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19 条记录 (耗时 0.025 秒)

    Transgenic Pig with Diabetes and Method for Producing the Same
    4.
    发明申请
    Transgenic Pig with Diabetes and Method for Producing the Same 审中-公开
    糖尿病转基因猪及其制备方法

    公开(公告)号：US20090271882A1

    公开(公告)日：2009-10-29

    申请号：US11992317

    申请日：2006-08-24

    申请人： Kazuhiro Umeyama ,  Hiroshi Nagashima ,  Masahito Watanabe ,  Keizaburo Miki

    发明人： Kazuhiro Umeyama ,  Hiroshi Nagashima ,  Masahito Watanabe ,  Keizaburo Miki

    IPC分类号： A01K67/027 ,  A01K67/02

    CPC分类号： A01K67/0275 ,  A01K2217/05 ,  A01K2227/108 ,  A01K2267/0325 ,  A01K2267/0362 ,  C07K14/4702 ,  C12N15/8509 ,  C12N2830/008 ,  C12N2830/40

    摘要： A transgenic animal having diabetes, which is more suitable as a model of human than rodents, and its preparation method are disclosed. The method for preparing the transgenic pig comprises introducing a nucleic acid into a fertilized egg, clonal egg or embryo, the nucleic acid comprising a foreign gene which contains a region encoding dimerization domain of hepatocyte nuclear factor-1α, but does not encode a normal hepatocyte nuclear factor-1α, and a promoter located upstream of the foreign gene, which promoter is capable of expressing the foreign gene in a pig cell; and developing an individual from the fertilized egg, clonal egg or embryo.

    摘要翻译： 公开了一种具有比啮齿动物更适合作为人类模型的糖尿病的转基因动物及其制备方法。 制备转基因猪的方法包括将核酸引入受精卵，克隆卵或胚胎中，所述核酸包含含有编码肝细胞核因子-1alpha的二聚化结构域但不编码正常肝细胞的区域的外源基因 核因子-1alpha和位于外源基因上游的启动子，该启动子能够在猪细胞中表达外源基因; 并从受精卵，克隆蛋或胚胎培养个体。

    Document placement mechanism and image reading device for books
    5.
    发明授权
    Document placement mechanism and image reading device for books 失效
    书籍文件放置机制和图像阅读装置

    公开(公告)号：US5614991A

    公开(公告)日：1997-03-25

    申请号：US400676

    申请日：1995-03-08

    申请人： Fuminori Moro ,  Hiroshi Nagashima

    发明人： Fuminori Moro ,  Hiroshi Nagashima

    IPC分类号： B42D9/04 ,  G03B27/62 ,  G03G15/00 ,  H04N1/10 ,  H04N1/107 ,  H04N1/193 ,  H04N1/195 ,  G09F19/00

    CPC分类号： G03G15/605 ,  G03B27/62 ,  H04N1/195 ,  H04N1/193 ,  H04N2201/0434 ,  H04N2201/0436

    摘要： The present invention relates to a document placement device suitable for accommodating book-like documents for image reading and image reader device provided with the document placement device. The document placement device has a first platform for placement of pages on the right side of an open book document on the top surface thereof and a second platform provided adjacent to said first platform for placement of pages on the left side of an open book document on the top surface thereof. The first platform slides in a rightward direction when raised thereby inducing the second platform to slide in a rightward direction while being moved in a downward direction, and the first platform slides in a leftward direction when lowered thereby inducing the second platform to slide in a leftward direction while being moved in an upward direction.

    摘要翻译： 本发明涉及一种适合于容纳用于图像读取的书本文件的文档放置装置和具有该文件放置装置的图像读取装置。 文档放置装置具有第一平台，用于在其顶表面上的打开的书本文档的右侧放置页面，以及与所述第一平台相邻设置的第二平台，用于在打开的书籍文档的左侧放置页面 其顶面。 第一平台在向上方向滑动，从而使第二平台沿向右方向向右滑动，第一平台在向下方向滑动时向左方向滑动，导致第二平台向左滑动 方向同时向上移动。

    Image creation apparatus and image creation method
    6.
    发明授权
    Image creation apparatus and image creation method 失效
    图像创建装置和图像创建方法

    公开(公告)号：US06329995B1

    公开(公告)日：2001-12-11

    申请号：US09216848

    申请日：1998-12-21

    申请人： Hiroshi Nagashima

    发明人： Hiroshi Nagashima

    IPC分类号： G06T120

    CPC分类号： G06T1/20

    摘要： To accelerate drawing input processing, a plurality of drawing pipelines 20 are provided and each drawing pipeline comprises a queue 21, a density data generator 23, a multiplier 24, an accumulator 25, and a cache 26. A stroke is divided, for example, into four, and allocated to each drawing pipeline 20. By each drawing pipeline 20, a next pixel is processed after a former pixel is processed for a plurality of patches according to the scan order.

