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1.发明申请BRIDGED SECONDARY AMINES AND USE THEREOF AS IAP BIR DOMAIN BINDING COMPOUNDS 审中-公开连接的二级氨基酸和作为IAP双键结合化合物的用途公开(公告)号：US20110171171A1
公开(公告)日：2011-07-14
申请号：US13001028
申请日：2009-06-26
IPC分类号： A61K38/20 , C07D403/12 , C07D405/14 , C07D401/14 , C07D417/14 , C07D401/12 , C07D413/12 , A61K38/05 , A61K39/395 , C12N5/071 , A61P35/00 , A61P19/02 , A61P29/00 , A61P37/02 , A61P7/06 , A61P7/00 , A61P1/08
CPC分类号： G01N33/6872 , A61K38/00 , C07K5/06026 , G01N2333/4704 , G01N2500/00
摘要： A compound of Formula 1.1A: 1.1A or salt thereof, as well as methods of making compounds of Formula 1.1A, methods of using compounds of Formula 1.1A to treat proliferative disorders such as cancer, and related compounds, composition, and methods.
摘要翻译： 式1.1A的化合物或其盐，以及制备式1.1A化合物的方法，使用式1.1A化合物治疗增殖性疾病如癌症的方法，以及相关化合物，组合物和方法。
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公开(公告)号：US20130040892A1
公开(公告)日：2013-02-14
申请号：US13578574
申请日：2011-02-11
申请人： Alain Laurent , Melanie Proulx , Yannick Rose , Irina Denissova , Kenza Dairi , Scott Jarvis , James B. Jaquith
发明人： Alain Laurent , Melanie Proulx , Yannick Rose , Irina Denissova , Kenza Dairi , Scott Jarvis , James B. Jaquith
IPC分类号： A61K38/05 , C12N5/078 , C12N5/0787 , A61P29/00 , C07D471/04 , A61P35/00 , A61P37/00 , C12N5/071 , C07K5/062
CPC分类号： C07K5/06026 , A61K38/00 , C07K5/06034
摘要： A compound of Formula 1: (I) or salt thereof, as well as methods of making compounds of Formula 1, methods of using compounds of Formula 1 to treat proliferative disorders such as cancer, and related compounds, composition, and methods.
摘要翻译： 式1化合物或其盐，以及制备式1化合物的方法，使用式1化合物治疗增殖性疾病如癌症的方法及其相关化合物，组合物和方法。
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公开(公告)号：US09284350B2
公开(公告)日：2016-03-15
申请号：US13578574
申请日：2011-02-11
申请人： Alain Laurent , Melanie Proulx , Yannick Rose , Irina Denissova , Kenza Dairi , Scott Jarvis , James B. Jaquith
发明人： Alain Laurent , Melanie Proulx , Yannick Rose , Irina Denissova , Kenza Dairi , Scott Jarvis , James B. Jaquith
CPC分类号： C07K5/06026 , A61K38/00 , C07K5/06034
摘要： A compound of Formula 1: (I) or salt thereof, as well as methods of making compounds of Formula 1, methods of using compounds of Formula 1 to treat proliferative disorders such as cancer, and related compounds, composition, and methods.
摘要翻译： 式1化合物或其盐，以及制备式1化合物的方法，使用式1化合物治疗增殖性疾病如癌症的方法及其相关化合物，组合物和方法。
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公开(公告)号：US20150210696A1
公开(公告)日：2015-07-30
申请号：US14008977
申请日：2012-04-03
申请人： Alain Laurent , Yannick Rose , Stephen Morris , James Jaquith
发明人： Alain Laurent , Yannick Rose , Stephen Morris , James Jaquith
IPC分类号： C07D487/04 , C07C253/30 , C07D209/52 , C07D413/12 , C07C269/06 , C07D491/147 , C07D261/14
CPC分类号： C07D487/04 , C07C253/30 , C07C269/06 , C07D209/52 , C07D261/14 , C07D413/12 , C07D491/147
摘要： The present invention relates to novel kinase inhibitors. Compounds of this class have been found to be effective inhibitors of protein kinases; including members of PDGFR and VEGFR families.
