange membrane, comprising a first semi-permeable film having a number of pores passing through the film from a front surface to a back surface, a first ion-exchange membrane formed of ion-exchange resin filling the pores of the first semi-permeable film and selective ions of a first polarity, and a working electrode structure having a drug holding part placed on a back surface of the first ion-exchange membrane and holding a drug solution containing drug ions charged in the first polarity, wherein a layer of a water-soluble polymer compound is chemically bonded on the surface of the first semi-permeable film.

摘要翻译： 1.一种用于经由第一离子交换膜施用药物离子的离子电渗疗法装置，其特征在于，具有从前表面到背面通过所述膜的多孔的第一半透膜，由离子交换膜形成的第一离子交换膜， 填充第一半透膜的孔和第一极性的选择性离子的交换树脂，以及具有放置在第一离子交换膜的背面上的药物保持部并保持含有药物离子的药液的工作电极结构 以第一极性充电，其中水溶性聚合物化合物层化学键合在第一半透膜的表面上。

公开(公告)号：US20070027426A1

公开(公告)日：2007-02-01

申请号：US11475838

申请日：2006-06-26

申请人： Takehiko Matsumura ,  Mizuo Nakayama ,  Hidero Akiyama ,  Akihiko Tanioka ,  Kiyoshi Kanamura

发明人： Takehiko Matsumura ,  Mizuo Nakayama ,  Hidero Akiyama ,  Akihiko Tanioka ,  Kiyoshi Kanamura

IPC分类号： A61N1/30

CPC分类号： A61N1/0444 ,  A61N1/0436 ,  A61N1/0448

摘要： An iontophoresis device includes an active electrode assembly which comprises an active electrode element and an outermost active electrode ion selective membrane that caches an active agent. The outermost active electrode ion selective membrane may be formed by one or more ion exchange membranes. The active electrode assembly may also comprise an electrolyte and/or one or more inner active electrode ion selective membranes. The inner active electrode ion selective membrane may be a “leaky” ion selective membrane. The inner active electrode ion exchange membrane may be spaced from the outermost active electrode ion selective membrane, for example, by one or more non-ion selective porous membranes or by a buffer material and/or buffer reservoir. An iontophoresis device may also include a counter electrode assembly and/or voltage source.

摘要翻译： 离子电渗装置包括活性电极组件，其包括活性电极元件和缓冲活性剂的最外面的活性电极离子选择性膜。 最外面的活性电极离子选择膜可以由一个或多个离子交换膜形成。 有源电极组件还可以包括电解质和/或一个或多个内部有源电极离子选择膜。 内部活性电极离子选择性膜可以是“泄漏”离子选择性膜。 内部有源电极离子交换膜可以与最外面的有源电极离子选择膜间隔开，例如通过一个或多个非离子选择性多孔膜或通过缓冲材料和/或缓冲储器隔开。 离子电渗装置还可以包括对电极组件和/或电压源。

公开(公告)号：US20100100031A1

公开(公告)日：2010-04-22

申请号：US12643720

申请日：2009-12-21

申请人： Akihiko Tanioka ,  Mie Minegawa ,  Kiyoshi Kanamura ,  Akihiko Matsumura ,  Mizuo Nakayama ,  Takehiko Matsumura ,  Hidero Akiyama

发明人： Akihiko Tanioka ,  Mie Minegawa ,  Kiyoshi Kanamura ,  Akihiko Matsumura ,  Mizuo Nakayama ,  Takehiko Matsumura ,  Hidero Akiyama

IPC分类号： A61N1/30

CPC分类号： A61N1/044 ,  A61N1/0436 ,  A61N1/0444

摘要： The present invention provides an iontophoresis device with high administration efficient of a drug. An iontophoresis device, including an active electrode structure including: an electrode to which a positive electrical potential is applied; a drug holding part for holding a drug solution containing positively charged drug ions, the drug holding part being placed on a front side of the electrode; a cellulose-based resin film placed on a front side of the drug holding part or a complex film composed of a cation exchange membrane and a cellulose-based resin film placed on a front side of the cation exchange membrane, the complex film being placed on a front side of the drug holding part, in which the drug ions are administered through the cellulose-based resin film.

摘要翻译： 本发明提供了具有药物高效给药的离子电渗疗法装置。 一种离子电渗疗法装置，包括有源电极结构，包括：施加正电位的电极; 用于保持含有带正电荷的药物离子的药液的药物保持部，药物保持部位于电极的前侧; 将放置在药物保持部的前侧的纤维素系树脂膜或配置在阳离子交换膜前侧的阳离子交换膜和纤维素系树脂膜构成的复合膜，将复合膜置于 药物保持部的前侧，其中通过纤维素系树脂膜施用药物离子。

公开(公告)号：US20090216175A1

公开(公告)日：2009-08-27

申请号：US11917733

申请日：2006-08-04

申请人： Takehiko Matsumura ,  Mizuo Nakayama ,  Hidero Akiyama ,  Akihiko Matsumura ,  Kiyoshi Kanamura ,  Akihiko Tanioka

发明人： Takehiko Matsumura ,  Mizuo Nakayama ,  Hidero Akiyama ,  Akihiko Matsumura ,  Kiyoshi Kanamura ,  Akihiko Tanioka

IPC分类号： A61N1/30

CPC分类号： A61N1/0444 ,  A61N1/0428 ,  A61N1/0436 ,  A61N1/0448

摘要： To provide a transdermal administration device capable of increasing the speed at which a drug is transferred into a skin and the amount of the drug to be transferred into the skin. A transdermal administration device is constituted by: an electrode supplied with a voltage of a first conductivity type; an electrolyte solution holding portion holding an electrolyte solution energized by the electrode; and a bipolar membrane that is placed on the front surface side of the electrolyte solution holding portion, and is composed of a first ion exchange membrane that selectively passes an ion of the first conductivity type and a second ion exchange membrane that selectively passes an ion of a second conductivity type.

摘要翻译： 提供能够增加药物转移到皮肤中的速度和要转移到皮肤中的药物的量的透皮给药装置。 透皮给药装置由以下部分构成：供给第一导电型电压的电极; 电解液保持部，其保持由所述电极通电的电解液; 以及放置在电解液保持部的前表面侧的双极性膜，其由选择性地通过第一导电类型的离子的第一离子交换膜和选择性地通过第一导电类型的离子的第二离子交换膜 第二导电类型。