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公开(公告)号：US07871435B2
公开(公告)日：2011-01-18
申请号：US11039522
申请日：2005-01-19
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/24 , A61F2/2403 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2230/0008 , A61F2230/0069 , A61F2230/0076 , A61F2230/0095
摘要： An anatomically approximate prosthetic heart valve includes dissimilar flexible leaflets, dissimilar commissures and/or a non-circular flow orifice. The heart valve may be implanted in the mitral position and have one larger leaflet oriented along the anterior aspect so as to mimic the natural anterior leaflet. Two other smaller leaflets extend around the posterior aspect of the valve. A basic structure providing peripheral support for the leaflets includes two taller commissures on both sides of the larger leaflet, with a third, smaller commissure between the other two leaflets. The larger leaflet may be thicker and/or stronger than the other two leaflets. The base structure defines a flow orifice intended to simulate the shape of the mitral annulus during the systolic phase. For example, the flow orifice may be elliptical. A relatively wide sewing ring has a contoured inflow end and is attached to the base structure in such a way that the valve can be implanted in an intra-atrial position and the taller commissures do not extend too far into the left ventricle, therefore avoiding injury to the ventricle.
摘要翻译： 解剖学近似的假体心脏瓣膜包括不同的柔性小叶，不同的连合和/或非圆形流动孔。 心脏瓣膜可以植入二尖瓣位置，并且具有沿着前方面定向的一个较大的小叶以模拟天然前叶。 另外两个较小的小叶围绕阀的后部延伸。 为传单提供外围支撑的基本结构包括较大传单两侧两个更高的连合体，其他两个传单之间的第三个较小的连接。 较大的传单可以比其他两个传单更厚和/或更强。 基部结构限定了用于在收缩期期间模拟二尖瓣环形状的流动孔。 例如，流动孔口可以是椭圆形的。 相对宽的缝合环具有轮廓流入端，并且以这样的方式附接到基部结构，使得瓣膜可以植入心房内的位置，并且更高的连合部不会延伸到太远的左心室，因此避免受伤 到脑室
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公开(公告)号：US08721716B2
公开(公告)日：2014-05-13
申请号：US13229346
申请日：2011-09-09
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/24 , A61F2/2403 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2230/0008 , A61F2230/0069 , A61F2230/0076 , A61F2230/0095
摘要： An anatomically approximate prosthetic heart valve includes dissimilar flexible leaflets, dissimilar commissures and/or a non-circular flow orifice. The heart valve may be implanted in the mitral position and have one larger leaflet oriented along the anterior aspect so as to mimic the natural anterior leaflet. Two other smaller leaflets extend around the posterior aspect of the valve. A basic structure providing peripheral support for the leaflets includes two taller commissures on both sides of the larger leaflet, with a third, smaller commissure between the other two leaflets. The larger leaflet may be thicker and/or stronger than the other two leaflets. The base structure defines a flow orifice intended to simulate the shape of the mitral annulus during the systolic phase.
摘要翻译： 解剖学近似的假体心脏瓣膜包括不同的柔性小叶，不同的连合和/或非圆形流动孔。 心脏瓣膜可以植入二尖瓣位置，并且具有沿着前方面定向的一个较大的小叶以模拟天然前叶。 另外两个较小的小叶围绕阀的后部延伸。 为传单提供外围支撑的基本结构包括较大传单两侧两个更高的连合体，其他两个传单之间的第三个较小的连接。 较大的传单可以比其他两个传单更厚和/或更强。 基部结构限定了用于在收缩期期间模拟二尖瓣环形状的流动孔。
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公开(公告)号：US20110015731A1
公开(公告)日：2011-01-20
申请号：US12889223
申请日：2010-09-23
申请人： Alain F. Carpentier , Hung L. Lam
发明人： Alain F. Carpentier , Hung L. Lam
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/24 , A61F2/2403 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2230/0008 , A61F2230/0069 , A61F2230/0076 , A61F2230/0095
摘要： An anatomically approximate prosthetic heart valve includes dissimilar flexible leaflets, dissimilar commissures and/or a non-circular flow orifice. The heart valve may be implanted in the mitral position and have one larger leaflet oriented along the anterior aspect so as to mimic the natural anterior leaflet. Two other smaller leaflets extend around the posterior aspect of the valve. A basic structure providing peripheral support for the leaflets includes two taller commissures on both sides of the larger leaflet, with a third, smaller commissure between the other two leaflets. The larger leaflet may be thicker and/or stronger than the other two leaflets. The base structure defines a flow orifice intended to simulate the shape of the mitral annulus during the systolic phase. For example, the flow orifice may be elliptical. A relatively wide sewing ring has a contoured inflow end and is attached to the base structure in such a way that the valve can be implanted in an intra-atrial position and the taller commissures do not extend too far into the left ventricle, therefore avoiding injury to the ventricle.
