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    Supports and combinatorial chemical libraries thereof encoded by non-sequencable tags
    9.
    发明授权
    Supports and combinatorial chemical libraries thereof encoded by non-sequencable tags 失效
    由非可序列标签编码的支持体和组合化学文库

    公开(公告)号：US6001579A

    公开(公告)日：1999-12-14

    申请号：US485018

    申请日：1995-06-07

    申请人： W. Clark Still ,  Michael H. Wigler ,  Michael H. J. Ohlmeyer ,  Lawrence W. Dillard ,  John C. Reader

    发明人： W. Clark Still ,  Michael H. Wigler ,  Michael H. J. Ohlmeyer ,  Lawrence W. Dillard ,  John C. Reader

    IPC分类号： C07D243/16 ,  G01N33/53 ,  G01N33/543 ,  G01N33/546 ,  G01N33/566 ,  G01N33/58

    CPC分类号： C07D243/28 ,  C07D491/048 ,  C40B40/04 ,  C40B50/16 ,  C40B70/00 ,  G01N33/54313 ,  G01N33/54353 ,  C07B2200/11

    摘要： Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and synthetic non-repetitive organic molecules. Conveniently, nested families of compounds can be employed as identifiers, where number and/or position of a substituent define the choice. Alternatively, detectable functionalities may be employed, such as radioisotopes, fluorescers, halogens, and the like, where presence and ratios of two different groups can be used to define stage or choice. Particularly, pluralities of identifiers may be used to provide a binary or higher code, so as to define a plurality of choices with only a few detachable tags. The particles may be screened for a characteristic of interest, particularly binding affinity, where the products may be detached from the particle or retained on the particle. The reaction history of the particles which are positive for the characteristic can be determined by the release of the tags and analysis to define the reaction history of the particle.

    摘要翻译： 提供了编码的组合化学，其中使用有机分子记录顺序合成方案，其定义了反应物的选择和阶段，作为相同或不同的信息位。 可以在多级合成中产生各种产物，例如低聚物和合成的非重复有机分子。 方便地，化合物的嵌套族可以用作标识符，其中取代基的数目和/或位置定义了选择。 或者，可以使用可检测的官能团，例如放射性同位素，荧光剂，卤素等，其中两个不同基团的存在和比例可用于限定阶段或选择。 特别地，可以使用多个标识符来提供二进制或更高代码，以便仅限定几个可拆卸标签来定义多个选择。 可以筛选颗粒以获得感兴趣的特征，特别是结合亲和力，其中产物可以与颗粒分离或保留在颗粒上。 对特征呈阳性的颗粒的反应历程可以通过标签的释放和分析来确定以确定颗粒的反应历程。

    Complex combinatorial chemical libraries encoded with tags
    10.
    发明授权
    Complex combinatorial chemical libraries encoded with tags 失效
    用标签编码的复杂组合化学文库

    公开(公告)号：US06503759B1

    公开(公告)日：2003-01-07

    申请号：US08722014

    申请日：1997-02-07

    申请人： W. Clark Still ,  Michael H. J. Ohlmeyer ,  Lawrence W. Dillard ,  John C. Reader ,  Michael H. Wigler

    发明人： W. Clark Still ,  Michael H. J. Ohlmeyer ,  Lawrence W. Dillard ,  John C. Reader ,  Michael H. Wigler

    IPC分类号： G01N33543

    CPC分类号： G01N33/68 ,  B01J2219/00572 ,  C07B2200/11 ,  C07D243/24 ,  C07H21/00 ,  C07K1/047 ,  C40B50/16 ,  C40B70/00 ,  G01N33/532 ,  G01N33/54353

    摘要： Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and synthetic non-repetitive organic molecules. Conveniently, nested families of compounds can be employed as identifiers, where number and/or position of a substituent define the choice. Alternatively, detectable functionalities may be employed, such as radioisotopes, fluorescers, halogens, and the like, where presence and ratios of two different groups can be used to define stage or choice. Particularly, pluralities of identifiers may be used to provide a binary or higher code, so as to define a plurality of choices with only a few detachable tags. The particles may be screened for a characteristic of interest, particularly binding affinity, where the products may be detached from the particle or retained on the particle. The reaction history of the particles which are positive for the characteristic can be determined by the release of the tags and analysis to define the reaction history of the particle.

    摘要翻译： 提供了编码的组合化学，其中使用有机分子记录顺序合成方案，其定义了反应物的选择和阶段，作为相同或不同的信息位。 可以在多级合成中产生各种产物，例如低聚物和合成的非重复有机分子。 方便地，化合物的嵌套族可以用作标识符，其中取代基的数目和/或位置定义了选择。 或者，可以使用可检测的官能团，例如放射性同位素，荧光剂，卤素等，其中两个不同基团的存在和比例可用于限定阶段或选择。 特别地，可以使用多个标识符来提供二进制或更高代码，以便仅限定几个可拆卸标签来定义多个选择。 可以筛选颗粒以获得感兴趣的特征，特别是结合亲和力，其中产物可以与颗粒分离或保留在颗粒上。 对特征呈阳性的颗粒的反应历程可以通过标签的释放和分析来确定以确定颗粒的反应历程。