    摘要翻译： 为了加速绘图输入处理，提供了多个绘图管线20，并且每个绘图管线包括队列21，密度数据生成器23，乘法器24，累加器25和高速缓存26.例如， 分配到四个，并分配给每个绘制管线20.通过每个绘制管线20，根据扫描顺序在针对多个补丁处理前一像素之后处理下一个像素。

    Image reading apparatus for reading a bookform document placed on a document table in face-up state
    8.
    发明授权
    Image reading apparatus for reading a bookform document placed on a document table in face-up state 失效
    用于以面朝上的状态读取放置在文件台上的书本文件的图像读取装置

    公开(公告)号：US06345763B1

    公开(公告)日：2002-02-12

    申请号：US09220768

    申请日：1998-12-28

    申请人： Shinya Matsuda ,  Fuminori Moro ,  Hiroshi Nagashima

    发明人： Shinya Matsuda ,  Fuminori Moro ,  Hiroshi Nagashima

    IPC分类号： G06K710

    CPC分类号： H04N1/00708 ,  H04N1/00737 ,  H04N1/0075 ,  H04N1/1013 ,  H04N1/1021 ,  H04N1/1043 ,  H04N1/193 ,  H04N2201/0416 ,  H04N2201/0422 ,  H04N2201/0434

    摘要： An image reading apparatus which reads out a document, such as as a book, placed face-up and opened on a document table. The apparatus includes an image reading device for reading out the document image placed on the document table, a mirror for imaging the document upper side plane, a projecting device which projects marks onto the document and mirror, and an image processing unit. A document characterized portion imaged on the mirror is read out by the image reading device and the image processing unit rectifies image distortion of the read out document image based on the characterized portion.

    摘要翻译： 一种图像读取装置，其读出诸如书籍的文件，面朝上放置在文件台上。 该装置包括用于读出放置在文件台上的文件图像的图像读取装置，用于对文件上侧平面进行成像的反射镜，将标记投影到文档和反射镜上的投影装置，以及图像处理单元。 由图像读取装置读出在镜子上成像的文件特征部分，图像处理部根据特征部分对读出的原稿图像的图像失真进行整流。

    Biocompatible ceramic-polymer hybrids and calcium phosphate porous body
    9.
    发明授权
    Biocompatible ceramic-polymer hybrids and calcium phosphate porous body 有权
    生物相容陶瓷聚合物杂化物和磷酸钙多孔体

    公开(公告)号：US08871167B2

    公开(公告)日：2014-10-28

    申请号：US13308459

    申请日：2011-11-30

    申请人： Mamoru Aizawa ,  Masahiro Rikukawa ,  Yusuke Shigemitsu ,  Hiroshi Nagashima

    发明人： Mamoru Aizawa ,  Masahiro Rikukawa ,  Yusuke Shigemitsu ,  Hiroshi Nagashima

    IPC分类号： C01B15/16 ,  C01B25/26 ,  A61L27/56 ,  A61L27/42

    CPC分类号： A61L27/425 ,  A61L27/56

    摘要： A hydroxyapatite ceramic hybrid material, which includes a biodegradable polymer included in the pores in a hydroxyapatite ceramic structure, and a method thereof, and a calcium phosphate porous body, which is formed by an intertwining of fibrous calcium phosphates and includes a plurality of first pores formed where the fibrous calcium phosphates interconnect and plurality of equal diameter substantially spherical second pores with a larger inside diameter than the first pores, and a method thereof are provided.

    摘要翻译： 羟基磷灰石陶瓷混合材料，其包括羟基磷灰石陶瓷结构的孔中包含的生物可降解聚合物及其方法，以及磷酸钙多孔体，其通过纤维状磷酸钙的交织而形成，并且包括多个第一孔 其中纤维状磷酸钙互相连接，并且具有比第一孔更大的内径的多个等直径的大致球形的第二孔，以及其方法。

    METHOD FOR EVALUATION OF DIFFERENTIATION ABILITY OF STEM CELL
    10.
    发明申请
    METHOD FOR EVALUATION OF DIFFERENTIATION ABILITY OF STEM CELL 审中-公开
    评估干细胞分化能力的方法

    公开(公告)号：US20110262959A1

    公开(公告)日：2011-10-27

    申请号：US13142222

    申请日：2009-06-30

    申请人： Eiji Kobayashi ,  Takashi Yokoo ,  Yutaka Hanazono ,  Hiroshi Nagashima

    发明人： Eiji Kobayashi ,  Takashi Yokoo ,  Yutaka Hanazono ,  Hiroshi Nagashima

    IPC分类号： C12Q1/02

    CPC分类号： A01K67/0271 ,  A01K2227/105 ,  A01K2227/106 ,  A01K2227/108 ,  A01K2267/03 ,  C12N15/873 ,  G01N33/5005

    摘要： The present invention provides a method of evaluating the possibility of a stem cell being able to differentiate into a cell that constitutes a desired tissue in a living organism, comprising the following steps of: (1) transplanting a stem cell to be evaluated into a primordium of a desired tissue of a non-human mammal, (2) culturing the tissue primordium in vitro, and (3) determining the possibility that the stem cell differentiates into a cell that constitutes the tissue in a living organism, with the degree of the dispersion of cells derived from the transplanted stem cell in the cultured tissue primordium as an index.

    摘要翻译： 本发明提供一种评估干细胞能够分化为构成生物体中所需组织的细胞的可能性的方法，包括以下步骤：（1）将要评估的干细胞移植到原基中 的非人哺乳动物的期望组织，（2）在体外培养组织原基，和（3）确定干细胞分化为构成活生物体组织的细胞的可能性，其程度为 作为指标，将来自移植干细胞的细胞分散在培养的组织原基中。