摘要翻译： 解剖学近似的假体心脏瓣膜包括不同的柔性小叶，不同的连合和/或非圆形流动孔。 心脏瓣膜可以植入二尖瓣位置，并且具有沿着前方面定向的一个较大的小叶以模拟天然前叶。 另外两个较小的小叶围绕阀的后部延伸。 为传单提供外围支撑的基本结构包括较大传单两侧两个更高的连合体，其他两个传单之间的第三个较小的连接。 较大的传单可以比其他两个传单更厚和/或更强。 基部结构限定了用于在收缩期期间模拟二尖瓣环形状的流动孔。 例如，流动孔口可以是椭圆形的。 相对宽的缝合环具有轮廓流入端，并且以这样的方式附接到基部结构，使得瓣膜可以植入心房内的位置，并且更高的连合部不会延伸到太远的左心室，因此避免受伤 到脑室
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公开(公告)号：US20120123530A1
公开(公告)日：2012-05-17
申请号：US13229346
申请日：2011-09-09
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/24 , A61F2/2403 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2230/0008 , A61F2230/0069 , A61F2230/0076 , A61F2230/0095
摘要： An anatomically approximate prosthetic heart valve includes dissimilar flexible leaflets, dissimilar commissures and/or a non-circular flow orifice. The heart valve may be implanted in the mitral position and have one larger leaflet oriented along the anterior aspect so as to mimic the natural anterior leaflet. Two other smaller leaflets extend around the posterior aspect of the valve. A basic structure providing peripheral support for the leaflets includes two taller commissures on both sides of the larger leaflet, with a third, smaller commissure between the other two leaflets. The larger leaflet may be thicker and/or stronger than the other two leaflets. The base structure defines a flow orifice intended to simulate the shape of the mitral annulus during the systolic phase.
摘要翻译： 解剖学近似的假体心脏瓣膜包括不同的柔性小叶，不同的连合和/或非圆形流动孔。 心脏瓣膜可以植入二尖瓣位置，并且具有沿着前方面定向的一个较大的小叶以模拟天然前叶。 另外两个较小的小叶围绕阀的后部延伸。 为传单提供外围支撑的基本结构包括较大传单两侧两个更高的连合体，其他两个传单之间的第三个较小的连接。 较大的传单可以比其他两个传单更厚和/或更强。 基部结构限定了用于在收缩期期间模拟二尖瓣环形状的流动孔。
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公开(公告)号：US08915960B2
公开(公告)日：2014-12-23
申请号：US13221700
申请日：2011-08-30
申请人： Alain F. Carpentier , William C. Brunnett , Louis A. Campbell , Da-Yu Chang , Steven Ford , John F. Migliazza , Anand Rao
发明人： Alain F. Carpentier , William C. Brunnett , Louis A. Campbell , Da-Yu Chang , Steven Ford , John F. Migliazza , Anand Rao
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2466 , A61F2230/0039 , A61F2230/0052
摘要： A prosthetic tricuspid remodeling annuloplasty ring for use in tricuspid valve repairs to provide annular support after reconstructive valve surgery. The ring maintains an optimal annular dimension to prevent excessive dilatation of the natural valve annulus while adapting to the dynamic motion of the tricuspid annulus during the cardiac cycle. An exemplary ring features a waveform contour and may be constructed of a titanium core having a varying cross-section for selective flexibility for good Z-axis or out-of plane movement. The “waveform” contour and selective flexibility of the different segments of this ring are designed to adapt to the complex motion of the annulus. This reduces the stress on the anatomical structures and therefore minimizes the risk of arrhythmia and ring dehiscence.