摘要翻译： 本发明涉及新型激酶抑制剂。 已经发现该类化合物是蛋白激酶的有效抑制剂; 包括PDGFR和VEGFR家族成员。
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公开(公告)号：US20140045833A1
公开(公告)日：2014-02-13
申请号：US14009635
申请日：2012-04-03
申请人： Alain Laurent , Yannick Rose , Stephen Morris , James Jaquith
发明人： Alain Laurent , Yannick Rose , Stephen Morris , James Jaquith
IPC分类号： C07D495/14 , C07D491/147 , C07D487/04
CPC分类号： C07D495/14 , C07D487/04 , C07D487/14 , C07D491/147 , C07K14/4703 , C12N9/1205 , C12Q1/485
摘要： The present invention relates to a novel family of inhibitors of protein kinases of Formula (1) wherein X is selected from CH2, O, S(0)n, or NR6; and process for their production and pharmaceutical compositions thereof. In particular, the present invention relates to inhibitors of the members of the Tec, Src, Btk and Lck protein kinase families.
摘要翻译： 本发明涉及一种新型的式（1）蛋白激酶抑制剂，其中X选自CH 2，O，S（O）n或NR 6; 及其制备方法及其药物组合物。 特别地，本发明涉及Tec，Src，Btk和Lck蛋白激酶家族成员的抑制剂。
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公开(公告)号：US09624239B2
公开(公告)日：2017-04-18
申请号：US14009635
申请日：2012-04-03
申请人： Alain Laurent , Yannick Rose , Stephen Morris , James Jaquith
发明人： Alain Laurent , Yannick Rose , Stephen Morris , James Jaquith
IPC分类号： A61K31/519 , C07D487/04 , C07D491/147 , C07D495/14 , C12Q1/48 , C07D487/14 , C07K14/47 , C12N9/12
CPC分类号： C07D495/14 , C07D487/04 , C07D487/14 , C07D491/147 , C07K14/4703 , C12N9/1205 , C12Q1/485
摘要： The present invention relates to a novel family of inhibitors of protein kinases of Formula (1) wherein X is selected from CH2, O, S(0)n, or NR6; and process for their production and pharmaceutical compositions thereof. In particular, the present invention relates to inhibitors of the members of the Tec, Src, Btk and Lck protein kinase families.
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公开(公告)号：US09284318B2
公开(公告)日：2016-03-15
申请号：US14008977
申请日：2012-04-03
申请人： Alain Laurent , Yannick Rose , Stephen Morris , James Jaquith
发明人： Alain Laurent , Yannick Rose , Stephen Morris , James Jaquith
IPC分类号： C07D487/04 , C07D491/147 , C07C253/30 , C07C269/06 , C07D209/52 , C07D261/14 , C07D413/12
CPC分类号： C07D487/04 , C07C253/30 , C07C269/06 , C07D209/52 , C07D261/14 , C07D413/12 , C07D491/147
摘要： The present invention relates to novel kinase inhibitors. Compounds of this class have been found to be effective inhibitors of protein kinases, including members of PDGFR and VEGFR families.
摘要翻译： 本发明涉及新型激酶抑制剂。 已经发现该类化合物是蛋白激酶的有效抑制剂，包括PDGFR和VEGFR家族的成员。
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公开(公告)号：US20100203012A1
公开(公告)日：2010-08-12
申请号：US12601997
申请日：2008-05-30
申请人： Alain Laurent , Patrick Bureau , James Jaquith , John Gillard , Yannick Rose
发明人： Alain Laurent , Patrick Bureau , James Jaquith , John Gillard , Yannick Rose
IPC分类号： A61K38/21 , C07D241/04 , A61K31/497 , C12N5/071 , A61P37/06 , A61P35/00
CPC分类号： C07D241/04 , A61K49/0002 , A61K49/0021 , A61K49/0043 , A61K49/0056 , C07D401/14 , C07D403/14 , C07D409/14 , G01N33/57415 , G01N33/57449
摘要： Disclosed herein is a compound of Formula 1: or a salt thereof, in which R1, R1a, R100, R100a, R2, R200, R3, R300, A, A1, Q, Q1 and BG are as defined herein. Also disclosed is the use of the compounds of Formula 1 to treat disorders of dysregulated apoptosis, such as cancer and cellular proliferative disorders.
摘要翻译： 本文公开了式1的化合物或其盐，其中R 1，R 1a，R 100，R 100，R 2a，R 100，R 3，R 300，A，A 1，Q，Q 1和BG如本文所定义。 还公开了式1的化合物用于治疗失调性细胞凋亡的疾病，例如癌症和细胞增殖性疾病。
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