摘要翻译： 用于三尖瓣修复的假体三尖瓣重塑瓣环成形术环，以在重建瓣膜手术后提供环形支撑。 环保持最佳的环形尺寸，以防止自然瓣膜环的过度膨胀，同时适应心动周期期间三尖瓣环的动态运动。 示例性环具有波形轮廓，并且可以由具有变化横截面的钛芯构成，用于选择性的灵活性以获得良好的Z轴或平面外的运动。 该环的不同段的“波形”轮廓和选择性灵活性被设计成适应环的复杂运动。 这减少了对解剖结构的压力，从而使心律失常和环开裂的风险最小化。
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6.发明授权公开(公告)号：US08632608B2
公开(公告)日：2014-01-21
申请号：US13352027
申请日：2012-01-17
CPC分类号： B65B63/08 , A61L27/3604 , A61L27/3687 , A61L2400/02
摘要： Bioprosthetic tissues are treated by immersing or otherwise contacting fixed, unfixed or partially fixed tissue with a glutaraldehyde solution that has previously been heat-treated or pH adjusted prior to its contact with the tissue. The prior heat treating or pH adjustment of the glutaraldehyde solution causes its free aldehyde concentration to decrease by about 25% or more, preferably by as much as 50%, and allows a “stabilized” glutaraldehyde solution to be obtained at the desired concentration and pH for an optimal fixation of the tissue at high or low temperature. This treatment results in a decrease in the tissue's propensity to calcify after being implanted within the body of a human or animal patient.
摘要翻译： 通过将固定的，未固定的或部分固定的组织与预先在与组织接触之前进行热处理或pH调节的戊二醛溶液浸渍或以其它方式接触来处理生物假体组织。 戊二醛溶液的现有热处理或pH调节使其游离醛浓度降低约25％以上，优选降低多达50％，并且允许以所需浓度和pH获得“稳定化”戊二醛溶液 用于在高温或低温下组织的最佳固定。 这种治疗导致在植入人或动物患者的身体之后组织的钙化倾向降低。
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公开(公告)号：US20120215304A1
公开(公告)日：2012-08-23
申请号：US13422706
申请日：2012-03-16
申请人： Alain F. Carpentier , David H. Adams , Vaso Adzich
发明人： Alain F. Carpentier , David H. Adams , Vaso Adzich
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/24 , A61F2/2409 , A61F2/2445 , A61F2230/0034 , A61F2230/0065 , A61F2250/0018 , A61F2250/0037 , Y10T29/49
摘要： Annuloplasty rings optimally sized to take into account more of the common degenerative valve pathologies. Each ring has a structural ring body with a shape that complies with predicted shapes of degenerative valvular diseases. The predicted shapes are obtained through careful echocardiographic and intraoperative measurements, and often differ for different annulus orifice sizes. For instance, in mitral rings the larger rings have larger minor axis and oblique axis dimensions relative to their major axis dimensions, and are more circular as opposed to D-shaped. The rings may also be three-dimensional and the relative heights around the rings may change for different sized rings. A mitral ring may have a higher anterior saddle relative to a posterior saddle, with the relative heights varying across the ring sizes. The ring may have varying flexibility around the ring periphery which also changes for different ring sizes.
摘要翻译： 瓣膜成形术环最优化以考虑更多的常见的退行性瓣膜病变。 每个环具有结构环体，其形状符合退化性瓣膜疾病的预测形状。 通过仔细的超声心动图和术中测量获得预测的形状，并且对于不同的环形孔尺寸通常是不同的。 例如，在二尖瓣环中，较大的环相对于其长轴尺寸具有较大的短轴和倾斜轴尺寸，并且与D形相反更圆。 环也可以是三维的，并且围绕环的相对高度可以针对不同尺寸的环而改变。 二尖瓣环可能具有相对于后鞍座的较高的前鞍座，相对高度在环尺寸之间变化。 环可能围绕环周围具有不同的柔性，这也适用于不同的环尺寸。
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8.发明申请DOUBLE CROSS-LINKAGE PROCESS TO ENHANCE POST-IMPLANTATION BIOPROSTHETIC TISSUE DURABILITY 有权双重交叉连接过程，以增强后植入生物组织耐久性公开(公告)号：US20120123557A1
公开(公告)日：2012-05-17
申请号：US13297192
申请日：2011-11-15
CPC分类号： A61F2/02 , A61F2/2415 , A61F2240/001 , A61J1/00 , A61K35/34 , A61L27/24 , A61L27/3612 , A61L27/362 , A61L27/3625 , A61L27/3629 , A61L27/3687 , A61L2400/02 , A61L2430/20
摘要： Bioprosthetic tissues and methods for making same, comprising fixing bioprosthetic implant tissue by treatment with 0.1 to 10 wt. % glutaraldehyde at elevated temperature, capping said fixed tissue by treatment with a diamine crosslinking agent, and treating said capped tissue with about 0.6 wt. % glutaraldehyde.
摘要翻译： 生物假体组织及其制备方法，包括用0.1至10重量％的处理固定生物假体植入物组织。 ％戊二醛，并用二胺交联剂处理封盖所述固定组织，并用约0.6wt。 ％戊二醛。
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9.发明申请TREATMENT OF BIOPROSTHETIC TISSUES TO MITIGATE POST IMPLANTANATION CALCIFICATION 有权生物多样性组织治疗减轻后期植入计算公开(公告)号：US20120117734A1
公开(公告)日：2012-05-17
申请号：US13352027
申请日：2012-01-17
CPC分类号： B65B63/08 , A61L27/3604 , A61L27/3687 , A61L2400/02
摘要： Bioprosthetic tissues are treated by immersing or otherwise contacting fixed, unfixed or partially fixed tissue with a glutaraldehyde solution that has previously been heat-treated or pH adjusted prior to its contact with the tissue. The prior heat treating or pH adjustment of the glutaraldehyde solution causes its free aldehyde concentration to decrease by about 25% or more, preferably by as much as 50%, and allows a “stabilized” glutaraldehyde solution to be obtained at the desired concentration and pH for an optimal fixation of the tissue at high or low temperature. This treatment results in a decrease in the tissue's propensity to calcify after being implanted within the body of a human or animal patient.
摘要翻译： 通过将固定的，未固定的或部分固定的组织与预先在与组织接触之前进行热处理或pH调节的戊二醛溶液浸渍或以其它方式接触来处理生物假体组织。 戊二醛溶液的现有热处理或pH调节使其游离醛浓度降低约25％以上，优选降低多达50％，并且允许以所需浓度和pH获得“稳定化”戊二醛溶液 用于在高温或低温下组织的最佳固定。 这种治疗导致在植入人或动物患者的身体之后组织的钙化倾向降低。
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公开(公告)号：US07993393B2
公开(公告)日：2011-08-09
申请号：US12557404
申请日：2009-09-10
申请人： Alain F. Carpentier , Stefan G. Schreck , Richard S. Rhee , Diana Nguyen-Thien-Nhon , Hung Ly Lam , William J. Recktenwald , Robert Frater
发明人： Alain F. Carpentier , Stefan G. Schreck , Richard S. Rhee , Diana Nguyen-Thien-Nhon , Hung Ly Lam , William J. Recktenwald , Robert Frater
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2/2427 , A61F2220/005 , A61F2220/0066 , A61F2220/0075
摘要： A highly flexible tissue-type heart valve is disclosed having a structural stent in a generally cylindrical configuration with cusps and commissures that are permitted to move radially. The stent commissures are constructed so that the cusps are pivotably or flexibly coupled together at the commissures to permit relative movement therebetween. The stent may be cloth-covered and may be a single element or may be made in three separate elements for a three cusp valve, each element having a cusp portion and two commissure portions; adjacent commissure portions for each pair of adjacent stent element combining to form the stent commissures. If the stent has separate elements their commissure portions may be pivotably or flexible coupled, or may be designed to completely separate into independent leaflets at bioresorbable couples. The cloth covering may have an outwardly projecting flap that mates with valve leaflets (e.g., pericardial leaflets) along the cusps and commissures. A connecting band may be provided that follows the cusps and commissures and extends outwardly. The valve is connected to the natural tissue along the undulating connecting band using conventional techniques, such as sutures. The connecting band may be a cloth-covered silicon member and attaches to the underside of the valve at the cusps to provide support to the stent and to the outer side of the valve at the commissures. The connecting band includes commissure portions defining generally axial gaps that help permit flexing of the valve.
摘要翻译： 公开了一种高度灵活的组织型心脏瓣膜，其具有大致圆柱形构造的结构支架，其具有允许径向移动的尖端和连合。 支架接合构造成使得尖端在连合处可枢转地或柔性地联接在一起以允许它们之间的相对运动。 支架可以是布覆盖的，并且可以是单个元件，或者可以用于三个阀瓣的三个单独的元件，每个元件具有尖部和两个连合部分; 每对相邻支架元件的相邻连合部分组合以形成支架连合。 如果支架具有单独的元件，则其连合部分可以可枢转地或柔性地联接，或者可以被设计成在生物可再吸附的对处完全分离成独立的叶片。 布覆盖物可以具有向外突出的翼片，其与沿着尖端和连合处的瓣叶（例如心包传单）配合。 可以提供连接带，其沿着尖端和连接并且向外延伸。 使用诸如缝合线的常规技术，瓣膜沿起伏的连接带连接到天然组织。 连接带可以是布覆盖的硅构件，并且在尖端处附接到阀的下侧，以在连合处向支架和阀的外侧提供支撑。 连接带包括限定大致轴向间隙的合缝部分，其有助于允许阀的挠曲。
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